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Bioavailability Enhancement for Insoluble Compounds & PROTAC & Oral Peptides Recent statistics indicate that approximately 40% of currently marketed drugs and nearly 90% of candidates in R&D pipeline belong to Biopharmaceutics Classification System (BCS) II or IV poorly water-soluble drugs. Consequently, enhancing drug solubility and improving bioavailability are pressing challenges in the realm of new drug development. Widely employed methods for solubility enhancement include:

Glucosamine hydrochloride is extracted from natural chitin, is a kind of Marine biological preparation. It can also be used in food, cosmetics and feed additives, the usage is quite extensive. Glucosamine hydrochloride is a substance that may improve bone and joint disease. Glucosamine is used in combination with chondroitin sulfate and vitamin D and calcium supplements. Odorless, slightly sweet, soluble in water, slightly soluble in methanol, insoluble in ethanol and other solvents.

Guar Gum Also known as guaran, guar gum is made from legumes called guar beans. It's a type of polysaccharide, or long chain of bonded carbohydrate molecules, and composed of two sugars called mannose and galactose. Guar gum is frequently used as a food additive in many processed foods. It's especially useful in food manufacturing because it's soluble and able to absorb water, forming a gel that can thicken and bind products. Guar gum is a food additive that is used to thicken and bind food products. It's high in soluble fiber and low in calories.

Inositol is a fine white crystal or crystalline powder. Odorless, sweet. Relative density is 1.752,1.524 (dihydrate). Stability in the air. To heat, acid and alkali stability. Its aqueous solution was neutral to litmus. No optical activity. Soluble in water 6ml per gram. Hardly soluble in ethanol, insoluble in ether and chloroform.  Where to Buy CAS 87-89-8

Calcium gluconate is an organic calcium salt, easily soluble in boiling water (20g/100mL), slightly soluble in cold water (3g/100mL, 20℃), and the aqueous solution is neutral (pH 6-7). Calcium gluconate is mainly used as calcium fortifier and nutrient, buffer, curing agent and chelating agent in food.

L-carnitine Tartrate is a stable form of L-carnitine. L-carnitine tartrate is not easy to absorb moisture and remains stable under humid conditions. L-carnitine tartrateis a white crystalline powder with a pleasant acidic odor. It is easily soluble in water, but not easily soluble in organic solvents.

Bosenbio, established in Xi'an High-Tech Industrial Development Zone, has been adhering to the business philosophy of "From Nature, From People" for many years. We are a leading manufacturer of standardized natural plant extracts, APIs, fruit and vegetable powders, and raw material powders. bosenbio will be the market leader in providing high quality ingredients for the pharmaceutical, cosmetic, beverage, food, nutraceutical, and feed industries.

Searching for groundwater requires the aid of a professional pqwt underground water detector to study topography by analyzing profiles. Groundwater is easier to find in low-lying terrain or terrain which is conducive to catchment. Secondly, combined with the water-rich of local rocks, it feels brittle when hammering, and soluble rocks such as brittle rocks and limestone are easier to find groundwater.

Ferrous lactate which functions to enrich and fortify. It is of neutral color and flavor, and is soluble. It is used in acid foods below a pH of 4.5, where there is less susceptibility to oxidation and conversion to the ferric form, which results in discoloration. In higher pH foods, the instability can be prevented by complexing with ligands which prevent browning discoloration. It is used in fortification of drinks and juices.

L-Alanine colorless to white crystalline powder, soluble in water, ethanol, insoluble in ether and acetone. Mainly used for biochemical research, tissue culture, liver function measurement, flavor enhancer, can increase the flavoring effect of seasoning, can also be used as sour taste correcting agent to improve the acidity of organic acid.

L-cysteine hydrochloride is colorless to white crystal or crystalline powder, with a slight special odor and sour taste, melting point is 175℃ (decomposition). Soluble in water, the aqueous solution is acidic, the pH value of 1% solution is about 1.7, and the pH value of 0.1% solution is about 2.4.

Butylated Hydroxytoluene(BHT) is a white crystalline solid with a faint characteristic odor. It is insoluble in water and in propylene glycol, but is freely soluble in alcohol. It is obtained by alkylation of p-cresol with isobutene or by monobutylation of m,p-cresol mixtures.

The enzyme is an incision enzyme it hydrolyzes the α -1,4-glucosidic linkages of gelatinized starch and soluble dextrins randomly, reducing the high viscosity of the starch slurry. Resulted to different length of oligosaccharides and a few dextrins.

Calcium lactate, white granules or powder, soluble in hot water, insoluble in ethanol, ether or chloroform; it is a good agent for calcium supplementation and an ideal additive for calcium fortified food;.

It exhibits strong inhibition effect on melanogenesis, reduces dark spots and age spots, fights photoaging by interfering with inflammatory cytokines, such as IL-6, and reverse ROS production to achieve free radical scavenging purpose. 3-O-ethyl ascorbic acid is effectively a newer form of Vitamin C that offers a better overall performance. It is water soluble with excellent heat and photostability profile. Best of all, it is highly stable and easy to formulate.

Dyes are compounds that can impart bright and durable colors to other substances in a molecular or dispersed state. In the printing and dyeing process, besides using raw dye powder, dye auxiliaries are also added to enhance dyeing efficiency and effectiveness. Among these auxiliaries, dye dispersants play a vital role. Dye dispersants are non-ionic surfactants that aid in achieving a leveling effect, maintaining dye dispersion, preventing aggregation and precipitation, and improving dye solubility. By incorporating dispersants and protective colloids, uniform dyeing is ensured, and stains are prevented.

Amorphous Solid Dispersions pharmaceutical amorphous solid dispersions have been shown to alter the properties of an API, including solubility, dissolution, and bioavailability. A variety of polymers or additives are available, and screening is needed to find possible miscible dispersions that will have the properties needed for development. Our service including: The amorphous spray dried dispersion will then be used in simple formulations for early development (such as suspensions, drug in capsules, or preliminary formulations) or formulated into a drug product (such as tablets or capsules) for late-stage development and marketed products.

Chemical and physical stability The stability study intends to evaluate the API's chemical and physical stability in solution and solid-state. The solid-state evaluation will probe the propensity of form change, crystallization (for amorphous), and deliquescence (for salts). The chemical stability testing will screen the set of conditions in which the API is unstable and could cause difficulties in development.

Highlights of API Form and solid state services Serving over 1000 clients worldwide Supported solid form screening, crystallization, and preclinical formulation development of over 2,000 new drug molecules The world's leading technology supports the understandingof molecule and formulation with a high-end platform High-quality service, a culture of confidentiality, and fast turnaround with cost-effective pricing Customized solution for your molecule, spanning the entire drug lifecycle API Form and solid state chemistry services Solid Form Screening and Selection Solid form is a general term that refers to both crystalline and amorphous materials. The solid form will impact active pharmaceutical ingredient (API) development properties such as solubility, dissolution rate, stability, hygroscopicity, and bioavailability.

In the preceding article, we discussed the application of hot-melt extrusion technology in developing amorphous solid dispersions (ASD) for pharmaceutical formulations. The process involves dispersing a solution through a spray dryer, where it meets hot gas, quickly evaporates, and forms amorphous solids. Spray drying techniques are extensively employed in developing formulations for drugs with low solubility, largely due to their well-established scalability from small-scale experiments to large-scale commercial production, aligning with Good Manufacturing Practice (GMP) standards. Table 1 in the article provides examples of various drugs that have been commercially produced using spray drying technology to prepare amorphous solid dispersions.

Non ionic contrast medium is the second generation of CT contrast medium. For advantages of non ionic contrast media, compared with the first generation of ionic contrast medium, the non ionic contrast medium has greater water solubility. In addition, it does not ionize in water, which has the advantages of low viscosity and low osmotic pressure. Clinically, the incidence and severity of toxic side effects of the non-ionic contrast medium are significantly lower than that of the ionic contrast medium.