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For more than 20 years, theoretical mathematical models have predicted that a delay built into a negative feedback system is at the heart of the molecular mechanism that governs circadian clocks in mammalian cells. Now, the first experimental proof of this theory has been provided by an international research team led by molecular biologists and information scientists from the RIKEN Center for Developmental Biology in Kobe. The demonstration of the feedback delay should lead to a better understanding of how cellular clocks function, and therefore how mammals adjust to the regular daily and seasonal changes in their environment. The work could also open the way to the development of treatments for circadian disorders, such as seasonal affective disorder, jet lag and even bipolar disorder.

Reports of sleeping air traffic controllers highlight a long-known and often ignored hazard: Workers on night shifts can have trouble concentrating and even staying awake.