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Javier E

Opinion | Why Strangers Are Good for Us - The New York Times - 0 views

  • When I lived in New York City a decade ago, I couldn’t spend 10 minutes outside without speaking to someone. That’s the thing I loved about the place: how New Yorkers will kibbitz and comment and carry on a conversation in line for pizza, on the sidewalk or in the subway; ask for directions or compliment a particularly awesome hat of someone they have never met, without any awkwardness.
  • Today, you can spend a week in New York, shopping, traveling, eating and working, and never utter a sound to another human being, or even take your headphones off.
  • It shouldn’t be this way. Engagement with strangers is at the core of our social contract.
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  • Most religious faiths instruct us to welcome the strangers we encounter, and there’s good reason for this. If we engaged only with the people we knew, our world would be small.
  • That leap of faith toward the unknown other is what allows us to grow beyond the family unit, tribe or nation. Everyone you converse with who is not a biological relative — your best friend, neighbor, lover, spouse or even that chatty taxi driver from last weekend — was a stranger before you spoke to that person. Anytime we ignore strangers in our vicinity, whether because of fear, bigotry or the everyday convenience and efficiency of digital technology, we weaken that contract.
  • Far from random human inconveniences, strangers are actually one of the richest and most important resources we have. They connect us to the community, teach us empathy, build civility and are full of surprise and potentially wonder.
  • the small, transactional relationships we create by talking to strangers are important pillars of our social and emotional well-being.
  • “We have all these kinds of people who populate our lives, who we aren’t that close to and we don’t share our deepest, darkest secrets with,” said Dr. Sandstrom, who forces herself to speak to strangers every day, despite identifying as an introvert. “But they form this tapestry that when we’re not there, our life feels kind of empty.”
  • A study published last fall showed that despite our fears of awkwardness, deep, meaningful conversations with strangers are not only easier than expected but also left participants feeling better about themselves.
  • In some ways, our recent aversion to strangers is a byproduct of technological evolution. Sure, newspapers and magazines, cassette players and televisions were all potential distractions, but none of them fully normalized ignoring other people in the way that smartphones have. E-commerce sites and third-party restaurant delivery apps incentivize us against entering stores and restaurants filled with strangers
  • Then came the pandemic, and suddenly, each physical encounter with a stranger carried the potential of death. We were ordered to stay home, avoid public spaces and to speak only within our trusted bubbles.
peterconnelly

Canada Decriminalizes Opioids and Other Drugs in British Columbia - The New York Times - 0 views

  • Facing soaring levels of opioid deaths since the pandemic began in 2020, the Canadian government announced Tuesday that it would temporarily decriminalize the possession of small amounts of illegal drugs, including cocaine and methamphetamines, in the western province of British Columbia that has been ground zero for the country’s overdoses.
  • The announcement was applauded by families of deceased opioid users and by peer support workers
  • British Columbia declared drug-related deaths a public health emergency in 2016.
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  • “For too many years, the ideological opposition to harm reduction has cost lives,” said Dr. Carolyn Bennett, the federal minister of mental health and addictions, at a news conference on Tuesday.
  • British Columbia has been a leader in Canada’s harm reduction movement.
  • The exemption will go into effect on Jan. 31, 2023, and will expire after three years.
  • Decriminalization will allow police to focus on organized crime and drug traffickers, instead of individual users, said Sheila Malcolmson, the provincial minister of mental health and addictions. “We will take this year ahead to ready our justice and health systems,” she added.
  • “I think making drug use easier for them is kind of like palliative care,” said Mr. Doucette, who spent 35 years working for the Royal Canadian Mounted Police before retiring, most of which he spent in drug enforcement. “It’s just condemning them to a slow death because of drugs, whereas if you get them off drugs, get them a life back, they can enjoy life.”
  • British Columbia has one of the highest per capita rates of drug death across North America, at 42.8 deaths per 100,000 people in 2021, according to provincial data.
  • In the U.S., the 10 states with the highest level of drug overdose, have rates ranging between 39.1 deaths per 100,000 in Connecticut, to 81.4 deaths per 100,000 in West Virginia, according to the latest mortality data, for 2020, by the Centers for Disease Control.
Javier E

Russian Women Flock to Argentina to Give Birth - WSJ - 0 views

  • With the temporary residency, parents can begin the process to gain citizenship, migration authorities say. An Argentine passport can be obtained in as little as two years, immigration lawyers and migration officials say, and gives the holder the ability to travel visa-free to Europe, which Russians can’t do.
  • Ms. Davydova and other new arrivals say they feel welcomed. Argentina has historically been a destination for emigrants from Europe and more recently from Bolivia, Paraguay and Venezuela.
  • On Feb. 9, 33 young Russians in advanced stages of pregnancy arrived on that flight, Ms. Carignano told a local radio station. Two days later, another 83 passengers, 16 of them pregnant Russian women, arrived via the same route, she said.
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  • Many take the daily Ethiopian Airlines flight that originates in Moscow, stopping in Addis Ababa and São Paulo before landing in Buenos Aires—considered a relatively inexpensive route at around $2,500. They usually buy a round-trip ticket but don’t use the return.
  • The Buenos Aires Health Ministry said at its busiest public hospital, the Fernández Hospital, 85 of the 985 births last year, or 8.6%, were to Russian women. This year through Feb. 14, 38 of the 168 births, or 22.6%, have been babies born to Russian women. At the private Finochietto Hospital, doctors delivered 50 Russian babies in December of the total 180 births recorded, said Dr. Guido Manrique, chief of obstetrics.
criscimagnael

Methane Leaks Plague New Mexico Oil and Gas Wells - The New York Times - 0 views

  • Startlingly large amounts of methane are leaking from wells and pipelines in New Mexico, according to a new analysis of aerial data, suggesting that the oil and gas industry may be contributing more to climate change than was previously known.
  • The study, by researchers at Stanford University, estimates that oil and gas operations in New Mexico’s Permian Basin are releasing 194 metric tons per hour of methane, a planet-warming gas many times more potent than carbon dioxide. That is more than six times as much as the latest estimate from the Environmental Protection Agency.
  • He and Ms. Chen, a Ph.D. student in energy resources engineering, said they believed their results showed the necessity of surveying a large number of sites in order to accurately measure the environmental impact of oil and gas production.
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  • The largest previous assessment of methane emissions from oil and gas in the United States, published in 2018, reviewed studies covering about 1,000 well sites, a tiny fraction of the more than one million active wells in the country. The new study, by contrast, used aerial data to examine nearly 27,000 sites from above: more than 90 percent of all wells in the New Mexico portion of the Permian Basin, which also extends into Texas.
  • estimated about a decade ago that the break-even point — the point above which natural gas would actually hurt the climate more than coal — was a 3.1 percent methane leakage rate. Based on more recent data from the Intergovernmental Panel on Climate Change, Dr. Howarth estimates that the threshold is closer to 2.8 or 2.9 percent.That makes the 9.4 percent leakage rate in the new study highly alarming,
  • Methane can be released by wells both on purpose, in a process known as venting, and through unintentional leaks from aging or faulty equipment.
  • Natural gas accounts for about a third of American energy consumption, and because it is less costly than coal in terms of carbon dioxide emissions, many policymakers have promoted it as a “bridge” that could do less damage to the climate while society works on a longer-term transition to renewable energy. But compared to coal, natural gas results in much higher emissions of methane, which is a more potent greenhouse gas than carbon dioxide, but doesn’t last as long in the atmosphere.
  • They found that a small number of wells and pipelines accounted for “the vast majority” of methane leaks, Ms. Chen said, adding, “Comprehensive point source surveys find more high-consequence emission events, which drive total emissions.”
  • If there was good news in the study, it was that a small number of oil and gas sites contributed disproportionately to emissions — suggesting that, if the worst offenders change their practices, it is possible for the industry to operate more cleanly.
  • The Stanford researchers emphasized that the same methodology they used to quantify methane emissions could be used to identify problem sites and target regulations accordingly.“Aerial technology found high methane emissions,” Ms. Chen said, “but can also help fix them cost effectively.”
lilyrashkind

FDA expected to OK additional Covid-19 booster shots for adults over 50 next week - CNN - 0 views

  • The US Centers for Disease Control and Prevention is expected to follow soon after with what's known as a permissive recommendation, which means that the shots will not be officially recommended but may be given to people who want them, said a source who spoke to CNN on the condition of anonymity since they had not been given permission to discuss the details with reporters.
  • "There are solid data from Israel for age 60+ (the only group reported on to date) for enhanced protection (vs severe illness) out to 3 months compared with 3 doses. It is reasonable to extend that and provide it as an option, since the 3rd dose has pronounced benefit in age 50+," Topol wrote in an email to CNN.
  • Dr. Eric Rubin, editor in chief of The New England Journal of Medicine who sits on the FDA's VRBPAC, said he hadn't yet seen enough data on fourth doses to make a determination about whether they are needed for anyone beyond those who are already recommended to get them -- adults who are severely immune deficient."The only data that I've seen has been for participants followed for just a few weeks. The most important information is going to be how well a fourth dose protects highly vulnerable people against serious disease and death, and I don't know when that will be available," Rubin said in an email to CNN. Rubin said the FDA might have access to that data, but he had not seen it yet.
Javier E

He's Narrating Your New Audiobook. He's Also Been Dead for Nearly 10 Years. - WSJ - 0 views

  • AI’s reach into audiobook narration isn’t merely theoretical. Thousands of AI-narrated audiobooks are available on popular marketplaces including Alphabet Inc.’s Google Play Books and Apple Inc.’s Apple Books. Amazon.com Inc., AMZN +0.25% whose Audible unit is the largest U.S. audiobook service, doesn’t offer any for now, but says it is evaluating its position.
  • The technology hasn’t been widely embraced by the largest U.S. book publishers, which mostly use it for marketing efforts and some foreign-language title
  • it is a boon for smaller outfits and little-known authors, whose books might not have the sales potential to warrant the cost—traditionally at least $5,000—of recording an audio version.
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  • Apple and Google said they allow users to create audiobooks free of charge that use digitally replicated human voices. The voices featured in audiobooks generated by Apple and Google come from real people, whose voices helped train their automated-narration engines.
  • Ms. Papel said there is still plenty of work for professional narrators because the new era of AI auto-narration is just getting under way, though she said that might not be the case in the future.
  • “From what I can see, human narrators are freaking out,
  • Melissa Papel, a Paris-born actress who records from her home studio in Los Angeles, said she recorded eight hours of content for DeepZen, reading in French from different books. “One called for me to read in an angry way, another in a disgusted way, a humorous way, a dramatic way,” she said.
  • Charles Watkinson, director of the University of Michigan Press, said the publisher has made about 100 audiobooks using Google’s free auto-narrated audiobook platform since early last year. The new technology made those titles possible because it eliminated the costs associated with using a production studio, support staff and human narrators.
  • “I understood that they would use my voice to teach software how to speak more humanly,” Ms. Papel said. “I didn’t realize they could use my voice to pronounce words I didn’t say. That’s incredible.”
  • DeepZen pays its narrators a flat fee plus a royalty based on the revenue the company generates from different projects. The agreements span multiple years
  • a national union that represents performers, including professional audiobook narrators, said he expects AI to eventually disrupt the industry.
  • Audiobook sales rose 7% last year, according to the Association of American Publishers, while print book sales declined by 5.8%, according to book tracker Circana BookScan.
  • eepZen says it has signed deals with 35 publishers in the U.S. and abroad and is working with 25 authors.
  • Josiah Ziegler, a psychiatrist in Fort Collins, Colo., last year created Intellectual Classics, which focuses on nonfiction works that are out of copyright and don’t have an audiobook edition. 
  • He chose Mr. Herrmann as the narrator for “The War with Mexico,” a work by Justin H. Smith that won the 1920 Pulitzer Prize for history whose audiobook version Dr. Ziegler expects to publish later this year.
  • DeepZen, which has created nearly a hundred audiobooks featuring Mr. Herrmann’s voice, is pursuing the rights of other well-known stars who have died.
Javier E

The Liberal Maverick Fighting Race-Based Affirmative Action - The New York Times - 0 views

  • The paper inspired him to write his influential 1996 book, “The Remedy,” which developed his theory that affirmative action had set back race relations by becoming a source of racial antagonism.
  • “If you want working-class white people to vote their race, there’s probably no better way to do it than to give explicitly racial preferences in deciding who gets ahead in life,” he said. “If you want working-class whites to vote their class, you would try to remind them that they have a lot in common with working-class Black and Hispanic people.”
  • Today, as in the mid-1990s, polls show that a majority of people oppose race-conscious college admissions, even as they support racial diversity. Public opinion may not always be right, Mr. Kahlenberg said, but surely it should be considered when developing public policy.
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  • If Mr. Kahlenberg had his way, college admissions would be upended.
  • His basic recipe: Get rid of preferences for alumni children, as well as children of faculty, staff and big donors. Say goodbye to recruited athletes in boutique sports like fencing. Increase community college transfers. Give a break to students who have excelled in struggling schools, who have grown up in neighborhoods of concentrated poverty, in families with low income, or better yet, low net worth. Pump up financial aid. Look for applicants in towns that do not normally send students to highly selective colleges.
  • elite colleges have become fortresses for the rich, he said. Harvard had “23 times as many rich kids as poor kids,” Mr. Kahlenberg testified in 2018 at the federal court trial in the Harvard case, referring to a 2017 paper by Raj Chetty, then a Stanford economist, and colleagues.
  • his 2012 study that found seven of 10 leading universities were able to return to previous levels of diversity through race-neutral means.
  • In 2020, Berkeley boasted that it had admitted its most diverse class in 30 years, with offers to African American and Latino students rising to the highest numbers since at least the late-1980s, without sacrificing academic standards.
  • In a simulation of the class of 2019, he found that the share of Black students at Harvard would drop to 10 percent from 14 percent, but the share of white students would also drop, to 33 percent from percent from 40 percent, mainly because of the elimination of legacy and other preferences. The share of Hispanic students would rise to 19 percent from 14 percent and the Asian American share would rise to 31 percent from 24 percent.
  • The share of “advantaged” students (parents with a bachelor’s degree, family income over $80,000, living in a neighborhood not burdened by concentrated poverty) would make up about half of the class, from 82 percent. SAT scores would drop to the 98th percentile from the 99th.
  • In the affirmative action trial, Harvard said that Mr. Kahlenberg’s model would produce too little diversity, and water down academic quality. Its actual class of 2026 is 15.2 percent African American, 12.6 percent Hispanic and 27.9 percent Asian American.
  • Edward Blum, the conservative activist behind the lawsuits against Harvard and U.N.C., said Mr. Kahlenberg came to his attention when “The Remedy” was published. The focus on class seemed like a powerful bridge between the left and the right, Mr. Blum said
  • Dr. Laycock, of the University of Virginia, expects that once the Supreme Court rules, conservative groups that are now promoting race-neutral alternatives will claim they are racial proxies and turn against them. “Everybody knows that’s why it’s being used,” he said. (Mr. Blum said his group will not, though other conservative groups could do so.)
  • There is no “We Believe” sign in the yard. But on the living room wall, a sign says, “Live simply, dream big, be grateful, give love, laugh lots.”
  • In that spirit, his stubborn campaign might be traced to being the son of a pastor whose family could afford to make him a Harvard graduate, twice over. “I do have some measure of class guilt,” he said. “I wish people who are far richer than I am had more class guilt.”
Javier E

'Tragic Battle': On the Front Lines of China's Covid Crisis - The New York Times - 0 views

  • China was the first country to experience the panic of Covid when it emerged from Wuhan in 2019. Then, for the past three years, the country largely suppressed the virus with a costly mix of mass testing, strict lockdowns and border closures. The government could have used the time to bolster its health system by stockpiling medicine and building more critical care units. It could have launched a major vaccination drive targeting the millions of vulnerable older adults who were reluctant to receive a jab or booster. China did little of that, however, plunging into crisis mode again like in the early days of Wuhan.
  • A Shanghai hospital predicted half of Shanghai’s 25 million residents would eventually be infected and warned its staff of a “tragic battle” in the coming weeks, according to a now-deleted statement the hospital posted last week on the social media platform WeChat.
  • “In this tragic battle, all of Shanghai will fall, and all the staff of the hospital will be infected! Our whole families will be infected! Our patients will all be infected!” the statement read. “We have no choice, and we cannot escape.”
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  • Medical staff say they could have avoided the medicine shortages that have forced some facilities to ration drugs. There also could have been more time to set up a more effective triage system to avoid overcrowding
  • ne of the fundamental problems with China’s health system is its overreliance on hospitals for even the most basic care.
  • “In the U.S. people have their own primary physicians, but there are few ways in China to get care from the medical system except to go to an E.R. at a big hospital,” said Dr. Qiao Renli, a pulmonary and critical care doctor at the University of Southern California, who has taught and practiced medicine in both China and the United States.
  • The deluge of Covid patients is not the only challenge hospitals are facing. One of the ripple effects of the outbreak has been a widespread shortage of blood for transfusions because of the shrinking pool of eligible donors.In the southwestern city of Kunming, a blood bank said in a statement that the city was getting a fraction of the 500 donors per day it needs to keep up with demand, and that the shortage had started to affect pregnant women and patients in intensive care units.
Javier E

Opinion | Empathy Is Exhausting. There Is a Better Way. - The New York Times - 0 views

  • “What can I even do?”Many people are feeling similarly defeated, and many others are outraged by the political inaction that ensues. A Muslim colleague of mine said she was appalled to see so much indifference to the atrocities and innocent lives lost in Gaza and Israel. How could anyone just go on as if nothing had happened?
  • inaction isn’t always caused by apathy. It can also be the product of empathy. More specifically, it can be the result of what psychologists call empathic distress: hurting for others while feeling unable to help.
  • I felt it intensely this fall, as violence escalated abroad and anger echoed across the United States. Helpless as a teacher, unsure of how to protect my students from hostility and hate. Useless as a psychologist and writer, finding words too empty to offer any hope. Powerless as a parent, searching for ways to reassure my kids that the world is a safe place and most people are good. Soon I found myself avoiding the news altogether and changing the subject when war came up
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  • Understanding how empathy can immobilize us like that is a critical step for helping others — and ourselves.
  • Empathic distress explains why many people have checked out in the wake of these tragedies
  • Having concluded that nothing they do will make a difference, they start to become indifferent.
  • The symptoms of empathic distress were originally diagnosed in health care, with nurses and doctors who appeared to become insensitive to the pain of their patients.
  • Early researchers labeled it compassion fatigue and described it as the cost of caring.
  • when two neuroscientists, Olga Klimecki and Tania Singer, reviewed the evidence, they discovered that “compassion fatigue” is a misnomer. Caring itself is not costly. What drains people is not merely witnessing others’ pain but feeling incapable of alleviating it.
  • In times of sustained anguish, empathy is a recipe for more distress, and in some cases even depression. What we need instead is compassion.
  • empathy and compassion aren’t the same. Empathy absorbs others’ emotions as your own: “I’m hurting for you.”
  • Compassion focuses your action on their emotions: “I see that you’re hurting, and I’m here for you.”
  • “Empathy is biased,” the psychologist Paul Bloom writes. It’s something we usually reserve for our own group, and in that sense, it can even be “a powerful force for war and atrocity.”
  • Dr. Singer and their colleagues trained people to empathize by trying to feel other people’s pain. When the participants saw someone suffering, it activated a neural network that would light up if they themselves were in pain. It hurt. And when people can’t help, they escape the pain by withdrawing.
  • To combat this, the Klimecki and Singer team taught their participants to respond with compassion rather than empathy — focusing not on sharing others’ pain but on noticing their feelings and offering comfort.
  • A different neural network lit up, one associated with affiliation and social connection. This is why a growing body of evidence suggests that compassion is healthier for you and kinder to others than empathy:
  • When you see others in pain, instead of causing you to get overloaded and retreat, compassion motivates you to reach out and help
  • The most basic form of compassion is not assuaging distress but acknowledging it.
  • in my research, I’ve found that being helpful has a secondary benefit: It’s an antidote to feeling helpless.
  • To figure out who needs your support after something terrible happens, the psychologist Susan Silk suggests picturing a dart board, with the people closest to the trauma in the bull’s-eye and those more peripherally affected in the outer rings.
  • Once you’ve figured out where you belong on the dart board, look for support from people outside your ring, and offer it to people closer to the center.
  • Even if people aren’t personally in the line of fire, attacks targeting members of a specific group can shatter a whole population’s sense of security.
  • If you notice that people in your life seem disengaged around an issue that matters to you, it’s worth considering whose pain they might be carrying.
  • Instead of demanding that they do more, it may be time to show them compassion — and help them find compassion for themselves, too.
  • Your small gesture of kindness won’t end the crisis in the Middle East, but it can help someone else. And that can give you the strength to help more.
Javier E

Order and Calm Eased Evacuation from Burning Japan Airlines Jet - The New York Times - 0 views

  • While a number of factors aided what many have called a miracle at Haneda Airport — a well trained crew of 12; a veteran pilot with 12,000 hours of flight experience; advanced aircraft design and materials — the relative absence of panic onboard during the emergency procedure perhaps helped the most.
  • “Even though I heard screams, mostly people were calm and didn’t stand up from their seats but kept sitting and waiting,” said Aruto Iwama, a passenger who gave a video interview to the newspaper The Guardian. “That’s why I think we were able to escape smoothly.”
  • Experts said that while crews are trained — and passenger jets are tested — for cabin evacuations within 90 seconds in an emergency landing, technical specifications on the 2-year-old Airbus A350-900 most likely gave those on the flight a bit more time to escape.
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  • Firewalls around the engines, nitrogen pumps in fuel tanks that help prevent immediate burning, and fire-resistant materials on seats and flooring most likely helped to keep the rising flames at bay, said Sonya A. Brown, a senior lecturer in aerospace design at the University of New South Wales in Sydney, Australia.
  • “Really, the Japan Airlines crew in this case performed extremely well,” Dr. Brown said. The fact that passengers did not stop to retrieve carry-on luggage or otherwise slow down the exit was “really critical,” she added.
  • Tadayuki Tsutsumi, an official at Japan Airlines, said the most important component of crew performance during an emergency was “panic control” and determining which exit doors were safe to use.
  • Former flight attendants described the rigorous training and drills that crew members undergo to prepare for emergencies. “When training for evacuation procedures, we repeatedly used smoke/fire simulation to make sure we could be mentally ready when situations like those occurred in reality,” Yoko Chang, a former cabin attendant and an instructor of aspiring crew members, wrote in an Instagram message.
  • Ms. Chang, who did not work for JAL, added that airlines require cabin crew members to pass evacuation exams every six months.
Javier E

Who's Afraid of Early Cancer Detection? - WSJ - 0 views

  • A diagnosis of pancreatic cancer usually means a quick death—but not for Roger Royse, who was in Stage II of the disease when he got the bad news in July 2022. The five-year relative survival rate for late-stage metastatic pancreatic cancer is 3%—which means that patients are 3% as likely to live five years after their diagnosis as other cancer-free individuals. But if pancreatic cancer is caught before it has spread to other organs, the survival rate is 44%.
  • some public-health experts think that’s just as well. They fret that widespread use of multicancer early-detection tests would cause healthcare spending to explode. Those fears have snarled Galleri and similar tests in a web of red tape.
  • Early diagnosis is the best defense against most cancers,
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  • But only a handful of cancers—of the breast, lung, colon and cervix—have screening tests recommended by the U.S. Preventive Services Task Force
  • Many companies are developing blood tests that can detect cancer signals before symptoms occur, and Grail’s is the most advanced. A study found it can identify more than 50 types of cancer 52% of the time and the 12 deadliest cancers in Stages I through III 68% of the time.
  • There’s a hitch. The test costs $949 and isn’t covered by Medicare or most private insurance.
  • The trouble is that this cancer is almost never caught early. There’s no routine screening for it, and symptoms don’t develop until it is advanced. Mr. Royse, 64, had no idea he was sick until he took a blood test called Galleri, produced by the Menlo Park, Calif., startup Grail. He had surgery and chemotherapy and is now cancer-free.
  • Mr. Royse visited Grail’s website, which referred him to a telemedicine provider who ordered a test. Another telemedicine doctor walked him through his results, which showed a cancer signal likely emanating from the pancreas, gallbladder, stomach or esophagus.
  • An MRI revealed a suspicious mass on his pancreas, which a biopsy confirmed was cancerous. Mr. Royse had three months of chemotherapy, surgery and another three months of chemotherapy, which ended last February. Because pancreatic cancer often recurs, he gets CT and MRI scans every three months. In addition, he has signed up for startup Natera’s Signatera customized blood test, which checks DNA specific to the patient’s cancer and can signal its return before signs are visible on the scans
  • Grail’s test likewise looks for DNA shed by cancer cells, which is tagged by molecules called methyl groups that are specific to a cancer’s origin. Grail uses genetic sequencing and machine learning to recognize links between DNA methyl groups and particular cancers
  • The test “is based on how much DNA is being shed by tumor,” Grail’s president, Josh Ofman, says. “Some tumors shed a lot of DNA. Some shed almost none.
  • ut slow-growing tumors typically aren’t shedding a lot of DNA.” That reduces the probability that Grail’s test will identify indolent cancers that pose no immediate danger.
  • Grail’s test has a roughly 0.5% false-positive rate, meaning 1 in 200 patients who don’t have cancer will get a positive signal
  • Its positive predictive value is 43%, so that of every 100 patients with a positive signal, 43 actually have cancer
  • the legislation’s price tag could reduce political support. According to one private company’s estimate, the test could cost the government $39 billion to $145 billion over a decade. Mr. Goldman counters that analysts usually overestimate the costs and underestimate the benefits of medical interventions.
  • Because Grail uses machine learning to detect DNA-methylation cancer linkages, the Grail test’s accuracy should improve as more tests and patient data are collected
  • regulators may balk at approving the test, and insurers at covering it, until it becomes cheaper and more reliable.
  • How would the FDA weigh the risk that a false positive on a test like Grail’s could require invasive follow-up testing against the dire but hard-to-quantify risk that a deadly cancer wouldn’t be caught until it’s much harder to treat? It’s unclear.
  • some experts urge the FDA to require large randomized controlled trials before approving blood cancer tests. “Multicancer screening would entail tremendous costs and potentially substantial harms,” H. Gilbert Welch and Tanujit Dey of Brigham and Women’s Hospital wrote
  • Dr. Welch and Mr. Dey also suggested that companies should be required to prove their tests reduce overall mortality, even though the FDA doesn’t require drugmakers to prove their products reduce deaths or extend life. Clinical trials for the mRNA Covid vaccines didn’t show they reduced deaths.
  • One alternative is to rely on real-world studies, which Grail is already doing. One study of patients 50 and older without signs of cancer showed that the test doubled the number of cancers detected.
  • One recurring problem he has seen: “Epidemiologists are always getting cancer wrong,” he says. “Epidemiologists a decade ago said U.S. overtreats cancers. Well, no, the EU undertreats cancer.”
  • A 2012 study that he co-authored found that the higher U.S. spending on cancer care relative to Europe between 1983 and 1999 resulted in significantly higher survival rates for American patients than for those in Europe
  • By his study’s calculation, U.S. spending on cancer treatments during that period resulted in $556 billion in net benefits owing to reduced mortality.
  • He expects Galleri and other multicancer early-detection tests to reduce deaths and produce public-health and economic benefits that exceed their monetary costs
  • Expanding access to multicancer early-detection tests could also help solve the chicken-and-egg problem of drug development. Because few patients are diagnosed at early stages of some cancers, it’s hard to develop treatments for them
  • the positive predictive value for some recommended cancer screenings is far lower. Fewer than 1 in 10 women with an abnormal finding on a mammogram are diagnosed with breast cancer.
  • Mr. Royse makes the same point with personal force. “I would be dead right now if not for multicancer early-detection testing,” Mr. Royse told an FDA advisory committee last fall. “The longer the FDA waits, the more people are going to die. It’s that simple.”
Javier E

Opinion | How to Reboot Free Speech on Campus - The New York Times - 0 views

  • In the course of those cases and confrontations, I’ve learned that the issue of campus protest is remarkably complex and that campus culture is at least as important as law and policy in setting the boundaries of debate.
  • There is profound confusion on campus right now around the distinctions between free speech, civil disobedience and lawlessness. At the same time, some schools also seem confused about their fundamental academic mission
  • Does the university believe it should be neutral toward campus activism — protecting it as an exercise of the students’ constitutional rights and academic freedoms, but not cooperating with student activists to advance shared goals — or does it incorporate activism as part of the educational process itself, including by coordinating with the protesters and encouraging their activism?
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  • The simplest way of outlining the ideal university policy toward protest is to say that it should protect free speech, respect civil disobedience and uphold the rule of law
  • universities should protect the rights of students and faculty on a viewpoint-neutral basis, and they should endeavor to make sure that every member of the campus community has the same access to campus facilities and resources.
  • That also means showing no favoritism between competing ideological groups in access to classrooms, in the imposition of campus penalties and in access to educational opportunities
  • Indefinitely occupying a quad violates the rights of other speakers to use the same space. Relentless, loud protest violates the rights of students to sleep or study in peace. And when protests become truly threatening or intimidating, they can violate the civil rights of other students, especially if those students are targeted on the basis of their race, sex, color or national origin.
  • Noise limits can protect the ability of students to study and sleep. Restricting the amount of time any one group can demonstrate on the limited open spaces on campus permits other groups to use the same space.
  • Civil disobedience is distinct from First Amendment protected speech. It involves both breaking an unjust law and accepting the consequences.
  • In a 1965 appearance on “Meet the Press,” the Rev. Dr. Martin Luther King Jr. described the principle perfectly: “When one breaks the law that conscience tells him is unjust, he must do it openly, he must do it cheerfully, he must do it lovingly, he must do it civilly — not uncivilly — and he must do it with a willingness to accept the penalty.”
  • But what we’re seeing on a number of campuses isn’t free expression, nor is it civil disobedience. It’s outright lawlessness
  • reasonable time, place and manner restrictions are indispensable in this context. Time, place and manner restrictions are content-neutral legal rules that enable a diverse community to share the same space and enjoy equal rights.
  • Administrators and faculty members will often abandon any pretense of institutional neutralit
  • For many administrators, the very idea of neutrality is repugnant. It represents a form of complicity in injustice that they simply can’t and won’t stomach. So they nurture and support one side. They scorn the opposition, adopting a de facto posture that says, “To my friends, everything; for my enemies, the law.”
  • In March, a small band of pro-Palestinian students at Vanderbilt University in Nashville pushed past a security guard so aggressively that they injured him, walked into a university facility that was closed to protest, and briefly occupied the building. The university had provided ample space for protest, and both pro-Israel and pro-Palestinian students had been speaking and protesting peacefully on campus since Oct. 7.
  • But these students weren’t engaged in free speech. Nor were they engaged in true civil disobedience. Civil disobedience does not include assault, and within hours the university shut them down. Three students were arrested in the assault on the security guard, and one was arrested on charges of vandalism. More than 20 students were subjected to university discipline; three were expelled; and one was suspended.
  • The University of Chicago has long adhered to the Kalven principles, a statement of university neutrality articulated in 1967 by a committee led by one of the most respected legal scholars of the last century, Harry Kalven Jr. At their heart, the Kalven principles articulate the view that “the instrument of dissent and criticism is the individual faculty member or the individual student. The university is the home and sponsor of critics; it is not itself the critic. It is, to go back once again to the classic phrase, a community of scholars.”
Javier E

Dilemma on Wall Street: Short-Term Gain or Climate Benefit? - The New York Times - 0 views

  • team of economists recently analyzed 20 years of peer-reviewed research on the social cost of carbon, an estimate of the damage from climate change. They concluded that the average cost, adjusted for improved methods, is substantially higher than even the U.S. government’s most up-to-date figure.
  • That means greenhouse gas emissions, over time, will take a larger toll than regulators are accounting for. As tools for measuring the links between weather patterns and economic output evolve — and the interactions between weather and the economy magnify the costs in unpredictable ways — the damage estimates have only risen.
  • It’s the kind of data that one might expect to set off alarm bells across the financial industry, which closely tracks economic developments that might affect portfolios of stocks and loans. But it was hard to detect even a ripple.
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  • In fact, the news from Wall Street lately has mostly been about retreat from climate goals, rather than recommitment. Banks and asset managers are withdrawing from international climate alliances and chafing at their rules. Regional banks are stepping up lending to fossil fuel producers. Sustainable investment funds have sustained crippling outflows, and many have collapsed.
  • In some cases, it’s a classic prisoner’s dilemma: If firms collectively shift to cleaner energy, a cooler climate benefits everyone more in the future
  • in the short term, each firm has an individual incentive to cash in on fossil fuels, making the transition much harder to achieve.
  • when it comes to avoiding climate damage to their own operations, the financial industry is genuinely struggling to comprehend what a warming future will mean.
  • A global compact of financial institutions made commitments worth $130 trillion to try to bring down emissions, confident that governments would create a regulatory and financial infrastructure to make those investments profitable. And in 2022, the Inflation Reduction Act passed.
  • What about the risk that climate change poses to the financial industry’s own investments, through more powerful hurricanes, heat waves that knock out power grids, wildfires that wipe out towns?
  • “If we think about what is going to be the best way to tilt your portfolios in the direction to benefit, it’s really difficult to do,”
  • “These will probably be great investments over 20 years, but when we’re judged over one to three years, it’s a little more challenging for us.”
  • Some firms cater to institutional clients, like public employee pension funds, that want combating climate change to be part of their investment strategy and are willing to take a short-term hit. But they aren’t a majority
  • And over the past couple of years, many banks and asset managers have shrunk from anything with a climate label for fear of losing business from states that frown on such concerns.
  • On top of that, the war in Ukraine scrambled the financial case for backing a rapid energy transition. Artificial intelligence and the movement toward greater electrification are adding demand for power, and renewables haven’t kept up
  • All of that is about the relative appeal of investments that would slow climate change
  • If you bought some of the largest solar-energy exchange-traded funds in early 2023, you would have lost about 20 percent of your money, while the rest of the stock market soared.
  • There is evidence that banks and investors price in some physical risk, but also that much of it still lurks, unheeded.
  • “I’m very, very worried about this, because insurance markets are this opaque weak link,” Dr. Sastry said. “There are parallels to some of the complex linkages that happened in 2008, where there is a weak and unregulated market that spills over to the banking system.”
  • Regulators worry that failing to understand those ripple effects could not just put a single bank in trouble but even become a contagion that would undermine the financial system.
  • But while the European Central Bank has made climate risk a consideration in its policy and oversight, the Federal Reserve has resisted taking a more active role, despite indications that extreme weather is feeding inflation and that high interest rates are slowing the transition to clean energy.
  • “The argument has been, ‘Unless we can convincingly show it’s part of our mandate, Congress should deal with it, it’s none of our business,’”
  • a much nearer-term uncertainty looms: the outcome of the U.S. election, which could determine whether further action is taken to address climate concerns or existing efforts are rolled back. An aggressive climate strategy might not fare as well during a second Trump administration, so it may seem wise to wait and see how it shakes out.
  • big companies are hesitating on climate-sensitive investments as November approaches, but says that “two things are misguided and quite dangerous about that hypothesis.”
  • One: States like California are establishing stricter rules for carbon-related financial disclosures and may step it up further if Republicans win
  • And two: Europe is phasing in a “carbon border adjustment mechanism,” which will punish polluting companies that want to do business there.
  • at the moment, even European financial institutions feel pressure from the United States, which — while providing some of the most generous subsidies so far for renewable-energy investment — has not imposed a price on carbon.
  • The global insurance company Allianz has set out a plan to align its investments in a way that would prevent warming above 1.5 degrees Celsius by the end of the century, if everyone else did the same. But it’s difficult to steer a portfolio to climate-friendly assets while other funds take on polluting companies and reap short-term profits for impatient clients.
  • “This is the main challenge for an asset manager, to really bring the customer along,” said Markus Zimmer, an Allianz economist. Asset managers don’t have sufficient tools on their own to move money out of polluting investments and into clean ones, if they want to stay in business,
  • “Of course it helps if the financial industry is somehow ambitious, but you cannot really substitute the lack of actions by policymakers,”
  • According to new research, the benefit is greater when decarbonization occurs faster, because the risks of extreme damage mount as time goes on. But without a uniform set of rules, someone is bound to scoop up the immediate profits, disadvantaging those that don’t — and the longer-term outcome is adverse for all.
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