Ghana's President Nana Akufo-Addo said Black people across the world are "shocked and distraught" by Floyd's killing.
"Black people, the world over, are shocked and distraught by the killing of an unarmed Black man, George Floyd, by a white police officer in the United States of America," Akufo-Addo said in a statement.
"We stand with our kith and kin in America in these difficult and trying times."
Kenyan opposition leader and former prime minister Raila Odinga offered a prayer for the US "that there be justice and freedom for all human beings who call America their country".
Like some in Africa who have spoken out, Odinga also noted troubles at home, saying the judging of people by character instead of skin colour "is a dream we in Africa, too, owe our citizens".
And South Africa's finance minister, Tito Mboweni, recalled leading a small protest outside the US Embassy several years ago over the apparent systemic killings of Blacks. Mboweni said the US ambassador at the time, Patrick Gaspard, "invited me to his office and said: 'What you see is nothing, it is much worse'."
Zimbabwe summoned the ambassador of the United States to the country over remarks by a senior US official accusing it of stirring anti-racism protests following Floyd's death.
In an interview with ABC News, US national security adviser Robert O'Brien referred to Zimbabwe and China as "foreign adversaries" using social media to stoke unrest and "sow discord" after the killing.
Zimbabwe's foreign ministry spokesman James Manzou said US Ambassador Brian Nichols was called in to explain O'Brien's remarks. Government spokesman Nick Mangwana said Zimbabwe did not consider itself "America's adversary".
"We prefer having friends and allies to having unhelpful adversity with any other nation including the USA," Mangwana said.