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Based on the suggestions of the observers above, and my own active imagination, I offer the following as possible near-term advances in the evolution of the scientific method. Compiled Negative Results - Negative results are saved, shared, compiled and analyzed, instead of being dumped. Positive results may increase their credibility when linked to negative results. We already have hints of this in the recent decision of biochemical journals to require investigators to register early phase 1 clinical trials. Usually phase 1 trials of a drug end in failure and their negative results are not reported. As a public heath measure, these negative results should be shared. Major journals have pledged not to publish the findings of phase 3 trials if their earlier phase 1 results had not been reported, whether negative or not. Return of the Subjective - Science came into its own when it managed to refuse the subjective and embrace the objective. The repeatability of an experiment by another, perhaps less enthusiastic, observer was instrumental in keeping science rational. But as science plunges into the outer limits of scale - at the largest and smallest ends - and confronts the weirdness of the fundamental principles of matter/energy/information such as that inherent in quantum effects, it may not be able to ignore the role of observer. Existence seems to be a paradox of self-causality, and any science exploring the origins of existence will eventually have to embrace the subjective, without become irrational. The tools for managing paradox are still undeveloped.

Increases in temperature as a result of climate change are mirrored in lake waters where temperatures are also on the rise. A new study, by Dr. Martin Dokulil, retired researcher from the Institute for Limnology at the University of Innsbruck in Austria, forecasts surface water temperatures in large Austrian lakes for 2050 and discusses the impact on the lakes' structure, function and water quality. The research is published online in Springer's journal Hydrobiologia.

There are few things journalists like to discuss more than, well, themselves and the long-term prospects for their industry. How long will print newspapers survive? Are news aggregation sites the future? Or are online paywalls - such as the one the New York Times just launched - the way to go? As media organizations plot their future, it's worth discarding some misconceptions about what it will take to keep the press from becoming yesterday's news.

Lake Bonney in Antarctica is perennially covered in ice. It is exposed to severe environmental stresses, including minimal nutrients, low temperatures, extreme shade, and, during the winter, 24-hour darkness. But, for the single-celled organisms that live there, the lake is home. To study them, Dr. Rachel Morgan-Kiss from the University of Miami, Ohio, and her team went to Antarctica to sample the ice-covered lake. The article describing her method will be published April 20, in the JoVE (the Journal of Visualized Experiments)

"A new Arctic study in the journal Science is helping to unravel an important mystery surrounding climate change: How quickly glaciers can melt and grow in response to shifts in temperature."

Declaring the eradication of polio will be far more difficult than it was for smallpox, according to a review published in the Journal of General Virology. Further research into the complex virus - host interactions and how the vaccine is used in the final stages of the eradication programme is crucial to its success.

As global temperatures rise and climatic zones move polewards, species will need to find different environments to prevent extinction. New research, published today in the journal Molecular Ecology, has revealed that climate change is causing certain species to move and adapt to a range of new habitats.

The concept of the hydrogen economy (HE), in which hydrogen would replace the carbon-based fossil fuels of the twentieth century was first mooted in the 1970s. Today, HE is seen as a potential solution to the dual global crises of climate change and dwindling oil reserves. A research paper to be published in the International Journal of Sustainable Design suggests that HE is wrong and SHE has the answer in the sustainable hydrogen economy.

Indonesia has the potential to realize major reductions in national greenhouse gas emissions from deforestation, and simultaneously earn significant new income for national and regional governments, if policies to Reduce Emissions from Deforestation and forest Degradation (REDD+) are developed with strong and specific economic incentives, said scientists in a new paper published in the leading scientific journal Proceedings of the National Academy of Sciences

Wandering albatrosses have altered their foraging due to changes in wind fields in the southern hemisphere during the last decades. Since winds have increased in intensity and moved to the south, the flight speed of albatrosses increased and they spend less time foraging. As a consequence, breeding success has improved and birds have gained 1 kilogram. These are the results of the study of an international research team published in the latest issue of the Science journal. However, these positive consequences of climate change may last short if future wind fields follow predictions of climate change scenarios, researchers warn.

The incidence of type 2 diabetes and hypertension increases with cumulative levels of exposure to nitrogen oxides, according to a new study led by researchers from the Slone Epidemiology Center (SEC) at Boston University. The study, which appears online in the journal Circulation, was led by Patricia Coogan, D.Sc., associate professor of epidemiology at the Boston University School of Public Health and the SEC.

Both climate change and humans were responsible for the extinction of some large mammals, like the musk ox in this photo, according to research that is the first of its kind to use genetic, archeological, and climatic data together to infer the population history of large Ice-Age mammals. The large international team's research, which will be published in the journal Nature, is expected to shed light on the possible fates of living species of mammals as our planet continues its current warming cycle.

UCLA researchers have developed a new transparent solar cell that is an advance toward giving windows in homes and other buildings the ability to generate electricity while still allowing people to see outside. Their study appears in the journal ACS Nano.   The UCLA team describes a new kind of polymer solar cell (PSC) that produces energy by absorbing mainly infrared light, not visible light, making the cells nearly 70% transparent to the human eye. They made the device from a photoactive plastic that converts infrared light into an electrical current

Bird migration timing across North America has been affected by climate change, according to a study published Feb. 22 in the open access journal PLoS ONE.

Past waves of extinctions which removed some of the world's largest animals were caused by both people and climate change, according to new research from the University of Cambridge. Their findings were reported today, 05 March, in the journal Proceedings of the National Academy of Sciences (PNAS).

A new research paper written by Simon Fraser University biologists and published in the journal Science concludes that the abundance of salmon in spawning streams determines the diversity and productivity of plants in surrounding forests.

Collectively, malaria, TB & HIV/AIDS cause more than five million deaths per year - nearly the entire population of the state of Washington - and represent one of the world's major public health challenges as we move into the second decade of the 21st century. In the May 26, 2011, edition of scientific journal Nature, Seattle BioMed Director Alan Aderem, Ph.D., along with Rino Rappuoli, Ph.D., Global Head of Vaccines Research for Novartis Vaccines & Diagnostics, discuss recent advances in vaccine development, along with new tools including systems biology and structure-based antigen design that could lead to a deeper understanding of mechanisms of protection. This, in turn, will illuminate the path to rational vaccine development to lift the burden of the world's most devastating infectious diseases.

Each year, the cost of health care pushes some 39 million people back into poverty, according to a study published in the Lancet medical journal. Patients shoulder up to 80 percent of India's medical costs. Their share averages about $66 (3,000 rupees) annually per person - a crippling sum for the 800 million or so Indians living on less than $2 a day.

Animals and plants may not be able to evolve their way out of the threat posed by climate change, according to a UC Davis study of a tiny seashore animal. The work was published today (June 8) in the journal Proceedings of the Royal Society B.

In the first study of its kind, researchers have linked a natural global climate cycle to periodic increases in warfare. The arrival of El Niño, which every three to seven years boosts temperatures and cuts rainfall, doubles the risk of civil wars across 90 affected tropical countries, and may help account for a fifth of worldwide conflicts during the past half-century, say the authors. The paper, written by an interdisciplinary team at Columbia University's Earth Institute, appears in the current issue of the leading scientific journal Nature.