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“That amount of memory would likely prevent the vast majority of people from getting hospitalized disease, severe disease, for many years,” said Shane Crotty, a virologist at the La Jolla Institute of Immunology who co-led the new study.

A study published last week also found that people who have recovered from Covid-19 have powerful and protective killer immune cells even when antibodies are not detectable.

These studies “are all by and large painting the same picture, which is that once you get past those first few critical weeks, the rest of the response looks pretty conventional,” said Deepta Bhattacharya, an immunologist at the University of Arizona

A small number of infected people in the new study did not have long-lasting immunity after recovery, perhaps because of differences in the amounts of coronavirus they were exposed to.

How long might immunity to the coronavirus last? Years, maybe even decades, according to a new study

More often, people become infected a second time with a particular pathogen, and the immune system recognizes the invader and quickly extinguishes the infection. The coronavirus in particular is slow to do harm, giving the immune system plenty of time to kick into gear.

“It may be terminated fast enough that not only are you not experiencing any symptoms but you are not infectious,” Dr. Sette said.

Dr. Sette and his colleagues recruited 185 men and women, aged 19 to 81, who had recovered from Covid-19. The majority had mild symptoms not requiring hospitalization

The team tracked four components of the immune system: antibodies, B cells that make more antibodies as needed; and two types of T cells that kill other infected cells.

He and his colleagues found that antibodies were durable, with modest declines at six to eight months after infection, although there was a 200-fold difference in the levels among the participants.

The study is the first to chart the immune response to a virus in such granular detail, experts said. “For sure, we have no priors here,” Dr. Gommerman said. “We’re learning, I think for the first time, about some of the dynamics of these populations through time.”

Exactly how long immunity lasts is hard to predict, because scientists don’t yet know what levels of various immune cells are needed to protect from the virus. But studies so far have suggested that even small numbers of antibodies or T and B cells may be enough to shield those who have recovered.

Infection numbers in Massachusetts are eight times what they were on Labor Day and hospitalizations have quadrupled.

In Illinois, the virus is now the third leading cause of death behind heart disease and cancer.

More than 250,000 Americans have so far died of the virus -- a higher death toll than any other country -- and a forecast by the US Centers for Disease Control and Prevention projects that number could rise up to 298,000 by December 12.

"It's all about absolute adherence to wearing a mask, avoiding crowds, and yes, we can keep the economy open but we're going to have to diminish indoor places like indoor dining and restaurants."

Only one US state, Hawaii, is showing a decrease in new cases greater than 10% compared to the previous week. Five others -- Idaho, North Dakota, Iowa, Illinois and Arkansas -- are holding steady, while the remaining 44 states are showing increases in new cases greater than at least 10% compared to the week prior.

the 7-day average of new cases is at its highest ever: 161,165 cases a day. That's up 27% compared to last week.

"Virtual gatherings remain the safest way to bring friends and family together from distant points. Outdoor settings can reduce the risks of gatherings with people outside of your household," the group said, also highlighting the importance of face coverings.

New Jersey Gov. Phil Murphy told CNN he wanted people to stay with their immediate family on Thanksgiving and to keep gatherings small -- "not just for next Thursday ... but for the next couple of months."

"This is not a normal year, it's not a normal Thanksgiving, Hanukkah, Christmas, New Year's. Folks have got to stay small, stay within the bubble of their own loved ones, and if we do that, that will be a down payment on a back-to-normal holiday season next year."

There were 79,410 hospitalizations reported on Wednesday, a record high for the United States, according to the Covid Tracking Project. The country is now averaging 72,120 hospitalizations over the last 7 days -- a 19.76% increase compared to last week.

"As a health care provider we are on 250 days of having a Covid patient in our ICU right now,"

"So every day, you walk into work, someone is super sick, someone is potentially dying that day."

"On a normal day, I don't have people dying every day," she said, adding that first week she had three people die in one day -- two of them, from Covid-19.

Students in the country's largest school district are transitioning to remote learning on Thursday following the closure of New York City schools. The decision came after the city's test infection rate reached 3%, a threshold Mayor Bill de Blasio said would trigger such a closure.

Kentucky Gov. Andy Beshear also announced new measures that will go into effect Friday, including limiting social gatherings to a maximum of two people from no more than two households, and prohibiting indoor service for restaurants and bars. And starting Monday, schools should begin remote learning, the governor said.

In Minnesota, the governor said the state is at a "breaking point" and announced a four-week dial back that will "help prevent more families from losing a loved one and ensure our hospitals can treat those who fall ill."

"As hospitals near the crisis of turning away new patients, continuing as things are is simply not sustainable," Gov. Tim Walz said.

A final analysis of the Phase 3 trial of Pfizer's Covid-19 vaccine shows it was 95% effective in preventing infections, even in older adults and caused no serious safety concerns, the company said Wednesday. It said it will seek a US Food and Drug Administration emergency use authorization "within days."

The Pfizer analysis came just days after a separate vaccine maker, Moderna, released early data showing its vaccine was about 95% effective.

Distribution is expected to begin within 24 hours after a vaccine receives the green light, according to Gen. Gustave Perna, who is helping oversee Operation Warp Speed.

"We'll be more ready next week, and if the vaccine is available, we have to go with what we have. We may not be perfect, but every day we're more prepared than we were the day before," he added.

Mr. Trump himself has provided no evidence to back up his assertions, apart from citing a handful of Pennsylvania ballots discarded in a dumpster — and immediately tracked down, and counted, by election officials.

Meanwhile, the Department of Homeland Security and the F.B.I. have been issuing warnings, as recently as 24 hours before the debate, about the dangers of disinformation in what could be a tumultuous time after the election.

“There’s a huge financial advantage to being first out of the gate,” said Dr. Megan Ranney, an associate professor of emergency medicine and public health at Brown University. She was one of 60 public health officials and others in the medical community who signed a letter to Pfizer urging it not to rush its vaccine.

The F.D.A. has also told vaccine makers that they will need to track at least half of the patients’ safety data for two months before the agency will grant emergency access. That would push the earliest possible date into at least November.

Participants in Pfizer’s trial are given two doses of a vaccine 21 days apart, whereas those in Moderna’s wait 28 days in between. Pfizer begins looking for sick volunteers seven days after the second dose, whereas Moderna does so at 14 days. And Pfizer’s plan allows an outside review panel to look at early data after just 32 volunteers have become ill with Covid-19. Moderna’s plan doesn’t allow for a first peek until 53 cases.

Ultimately, Pfizer’s strategy may be about managing the public’s expectations, said Brandon Barford, a partner at Beacon Policy Advisors, a research firm. Pfizer could now explain any delay past October by “saying, ‘We’re being extra cautious.’ And you get kudos for it.”But if the opposite occurs, and Pfizer is seen to be pushing a vaccine before it is ready, the “potential fallout is enormous,” said Dr. Ranney, of Brown University. “We cannot afford to have a vaccine released for Covid-19 that is either unsafe or ineffective.”

The average daily death toll in the United States is inching back toward 1,000, and hospitals nationwide are strained with patients. The president-elect said that Americans would need to rely on basic precautions, like wearing masks, to “get back to normal as fast as possibl

The country now averages 900 deaths each day, and 28 states added more cases in the seven-day period ending Sunday than in any other weeklong stretch of the pandemic. No states are reporting sustained reductions in cases.

Coronavirus hospitalizations, perhaps the clearest measure of how many people are severely ill, are approaching record levels set during earlier surges of the pandemic, according to data collected by the Covid Tracking Project

At the White House, which has been the site of several high-profile outbreaks in recent months, Ben Carson, the secretary of housing and urban development, tested positive for the coronavirus on Monday, according to a spokesman for the agency. He became the latest in a long list of administration officials, including Mr. Trump himself, to contract the virus.

At least three people who attended an election party at the White House last week, including Mr. Carson, have tested positive for the virus. At the event, several hundred people gathered in the East Room for several hours, many of them not wearing masks as they mingled while watching the election returns.

Beyond the impact of the virus itself, when Mr. Biden takes office, he will face a sobering economic reality.

There were 10 million fewer Americans working in October than in February, according to the Labor Department, and the pace of job growth has slowed every month since June.

Mr. Biden, moving to signal to Americans that he is prepared to take charge after a chaotic year, named a new coronavirus task force headed by a former commissioner of food and drugs, Dr. David Kessler; a former surgeon general, Dr. Vivek Murthy; and a Yale public health expert, Dr. Marcella Nunez-Smith.

The president-elect vowed to “spare no effort” in fighting the virus, with the goal of getting the economy “running at full speed again.”

His comments contrasted Mr. Trump’s. The president has spent the past eight months dismissing or playing down the need for Americans to wear masks, saying frequently — and falsely — that public health experts disagree about masks’ effectiveness.

Vice President Mike Pence, who serves as the chairman of Mr. Trump’s coronavirus task force, convened the group on Monday after meeting about once a week over the past several months. But Mr. Trump, who remains in office until January, is openly at odds with his own virus advisers, including about mask wearing.

More than half of the states issued mask mandates at some point this year, and some officials have tried targeted shutdowns on bars and indoor dining. But public health officials acknowledge that there is little public appetite for a return to full lockdowns.

“The virus is winning the war by now,” Mr. Pritzker said, urging the public to wear masks. “The situation has worsened considerably in certain areas of the state.”

In New York City, Mayor Bill de Blasio warned on Monday that the city was “getting dangerously close” to a second wave and said that further lockdowns were possible if New Yorkers did not regain control of the virus. “Unfortunately, it could mean even having to shut down parts of our economy again,” he said.At Mr. Biden’s closed-door briefing with his Covid advisory board, which took place remotely over a video conference call on Monday, three leaders of the panel provided updates on the pandemic while others members of the group introduced themselves, according to a person familiar with the discussion.

He told lawmakers that officials in the government had failed to heed his warnings about acquiring masks and other supplies

A new composite forecast from the US Centers for Disease Control and Prevention projects a total of 332,000 to 362,000 Covid-19 deaths by January 2.

Covid-19 hospitalizations also reached a new record high of 106,688 on Wednesday, according to the COVID Tracking Project.

more than 221,000 new infections were reported in just one da

"We are in a totally unprecedented health crisis in this country,"

Health care workers are exhausted. Hospitals are totally full."

"Unfortunately, with the volume of new cases that we are seeing and the implications it has on hospital utilization, during a period of widespread, community transmission, activities such as eating, drinking and smoking in close proximity to others, should not continue."

If the FDA grants emergency use authorization in the coming days, the first Americans outside of clinical trials could start getting inoculated this month.

in the coming months it's crucial that Americans stay vigilant and follow safety guidelines, like wearing face masks, social distancing and hunkering down in their social bubbles.

But the country will likely not see any meaningful impact until well into 2021 -- and that's if enough people get vaccinated, said Dr. Anthony Fauci, director of the National Institute for Allergy and Infectious Diseases.

"Let's say we get 75%, 80% of the population vaccinated. I believe if we do it efficiently enough over the second quarter of 2021, by the time we get to the end of the summer ... we may actually have enough herd immunity protecting our society that as we get to the end of 2021, we could approach very much, some degree of normality that is close to where we were before,"

"We want to make sure that the vaccines are actually administered, and we're afraid that won't happen," Paul Ostrowski, who is leading supply, production and distribution for Operation Warp Speed, told "Good Morning America" Wednesday.

"Baltimore City has not had to implement such severe restrictions since the very earliest days of the pandemic and the implementation of the stay-at-home order," the city's health department tweeted.

The daily death toll from Covid-19 reached a record high of 3,124 Wednesday, according to Johns Hopkins University.

Indiana's Republican Gov. Eric Holcomb ordered hospitals to postpone or reschedule non-emergency procedures done in an inpatient hospital setting from December 16 through January 3 to preserve hospital capacity.

In Alabama, Republican Gov. Kay Ivey announced Wednesday she's extending the state's Safer at Home order, which includes a statewide mask mandate for another six weeks.

About 53% of respondents said they would get the vaccine promptly -- up from 51% before Thanksgiving and 38% in early October.

The first emergency use authorization for a vaccine is expected soon, and about 20 million people could likely get vaccinated in the next few weeks, Secretary of Health and Human Services Alex Azar said Wednesday.

In the UK, "thousands" of people were already vaccinated Tuesday, the first day of the Pfizer/BioNTech vaccine rollout there, according to the National Health Service (NHS).

The FDA will not "cut any corners" when deciding whether to authorize the vaccine, Azar said, saying he was sure what happened in the UK would be "something the FDA looks at."

"For now, we need to double down on the steps that can keep us all safe."

Capital and Ideology, Thomas Piketty’s recent entry into the genre, places inequality as the ultimate driving force of politics, society, and religion

The Upswing proposes another, similar arc

this one is “a long arc of increasing solidarity and then increasing individualism” which “had implications for equality, for politics, for social capital, and for culture. It led to an increasingly zero-sum, tribal view of society, and, eventually, to Trumpism.”

The evidence justifying the thesis, intriguing as it is, is not nearly so strong.

The authors assign ultimate importance to the route from individualism to communitarianism and back again, called the “I-we-I” curve in their shorthand.

Was it possible for America to become a society of solidarity, a “we” society (as Putnam and Garrett term it), only because it was a Mad Men one, undergirded by the exclusion of blacks and women?

Many concurrent transformations, of course, could also have driven these trends

Putnam and Garrett nonetheless present a clear story. They propose that the communitarian ethos of the Progressive Era—of muckrakers like Ida B. Wells and Jacob Riis and social reformers like the suffragette Jane Addams and education evangelist John Dewey—is the generating impulse of the upswing. And the various traumas of the 1960s—assassinations, campus violence, the civil-rights struggle, urban riots, the Vietnamese debacle—are proposed as the instigators for the downswing.

Google’s ambition to digitize millions of books has yielded a database that the curious can use to check trends in English usage over decades with only a few keystrokes. Putnam and Garrett rely on this tool to track the rate of usage of “we” compared to “I”—and find that the resulting curve traces the familiar U-turn that recurs everywhere else in the book.

Similar accounts of increasing selfishness fossilized in Google Books data have been offered before, most notably by the psychologist Jean Twenge, but they do not seem to be taken that seriously by many linguists.

My brief experimentation also showed that writers also discuss “you” more than “I” these days. From these analogies, one could conclude the exact opposite: a resurrected communitarianism after all.

Other attempts at constructing a meta-narrative for American history, like the recent These Truths by Kemper professor of American history Jill Lepore, place at their center the crisis of race and the centuries-long inability of whites to accept blacks as equal.

What evidence is there that, in the midst of all of these bewildering changes, it was really “most fundamentally the self-centeredness” that accounted for present-day malaise?

the argument is that “America took its foot off the gas”—so the drive toward equality decelerated and stalled. “As that ‘we’ came apart, racial progress in many important realms came to a halt,” they claim

This is certainly true in some respects. But it does feel like a disservice to give the overriding impression that to be black in 2020 is only marginally better than it was in 197

In fact, there has been substantial convergence in life expectancy, high-school graduation rates, and voter turnout between black and white Americans, for example. And the notion that the communitarian ethos of the “we” society reinforces the drive toward equality for the disadvantaged is difficult to square with the continuous progress of women,

By reaching further back in time than most academics ever venture (because data are scant and require more care to interpret), he and Garrett are able to focus on a more positive period in which the United States was broadly improving, when children could expect almost surely to earn more than their parents, and Congress was not wrecked by partisanship. It cannot be wrong to yearn for a time when progress was palpable, when projects like the Great Society were being proposed and enacted. Even if we do not precisely know the reasons for the upswing all those years ago, one happened all the same.

at the 1968 Summer Olympics in Mexico City, when the American sprinters John Carlos and Tommie Smith were expelled from the Games for raising their fists on the medals podium during the playing of the U.S. national anthem.

For now, the change in policy from the U.S.O.P.C. does not mean that American athletes will be free to protest at the Summer Olympics in Tokyo next year without the threat of punishment.

In practice, the I.O.C. has historically called on individual organizing committees to dole out punishments for violations.

“When you specify kneeling and you talk about fists when you’re defining what protest can and can’t be, you’re saying you don’t want Black athletes to come,” Moushaumi Robinson, a gold medalist in track and field who leads the Team U.S.A.

The U.S.O.P.C.’s split from the I.O.C. on this rule comes at a delicate time, with the Olympics set to take place in Los Angeles in 2028.

“As long as they do it respectfully, with due deference that there will be other athletes on that podium with them, I am not going to get sleepless nights on this.”

The I.O.C. clarified its rule last January, specifying that kneeling or raising a fist during a medal ceremony was a form of demonstration that would not be tolerated.

Because the U.S. is a big market and a big national Olympic committee, “it does make a difference in terms of what the discourse is going to be at the I.O.C. around this issue,”

“Once the clock is at double zero, once the race finishes, the three individuals or three teams, they own that time, and it is their time to express or not express, to do or not do, to stand or not stand, in that moment that they’ve earned.”

The president’s tirade came the morning after an outside advisory panel of experts voted overwhelmingly to recommend that F.D.A. regulators approve a vaccine developed by Pfizer

in a statement on Friday said it put the Centers for Disease Control and Prevention and those involved with Operation Warp Speed on notice “so they can execute their plans for timely vaccine distribution.”

In Canada, the first shipments of the Pfizer-BioNTech vaccine arrived on Sunday, Prime Minister Justin Trudeau announced on Twitter.

If authorized, the US plans to start by shipping about 6 million doses across the country, said Gen. Gustave Perna, chief operating officer of Operation Warp Speed.

"We're going to have enough for 20 million people to get vaccinated by the end of December," Health and Human Services Secretary Alex Azar said.

About 2.9 million doses of the vaccine either have been or will be received nationwide this week. That's enough to start vaccinating 1.45 million people, since each person needs two doses.

More than 300,000 people in the US have died from coronavirus in 10 months, according to Johns Hopkis.

In the past week, the US has reported an average of more than 215,000 new infections a day, according to Johns Hopkins University.

The CDC has recommended that health care workers and residents of long-term care facilities get the vaccine first.

And another 186,000 are projected to die over the next three months, according to the University of Washington's Institute for Health Metrics and Evaluation. "

"There are tens of thousands of Black and brown people dying every year because they are distrustful of the system," Adams said. "In many cases, rightly so, but also because they're not getting the facts to help restore their trust in the system."

In California, Gov. Gavin Newsom said that while the vaccines offered a moment of hope, he added "we are in the midst of the worst moment of this pandemic."

Los Angeles County health officials said Monday new cases have increased 625% since November 1, with "younger people continuing to drive the increase in community transmission."

"Our reality is frightening at the moment," they said in a statement. "By next weekend, there are likely to be over 5,000 patients hospitalized and more than 50% of ICU beds occupied by COVID-19 patients."

In New York City, Mayor Bill de Blasio hinted at tighter restrictions in the coming weeks, saying the city was on a "very troubling" trajectory, "in terms of the number of people who get sick, the number of people we would lose ... and obviously the impact on hospitals, their ability to treat people."

"We will be monitoring and evaluating our current situation day to day and ... (we) will remain under the current restrictions for now, with the goal of getting through the next month."

"If officials and experts agree that our trends are going beyond our ability to respond, I will be forced to come in front of you all again with tougher actions."

the same week the U.S. began the rollout of its COVID-19 vaccination program and surpassed 300,000 deaths from the virus.

comes on the heels of the Thanksgiving holiday, when many Americans gathered with family and friends against health officials' warnings. Authorities are concerned about a similar spike following the Christmas and New Year's holidays.

"We are still at a dangerous and critical part of this pandemic and tens of thousands of American lives are at stake really every week,"

Pence will be the highest-ranking person yet to receive a COVID-19 vaccine publicly as distribution begins.

Trump has credited his administration with fast-tracking vaccine development and has hailed it as among his greatest accomplishments in office.

Traditionally, a scientist submits her paper to a journal, which sends it to a (surprisingly small) group of peers for (several rounds of usually anonymous) comments; if the paper passes this (typically months-long) peer-review gantlet, it is published (often behind an expensive paywall). Languid and opaque, this system is ill-suited to a fast-moving outbreak. But biomedical scientists can now upload preliminary versions of their papers, or “preprints,” to freely accessible websites, allowing others to immediately dissect and build upon their results. This practice had been slowly gaining popularity before 2020, but proved so vital for sharing information about COVID‑19 that it will likely become a mainstay of modern biomedical research. Preprints accelerate science, and the pandemic accelerated the use of preprints. At the start of the year, one repository, medRxiv (pronounced “med archive”), held about 1,000 preprints. By the end of October, it had more than 12,000.

The U.S. is now catching up. In April, the NIH launched a partnership called ACTIV, in which academic and industry scientists prioritized the most promising drugs and coordinated trial plans across the country. Since August, several such trials have started.

Researchers have begun to uncover how SARS‑CoV‑2 compares with other coronaviruses in wild bats, the likely reservoir; how it infiltrates and co-opts our cells; how the immune system overreacts to it, creating the symptoms of COVID‑19. “We’re learning about this virus faster than we’ve ever learned about any virus in history,” Sabeti said.

Similar triumphs occurred last year—in other countries. In March, taking advantage of the United Kingdom’s nationalized health system, British researchers launched a nationwide study called Recovery, which has since enrolled more than 17,600 COVID‑19 patients across 176 institutions. Recovery offered conclusive answers about dexamethasone and hydroxychloroquine and is set to weigh in on several other treatments. No other study has done more to shape the treatment of COVID‑19.

SARS‑CoV‑2’s genome was decoded and shared by Chinese scientists just 10 days after the first cases were reported. By November, more than 197,000 SARS‑CoV‑2 genomes had been sequenced. About 90 years ago, no one had even seen an individual virus; today, scientists have reconstructed the shape of SARS‑CoV‑2 down to the position of individual atoms

Respiratory viruses, though extremely common, are often neglected. Respiratory syncytial virus, parainfluenza viruses, rhinoviruses, adenoviruses, bocaviruses, a quartet of other human coronaviruses—they mostly cause mild coldlike illnesses, but those can be severe. How often? Why? It’s hard to say, because, influenza aside, such viruses attract little funding or interest.

COVID‑19 has developed a terrifying mystique because it seems to behave in unusual ways. It causes mild symptoms in some but critical illness in others. It is a respiratory virus and yet seems to attack the heart, brain, kidneys, and other organs. It has reinfected a small number of people who had recently recovered. But many other viruses share similar abilities; they just don’t infect millions of people in a matter of months or grab the attention of the entire scientific community

Thanks to COVID‑19, more researchers are looking for these rarer sides of viral infections, and spotting them.

These factors pull researchers toward speed, short-termism, and hype at the expense of rigor—and the pandemic intensified that pull. With an anxious world crying out for information, any new paper could immediately draw international press coverage—and hundreds of citations.

“There’s a perception that they’re just colds and there’s nothing much to learn,” says Emily Martin of the University of Michigan, who has long struggled to get funding to study them. Such reasoning is shortsighted folly. Respiratory viruses are the pathogens most likely to cause pandemics, and those outbreaks could potentially be far worse than COVID‑19’s.

Their movements through the air have been poorly studied, too. “There’s this very entrenched idea,” says Linsey Marr at Virginia Tech, that viruses mostly spread through droplets (short-range globs of snot and spit) rather than aerosols (smaller, dustlike flecks that travel farther). That idea dates back to the 1930s, when scientists were upending outdated notions that disease was caused by “bad air,” or miasma. But the evidence that SARS‑CoV‑2 can spread through aerosols “is now overwhelming,”

Another pandemic is inevitable, but it will find a very different community of scientists than COVID‑19 did. They will immediately work to determine whether the pathogen—most likely another respiratory virus—moves through aerosols, and whether it spreads from infected people before causing symptoms. They might call for masks and better ventilation from the earliest moments, not after months of debate

They will anticipate the possibility of an imminent wave of long-haul symptoms, and hopefully discover ways of preventing them. They might set up research groups to prioritize the most promising drugs and coordinate large clinical trials. They might take vaccine platforms that worked best against COVID‑19, slot in the genetic material of the new pathogen, and have a vaccine ready within months

the single-minded focus on COVID‑19 will also leave a slew of negative legacies. Science is mostly a zero-sum game, and when one topic monopolizes attention and money, others lose out.

Long-term studies that monitored bird migrations or the changing climate will forever have holes in their data because field research had to be canceled.

negligence has left COVID‑19 long-haulers with few answers or options, and they initially endured the same dismissal as the larger ME community. But their sheer numbers have forced a degree of recognition. They started researching, cataloging their own symptoms. They gained audiences with the NIH and the World Health Organization. Patients who are themselves experts in infectious disease or public health published their stories in top journals. “Long COVID” is being taken seriously, and Brea hopes it might drag all post-infection illnesses into the spotlight. ME never experienced a pivot. COVID‑19 might inadvertently create one

Other epistemic trespassers spent their time reinventing the wheel. One new study, published in NEJM, used lasers to show that when people speak, they release aerosols. But as the authors themselves note, the same result—sans lasers—was published in 1946, Marr says. I asked her whether any papers from the 2020 batch had taught her something new. After an uncomfortably long pause, she mentioned just one.

The incentives to trespass are substantial. Academia is a pyramid scheme: Each biomedical professor trains an average of six doctoral students across her career, but only 16 percent of the students get tenure-track positions. Competition is ferocious, and success hinges on getting published

Conservationists who worked to protect monkeys and apes kept their distance for fear of passing COVID‑19 to already endangered species.

Among scientists, as in other fields, women do more child care, domestic work, and teaching than men, and are more often asked for emotional support by their students. These burdens increased as the pandemic took hold, leaving women scientists “less able to commit their time to learning about a new area of study, and less able to start a whole new research project,

published COVID‑19 papers had 19 percent fewer women as first authors compared with papers from the same journals in the previous year. Men led more than 80 percent of national COVID‑19 task forces in 87 countries. Male scientists were quoted four times as frequently as female scientists in American news stories about the pandemic.

American scientists of color also found it harder to pivot than their white peers, because of unique challenges that sapped their time and energy.

Science suffers from the so-called Matthew effect, whereby small successes snowball into ever greater advantages, irrespective of merit. Similarly, early hindrances linger. Young researchers who could not pivot because they were too busy caring or grieving for others might suffer lasting consequences from an unproductive year. COVID‑19 “has really put the clock back in terms of closing the gap for women and underrepresented minorities,”

In 1848, the Prussian government sent a young physician named Rudolf Virchow to investigate a typhus epidemic in Upper Silesia. Virchow didn’t know what caused the devastating disease, but he realized its spread was possible because of malnutrition, hazardous working conditions, crowded housing, poor sanitation, and the inattention of civil servants and aristocrats—problems that require social and political reforms. “Medicine is a social science,” Virchow said, “and politics is nothing but medicine in larger scale.”

entists discovered the microbes responsible for tuberculosis, plague, cholera, dysentery, and syphilis, most fixated on these newly identified nemeses. Societal factors were seen as overly political distractions for researchers who sought to “be as ‘objective’ as possible,” says Elaine Hernandez, a medical sociologist at Indiana University. In the U.S., medicine fractured.

New departments of sociology and cultural anthropology kept their eye on the societal side of health, while the nation’s first schools of public health focused instead on fights between germs and individuals. This rift widened as improvements in hygiene, living standards, nutrition, and sanitation lengthened life spans: The more social conditions improved, the more readily they could be ignored.

The ideological pivot away from social medicine began to reverse in the second half of the 20th century.

Politicians initially described COVID‑19 as a “great equalizer,” but when states began releasing demographic data, it was immediately clear that the disease was disproportionately infecting and killing people of color.

These disparities aren’t biological. They stem from decades of discrimination and segregation that left minority communities in poorer neighborhoods with low-paying jobs, more health problems, and less access to health care—the same kind of problems that Virchow identified more than 170 years ago.

In March, when the U.S. started shutting down, one of the biggest questions on the mind of Whitney Robinson of UNC at Chapel Hill was: Are our kids going to be out of school for two years? While biomedical scientists tend to focus on sickness and recovery, social epidemiologists like her “think about critical periods that can affect the trajectory of your life,” she told me. Disrupting a child’s schooling at the wrong time can affect their entire career, so scientists should have prioritized research to figure out whether and how schools could reopen safely. But most studies on the spread of COVID‑19 in schools were neither large in scope nor well-designed enough to be conclusive. No federal agency funded a large, nationwide study, even though the federal government had months to do so. The NIH received billions for COVID‑19 research, but the National Institute of Child Health and Human Development—one of its 27 constituent institutes and centers—got nothing.

The horrors that Rudolf Virchow saw in Upper Silesia radicalized him, pushing the future “father of modern pathology” to advocate for social reforms. The current pandemic has affected scientists in the same way

COVID‑19 could be the catalyst that fully reunifies the social and biological sides of medicine, bridging disciplines that have been separated for too long.

“To study COVID‑19 is not only to study the disease itself as a biological entity,” says Alondra Nelson, the president of the Social Science Research Council. “What looks like a single problem is actually all things, all at once. So what we’re actually studying is literally everything in society, at every scale, from supply chains to individual relationships.”

SolarWinds has some 300,000 customers but says "fewer than 18,000" installed the version of its Orion products earlier this year that now appears to have been compromised.

Microsoft has now taken control of the domain name that hackers used to communicate with systems that were compromised by the Orion update, according to security expert Brian Krebs. The company's analysis, he added, should help reveal the scope of the affected companies and agencies.

Many U.S. national security agencies made major efforts to prevent Russia from interfering in this year's election. But those same agencies seem to have been blindsided by news that hackers — suspected to be Russia's foreign intelligence service, the SVR — were digging around inside U.S. government systems, possibly since the spring.

The intruders were careful to cover their tracks, Gerstell said. "You couldn't tell that they came in, you couldn't tell that they left the back door open. You couldn't even tell necessarily when they came in, took a look around and when they left."

The incident is the latest in what has become a long list of suspected Russian electronic incursions into other nations – particularly the U.S. – under President Vladimir Putin.

So far, some U.S. government departments and agencies have acknowledged they are investigating the breaches but have provided few details. The White House has been silent about the suspected Russian hack.

"This SolarWinds hack is very problematic, very troublesome, because it's not at all clear exactly how we should respond," Gerstell said. Part of the problem, he added, is that it's not clear what the hackers did after gaining access.

The intrusion could simply be a case of espionage, he said, of one government trying to understand what its adversary is doing.

The company said, "We have been advised that this incident was likely the result of a highly sophisticated, targeted, and manual supply chain attack by an outside nation state, but we have not independently verified the identity of the attacker."

The cybersecurity firm announced last week that a "highly sophisticated state-sponsored adversary" stole its "red team" tools, which are used to test security vulnerabilities in its customers' computer networks. FireEye's clients include government agencies.

"We believe this is nation-state activity at significant scale, aimed at both the government and private sector," the company said as it shared some details about what it called "the threat activity we've uncovered over the past weeks."

The agency said Sunday that it "is aware of active exploitation of SolarWinds Orion Platform software" that was released between March and June. The agency is urging any affected organizations to take steps to detect intrusions and to take countermeasures.

Those students, he says, "ought to be benefited. And by the way, a majority of those students are African American, and that's an issue that can't be ignored in this discussion either."

Popular sports bring in money for other athletic programs But at the same time, Roberts notes the NCAA system has benefited students who have scholarships to play other sports

The case before the Supreme Court involves 126 teams that play big-time football and men's and women's basketball. But for all of college sports, Roberts and other sports law experts say, the lower courts have left these issues in a legal mess.

California, for instance, passed a law last year effectively requiring schools to allow athletes to profit from their names, images, and likenesses. After the law was enacted, the NCAA abruptly reversed its long-held opposition to such benefits, and said it would issue new policies early next year.

its long-held opposition to such benefits, and said it would issue new policies early nex

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A Supreme Court decision siding with the NCAA would likely fortify the NCAA's effort to maintain tighter restrictions on benefits for big-time college and basketball players. A decision holding that the NCAA has gone too far would likely lead to more benefits for players whose hard work and frequent injuries allow the schools they play for to reap billions in TV and other revenue.

While that revenue sometimes benefits lesser-known sports and players at those schools, many experts say it more often benefits coaches and assistant coaches who are paid tens of millions of dollars, and allows schools to spend millions on mammoth stadiums and lavish locker rooms.

Last week 60 minutes reported that "at least 30 universities have cut almost 100 programs: soccer, squash, golf, gymnastics. Football powerhouse Clemson cut men's track and field. Stanford eliminated 11 sports. Schools are honoring existing scholarships, but more than 1,500 student-athletes, both men and women, will no longer have a team to compete for."

Zig-zagging through this legal minefield will be difficult for the Supreme Court, to say the least. And it may well issue a narrow opinion that still leaves most of these questions unresolved. But the fact that the justices decided to take on the this case, when it has dodged similar ones in the past, indicates they are at least serious about the issues.

the FBI released new information in hopes of catching the person suspected of leaving behind two pipe bombs on Capitol Hill the night before the riot, one of the enduring, unsolved mysteries of that chaotic week.

The potential presence of the extremist groups at next week’s event is concerning because, while members and associates of Oath Keepers and Proud Boys make up just a fraction of the nearly 600 people who have been charged so far in the riot, they are facing some of the most serious charges brought.

Those charges include allegations that they conspired to block the certification of Biden’s victory. Several Oath Keepers have pleaded guilty to conspiracy charges and are cooperating with investigators in the case against their fellow extremists, who authorities say came to Washington ready for violence and willing to do whatever it took to stop the certification of the Electoral College vote.

Perhaps the most concerning: A series of unexploded pipe bombs placed near the Capitol on Jan. 5 remain unexplained and no suspect has been charged.

“I would hope that we wouldn’t have to fence in the Capitol every time there’s a demonstration,” Norton said. But she added, “If they go with the fence, I’m not going to criticize them.”

vaccine hesitancy is high.

The Economist’s normalcy index finds life in Hong Kong to be more similar to pre-pandemic times than anywhere else in the world. But restrictions are starting to chafe.

The territory reacted quickly to the spread of covid-19. The government closed the border with mainland China in February last year and banned all non-residents from entering. Laws mandate mask-wearing, the use of contact-tracing apps and testing.

With the rest of the world slowly opening up, Hong Kong is stuck in isolation. The border with China is still closed, to the frustration of many families and businesses

Vaccination rates were boosted somewhat by incentives, including prize draws for flats and Rolex watches, and within younger groups around 70-80% have had a second dose. But among the vulnerable over-80s just 13% have had two shots, leaving them at risk when Delta does arrive.

Hong Kong has offered free shots for all since April but many people opted to wait and see. Some worry about side effects; others do not trust their government which has pushed a jab produced by Sinovac, a Chinese firm, despite questions over its efficacy (Pfizer’s vaccine is also available for free).

Since September Hong Kong has allowed 2,000 people from the mainland and Macau (Hong Kong’s tiny neighbour) to enter each day without quarantine. But the offer has not been reciprocated.

Hong Kong must go further: more vaccines, better testing and longer hospital stays for recovering patients.

Giving the government in Beijing access to its data will make many Hong Kongers uncomfortable, but the dismantling of the territory’s political opposition has intimidated many people, forcing them to swallow any such grievances.

The only clear way out is through vaccinations. Hong Kong could do more to encourage its citizens to get jabbed.

Some places offer more freedoms to vaccinated citizens. For example New South Wales, an Australian state, will allow them to use gyms and visit each other’s homes.

monetary incentives have been effective at encouraging vaccination. But spending vouchers distributed to Hong Kongers this year were not linked to vaccine status.

As most of the world accepts that covid-19 will become endemic, Hong Kong will be forced to close itself off even further.

According to the documents, Facebook is aware that its products are being used to facilitate hate speech in the Middle East, violent cartels in Mexico, ethnic cleansing in Ethiopia, extremist anti-Muslim rhetoric in India, and sex trafficking in Dubai. It is also aware that its efforts to combat these things are insufficient. A March 2021 report notes, “We frequently observe highly coordinated, intentional activity … by problematic actors” that is “particularly prevalent—and problematic—in At-Risk Countries and Contexts”; the report later acknowledges, “Current mitigation strategies are not enough.”

As recently as late 2020, an internal Facebook report found that only 6 percent of Arabic-language hate content on Instagram was detected by Facebook’s systems. Another report that circulated last winter found that, of material posted in Afghanistan that was classified as hate speech within a 30-day range, only 0.23 percent was taken down automatically by Facebook’s tools. In both instances, employees blamed company leadership for insufficient investment.

last year, according to the documents, only 13 percent of Facebook’s misinformation-moderation staff hours were devoted to the non-U.S. countries in which it operates, whose populations comprise more than 90 percent of Facebook’s users.

Among the consequences of that pattern, according to the memo: The Hindu-nationalist politician T. Raja Singh, who posted to hundreds of thousands of followers on Facebook calling for India’s Rohingya Muslims to be shot—in direct violation of Facebook’s hate-speech guidelines—was allowed to remain on the platform despite repeated requests to ban him, including from the very Facebook employees tasked with monitoring hate speech.

The granular, procedural, sometimes banal back-and-forth exchanges recorded in the documents reveal, in unprecedented detail, how the most powerful company on Earth makes its decisions. And they suggest that, all over the world, Facebook’s choices are consistently driven by public perception, business risk, the threat of regulation, and the specter of “PR fires,” a phrase that appears over and over in the documents.

“It’s an open secret … that Facebook’s short-term decisions are largely motivated by PR and the potential for negative attention,” an employee named Sophie Zhang wrote in a September 2020 internal memo about Facebook’s failure to act on global misinformation threats.

In a memo dated December 2020 and posted to Workplace, Facebook’s very Facebooklike internal message board, an employee argued that “Facebook’s decision-making on content policy is routinely influenced by political considerations.”

To hear this employee tell it, the problem was structural: Employees who are primarily tasked with negotiating with governments over regulation and national security, and with the press over stories, were empowered to weigh in on conversations about building and enforcing Facebook’s rules regarding questionable content around the world. “Time and again,” the memo quotes a Facebook researcher saying, “I’ve seen promising interventions … be prematurely stifled or severely constrained by key decisionmakers—often based on fears of public and policy stakeholder responses.”

And although Facebook users post in at least 160 languages, the company has built robust AI detection in only a fraction of those languages, the ones spoken in large, high-profile markets such as the U.S. and Europe—a choice, the documents show, that means problematic content is seldom detected.

Employees weren’t placated. In dozens and dozens of comments, they questioned the decisions Facebook had made regarding which parts of the company to involve in content moderation, and raised doubts about its ability to moderate hate speech in India. They called the situation “sad” and Facebook’s response “inadequate,” and wondered about the “propriety of considering regulatory risk” when it comes to violent speech.

A 2020 Wall Street Journal article reported that Facebook’s top public-policy executive in India had raised concerns about backlash if the company were to do so, saying that cracking down on leaders from the ruling party might make running the business more difficult.

“I have a very basic question,” wrote one worker. “Despite having such strong processes around hate speech, how come there are so many instances that we have failed? It does speak on the efficacy of the process.”

Two other employees said that they had personally reported certain Indian accounts for posting hate speech. Even so, one of the employees wrote, “they still continue to thrive on our platform spewing hateful content.”

Taken together, Frances Haugen’s leaked documents show Facebook for what it is: a platform racked by misinformation, disinformation, conspiracy thinking, extremism, hate speech, bullying, abuse, human trafficking, revenge porn, and incitements to violence

It is a company that has pursued worldwide growth since its inception—and then, when called upon by regulators, the press, and the public to quell the problems its sheer size has created, it has claimed that its scale makes completely addressing those problems impossible.

Instead, Facebook’s 60,000-person global workforce is engaged in a borderless, endless, ever-bigger game of whack-a-mole, one with no winners and a lot of sore arms.

Zhang details what she found in her nearly three years at Facebook: coordinated disinformation campaigns in dozens of countries, including India, Brazil, Mexico, Afghanistan, South Korea, Bolivia, Spain, and Ukraine. In some cases, such as in Honduras and Azerbaijan, Zhang was able to tie accounts involved in these campaigns directly to ruling political parties. In the memo, posted to Workplace the day Zhang was fired from Facebook for what the company alleged was poor performance, she says that she made decisions about these accounts with minimal oversight or support, despite repeated entreaties to senior leadership. On multiple occasions, she said, she was told to prioritize other work.

A Facebook spokesperson said that the company tries “to keep people safe even if it impacts our bottom line,” adding that the company has spent $13 billion on safety since 2016. “​​Our track record shows that we crack down on abuse abroad with the same intensity that we apply in the U.S.”

Zhang's memo, though, paints a different picture. “We focus upon harm and priority regions like the United States and Western Europe,” she wrote. But eventually, “it became impossible to read the news and monitor world events without feeling the weight of my own responsibility.”

Indeed, Facebook explicitly prioritizes certain countries for intervention by sorting them into tiers, the documents show. Zhang “chose not to prioritize” Bolivia, despite credible evidence of inauthentic activity in the run-up to the country’s 2019 election. That election was marred by claims of fraud, which fueled widespread protests; more than 30 people were killed and more than 800 were injured.

“I have blood on my hands,” Zhang wrote in the memo. By the time she left Facebook, she was having trouble sleeping at night. “I consider myself to have been put in an impossible spot—caught between my loyalties to the company and my loyalties to the world as a whole.”

What happened in the Philippines—and in Honduras, and Azerbaijan, and India, and Bolivia—wasn’t just that a very large company lacked a handle on the content posted to its platform. It was that, in many cases, a very large company knew what was happening and failed to meaningfully intervene.

solving problems for users should not be surprising. The company is under the constant threat of regulation and bad press. Facebook is doing what companies do, triaging and acting in its own self-interest.

The investigation into the Hastings massacres began in 2017 after a Bay Area lawyer, John Briscoe, published an opinion essay in The San Francisco Chronicle under the headline, “The Moral Case for Renaming Hastings College of the Law.”

A number of prominent Hastings alumni, including senior retired judges, disagree and have called for a renaming. They say that like the fortune of the Sackler family, derived from the opioids that ultimately killed multitudes of Americans, the gold Mr. Hastings donated to found the school is tainted.

Native leaders say they hope the Hastings controversy could be a possible catalyst to bring awareness to a terrible legacy that few Californians know about. Greg Sarris, the chairman of the Federated Indians of Graton Rancheria, a Northern California confederation of tribes, is donating proceeds from his tribe’s casino to fund efforts at the Smithsonian to produce curriculums about Native history, including an Indian perspective on the Gold Rush era.

That period was a particularly treacherous and murderous time in California — “a catalog of slit throats, gunshot wounds and crushed skulls,” wrote Kevin Starr, a California historian.

Brendan Lindsay, author of the 2012 book “Murder State: California’s Native American Genocide, 1846-1873,” says ranchers hunted Indians in the way they might track down a fox that ventured into a henhouse.

According to the chronology by Dr. Lindsay, one set of killings was carried out by H.L. Hall, who was hired to look after Mr. Hastings’s cattle and horse ranches in 1858. When four or six — accounts differ — of the nearly 400 horses on the ranch were killed, Mr. Hall and three other men raided a Yuki village and killed nine or 11 tribespeople. During subsequent massacres, he rode into Yuki villages and killed women and children, including the girl he said he killed for “stubbornness.”