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Ebola animal reservoir between outbreaks: Bats, gorillas, chimpanzees, dogs, pigs. - 0 views

www.slate.com/...s_chimpanzees_dogs.single.html ebolavirus
shared by Casey Finnerty on 23 Oct 14 - No Cached
  • So why bats? How come they can live with Ebola and so many other viruses, while humans can’t? Scientists bitterly disagree about this.
  • bats have more resilient DNA.
  • bats have overactive immune systems.
  • ...2 more annotations...
  • Bats make up nearly one-quarter of the mammalian species on Earth,
  • If we’re going to contract any disease from another species, there’s a decent chance it’ll be from a bat.
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HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST ... - 3 views

www.pnas.org/...E498.long
shared by apopp10 on 17 Oct 14 - No Cached
  • In mice and other animal model systems, the virus establishes latency in some neurons but multiplies in others (4). Ultimately, in mice, after an interval of 4 wk, only latent virus can be detected in the peripheral ganglia (5).
    • apopp10
      apopp10 on 17 Oct 14
       
      I'm wondering if there is a specific reason as to why the virus chooses to multiple in one neuron versus establish latency in another. Is it just random, or are there different mechanisms in different neurons that allow the virus to perform one act preferentially over another?
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An Inquiry into the Molecular Basis of HSV Latency and Reactivation - Annual Review of ... - 3 views

www.annualreviews.org/...annurev-micro-092412-155654
shared by laceemarie on 15 Oct 14 - No Cached
  • Primary HSV infection of the eye results in herpes simplex keratoconjunctivitis with latency established in the trigeminal nerve.
    • laceemarie
      laceemarie on 17 Oct 14
       
      I was wondering why the primary lit paper was doing there tests in corneal cells. I forgot that there is an HSV that infects the eyes.  What exactly happens to the host cell once the virus is derepressed after latency? I'm sure it has said it in one or both of that papers, but I'm confused by the mechanism. The virus doesn't kill the host cell does it? Being that it resides in nerve cells (which is something new to me) and nerve cells don't replicate, killing the nerve seems like a bad idea for them and for us. Does the presence of the active virus (not latent virus) affect the function of the nerve? As in, does the herpes simplex keratoconjunctivitis affect the trigeminal nerve in that the virus interferes with the transmitting of sensory information from the face to the brain?
    • laceemarie
      laceemarie on 17 Oct 14
       
      *Their tests
  • Notably, antibodies to HSV can routinely be detected in the cerebrospinal fluid of otherwise healthy individuals, implying that HSV can establish latency in the central nervous system and cause an adaptive immune response, as noted above by PCR data (24). It is unlikely that antibodies to HSV are passively transported across the intact blood-brain barrier.
    • laceemarie
      laceemarie on 17 Oct 14
       
      If antibodies can be found in the CSF, then HSV can be found in the CSF, right? Does or could HSV use the CSF as as way to travel to other tissues/nerve cellls?
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What Would Keep Ebola from Spreading in the US? Investing in Simple Research Years Ago.... - 0 views

www.wired.com/...ebola-ic-research ebolavirus
shared by Casey Finnerty on 16 Oct 14 - No Cached
  • Casey Finnerty on 16 Oct 14
     
    Maryn McKenna writes frequently and eloquently on infectious disease in her blog "Superbug". I recommend you check out her latest post on the Ebola cases in the US.
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One more question, Dr. Frieden: 11 things we'd like to know about the new Ebola ca... - 0 views

news.sciencemag.org/...-wed-know-about-new-ebola-case ebolavirus
shared by Casey Finnerty on 16 Oct 14 - No Cached
  • Casey Finnerty on 16 Oct 14
     
    Some good questions for the CDC director
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