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Scientists call these two shapes the prefusion and postfusion forms of the spike. Antibodies against the prefusion shape work powerfully against the coronavirus, but postfusion antibodies don’t stop it.

they discovered a way to keep the protein locked in a tulip-like prefusion shape. All they had to do was change two of more than 1,000 building blocks in the protein into a compound called proline.

All three of the vaccines that have been authorized so far in the United States — from Johnson & Johnson, Moderna and Pfizer-BioNTech — use the 2P spike.

Other vaccine makers are using it as well. Novavax has had strong results with the 2P spike in clinical trials and is expected to apply to the Food and Drug Administration for emergency use authorization in the next few weeks. Sanofi is also testing a 2P spike vaccine and expects to finish clinical trials later this year.

Dr. McLellan’s ability to find lifesaving clues in the structure of proteins has earned him deep admiration in the vaccine world. “This guy is a genius,” said Harry Kleanthous, a senior program officer at the Bill & Melinda Gates Foundation. “He should be proud of this huge thing he’s done for humanity.”

The potency of the vaccine brought an extra benefit: The researchers needed fewer viruses for an effective dose. A single egg may yield five to 10 doses of NDV-HXP-S, compared to one or two doses of influenza vaccines.

once Dr. McLellan and his colleagues handed off the 2P spike to vaccine makers, he turned back to the protein for a closer look. If swapping just two prolines improved a vaccine, surely additional tweaks could improve it even more.

The winner contained the two prolines in the 2P spike, plus four additional prolines found elsewhere in the protein. Dr. McLellan called the new spike HexaPro, in honor of its total of six prolines.

The structure of HexaPro was even more stable than 2P, the team found. It was also resilient, better able to withstand heat and damaging chemicals. Dr. McLellan hoped that its rugged design would make it potent in a vaccine.

the University of Texas set up a licensing arrangement for HexaPro that allows companies and labs in 80 low- and middle-income countries to use the protein in their vaccines without paying royalties.

The first wave of authorized Covid-19 vaccines require specialized, costly ingredients to make. Moderna’s RNA-based vaccine, for instance, needs genetic building blocks called nucleotides, as well as a custom-made fatty acid to build a bubble around them. Those ingredients must be assembled into vaccines in purpose-built factories.

The way influenza vaccines are made is a study in contrast. Many countries have huge factories for making cheap flu shots, with influenza viruses injected into chicken eggs. The eggs produce an abundance of new copies of the viruses. Factory workers then extract the viruses, weaken or kill them and then put them into vaccines.

In March, he joined forces with two fellow University of Texas biologists, Ilya Finkelstein and Jennifer Maynard. Their three labs created 100 new spikes, each with an altered building block. With funding from the Gates Foundation, they tested each one and then combined the promising changes in new spikes. Eventually, they created a single protein that met their aspirations.

PATH then connected the Mount Sinai team with influenza vaccine makers. On March 15, Vietnam’s Institute of Vaccines and Medical Biologicals announced the start of a clinical trial of NDV-HXP-S. A week later, Thailand’s Government Pharmaceutical Organization followed suit. On March 26, Brazil’s Butantan Institute said it would ask for authorization to begin its own clinical trials of NDV-HXP-S.

n vaccine maker Avi-Mex as an intranasal spray. The company will start clinical trials to see if the vaccine is even more potent in that form.

Before this study, continuous temperature record reconstruction only went back about 2,000 years. The temperature trend produces a line shaped like a "hockey stick" with a sudden spike after what had been a fairly steady line. That data came from tree rings, ice cores and lake sediments.

the general downward trend of temperatures that reversed 100 years ago seemed to indicate the Earth was heading either toward another ice age or little ice age from about 1550 to 1850. Or it was continuing to cool naturally until greenhouse gases from the burning of fossil fuels changed everything.

"We have, through human emissions of carbon dioxide and other heat-trapping gases, indefinitely delayed the onset of the next ice age and are now heading into an unknown future where humans control the thermostat of the planet,

Experts think the UK or "Kent" strain emerged in September and may be up to 70% more transmissible or infectious, although latest research by Public Health England puts it between 30% and 50%.

The South Africa variant emerged in October, and it has more potentially important changes in the spike protein than the UK variant. It has one of the same mutations as the UK one, plus two more that scientists think may interfere more with vaccine effectiveness. One of these may help the virus evade parts of the immune system called antibodies.The UK has imposed a ban on direct flights from South Africa and restrictions on flights to the country.

The Brazil variant emerged in July and has three key mutations in the spike protein that make it similar to the South Africa one.

The current vaccines were designed around earlier variants, but scientists are confident that they should still work against the new ones, although perhaps not quite as well.

Vaccines train the body to attack several parts of the virus, however, not just these sections of the spike protein. Variants could emerge in the future that are more different again.Even in the worst case scenario, the vaccines could be redesigned and tweaked to be a better match - in a matter or weeks or months, if necessary,

As with flu vaccines, where a new shot is given each year to account for any changes in circulating flu viruses, something similar could happen for coronavirus.

There is currently no evidence to suggest that any of them cause more serious illness.Measures such as washing your hands, keeping your distance from other people and wearing a face covering will still help prevent infections, and because the new variants spread more easily it is important to be extra vigilant.

Scientists around the world are on the look-out and any new variants will be closely studied and monitored. Researchers at the Kenya Medical Research Institute say they are analysing a new variant that is different to the UK and South Africa strains, for example. The UK's vaccine development minster Nadhim Zahawi says measures have already been put in place to produce another wave of vaccines if needed.

Dogged by skepticism and inconsistent funding, these coronavirus researchers were stymied from developing treatments and vaccines for SARS—many of which could have been helpful in the current crisis.

Another similarly affected researcher was Brenda Hogue, a virologist at Arizona State University in Tempe. Hogue had devoted her career to studying coronaviruses, focusing on the protein machinery that drives their assembly. After SARS, she and her colleagues turned part of their attention toward developing a vaccine. But when the funding dropped off in 2008, she said, the vaccine went into limbo “and we put our efforts into other directions.”

to some experts whose business it is to hunt potential pathogens before they spill over into human populations, the many years spent not girding for a serious coronavirus outbreak were tragically—and unnecessarily—wasted.

“We were out there on the ground after SARS, working on coronaviruses with Chinese colleagues in collaboration,” said Peter Daszak, president of the EcoHealth Alliance, a New York–based nonprofit group that took part in a large federally funded effort, called Predict, to hunt for new pandemic viruses in wildlife in 31 countries, including China. That program was famously defunded last fall, just before the SARS-CoV-2 outbreak began.

“But we were the only group of western scientists,” Daszak added. “How can we be the only people looking for these viruses when there was such a clear and present danger?”

when SARS emerged in late 2002, there was initially “general disbelief among medical people that a coronavirus could be the basis of such a huge outbreak.”

As that epidemic spread, an influx of new researchers crowded the field. More grants were awarded, and funding started to climb. “Everyone wanted to know where the virus had come from,” said Ralph Baric, a microbiologist at the University of North Carolina’s Gillings School of Global Public Health. Initial findings pointed to wild civets and raccoon dogs sold for meat and pelts, respectively, in Chinese markets. Later evidence began to implicate horseshoe bats as the original source of the infections. Some researchers whose pre-SARS careers had been grounded in basic coronavirus biology began working on therapies and vaccines—and they made steady progress for several years.

funding declines hobbled individual investigators who weren’t part of these larger consortia. Pharmaceutical companies that develop vaccines and therapies scaled back on coronavirus research, too. Within a few years after the SARS outbreak, public health funding agencies both in the United States and abroad “no longer regarded coronaviruses as a high public health threat compared to other diseases,” Saif wrote in an email.

Then on May 12, The Wall Street Journal reported that the Chinese government was responding in kind, “by stalling international efforts to find the source of the [SARS-CoV-2] virus amid an escalating U.S. push to blame China for the pandemic.”

To demonstrate that a particular virus is actually harmful to people, scientists need to isolate and culture the microbe and show it infects human cells in the lab

Led by virologist Zheng-Li Shi, the Wuhan team reported in 2013 that this particular virus, called WIV1, binds with ACE2 in civet and human cells, and then replicates efficiently inside them. “That was the red flag,” Saif said. Earlier evidence suggested that direct contact with these bats could lead to viral spillover in humans. “Now there was proof of that.”

hen cases of those diseases fell off, public-health responders shifted to other viral emergencies such as Ebola and Zika, and coronavirus research funding dropped sharply.

They created a hybrid microbe by attaching the spike protein from SHC014 to the genetic backbone of a SARS-like virus that was previously adapted to grow in mice. Called a chimera—an organism containing cells with more than one genotype—this lab-made microbe had no problem binding with ACE2 and infecting human cells. Baric’s research team concluded that like WIV1, any SARS-like viruses outfitted with the SHC014 spike could pose cross-species threats to people.

Baric acknowledged the risky nature of the research but emphasized the safety protocols. “In general, we don’t know the transmissibility or virulence potential of any bat viruses or chimeras,” Baric said in an email message. “Hence it’s best to keep and work with them under biosafety level 3 laboratory conditions to maximize safety.”

Baric also pointed out that a chimera would display a genetic signature “that says what it is.” The adjoining parts of a chimera segregate discreetly in a logical pattern.

A genetic analysis of the chimera produced in his lab, for instance, “would come out to be mouse-adapted SARS everywhere but the spike, which is SHC014.” Similar logical patterns are absent in SARS-CoV-2, indicating that the virus that causes COVID-19 evolved naturally.

ven as Baric and others were generating lab evidence that more SARS-like viruses were poised for human emergence, another outbreak—in pigs, not people—provided another strong and recent signal: Some 25,000 piglets were killed by a coronavirus in the Guangdong province of China, starting in 2016. That virus, too, was found in horseshoe bats, and Buchmeier described the outbreak as both a major cross-species spillover and a warning shot that was never really picked up by the broader public-health community.

The EcoHealth Alliance, which had been part of the Predict effort, maintained its own collaboration with the Wuhan Institute of Virology using funds supplied by the National Institutes of Health. But on April 24, the Trump administration—which is investigating whether SARS-CoV-2 escaped accidentally from the Wuhan Institute, an allegation that’s been broadly discredited—directed the NIH to cut off that support.

The bats had been trapped in a cave in Kunming, the capital of the Yunnan province. At least seven other SARS-like strains were present in that same colony, leading the researchers to speculate that bat coronaviruses remained “a substantial global threat to public health.”

To disease experts, the bickering is a worrying—perhaps even astonishing—indicator that at least some global leaders still aren’t hearing what they have to say about the threat of coronaviruses, and Baric asserted that the ongoing pandemic exposes the need for better communication between countries, not less. “That is absolutely key,” he said. “Critical information needs to be passed as quickly as possible.”

Many other warnings would follow.Indeed, evidence of a looming and more deadly coronavirus pandemic had been building for years. Yet experts who specialize in coronaviruses—a large family of pathogens, found especially in birds and mammals, that can cross over to humans from other mammals and cause varying degrees of illness—struggled to convince a broader audience of the risk

the number of coronavirus-research grants funded by the National Institutes of Health—which had increased from a low of 28 in 2002 to a peak of 103 in 2008—went into a tailspin.

Though support for coronavirus research spiked a bit with the MERS outbreak in 2012, the increase was short-lived. Since that outbreak was quickly contained, the disease didn’t raise wider concerns and grant opportunities declined further.

Ironically, just as funding for drugs and vaccines was drying up, evidence that other coronavirus threats lurked in wildlife was only getting stronger

Ten years would pass, however, before researchers could show there were other SARS-like viruses in nature that also bind with ACE2. The evidence came from a team based at the Wuhan Institute of Virology

The split suggests that Moderna’s vaccine doesn’t just block the virus in most cases, but also shields the people who do get sick from the worst outcomes of the disease. It also eases concerns that a vaccine for Covid-19 may make the disease worse, not better.

Pfizer’s outside board of experts analyzed 94 volunteers and estimated that the effectiveness of its vaccine was over 90 percent. They did not specify how many people who got sick had received the vaccine or the placebo.

The Pfizer and Moderna vaccines are similar not only because they use mRNA but also because they coax our cells to make the same viral protein, called spike. Other vaccines that don’t use mRNA also make the spike protein their target. The success of Moderna and Pfizer may bode well for them as well.

AstraZeneca and Johnson & Johnson are also conducting Phase 3 trials on adenoviruses that carry the spike protein gene. And other companies, including Novavax and Medicago, are running advanced trials on vaccines that deliver the spike protein itself, or pieces of it, to the body.

While scientists have investigated mRNA vaccines for years, no vaccine has yet been licensed as safe and effective to use in people.

It’s possible that the distribution of one or both vaccines will begin by the end of the year.

“This is not going to dig us out of what’s ahead this next month,” Natalie Dean, a biostatistician at the University of Florida, warned about Thanksgiving and the coming holiday season.

the eurozone, which is made up of 19 economies including France and Germany, is enduring big price hikes as a result of the economic recovery from the coronavirus pandemic and blockages in supply chains.

Across the eurozone, inflation is running at multiyear highs, including in Germany, Europe’s largest economy, where the annual rate has hit 6%.

Even that is below the 6.2% recorded at last count in the U.S., the biggest 12-month jump since 1990.

The eurozone’s core inflation rate, which strips out potentially volatile items such as alcohol, energy, food and tobacco, also spiked higher in November to an annual rate of 2.6% from 2%.

higher wages, for example.

However, the recently discovered omicron variant of the coronavirus has prompted some uncertainty over the global economic outlook, and as a result, central banks around the world are expected to hold back from announcing any big policy changes soon.

Many economists think the inflation spike over recent months will reverse next year as base effects linked with the sharp fall in prices during the pandemic last year, primarily of energy, are stripped out from annual comparisons.

Records started being compiled about the euro two years before its actual launch in 1999. For the first three years of its existence, it was an invisible currency that was traded on foreign exchange markets and used for accounting purposes and electronic payments. In 2002, euro notes and coins first came into circulation, replacing historic currencies such as the French franc, the German deutschmark and the Italian lira.

spike in anti-Muslim incidents across the United States in recent weeks that can be linked to last week’s mass shooting in California and the inflammatory rhetoric of Donald Trump

created an atmosphere ripe for these types of stereotypes and incidents,”

“I have never seen such fear and apprehension in the Muslim community, even after 9/11.”

racked more than three dozen incidents since the Nov. 13 terror attacks in Paris that left 130 dead.

spike began with the Paris attacks and has intensified with what happened in San Bernardino and now with what Donald Trump is proposing

pace of the incidents appears to have picked up since the Dec. 2 shooting in San Bernardino that killed 14 people and injured 21 others.

Rick Santorum who questioned whether the U.S. Constitution protected Islam

“After 9/11 there were hate crimes on the edges of society, but now it’s in the mainstream with the leading Republican presidential candidate saying Muslims are not wanted in America.”

police have stepped up patrols around houses of worship after a severed pig’s head was left outside the Al Aqsa Islamic Society

Florida man was arrested after authorities said he vandalized the Islamic Center

someone claiming to be a former Marine left a threatening voicemail message on the mosque’s answering machine on Saturday

man said he “killed a lot of Muslims” and, using expletives, said he would decapitate Muslims.

I kill Muslims,” before punching him in his left eye.

Despite a 20% pullback in recent weeks, random-length lumber futures are still up more than 400% from their April 2020 low. Lumber prices have skyrocketed so much that it's causing remodeling nightmares and creating even more sticker shock in the booming housing market.

Likewise, prices for US hot-rolled, coil steel, the most widely produced finished steel product, have spiked almost 270% since bottoming out last August and hit a record high of $1,616 per ton on Friday, according to S&P Global Platts. Before this boom, the prior peak was $1,100 in 2008.

Murphy, whose organization opposed the Section 232 steel tariffs from the beginning, argued tariff relief is a way government can help accelerate the recovery while simultaneously easing inflation jitters.

Meanwhile, both the steel and lumber industries are strongly urging Biden to keep the tariffs in place. Removing them could prove to be politically unpopular, especially among steel workers in battleground Rust Belt states.

Scott argued the steel tariffs effectively supported the industry and that removing them, along with quotas limiting imports, would lead to both a "hemorrhaging of jobs" and importing steel that is in many cases worse for the environment than what is made in America.

The Biden administration does not appear to have made a decision yet on lifting the steel or lumber tariffs, though new efforts are being made to address rising inflation concerns.

Biden announced late last week his administration will soon take unspecified steps to fight supply chain pressures, beginning with construction materials and transportation bottlenecks.

“I want to stress that we are deeply concerned that this strain is more transmissible and can accelerate outbreaks in the U.S.

Covid cases and deaths have broken record after record across the country, with a peak number of deaths, 4,400, announced on Tuesday. At least 3,973 new deaths and 238,390 new cases were reported on Thursday, and the nation is nearing a milestone of 400,000 deaths.

The new variant, called B 1.1.7 was first identified in Britain, where it rapidly became the primary source of infections, accounting for as many 60 percent of new cases diagnosed in London and surrounding areas.

In the new report, C.D.C. scientists modeled how quickly the variant might spread in the United States, assuming about 10 percent to 30 percent of people have pre-existing immunity to the virus, and another 1 million people will be vaccinated each week beginning this month.

It’s not yet clear what makes the new variants more contagious. They share at least one mutation, called N501Y, that is thought to be involved. One possibility, researchers said, is that the mutation may increase the amount of virus in the nose but not in the lungs — potentially explaining why it is more contagious, but not more deadly.A higher amount of virus in the nose means anyone infected would expel more virus while talking, singing, coughing or even breathing, said Trevor Bedford, an evolutionary biologist at the Fred Hutchinson Cancer Research Center in Seattle

Federal health officials sounded the alarm Friday about a fast spreading, far more contagious variant of the coronavirus that is projected to become the dominant source of infection in the country by March, potentially fueling another wrenching surge of cases and deaths.

The variant is not known to be more deadly or to cause more severe disease. But the dire warning — hedged by limited data about just how prevalent the variant first identified in Britain has become — landed in a week where the nation’s nascent vaccination campaign was hampered by confusion and limited supplies as demand grew among growing numbers of eligible people

Only 76 cases of the variant have been identified so far in the U.S., but the actual number is believed to be higher and is expected to spiral upward in the next few weeks, officials said.

One in 860 Americans have died of Covid-19 in the last year, according to new figures released by the C.D.C. But the burden of deaths has not fallen equally across racial, ethnic lines and geographic regions, and there is concern that vaccines will not reach the hardest hit communities, where access to health services is limited and distrust is rampant. Editors’ PicksFor Pro Athlete Leading Social Justice Push, a Victory and UncertaintyJames Comey’s View of Justice — and How It Differs From Donald Trump’sHow ‘Orwellian’ Became an All-Purpose InsultAdvertisementContinue reading the main storyImage

But spikes in cases threaten to cripple already overwhelmed hospitals and nursing homes in many parts of the country. Some are at or near capacity. Others have faced troubling rates of infection among their staff, causing shortages and increasing patient loads.

If the variant is about 50 percent more contagious, as suggested by data from Britain, it will become the predominant source of all infections in the United States by March, the model showed. A slow rollout of vaccinations will hasten that fate.

“It doesn’t have to do with UV light, it has to do with dilution,” she told TPM, a subtle poke at President Trump. “What it appears with this virus is that though it’s highly contagious, to get a good infectious process going, you need to start with a substantive amount. Dilution disperses viral particles present in the physical area.”

That level of dispersion just doesn’t happen inside, she said, especially during the summer when air conditioners are recirculating the same air. 

Wen added that mask-wearing can reduce the risk of transmission “five-fold.”

“This should help to inform people even more about big decisions they can make in their own lives, to be doing as much as they can outdoors vs. indoors,”

The nationwide lack of spikes also speaks to the uniformity with which protesters donned masks at the demonstrations, per Hassig.

“It takes engagement with mask-wearing somewhere above 70 percent, at least 60, to really dampen down transmission,”

If the data holds, though, she pointed out how this knowledge could play into how people live their lives while the pandemic still lingers.

The problem with masks, Hassig said, is the psychological element. She called it a “normative behavior” much like littering. It’s hard to be the first person to drop a wrapper on the ground; it’s much less hard to do so if the pavement is already dotted with trash. That dynamic, she said, can go both ways — people are apt to feel uncomfortable if they’re the odd one out in a group either mostly wearing masks or mostly not. 

this idea and its implications stir more controversy among criminologists than any other. Would you state your position as precisely as possible in this brief space?

Latzer: First of all, culture and race, in the biological or genetic sense, are very different. Were it not for the racism of the 18th and 19th centuries, we might not have had a marked cultural difference between blacks and whites in the U.S. But history cannot be altered, only studied and sometimes deplored. 28 28

Different groups of people, insofar as they consider themselves separate from others, share various cultural characteristics: dietary, religious, linguistic, artistic, etc. They also share common beliefs and values. There is nothing terribly controversial about this. If it is mistaken then the entire fields of sociology and anthropology are built on mistaken premises.

With respect to violent crime, scholars are most interested in a group's preference for violence as a way of resolving interpersonal conflict. Some groups, traditionally rural, developed cultures of “honor”—strong sensitivities to personal insult. We see this among white and black southerners in the 19th century, and among southern Italian and Mexican immigrants to the U.S. in the early 20th century. These groups engaged in high levels of assaultive crimes in response to perceived slights, mainly victimizing their own kind.

This honor culture explains the high rates of violent crime among African Americans who, living amidst southern whites for over a century, incorporated those values. When blacks migrated north in the 20th century, they transported these rates of violence. Elijah Anderson's book, The Code of the Streets, describes the phenomenon, and Thomas Sowell, in Black Liberals and White Rednecks, helps explain it. 28 28

Theories of crime that point to poverty and racism have the advantage of explaining why low-income groups predominate when it comes to violent crime. What they really explain, though, is why more affluent groups refrain from such crime. And the answer is that middle-class people (regardless of race) stand to lose a great deal from such behavior.

Likewise, the lead removal theory. The same "lead-free" generation that engaged in less crime from 1993 on committed high rates of violent crime between 1987 and 1992.

Frum: Let’s flash forward to the present day. You make short work of most of the theories explaining the crime drop-off since the mid-1990s: the Freakonomics theory that attributes the crime decline to easier access to abortion after 1970; the theory that credits reductions in lead poisoning; and the theory that credits the mid-1990s economic spurt. Why are these ideas wrong? And what would you put in their place? 28 28

both the abortion and leaded-gasoline theories are mistaken because of a failure to explain the crime spike that immediately preceded the great downturn. Abortions became freely available starting in the 1970s, which is also when lead was removed from gasoline. Fast-forward 15 to 20 years to the period in which unwanted babies had been removed from the population and were not part of the late adolescent, early adult, cohort. This cohort was responsible for the huge spike in crime in the late 1980s, early 1990s, the crack cocaine crime rise. Why didn't the winnowing through abortion of this population reduce crime?

The cultural explanation for violence is superior to explanations that rest of poverty or racism, however, because it can account for the differentials in the violent-crime rates of groups with comparable adversities

As for economic booms, it is tempting to argue that they reduce crime on the theory that people who have jobs and higher incomes have less incentive to rob and steal. This is true. But violent crimes, such as murder and manslaughter, assault, and rape, are not motivated by pecuniary interests. They are motivated by arguments, often of a seemingly petty nature, desires for sexual conquest by violence in the case of rape, or domestic conflicts, none of which are related to general economic conditions

Rises in violent crime have much more to do with migrations of high-crime cultures, especially to locations in which governments, particularly crime-control agents, are weak.

Declines are more likely when crime controls are strong, and there are no migrations or demographic changes associated with crime rises

In short, the aging of the violent boomer generation followed by the sudden rise and demise of the crack epidemic best explains the crime trough that began in the mid-1990s and seems to be continuing even today.

Contrary to leftist claims, strengthened law enforcement played a major role in the crime decline. The strengthening was the result of criminal-justice policy changes demanded by the public, black and white, and was necessitated by the weakness of the criminal justice system in the late ‘60s

On the other hand, conservatives tend to rely too much on the strength of the criminal-justice system in explaining crime oscillations, which, as I said, have a great to do with migrations and demographics

The contemporary challenge is to keep law enforcement strong without alienating African Americans, an especially difficult proposition given the outsized violent-crime rates in low-income black communities.

Frum: The sad exception to the downward trend in crime since 1990 is the apparent increase in mass shootings

Should such attacks be included in our thinking about crime? If so, how should we think about them? 28 28

If we separate out the ideologically motivated mass killings, such as Orlando (apparently) and San Bernardino, then we have a different problem. Surveilling potential killers who share a violent ideology will be extremely difficult but worthwhile. Limiting the availability of rapid-fire weapons with high-capacity ammunition clips is also worth doing, but politically divisive.

of course, developments abroad will affect the number of incidents, as will the copycat effect in the immediate aftermath of an incident. This is a complex problem, different from ordinary killings, which, by the way, take many more lives.

The workers I interviewed after the recession for my book on unemployment—less-educated factory workers—offer some tentative clues about what might be driving the disquieting trends described by the Case and Deaton study.

This is one of the groups hit hardest by the rising inequality and greater risk of unemployment and financial insecurity that have become features of today’s economy, and their experiences put in concrete terms how the economy and culture have become more hostile to workers not lucky enough to be working in posh offices on Wall Street or in Silicon Valley.

When it comes to explaining American economic trends, it is important to remember how critical a role manufacturing and unions have played in the building—and now dismantling—of a strong middle class.

or generations, factories provided good jobs to people who never went to college, allowing families—first white ethnic immigrants, and then others—to be upwardly mobile.

But in the late ’90s—the beginning of the crisis period that Case and Deaton identify—the number of manufacturing jobs in the U.S. dropped dramatically.

Political leaders, bankrolled by the wealthy, rolled back the interventionist policies of the New Deal and postwar period.

Corporations, once relatively tolerant of unions, tapped a cottage industry of anti-union consultants and adopted unseemly tactics to crush any organizing drives in their workplaces.

the two-thirds of Americans over the age of 25 who don’t have a bachelor’s degree

Certainly, it cannot be said enough that African Americans and Latinos continue to fare significantly worse than whites in terms of their overall rates of death and disease, even if the racial gap has narrowed.

. In the decades after World War II, racial minorities were denied many of the jobs, loans, and other resources that allowed the white majority to buy homes and accrue wealth.

If the gains of economic growth have gone largely to the rich in recent years, in that earlier period the white working class could count on hefty rises in living standards from generation to generation, and they grew accustomed to that upward trajectory of growing prosperity.

For example, while the disappearance of high-paying jobs for those with little education is a large part of the overall story of a shrinking middle class, it can’t wholly account for the uptick of mortality identified in the Case and Deaton study.

Likewise, the groups that have been affected most viciously by these market trends in the U.S., African Americans and Latinos, have not suffered the dramatic increases in death by suicide or substance abuse that whites have.

hite Americans, for instance, are more likely to see success as the result of individual effort than African Americans are (though not Hispanics). The less educated, particularly less-educated whites, also share this view to a disproportionate degree.

As scholars of family life as politically distinct as Andrew Cherlin and Charles Murray have stressed, college graduates and the less educated have greatly diverged in terms of when and how they partner up and have kids.

Nowadays, well-educated couples are much more likely to marry, stay married, and have children within marriage than those with less schooling.

A large part of the explanation for this must be that society’s attitudes about the sanctity and permanence of marriage have changed. But it’s important to note that there is an economic dimension to these trends, too—as the frequent separations and divorces I saw among the long-term unemployed made plain to me.

Those struggling financially are less likely to follow the traditional path of first comes marriage, then comes a baby.

The waning of religious belief may be another trend aggravating the modern malaise of the white working class. Since the ’90s, the number of Americans who declare no religious preference on surveys has almost tripled—from 8 percent at the beginning of that decade, to 21 percent in 2014.

Many said their faith was helping them get through their ongoing troubles, yet they rarely or never went to church. Some felt ashamed to be around people because they were out of work.

For others, their religious belief was somewhat a source of self-help, rather than a source of community.

The larger context of this isolation and alienation is America’s culture of individualism. It, too, can worsen the despair. Taken to an extreme, self-reliance becomes a cudgel: Those who falter and fail have only themselves to blame.

America’s frontier spirit of rugged individualism is strong, and it manifests itself differently by race and education level, too.

When asked in national surveys about the people with whom they discussed “important matters” in the past six months, those with just a high-school education or less are likelier to say no one (this percentage has risen over the years for college graduates, too).

To this day, the supreme value of education remains one of the few things that Americans of all persuasions (presidential candidates included) can agree on.

Some of the analysis of the Case and Deaton article has focused rightly on recent developments in this country’s drug crisis—namely, the surge in abuse of prescription opioids, and the resurgence in heroin use, notably among whites.

There is clearly a pressing need to deal more vigorously with this drug problem and the epidemic of fatal overdoses and liver disease that has affected the poor and working class in particular.

At the same time, it should be said that risky individual behaviors are shaped by broader social conditions. As the researchers Bruce Link and Jo Phelan have argued, effective health interventions need to consider the underlying factors that put people “at risk of risks”—specifically, socioeconomic status and social support.

One parting observation, then, is that policies to keep people from sinking into poverty and long-term unemployment can make a huge difference.

The U.S. has reported more than 1,100 deaths, according to Johns Hopkins.

"in view of the rapid spread of Covid-19 across the world, China has decided to temporarily suspend the entry into China by foreign nationals holding visas or residence permits" as of March 28.

country is returning to normal.

At a Beijing gym popular with expats, managers posted a sign saying "foreign friends" would no longer be allowed to enter, "because of (the) overseas epidemic threshold." CNN also saw doormen at a bar in Sanlitun, a popular Beijing nightlife area, refusing entry to non-Chinese-looking patrons.

Jim Boyce, a Beijing resident who posted on Twitter about restrictions on foreigners, said that one barber shop which put up a sign barring non-Chinese still allowed at least one expat to get his hair cut there.

Sars-CoV-2 shares between 80% and 90% of its genetic material with the virus that caused Sars – hence its name. Both consist of a strip of ribonucleic acid (RNA) inside a spherical protein capsule that is covered in spikes. The spikes lock on to receptors on the surface of cells lining the human lung – the same type of receptor in both cases – allowing the virus to break into the cell. Once inside, it hijacks the cell’s reproductive machinery to produce more copies of itself, before breaking out of the cell again and killing it in the process.

Coronaviruses have caused two other recent epidemics – severe acute respiratory syndrome (Sars) in China in 2002-04, and Middle East respiratory syndrome (Mers), which started in Saudi Arabia in 2012. In both cases, work began on vaccines that were later shelved when the outbreaks were contained.

Though nobody could have predicted that the next infectious disease to threaten the globe would be caused by a coronavirus – flu is generally considered to pose the greatest pandemic risk – vaccinologists had hedged their bets by working on “prototype” pathogens.

All vaccines work according to the same basic principle. They present part or all of the pathogen to the human immune system, usually in the form of an injection and at a low dose, to prompt the system to produce antibodies to the pathogen. Antibodies are a kind of immune memory which, having been elicited once, can be quickly mobilised again if the person is exposed to the virus in its natural form.

Some of the Covid-19 vaccine projects are using these tried-and-tested approaches, but others are using newer technology.

Cepi’s original portfolio of four funded Covid-19 vaccine projects was heavily skewed towards these more innovative technologies, and last week it announced $4.4m (£3.4m) of partnership funding with Novavax and with a University of Oxford vectored vaccine project.

Clinical trials, an essential precursor to regulatory approval, usually take place in three phases. The first, involving a few dozen healthy volunteers, tests the vaccine for safety, monitoring for adverse effects. The second, involving several hundred people, usually in a part of the world affected by the disease, looks at how effective the vaccine is, and the third does the same in several thousand people. But there’s a high level of attrition as experimental vaccines pass through these phases.

There are good reasons for that. Either the candidates are unsafe, or they’re ineffective, or both. Screening out duds is essential, which is why clinical trials can’t be skipped or hurried. Approval can be accelerated if regulators have approved similar products before.

No vaccine made from genetic material – RNA or DNA – has been approved to date, for example. So the Covid-19 vaccine candidates have to be treated as brand new vaccines, and as Gellin says: “While there is a push to do things as fast as possible, it’s really important not to take shortcuts.”

It’s for these reasons that taking a vaccine candidate all the way to regulatory approval typically takes a decade or more, and why President Trump sowed confusion when, at a meeting at the White House on 2 March, he pressed for a vaccine to be ready by the US elections in November – an impossible deadline.

In the meantime, there is another potential problem. As soon as a vaccine is approved, it’s going to be needed in vast quantities – and many of the organisations in the Covid-19 vaccine race simply don’t have the necessary production capacity. Vaccine development is already a risky affair, in business terms, because so few candidates get anywhere near the clinic. Production facilities tend to be tailored to specific vaccines, and scaling these up when you don’t yet know if your product will succeed is not commercially feasible. Cepi and similar organisations exist to shoulder some of the risk, keeping companies incentivised to develop much-needed vaccines. Cepi plans to invest in developing a Covid-19 vaccine and boosting manufacturing capacity in parallel, and earlier this month it put out a call for $2bn to allow it to do so.

The problem is making sure the vaccine gets to all those who need it. This is a challenge even within countries, and some have worked out guidelines. In the scenario of a flu pandemic, for example, the UK would prioritise vaccinating healthcare and social care workers, along with those considered at highest medical risk – including children and pregnant women – with the overall goal of keeping sickness and death rates as low as possible. But in a pandemic, countries also have to compete with each other for medicines.

Because pandemics tend to hit hardest those countries that have the most fragile and underfunded healthcare systems, there is an inherent imbalance between need and purchasing power when it comes to vaccines.

Outside of pandemics, the WHO brings governments, charitable foundations and vaccine-makers together to agree an equitable global distribution strategy, and organisations like Gavi, the vaccine alliance, have come up with innovative funding mechanisms to raise money on the markets for ensuring supply to poorer countries. But each pandemic is different, and no country is bound by any arrangement the WHO proposes – leaving many unknowns.

It doesn’t require, for instance, quickly lifting quarantines based on outlying projections of low fatality rates, as some return-to-normalcy conservatives have been urging in the last week

Rational hope accepts that the situation is genuinely dark, but then it still looks around for signposts leading up and out. It recognizes that things are likely to get worse, but keeps itself alert to the contexts in which they seem to be getting better

three patterns where I’m finding optimism right now.

First, there is modest hope in data compiled by the smart-thermometer company Kinsa, which claims to be able to identify anomalous, unseasonal fever rates using data from its nationwide user base.

Kinsa’s data show a clear February-and-March anomaly across the U.S., especially in areas known to be affected by the coronavirus. But it also shows that anomaly diminishing as lockdowns and social distancing began

the sharp turn suggests that general infection curves can be changed quickly even during a pandemic, and that the policies of the last two weeks might be having a real epidemiological effect.

Second, there is hope in the differing course of the pandemic so far in Greater New York versus the Pacific Coast.

Washington State bent its curve after the initial surge and California’s case rate and death rate trends are a gentle incline — nothing like the New York area’s terrifying spike.

In the most optimistic case, the spike reflects New York’s unique density and heavy reliance on mass transit

maybe some of the divide reflects policy — the fact that West Coast leaders acted ever-so-slightly more swiftly and with more seriousness of purpose than the feckless Bill de Blasio in New York City.

it suggests that even if you initially fail to spot an outbreak, you can still hope to imitate South Korea rather than northern Italy.

the circumstantial evidence of Western versus Asian epidemic curves and the direct evidence of multiple studies suggest that masking works, and that its widespread adoption can change an epidemic’s course.

These three hopeful signs together hint at a path back toward quasi-normalcy. The current shutdown bends infection curves relatively quickly, outside a few major urban outbreaks. That policy response combines with America’s social-distancing sprawl and car culture and younger-than-Europe age profile to compensate for our initial incompetence and natural insubordination. And then the cheapest, lightest-weight means of slowing transmission becomes ubiquitous in U.S. cities by Memorial or Independence Day.

No one knows the depth of the recession, but it is hard to see how we will put the 16 million people who have filed for unemployment back to work without significant public investment.

rebounding from an economic disruption this large requires an equally large spike in demand and production. Outside of war, climate change is the only issue large enough to provide such a spike. Now is the time to create policies that provide immediate relief to communities, such as federal assistance to transition homes and businesses to renewable energy; give “green” fiscal aid to states; and fuel economic recovery with the creation of federally funded green jobs.

New York is conducting more testing per capita than countries such as South Korea, which may partially explain the spike in numbers.

“We need to be smarter about this … we need the federal help and we need it now,” he said, calling on Donald Trump to utilise the Defense Production Act (DPA) to force companies to produce medical equipment and provide them the necessary financial support to do so. So far, the administration has relied on volunteer efforts that Cuomo said were not appropriate for the urgency of crisis.

“What happens to New York is gonna wind up happening to California, and Washington state and Illinois. It’s just a matter of time. We’re just getting there first,” Cuomo said. “Look at us today … where we are today, you will be in four weeks or five weeks or six weeks. We are your future.”

Speaking later in the day, the vice-president, Mike Pence, said the Federal Emergency Management Agency (Fema) had sent New York 2,000 ventilators and plans to send 2,000 more on Wednesday.

With cases surging, Cuomo said new projections estimate his state will need 140,000 hospital beds once the crisis reaches its apex, which could happen within 14 to 21 days instead of in May as previously forecast.

uomo’s urgent message comes as a spokesperson for the World Health Organization (WHO) warned the US has the potential to become the next global hotspot for the pandemic. The country already has more than 46,000 confirmed Covid-19 cases, resulting in close to 600 deaths, according to Johns Hopkins University School of Medicine.

He also rejected the suggestion, floated by the president in recent days, that advice from public health officials could be rowed back in a matter of weeks to protect the US economy, saying that sensible steps in both areas could be made now without increasing risk to more vulnerable people in society.

The outbreak has led to a dramatic change in America’s social fabric: as of Monday, the New York Times estimated that more than 158 million people in 16 states would soon be under strict orders to stay at home – approaching half of the population.

The shift in messaging came after James Bullard, president of the Federal Reserve Bank of St Louis, predicted unemployment could reach 30% nationwide, according to Bloomberg News, and as negotiations for a coronavirus stimulus package dragged on for days in the US Senate. For weeks, suddenly jobless workers have been imploring the government for help, and Trump is staring down what could become a historic recession during an election year.

Even still, medical experts have cautioned against such an abrupt restart to the economy while the virus continues to spread exponentially. “You can’t call off the best weapon we have, which is social isolation, even out of economic desperation, unless you’re willing to be responsible for a mountain of deaths,” Arthur Caplan, founding head of the division of medical ethics at NYU School of Medicine, told the New York Times. “Can’t we try to put people’s lives first for at least a month?”

“If you ask the American people to choose between public health and the economy, then it’s no contest,” Cuomo said. “No American is going to say, accelerate the economy at the cost of human life, because no American is going to say how much a life is worth.”