Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model.
Ho YT, Yang JS, Lu CC, Chiang JH, Li TC, Lin JJ, Lai KC, Liao CL, Lin JG, Chung JG.
Phytomedicine. 2009 Sep;16(9):887-90. Epub 2009 Mar 20.
PMID: 19303753
Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10mg/kg of body weight) and doxorubicin (4mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4mg/kg of doxorubicin or with 10mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic.
It was concluded that omega-3 fatty acid could inhibit the proliferation of pancreatic cancer cell line SW1990 cells and promote their apoptosis. The down-regulation of the cyclin E expression by omega-3 fatty acid might be one of the mechanisms for its anti-tumor effect on pancreatic cancer.
Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells.
Zhang W, Long Y, Zhang J, Wang C.
J Huazhong Univ Sci Technolog Med Sci. 2007 Oct;27(5):547-50.
PMID: 18060632
Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus).
Chen S, Oh SR, Phung S, Hur G, Ye JJ, Kwok SL, Shrode GE, Belury M, Adams LS, Williams D.
Cancer Res. 2006 Dec 15;66(24):12026-34.
PMID: 17178902
doi: 10.1158/0008-5472.CAN-06-2206
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
Casanova ML, Blázquez C, Martínez-Palacio J, Villanueva C, Fernández-Aceñero MJ, Huffman JW, Jorcano JL, Guzmán M.
J Clin Invest. 2003 Jan;111(1):43-50.
PMID: 12511587
doi:10.1172/JCI16116
A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs.
Sun Y, Xun K, Wang Y, Chen X.
Anticancer Drugs. 2009 Oct;20(9):757-69.
PMID: 19704371
Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells.
Habbel P, Weylandt KH, Lichopoj K, Nowak J, Purschke M, Wang JD, He CW, Baumgart DC, Kang JX.
World J Gastroenterol. 2009 Mar 7;15(9):1079-84.
PMID: 19266600