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For more than 20 years, theoretical mathematical models have predicted that a delay built into a negative feedback system is at the heart of the molecular mechanism that governs circadian clocks in mammalian cells. Now, the first experimental proof of this theory has been provided by an international research team led by molecular biologists and information scientists from the RIKEN Center for Developmental Biology in Kobe. The demonstration of the feedback delay should lead to a better understanding of how cellular clocks function, and therefore how mammals adjust to the regular daily and seasonal changes in their environment. The work could also open the way to the development of treatments for circadian disorders, such as seasonal affective disorder, jet lag and even bipolar disorder.

Does climate change seriously threaten to wipe out the human species if left unchecked? Examining our evolutionary past suggests it might once have been the perfect catalyst for our extinction. But now?

Using simple robots to simulate genetic evolution over hundreds of generations, Swiss scientists provide quantitative proof of kin selection and shed light on one of the most enduring puzzles in biology: Why do most social animals, including humans, go out of their way to help each other? In next week's issue of the online, open access journal PLoS Biology, EPFL robotics professor Dario Floreano teams up with University of Lausanne biologist Laurent Keller to weigh in on the oft-debated question of the evolution of altruism genes.

How many times do we hear that some scientific view is "only theory" or that it is "not proven"? The hidden implication is that if we have not "proven" the case, then we do not know anything for certain about it, and any idea is as good as any other. A recent and vivid example of this problem is the ongoing argument in the popular media about global warming. Do we need to be absolutely certain before we take action?

In the first study of its kind, researchers have linked a natural global climate cycle to periodic increases in warfare. The arrival of El Niño, which every three to seven years boosts temperatures and cuts rainfall, doubles the risk of civil wars across 90 affected tropical countries, and may help account for a fifth of worldwide conflicts during the past half-century, say the authors. The paper, written by an interdisciplinary team at Columbia University's Earth Institute, appears in the current issue of the leading scientific journal Nature.