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Liz Richardson

Phyto-oestrogens: where are we now? - 0 views

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    What is known about phytoestrogens? How does it affect us? What can be done to improve the public knowledge concerning phytoestrogen intake? Do they interact with other nutritional factors?
Liz Richardson

Cellular and Physiological Effects of Soy Flavonoids - 0 views

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    Abstract describes how phytoestrogens can be estrogen receptor modulators. Recent studies suggest beneficial health effects of soy and recommend increasing the intake of isoflavone-rich soy protein to the level of intake commonly used in Asian countries. Must try to open this article at the library to gain access to the free full version of the article. Vanessa - Once I access the full version I will be better able to tell you whether this is related to the other article concerning cultural differences in soy consumption and its effects on obesity.
Vanessa Ward

San Francisco Medical Society | The Weight of Evidence - 0 views

  • “leading to neglect of other plausible mechanisms and well-intentioned but potentially ill-founded proposals for reducing obesity rates”
  • Since publication of that review, substantial evidence has emerged that increases the plausibility of one of the alternative mechanisms suggested by Keith et al: disruption of weight regulation by endocrine-disrupting chemicals (EDCs) in the environment.
  • Concerns about the potential contribution of EDCs to childhood obesity build from two considerations, one out of human biology and the other from animal experiments
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  • toxicologists were concerned more with weight loss, which was seen as an adverse outcome.
  • Many of these chemicals alter the behavior of specific genes that are involved in determining the number of fat cells (adipocytes) an individual will have as an adult.
  • he list of contaminants implicated by animal studies is substantial, including several estrogenic EDCs such as DES, bisphenol A, soy phytoestrogens
  • Almost no human data are available to test the obesogen hypothesis in people. No epidemiological evidence exists, because the hypothesis is so new
  • One in vitro experiment, however, has demonstrated that exposure to obesogens increases the rate of conversion of human stem cells to adipocytes (Kirchner et al 2010), confirming the validity of the basic mechanism and the relevance of the animal studies to people.
  • That would be a big win for medicine and public health.
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    San Francisco Medical Society discusses the possible relationship between chemical exposure and the obesity epidemic.
Vanessa Ward

Prenatal Genistein In Soy Reduces Obesity In Offspring - DukeHealth.org - 8 views

  • The agouti methylation consistently occurred throughout several germ layers of embryonic tissue, indicating that genistein acted during early embryonic development. Moreover, the methylation changes persisted into adulthood, providing the first evidence that in utero dietary genistein alters epigenetic gene regulation, coat color, and susceptibility to adult obesity in animals.
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    Vanessa - This pertains to both my study and yours. Is lack of soy consumption linked to obesity? Is it worth it to consume soy while pregnant if your child will lose risk of being fat but gain risk of being infertile?
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    This is awesome, thanks Liz.
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    This addresses the controversy of the role of estrogenics and the role they play in predispostion to obesity. DDE studies were positive for resulting in obesity but genistein studies show that in utero exposure results in a lower adult body weight. Both are estrogenics.
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