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We are interested in both risk and resilience - why are some individuals particularly vulnerable in response to negative life events, while others appear to be relatively resilient? And how can we promote enhanced resilience? As a part of the latter work, we study interventions designed to cultivate more positive affective styles. One such intervention that we have extensively studied over the past decade is meditation. In addition to the research on normal affective function, we also study a range of psychopathologies, all of which involve abnormalities in different aspects of emotion processing. Included among the disorders we have recently studied are adult mood and anxiety disorders, and autism, fragile X and Williams syndrome in children. Some of our current research involves: Voluntary and automatic emotion regulation. Resilience in aging. Interactions between emotion and cognitive function, particularly working memory and attention. Temperament in children, in hopes of determining early signs of vulnerability to psychopathology. Social and emotional processing differences in children and adults with autism and fragile X. Mood and anxiety disorders. The impact of pharmaco-therapy and psychotherapy on brain function in patients with mood and anxiety disorders. The effects of meditation on brain function in adept practitioners and novices. Relations between neural mechanisms of emotion and peripheral measures of inflammation and lung function in asthma.