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Another issue with AJAX is how the application interface is updated. When updates to the interface occur, it may not be visually apparent that a change has occurred. The problem is even more troublesome for screen reader users. Screen readers typically read in a linear fashion. When changes happen in the interface, the screen reader user may not be aware of the change and the new content will likely not be read.

In short, to allow dynamic interface changes to be accessible, the application must alert the user that a change has occurred, allow direct access to the new content, and then allow continued functionality of the web application. This process, while difficult to achieve, especially for screen reader users, is possible to achieve in many AJAX applications.