Group items tagged cancer inhibitor - Cancer

Experimental Drug May Work In Many Cancers - 2 views

Matti Narkia on 08 Oct 09

"SCIENTISTS have shown that a new class of cancer drugs called PARP inhibitors, currently being tested in clinical trials to treat breast and ovarian cancer could have dramatic results when used to treat other solid tumours, according to work presented at the NCRI Cancer Conference today. "

<div class="cArrow"> </div><div class="cContentInner">"SCIENTISTS have shown that a new class of cancer drugs called PARP inhibitors, currently being tested in clinical trials to treat breast and ovarian cancer could have dramatic results when used to treat other solid tumours, according to work presented at the NCRI Cancer Conference today. "</div>

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Compound found in beans, nuts and cereals beats cancer (inositol pentakisphosphate) - 0 views

Matti Narkia on 28 Mar 09

A collaborative study led by UCL (University College London) shows that the compound - inositol pentakisphosphate - found in beans, nuts and cereals inhibits a key enzyme (phosphoinositide 3-kinase) involved in tumour growth. The findings, published in the latest issue of Cancer Research, suggest that a diet enriched in such foods could help prevent cancer, while the inhibitor offers a new tool for anti-cancer therapy.

<div class="cArrow"> </div><div class="cContentInner">A collaborative study led by UCL (University College London) shows that the compound - inositol pentakisphosphate - found in beans, nuts and cereals inhibits a key enzyme (phosphoinositide 3-kinase) involved in tumour growth. The findings, published in the latest issue of Cancer Research, suggest that a diet enriched in such foods could help prevent cancer, while the inhibitor offers a new tool for anti-cancer therapy. </div>

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Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms... - 0 views

Matti Narkia on 09 Apr 09

Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. Attard G, Reid AH, Yap TA, Raynaud F, Dowsett M, Settatree S, Barrett M, Parker C, Martins V, Folkerd E, Clark J, Cooper CS, Kaye SB, Dearnaley D, Lee G, de Bono JS. J Clin Oncol. 2008 Oct 1;26(28):4563-71. Epub 2008 Jul 21. PMID: 18645193 DOI: 10.1200/JCO.2007.15.9749

<div class="cArrow"> </div><div class="cContentInner">Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. Attard G, Reid AH, Yap TA, Raynaud F, Dowsett M, Settatree S, Barrett M, Parker C, Martins V, Folkerd E, Clark J, Cooper CS, Kaye SB, Dearnaley D, Lee G, de Bono JS. J Clin Oncol. 2008 Oct 1;26(28):4563-71. Epub 2008 Jul 21. PMID: 18645193 DOI: 10.1200/JCO.2007.15.9749</div>

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Experimental insulin-like growth factor receptor inhibitor reduced pancreatic cancer gr... - 0 views

Matti Narkia on 14 Apr 09

PHILADELPHIA - Researchers at Amgen are testing a fully human monoclonal antibody that inhibits the activity of insulin-like growth factors (IGF-1 and IGF-2) and appears to reduce pancreatic cancer cells in early testing, according to a report in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research.

<div class="cArrow"> </div><div class="cContentInner">PHILADELPHIA - Researchers at Amgen are testing a fully human monoclonal antibody that inhibits the activity of insulin-like growth factors (IGF-1 and IGF-2) and appears to reduce pancreatic cancer cells in early testing, according to a report in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research.</div>

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PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexae... - 0 views

www.ncbi.nlm.nih.gov/...19426685

2009 May study research in_vitro PPARalpha clioquinol DHA omega-3 cancer nutrition medline synergy synergistic

shared by Matti Narkia on 03 Jun 09 - No Cached

Matti Narkia on 03 Jun 09

The combination effects index (CI) analysis confirmed the synergy of clioquinol and clofibrate on inhibiting cancer cell viability. Using inhibitors to block PPARalpha signaling diminished the synergistic cytotoxicity of clioquinol and DHA. These results provide pharmacological evidence that the synergistic anticancer action of clioquinol and DHA is mediated by PPARalpha signaling in human cancer cells. PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells. Tuller ER, Brock AL, Yu H, Lou JR, Benbrook DM, Ding WQ. Biochem Pharmacol. 2009 May 1;77(9):1480-6. Epub 2009 Feb 13. PMID: 19426685

<div class="cArrow"> </div><div class="cContentInner">The combination effects index (CI) analysis confirmed the synergy of clioquinol and clofibrate on inhibiting cancer cell viability. Using inhibitors to block PPARalpha signaling diminished the synergistic cytotoxicity of clioquinol and DHA. These results provide pharmacological evidence that the synergistic anticancer action of clioquinol and DHA is mediated by PPARalpha signaling in human cancer cells. PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells. Tuller ER, Brock AL, Yu H, Lou JR, Benbrook DM, Ding WQ. Biochem Pharmacol. 2009 May 1;77(9):1480-6. Epub 2009 Feb 13. PMID: 19426685 </div>

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Green Beans for Cancer Prevention and Treatment. ( It is well known that eating green v... - 0 views

www.bio-medicine.org/...evention-and-Treatment--4901-1

anti-cancer cancer nutrition diet green beans green beans green_beans wheat_bran inositol pentakisphosphate inositol_pentakisphosphate

shared by Matti Narkia on 28 Mar 09 - Cached

Matti Narkia on 28 Mar 09

It is well known that eating green vegetables, beans, nuts, cereals and fruits prevents cancer, now it is found that beans and wheat bran contains an enzyme inhibitor Inositol // pentakisphosphate which is found to have anti-cancer effects by blocking the action of enzyme Phosphoinositide 3 kinase.

<div class="cArrow"> </div><div class="cContentInner">It is well known that eating green vegetables, beans, nuts, cereals and fruits prevents cancer, now it is found that beans and wheat bran contains an enzyme inhibitor Inositol // pentakisphosphate which is found to have anti-cancer effects by blocking the action of enzyme Phosphoinositide 3 kinase. </div>

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Cancer Therapy With Tetrathiomolybdate: Antiangiogenesis by Lowering Body Copper-A Revi... - 0 views

Matti Narkia on 24 Feb 09

Brewer GJ, Merajver SD. Cancer therapy with tetrathiomolybdate: antiangiogenesis by lowering body copper--a review. Integr Cancer Ther. 2002 Dec;1(4):327-37. Review. PMID: 14664727 [PubMed - indexed for MEDLINE]

<div class="cArrow"> </div><div class="cContentInner">Brewer GJ, Merajver SD. Cancer therapy with tetrathiomolybdate: antiangiogenesis by lowering body copper--a review. Integr Cancer Ther. 2002 Dec;1(4):327-37. Review. PMID: 14664727 [PubMed - indexed for MEDLINE]</div>

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Phase II Trial of Tetrathiomolybdate in Patients with Advanced Kidney Cancer -- Redman ... - 0 views

Matti Narkia on 24 Feb 09

B. G. Redman, P. Esper, Q. Pan, R. L. Dunn, H. K. Hussain, T. Chenevert, G. J. Brewer, and S. D. Merajver Phase II Trial of Tetrathiomolybdate in Patients with Advanced Kidney Cancer Clin. Cancer Res., May 1, 2003; 9(5): 1666 - 1672.

<div class="cArrow"> </div><div class="cContentInner">B. G. Redman, P. Esper, Q. Pan, R. L. Dunn, H. K. Hussain, T. Chenevert, G. J. Brewer, and S. D. Merajver Phase II Trial of Tetrathiomolybdate in Patients with Advanced Kidney Cancer Clin. Cancer Res., May 1, 2003; 9(5): 1666 - 1672.</div>

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Tetrathiomolybdate: Cancer Protocol. The Treatment and Management of Cancer Today. A re... - 0 views

Matti Narkia on 24 Feb 09

If angiogenesis controls cancer growth, what controls angiogenesis? Researchers at the University of Michigan and the University of South Florida believe that the copper status is critical to the function growth factors.

<div class="cArrow"> </div><div class="cContentInner">If angiogenesis controls cancer growth, what controls angiogenesis? Researchers at the University of Michigan and the University of South Florida believe that the copper status is critical to the function growth factors.</div>

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Tetrathiomolybdate copper reduction anti-angiogenesis cancer treatment - anticopper, TM. - 0 views

Matti Narkia on 24 Feb 09

WARNING: This page was NOT created or approved by any doctor or medical researcher. The purpose of this page is to provide hard-to-find information on copper reduction cancer treatment, a new unapproved and experimental course of cancer treatment whose ef

<div class="cArrow"> </div><div class="cContentInner">WARNING: This page was NOT created or approved by any doctor or medical researcher. The purpose of this page is to provide hard-to-find information on copper reduction cancer treatment, a new unapproved and experimental course of cancer treatment whose ef</div>

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TGF-beta inhibitors: Tumors stopped from spreading to new sites - 0 views

Matti Narkia on 24 Feb 09

For several types of cancer, persistently high levels of the soluble factor TGF-beta in the blood after surgery, chemotherapy, or radiation therapy correlate with increased risk of early metastasis and a poor prognosis. Using a mouse model of breast cance

<div class="cArrow"> </div><div class="cContentInner">For several types of cancer, persistently high levels of the soluble factor TGF-beta in the blood after surgery, chemotherapy, or radiation therapy correlate with increased risk of early metastasis and a poor prognosis. Using a mouse model of breast cance</div>

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Vitamin D may inhibit prostate cancer growth - mechanism reported - 0 views

www.nutraingredients.com/...ng.asp

2006 february news prostate cancer prostate_cancer PCa vitamin_D vitamin D growth-inhibitory mechanism mechanisms

shared by Matti Narkia on 24 Feb 09 - Cached

Matti Narkia on 24 Feb 09

The in vitro study, reported in the journal Carcinogenesis (Vol. 27, pp. 32-42), showed that vitamin D, in the form of the highly active 1alpha, 25-dihydroxyvitamin D3 (1,25-VD), inhibited the function of protease enzymes that are involved in tumour invasion. "We found that 1,25-VD decreased matric metalloproteinases (MMP-9) and cathepsins (CPs), while it [also] increased the activity of their counterparts, tissue inhibitors of metalloproteinase-1 (TIMP-1) and cathepsin inhibitors," wrote lead author Bo-Ying Bao from the University of Rochester and Taipei Medical University. "Mechanistic studies showed that 1,25-VD did not suppress MMP-9 expression at the transcriptional level, but reduced its mRNA stability," said Bao.

<div class="cArrow"> </div><div class="cContentInner">The in vitro study, reported in the journal Carcinogenesis (Vol. 27, pp. 32-42), showed that vitamin D, in the form of the highly active 1alpha, 25-dihydroxyvitamin D3 (1,25-VD), inhibited the function of protease enzymes that are involved in tumour invasion. "We found that 1,25-VD decreased matric metalloproteinases (MMP-9) and cathepsins (CPs), while it [also] increased the activity of their counterparts, tissue inhibitors of metalloproteinase-1 (TIMP-1) and cathepsin inhibitors," wrote lead author Bo-Ying Bao from the University of Rochester and Taipei Medical University. "Mechanistic studies showed that 1,25-VD did not suppress MMP-9 expression at the transcriptional level, but reduced its mRNA stability," said Bao.</div>

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Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tu... - 0 views

Matti Narkia on 16 Apr 09

Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer. Lönnroth C, Andersson M, Arvidsson A, Nordgren S, Brevinge H, Lagerstedt K, Lundholm K. Cancer Immun. 2008 Feb 29;8:5. PMID: 18307280 MHC II protein (HLA-DP, -DQ, -DR) levels and infiltration by CD4+ T-helper cells of tumor stroma increased upon NSAID treatment, while CD8+ cytotoxic T-lymphocytes increased in both tumor stroma and epithelium. Molecules associated with immunosuppressive T regulatory cells (FOXP3, IL-10) were significantly decreased in indomethacin-exposed tumors. Standard oral administration of NSAID three days preoperatively was enough to increase tumor infiltration by seemingly activated immune cells. These findings agree with previous information that high pr

<div class="cArrow"> </div><div class="cContentInner">Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer. Lönnroth C, Andersson M, Arvidsson A, Nordgren S, Brevinge H, Lagerstedt K, Lundholm K. Cancer Immun. 2008 Feb 29;8:5. PMID: 18307280 MHC II protein (HLA-DP, -DQ, -DR) levels and infiltration by CD4+ T-helper cells of tumor stroma increased upon NSAID treatment, while CD8+ cytotoxic T-lymphocytes increased in both tumor stroma and epithelium. Molecules associated with immunosuppressive T regulatory cells (FOXP3, IL-10) were significantly decreased in indomethacin-exposed tumors. Standard oral administration of NSAID three days preoperatively was enough to increase tumor infiltration by seemingly activated immune cells. These findings agree with previous information that high pr</div>

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Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and prefe... - 0 views

Matti Narkia on 14 Apr 09

Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer. Cerchietti LC, Navigante AH, Castro MA. Nutr Cancer. 2007;59(1):14-20. PMID: 17927497

<div class="cArrow"> </div><div class="cContentInner">Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer. Cerchietti LC, Navigante AH, Castro MA. Nutr Cancer. 2007;59(1):14-20. PMID: 17927497</div>

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Scientists hail the first effective treatment for skin cancer victims - Hea... - 0 views

Matti Narkia on 04 Jun 09

Scientists have developed the first "personalised" drug shown to be effective against advanced melanoma, the deadliest type of skin cancer which is on the rise in Britain. Warnings about the risks of melanoma were heightened this weekend as the fine weather drew thousands to sunbathe outdoors, putting them at increased risk. "Binge tanning", where sunbathers allow their skin to burn in their eagerness to get a tan, is a key cause of the cancer. Melanoma, which starts as a blemish or change to a mole on the skin, is treatable in its early stages but once it has spread to other organs such as the lungs and liver there are no treatment options. Patients with melanoma that has spread usually die within months

<div class="cArrow"> </div><div class="cContentInner">Scientists have developed the first "personalised" drug shown to be effective against advanced melanoma, the deadliest type of skin cancer which is on the rise in Britain. Warnings about the risks of melanoma were heightened this weekend as the fine weather drew thousands to sunbathe outdoors, putting them at increased risk. "Binge tanning", where sunbathers allow their skin to burn in their eagerness to get a tan, is a key cause of the cancer. Melanoma, which starts as a blemish or change to a mole on the skin, is treatable in its early stages but once it has spread to other organs such as the lungs and liver there are no treatment options. Patients with melanoma that has spread usually die within months</div>

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CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependen... - 0 views

Matti Narkia on 09 Apr 09

CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer. Ang JE, Olmos D, de Bono JS. Br J Cancer. 2009 Mar 10;100(5):671-5. Epub 2009 Feb 17. PMID: 19223900 doi:10.1038/sj.bjc.6604904

<div class="cArrow"> </div><div class="cContentInner">CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer. Ang JE, Olmos D, de Bono JS. Br J Cancer. 2009 Mar 10;100(5):671-5. Epub 2009 Feb 17. PMID: 19223900 doi:10.1038/sj.bjc.6604904</div>

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Combination of an EGFR blocker and a COX-2 inhibitor for the treatment of advanced cuta... - 0 views

Matti Narkia on 15 Mar 09

Combination of an EGFR blocker and a COX-2 inhibitor for the treatment of advanced cutaneous squamous cell carcinoma. Jalili A, Pinc A, Pieczkowski F, Karlhofer FM, Stingl G, Wagner SN. J Dtsch Dermatol Ges. 2008 Dec;6(12):1066-9. English, German. PMID: 19138272 DOI: 10.1111/j.1610-0387.2008.06861.x

<div class="cArrow"> </div><div class="cContentInner">Combination of an EGFR blocker and a COX-2 inhibitor for the treatment of advanced cutaneous squamous cell carcinoma. Jalili A, Pinc A, Pieczkowski F, Karlhofer FM, Stingl G, Wagner SN. J Dtsch Dermatol Ges. 2008 Dec;6(12):1066-9. English, German. PMID: 19138272 DOI: 10.1111/j.1610-0387.2008.06861.x</div>

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Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumul... - 0 views

Matti Narkia on 07 Dec 09

Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma. Yoshiji H, Noguchi R, Toyohara M, Ikenaka Y, Kitade M, Kaji K, Yamazaki M, Yamao J, Mitoro A, Sawai M, Yoshida M, Fujimoto M, Tsujimoto T, Kawaratani H, Uemura M, Fukui H. J Hepatol. 2009 Aug;51(2):315-21. Epub 2009 May 15. PMID: 19501932 CONCLUSIONS: The combination treatment of VK and ACE-I may suppress the cumulative recurrence of HCC after the curative therapy, at least partly through suppression of the VEGF-mediated neovascularization.

<div class="cArrow"> </div><div class="cContentInner">Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma. Yoshiji H, Noguchi R, Toyohara M, Ikenaka Y, Kitade M, Kaji K, Yamazaki M, Yamao J, Mitoro A, Sawai M, Yoshida M, Fujimoto M, Tsujimoto T, Kawaratani H, Uemura M, Fukui H. J Hepatol. 2009 Aug;51(2):315-21. Epub 2009 May 15. PMID: 19501932 CONCLUSIONS: The combination treatment of VK and ACE-I may suppress the cumulative recurrence of HCC after the curative therapy, at least partly through suppression of the VEGF-mediated neovascularization.</div>

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Factors Associated With Clinical Benefit From Epidermal Growth Factor Receptor Inhibito... - 0 views

Matti Narkia on 08 Oct 09

Factors associated with clinical benefit from epidermal growth factor receptor inhibitors in recurrent and metastatic squamous cell carcinoma of the head and neck. Cohen EE, Halpern AB, Kasza K, Kocherginsky M, Williams R, Vokes EE. Oral Oncol. 2009 Oct;45(10):e155-60. Epub 2009 Jul 7. PMID: 19586795

<div class="cArrow"> </div><div class="cContentInner">Factors associated with clinical benefit from epidermal growth factor receptor inhibitors in recurrent and metastatic squamous cell carcinoma of the head and neck. Cohen EE, Halpern AB, Kasza K, Kocherginsky M, Williams R, Vokes EE. Oral Oncol. 2009 Oct;45(10):e155-60. Epub 2009 Jul 7. PMID: 19586795 </div>

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Zyflamend((R))-Mediated Inhibition of Human Prostate Cancer PC3 Cell Proliferation: Eff... - 0 views

Matti Narkia on 24 Feb 09

Yang P, Cartwright C, Chan D, Vijjeswarapu M, Ding J, Newman RA. Zyflamend((R))-Mediated Inhibition of Human Prostate Cancer PC3 Cell Proliferation: Effects on 12-LOX and Rb Protein Phosphorylation. Cancer Biol Ther. 2007 Feb 25;6(2) [Epub ahead of pr

<div class="cArrow"> </div><div class="cContentInner">Yang P, Cartwright C, Chan D, Vijjeswarapu M, Ding J, Newman RA. Zyflamend((R))-Mediated Inhibition of Human Prostate Cancer PC3 Cell Proliferation: Effects on 12-LOX and Rb Protein Phosphorylation. Cancer Biol Ther. 2007 Feb 25;6(2) [Epub ahead of pr</div>

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Group items tagged

Experimental Drug May Work In Many Cancers - 2 views

Compound found in beans, nuts and cereals beats cancer (inositol pentakisphosphate) - 0 views

Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms... - 0 views

Experimental insulin-like growth factor receptor inhibitor reduced pancreatic cancer gr... - 0 views

PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexae... - 0 views

Green Beans for Cancer Prevention and Treatment. ( It is well known that eating green v... - 0 views

Cancer Therapy With Tetrathiomolybdate: Antiangiogenesis by Lowering Body Copper-A Revi... - 0 views

Phase II Trial of Tetrathiomolybdate in Patients with Advanced Kidney Cancer -- Redman ... - 0 views

Tetrathiomolybdate: Cancer Protocol. The Treatment and Management of Cancer Today. A re... - 0 views

Tetrathiomolybdate copper reduction anti-angiogenesis cancer treatment - anticopper, TM. - 0 views

TGF-beta inhibitors: Tumors stopped from spreading to new sites - 0 views

Vitamin D may inhibit prostate cancer growth - mechanism reported - 0 views

Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tu... - 0 views

Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and prefe... - 0 views

Scientists hail the first effective treatment for skin cancer victims - Hea... - 0 views

CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependen... - 0 views

Combination of an EGFR blocker and a COX-2 inhibitor for the treatment of advanced cuta... - 0 views

Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumul... - 0 views

Factors Associated With Clinical Benefit From Epidermal Growth Factor Receptor Inhibito... - 0 views

Zyflamend((R))-Mediated Inhibition of Human Prostate Cancer PC3 Cell Proliferation: Eff... - 0 views

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