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Contents contributed and discussions participated by slgoogin8981

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The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation - 11 views

www.ncbi.nlm.nih.gov/...PMC3235490
shared by apopp10 on 14 Nov 14 - No Cached
    • slgoogin8981
      slgoogin8981 on 24 Nov 14
       
      It is interesting to see that there are 3 allelic variants that correlate with disease prognosis, but how does this information benefit society? We can't change peoples genetic so to alter their prognosis. Is this just a benefit to know what medications would be most beneficial with the least amount of side effects?
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Virus-Mediated Compartmentalization of the Host Translational Machinery - 22 views

mbio.asm.org/...e01463-14.full
shared by slgoogin8981 on 27 Oct 14 - No Cached
    • slgoogin8981
      slgoogin8981 on 19 Nov 14
       
      Does the viral factor protect the dsRNA from RIG-1? Earlier the paper spoke of energy balances, does the viral factor require a lot of energy to be created?
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HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST ... - 7 views

www.pnas.org/...E498.long
shared by slgoogin8981 on 15 Oct 14 - No Cached
    • slgoogin8981
      slgoogin8981 on 19 Nov 14
       
      It would be interesting to know the amount that REST is seen in non-neural cells and nerve cells in the absents of HSV-1. I was state earlier that REST is not normally found in never cells.
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Rabies Virus Hijacks and Accelerates the p75NTR Retrograde Axonal Transport Machinery - 14 views

www.ncbi.nlm.nih.gov/...PMC4148448
shared by Sean Hogan on 03 Nov 14 - No Cached
  • slgoogin8981 on 03 Nov 14
     
    Friday 11-7-14, paper
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Norovirus Translation Requires an Interaction between the C Terminus of the Genome-link... - 75 views

www.jbc.org/...21738.long
shared by apopp10 on 12 Sep 14 - No Cached
  • inability to culture many members of the virus family in immortalized cells.
    • slgoogin8981
      slgoogin8981 on 17 Sep 14
       
      What are the other options to culture these viruses?
  • we attempted
  • to identify
  • ...3 more annotations...
  • components of the complex that interacted with VPg directly and contribute to viral translation
    • slgoogin8981
      slgoogin8981 on 18 Sep 14
       
      Is this the same as saying, they were looking for promoters?
  • recombinant MNV was performed by infecting baby hamster kidney cells with fowlpox virus expressing T7 RNA polymerase followed by transfection of MNV cDNA expression constructs as described previously
    • slgoogin8981
      slgoogin8981 on 19 Sep 14
       
      Was the fowlpox used just for the purpose of its polymerase? What is cDNA?
    • slgoogin8981
      slgoogin8981 on 26 Sep 14
       
      Thank you for the link! I am very unskilled with the lab results and procedures done in lab. I appreciate the guidance and opportunity to learn. I have only had three biology labs: 241, 242 and Cell.
  • although these cells are not permissive to MNV infection due to the lack of a suitable receptor, robust MNV translation and replication occurs upon transfection of viral RNA into the cytoplasm (22).
    • slgoogin8981
      slgoogin8981 on 19 Sep 14
       
      It is very cool that this virus can still use human translation equipment even though it is a marine from of the virus. How did they enter the virus genome into the cytoplasm?
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Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets - 12 views

www.sciencemag.org/...1534.full
shared by laceemarie on 04 Dec 12 - No Cached
  • Influenza A viruses show pronounced genetic variation of the surface glycoproteins HA and NA
    • slgoogin8981
      slgoogin8981 on 05 Sep 14
       
      Why is this an important site for variation?
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