Compare the situation in the U.S. with the one in East Asia, where several countries have navigated the pandemic far more deftly. China, South Korea, Taiwan, Singapore, and Vietnam all updated their infectious-disease protocols based on what they learned from 21st-century epidemics: SARS in 2003, H1N1 in 2009, and MERS in 2012. These countries quickly understood what artillery would be necessary to take on COVID-19, including masks, tests, tracing, and quarantine spaces. Yet the CDC—armed with an $8 billion budget and a global team of scientists and officials—was somehow unprepared to read from the playbook.