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Completed study. In this feasibility study, hyperoxemia, as proximated by transcutaneous hemoglobin saturation with oxygen (Sp02), at the time of birth will cause sustained pulmonary oxidative stress as demonstrated by elevation of ulmonary protein carbonyl. Furthermore, this oxidative stress will be directly proportional to the imposed oxygen-burden during resuscitation at the time of birth. This study will give us information regarding the magnitude of protein carbonyl elevation in the preterm infant. With these results we will be able to 1. establish the technique for the running or protein carbonyl assays and 2. calculate an appropriate sample size for a future randomized control trial.

European study to find out whether 4 different protein sources affect the rate of gastric emptying and electrofysiology in this group of children.The protein composition of nutrition may affect the rate of gastric emptying and gastric fysiology. This is especially important in children with neurologic impariment, who commonly rely on tube feedings, have feeding problems, nausea, vomiting, gastroesophageal reflux and delayed gastric emptying.

"The focus of the study is on the plentiful neurons that communicate with each other through the neurotransmitter glutamate. While glutamate is a necessary excitatory substance in the nervous system, in excess, it overstimulates and becomes toxic - excitotoxic - to neurons. Fortunately, neighboring astrocytes can mop up the excess via molecular transporters embedded in their outer membranes. The chief transporter is a protein called EAAT2. Earlier Rothstein's group showed that astroglia - and their EAAT2 protein - are critical for normal neuron activity. In test rats whose astroglia lack the EAAT2 equivalent there's not only a flood of toxic glutamate but a resulting neuron death that leads to paralysis."

Developed by the National Center for Biotechnology Information (NCBI) at the National Library of Medicine (NLM), located at the U.S. National Institutes of Health (NIH). Text-based search and retrieval system used at NCBI for services including PubMed, Nucleotide and Protein Sequences, Protein Structures, Complete Genomes, Taxonomy, OMIM, and many others. Provides access to citations from biomedical literature. LinkOut provides access to full-text articles at journal Web sites and other related Web resources. PubMed also provides access and links to the other Entrez molecular biology resources.

Future planned study sponsored by Ullevaal University Hospital to find out whether 4 different protein sources affect the rate of gastric emptying and electrofysiology in study group of children

Study is conducted to examine the suitability of partially hydrolyzed low protein infant formula with and without pro- and prebiotics for healthy, term infants

Future planned study to assess the effect of the Protein Composition on the Gastric Emptying Rate in Children With Cerebral Paresis and find out whether 4 different protein sources affect the rate of gastric emptying and electrofysiology in children with cerebral palsy

Planned future study investigating the protein composition of nutrition may affect the rate of gastric emptying and gastric pysiology. This is espesially important in children with neurologic impariment, who commonly rely on tube feedings, have feeding proThe intent is to find out whether 4 different protein sources affect the rate of gastric emptying and electrofysiology in this group of children

Study will measure the frequency of several coagulation factor abnormalities (factor V Leiden, prothrombin 20210A, protein C, protein S, antithrombin III, and antiphospholipid antibodies) in children with a history of porencephaly and stroke, and will compare these to the prevalence of these mutations in population controls and family members.

Neurotrophins Definition at RCSB Protein Data Bank

PubMed Abstract: Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins

Fragile X syndrome is the leading hereditary cause of developmental disabilities in all populations. The absence of a functional fragile X gene shuts off production of a special protein in the brain needed for normal cognitive development. Without this protein, children with the syndrome will never learn normally, despite hours of therapy and rehabilitation.

Purpose of this study is to assess the effectiveness and safety of rabeprazole sodium, an inhibitor of gastric acid secretion of the protein pump inhibitor (PPI) class, compared with placebo in the treatment of gastrointestinal esophageal reflux disease (GERD) in infants 1 to 11 months of age.

Objective is to determine if a connection exists between proton pump inhibitor antacids and decreased rate of bone mineralization in neonates