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Matti Narkia

Selenium and the immune response: 2. Enhancement of murine cytotoxic T-lymphocyte and n... - 0 views

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    2: Selenium and the immune response: 2. Enhancement of murine cytotoxic T-lymphocyte and natural killer cell cytotoxicity in vivo. Petrie HT, Klassen LW, Klassen PS, O'Dell JR, Kay HD. J Leukoc Biol. 1989 Mar;45(3):215-20. PMID: 2564412
Matti Narkia

PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexae... - 0 views

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    The combination effects index (CI) analysis confirmed the synergy of clioquinol and clofibrate on inhibiting cancer cell viability. Using inhibitors to block PPARalpha signaling diminished the synergistic cytotoxicity of clioquinol and DHA. These results provide pharmacological evidence that the synergistic anticancer action of clioquinol and DHA is mediated by PPARalpha signaling in human cancer cells. PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells. Tuller ER, Brock AL, Yu H, Lou JR, Benbrook DM, Ding WQ. Biochem Pharmacol. 2009 May 1;77(9):1480-6. Epub 2009 Feb 13. PMID: 19426685
Matti Narkia

Exercise affects platelet-impeded antitumor cytotoxicity of natural killer cell. - [Med... - 0 views

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    Exercise affects platelet-impeded antitumor cytotoxicity of natural killer cell. Wang JS, Chung Y, Chow SE. Med Sci Sports Exerc. 2009 Jan;41(1):115-22. PMID: 19092699
Matti Narkia

Vitamin C Antagonizes the Cytotoxic Effects of Antineoplastic Drugs - 0 views

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    Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs.\nHeaney ML, Gardner JR, Karasavvas N, Golde DW, Scheinberg DA, Smith EA, O'Connor OA.\nCancer Res. 2008 Oct 1;68(19):8031-8.\nPMID: 18829561
Matti Narkia

Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tu... - 0 views

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    Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer. Lönnroth C, Andersson M, Arvidsson A, Nordgren S, Brevinge H, Lagerstedt K, Lundholm K. Cancer Immun. 2008 Feb 29;8:5. PMID: 18307280 MHC II protein (HLA-DP, -DQ, -DR) levels and infiltration by CD4+ T-helper cells of tumor stroma increased upon NSAID treatment, while CD8+ cytotoxic T-lymphocytes increased in both tumor stroma and epithelium. Molecules associated with immunosuppressive T regulatory cells (FOXP3, IL-10) were significantly decreased in indomethacin-exposed tumors. Standard oral administration of NSAID three days preoperatively was enough to increase tumor infiltration by seemingly activated immune cells. These findings agree with previous information that high pr
Matti Narkia

Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicit... - 0 views

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    Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity. Frank MB, Yang Q, Osban J, Azzarello JT, Saban MR, Saban R, Ashley RA, Welter JC, Fung KM, Lin HK. BMC Complement Altern Med. 2009 Mar 18;9(1):6. [Epub ahead of print] PMID: 19296830 doi:10.1186/1472-6882-9-6
Matti Narkia

Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disea... - 0 views

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    Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Kidd P. Altern Med Rev. 2003 Aug;8(3):223-46. Review. PMID: 12946237 Th1 pathways typically produce activation of cytotoxic T lymphocytes (Tc), NK cells, macrophages, and monocytes, all of which can attack cancer cells and generally defend against tumors.55 IFN-gamma and other Th1 cytokines are typically lower in advanced cancer patients, while the Th2 marker IL-4 can be higher or unchanged
Matti Narkia

Definition of beta-glucan - National Cancer Institute Drug Dictionary - 0 views

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    beta-glucan A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Matti Narkia

The immunobiology of mushrooms. - Exp Biol Med (Maywood). 2008 Mar - 0 views

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    The immunobiology of mushrooms. Borchers AT, Krishnamurthy A, Keen CL, Meyers FJ, Gershwin ME. Exp Biol Med (Maywood). 2008 Mar;233(3):259-76. Review. PMID: 18296732 doi: 10.3181/0708-MR-227
Matti Narkia

Hyperthermia Plus Chemotherapy Nearly Doubles Disease-Free Survival Compared to Chemoth... - 0 views

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    BSD Medical Corp. (Amex: BSM ) announced today that the results of a 340 patient randomized Phase III clinical trial testing the benefit of adding hyperthermia therapy to chemotherapy were presented at the annual American Society of Clinical Oncology (ASC
Matti Narkia

Multiple roles for CD4+ T cells in anti-tumor immune responses. - Wiley InterScience ::... - 0 views

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    Multiple roles for CD4+ T cells in anti-tumor immune responses. Kennedy R, Celis E. Immunol Rev. 2008 Apr;222:129-44. Review. PMID: 18363998 DOI: 10.1111/j.1600-065X.2008.00616.x
Matti Narkia

Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cel... - 0 views

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    Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Jirousková M, Degen JL. Blood. 2005 Jan 1;105(1):178-85. Epub 2004 Sep 14. PMID: 15367435 DOI 10.1182/blood-2004-06-2272
Matti Narkia

Lysis of tumor cells by natural killer cells in mice is impeded by platelets. - Cancer ... - 0 views

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    Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Nieswandt B, Hafner M, Echtenacher B, Männel DN. Cancer Res. 1999 Mar 15;59(6):1295-300. PMID: 10096562
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