In mice and other animal model systems, the virus establishes latency in some neurons but multiplies
in others (4). Ultimately, in mice, after an interval of 4 wk, only latent virus can be detected in the peripheral ganglia (5).
HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST ... - 3 views
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I'm wondering if there is a specific reason as to why the virus chooses to multiple in one neuron versus establish latency in another. Is it just random, or are there different mechanisms in different neurons that allow the virus to perform one act preferentially over another?
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An Inquiry into the Molecular Basis of HSV Latency and Reactivation - Annual Review of ... - 3 views
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Primary HSV infection of the eye results in herpes simplex keratoconjunctivitis with latency established in the trigeminal nerve.
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I was wondering why the primary lit paper was doing there tests in corneal cells. I forgot that there is an HSV that infects the eyes. What exactly happens to the host cell once the virus is derepressed after latency? I'm sure it has said it in one or both of that papers, but I'm confused by the mechanism. The virus doesn't kill the host cell does it? Being that it resides in nerve cells (which is something new to me) and nerve cells don't replicate, killing the nerve seems like a bad idea for them and for us. Does the presence of the active virus (not latent virus) affect the function of the nerve? As in, does the herpes simplex keratoconjunctivitis affect the trigeminal nerve in that the virus interferes with the transmitting of sensory information from the face to the brain?
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*Their tests
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Notably, antibodies to HSV can routinely be detected in the cerebrospinal fluid of otherwise healthy individuals, implying that HSV can establish latency in the central nervous system and cause an adaptive immune response, as noted above by PCR data (24). It is unlikely that antibodies to HSV are passively transported across the intact blood-brain barrier.
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If antibodies can be found in the CSF, then HSV can be found in the CSF, right? Does or could HSV use the CSF as as way to travel to other tissues/nerve cellls?
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Ebolavirus vaccines and antivirals - 0 views
ViralZone: Ebolavirus cycle - 0 views
ViralZone: Ebolavirus - 0 views
Cached
Infection Mechanism of Genus Ebolavirus - MicrobeWiki - 0 views
PLOS Pathogens: Antigenic Subversion: A Novel Mechanism of Host Immune Evasion by Ebola... - 0 views
What Would Keep Ebola from Spreading in the US? Investing in Simple Research Years Ago.... - 0 views
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Maryn McKenna writes frequently and eloquently on infectious disease in her blog "Superbug". I recommend you check out her latest post on the Ebola cases in the US.
Untitled - 0 views
One more question, Dr. Frieden: 11 things we'd like to know about the new Ebola ca... - 0 views
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Some good questions for the CDC director
Rotaviruses - Microbes - 0 views
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