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Joseph Grimes

Animal Primary Cells - 0 views

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    Creative Bioarray offers 160 different cell types by experimenting more than 13 types of animals. All the cells are taken form living animal tissues. Our scientists also select primary cells of human and other animal for comparative testing between human and other animal cells.
Matti Narkia

DHA reduces tumor growth - Life Extension Update - 0 views

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    Mice injected with cancer cells experienced significantly elevated levels of C-reactive protein, white blood cells, and lipid peroxidation compared with control mice. These levels were reduced in animals that received cisplatin and/or DHA. While treatment with 125 mg/kg DHA inhibited tumor growth by 38 percent compared to untreated animals, 250 mg/kg suppressed tumor growth by 79 percent, which was a greater effect than that of cisplatin alone (which was associated with a 55 percent reduction). The combination of DHA and cisplatin resulted in an 81 percent inhibition of growth, while reducing elevated white blood cell levels (leukocytosis) to normal levels. Treatment with the higher dose of DHA alone was associated with a similar reduction in white blood cells, which, when elevated, are associated with tumor growth. A strong relationship was observed between tumor growth and white blood cell levels as well as C-reactive protein levels. In another experiment with rats treated with cisplatin, the addition of 250 mg/kg DHA prevented lethal kidney toxicity in 88 percent of the animals that received it, while none of the rats that received cisplatin alone survived.
Matti Narkia

Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xeno... - 0 views

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    Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model. Ho YT, Yang JS, Lu CC, Chiang JH, Li TC, Lin JJ, Lai KC, Liao CL, Lin JG, Chung JG. Phytomedicine. 2009 Sep;16(9):887-90. Epub 2009 Mar 20. PMID: 19303753 Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10mg/kg of body weight) and doxorubicin (4mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4mg/kg of doxorubicin or with 10mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic.
Matti Narkia

Carbohydrate restriction may slow prostate tumor growth - eurekalert.org - 0 views

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    DURHAM, N.C. -- Restricting carbohydrates, regardless of weight loss, appears to slow the growth of prostate tumors, according to an animal study being published this week by researchers in the Duke Prostate Center. "Previous work here and elsewhere has shown that a diet light in carbohydrates could slow tumor growth, but the animals in those studies also lost weight, and because we know that weight loss can restrict the amount of energy feeding tumors, we weren't able to tell just how big an impact the pure carbohydrate restriction was having, until now," said Stephen Freedland, M.D., a urologist in the Duke Prostate Center and lead investigator on this study. The researchers believe that insulin and insulin-like growth factor contribute to the growth and proliferation of prostate cancer, and that a diet devoid of carbohydrates lowers serum insulin levels in the bodies of the mice, thereby slowing tumor growth, Freedland said.
Matti Narkia

Sloan-Kettering - AHCC - 0 views

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    A proprietary extract prepared from co-cultured mycelia of several species of Basidiomycete mushrooms, including shiitake (Lentinus edodes), active hexose correlated compound (AHCC) is extracted from mushrooms using hot water following an enzyme pretreatment, but specific mushroom source and preparation details have not been fully disclosed. Patients use this to prevent and treat cancer. Animal studies suggest that AHCC has antioxidant effects and may protect against disorders induced by oxidative stress (1) and may also enhance resistance against bacterial (2) (7)and viral infections (3). In healthy humans, AHCC increased dendritic cell number and function (4) In vitro and animal studies show that AHCC exhibits some anticancer activities, but the results of these studies are vague
Matti Narkia

Excessive Dietary Fat Caused 300 Percent Increase in Metastasizing Tumor Cells In Anima... - 0 views

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    ScienceDaily (Feb. 25, 2009) - Researchers at Purdue University have precisely measured the impact of a high-fat diet on the spread of cancer, finding that excessive dietary fat caused a 300 percent increase in metastasizing tumor cells in laboratory animals.
Tonny Johnson

Cell Based Reporter Assays vs. Animal Studies in Drug Discovery- Potential Limitations,... - 0 views

This blog critically analyzes the potential scientific limitations, risks and liabilities of cell based reporter assays, including non-natural protein based reporter assays (e.g. circularly permute...

cell absed reporter assays drug discovery circularly permuted firefly luciferase

started by Tonny Johnson on 18 Jan 12 no follow-up yet
stevencd

Mesothelioma Cells - 0 views

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    Creative Bioarray provides various human and animal cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray offers Mesothelioma Cells for your research.
stevencd

Leukemia/Lymphoma/Myeloma Cells - 0 views

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    Creative Bioarray provides various human and animal cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray offers Leukemia/Lymphoma/Myeloma Cells for your research.
stevencd

Skin Tumor Cells - 0 views

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    Creative Bioarray maintains various human and animal tumor cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray consistently attains the highest standards and uses the most reliable procedures to verify every cell line.
stevencd

Melanoma Cells - 0 views

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    Creative Bioarray provides various human and animal cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray offers Melanoma Cells for your research.
stevencd

Uterine/Cervix Tumor Cells - 0 views

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    Creative Bioarray provides various human and animal cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray offers Uterine/Cervix Tumor Cells for your research.
stevencd

Thyroid Tumor Cells - 0 views

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    Creative Bioarray provides various human and animal cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray offers Thyroid Tumor Cells for your research.
stevencd

Mouse Tumor Cells - 0 views

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    Creative Bioarray provides various human and animal cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray offers Mouse Tumor Cells for your research.
stevencd

Endocrine Cells - 0 views

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    Creative Bioarray provides various human and animal cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray offers Endocrine Cells for your research.
stevencd

Gastrointestinal Cells - 0 views

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    Creative Bioarray provides various human and animal cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray offers Gastrointestinal Cells for your research. Call 1-631-626-9181 or Email us at contact@creative-bioarray.com to know more.
stevencd

Gallbladder Cells - 0 views

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    Creative Bioarray provides various human and animal cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray offers Gallbladder Cells for your research. Call 1-631-626-9181 or Email us at contact@creative-bioarray.com to know more.
stevencd

Embryonic Stem Cells - 0 views

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    Creative Bioarray provides various human and animal cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray offers Embryonic Stem Cells for your research.
Matti Narkia

Technology Review: Implant Makes Cells Kill Cancer - 0 views

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    A new approach to cancer treatment called immunotherapy could spare patients at least some of the grueling battery of chemotherapy treatments by retraining the body's own defenders--the cells of the immune system--to recognize and destroy tumors. Now researchers at Harvard University have developed a simple way to do this inside the body: a polymer implant attracts and trains immune-system cells to go after cancer. The experimental approach has shown great success in animal studies, increasing the survival rate of mice with a deadly melanoma from 0 to 90 percent. The implant could also be used to treat diseases of the immune system such as arthritis and diabetes, and, potentially, to train other kinds of cells, including stem cells used to repair damage to the body.
Matti Narkia

Lingzhi mushroom - Wikipedia, the free encyclopedia - 0 views

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    "Língzhī (traditional Chinese: 靈芝; simplified Chinese: 灵芝; Japanese: reishi; Korean: yeongji, hangul: 영지) is the name for one form of the mushroom Ganoderma lucidum, and its close relative Ganoderma tsugae. Ganoderma lucidum enjoys special veneration in Asia, where it has been used as a medicinal mushroom in traditional Chinese medicine for more than 4,000 years, making it one of the oldest mushrooms known to have been used in medicine. Lingzhi may possess anti-tumor, immunomodulatory and immunotherapeutic activities, supported by studies on polysaccharides, terpenes, and other bioactive compounds isolated from fruiting bodies and mycelia of this fungus (reviewed by R. R. Paterson[4] and Lindequist et al.[7]). It has also been found to inhibit platelet aggregation, and to lower blood pressure (via inhibition of angiotensin-converting enzyme[8]), cholesterol and blood sugar.[9] Laboratory studies have shown anti-neoplastic effects of fungal extracts or isolated compounds against some types of cancer. In an animal model, Ganoderma has been reported to prevent cancer metastasis,[10] with potency comparable to Lentinan from Shiitake mushrooms.[11] The mechanisms by which G. lucidum may affect cancer are unknown and they may target different stages of cancer development: inhibition of angiogenesis (formation of new, tumor-induced blood vessels, created to supply nutrients to the tumor) mediated by cytokines, cytoxicity, inhibiting migration of the cancer cells and metastasis, and inducing and enhancing apoptosis of tumor cells
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