Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials.
Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J.
BMJ. 2009 Oct 1;339:b3692. doi: 10.1136/BMJ.b3692.
PMID: 19797342
doi: 10.1136/BMJ.b3692
Conclusions Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D. Doses of supplemental vitamin D of less than 700 IU or serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l may not reduce the risk of falling among older individuals.
Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial.
Trivedi DP, Doll R, Khaw KT.
BMJ. 2003 Mar 1;326(7387):469.
PMID: 12609940
CONCLUSION: Four monthly supplementation with 100 000 IU oral vitamin D may prevent fractures without adverse effects in men and women living in the general community.
Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial.
Trivedi DP, Doll R, Khaw KT.
BMJ. 2003 Mar 1;326(7387):469.
PMID: 12609940
Conclusion: Four monthly supplementation with 100 000 IU oral vitamin D may prevent fractures without adverse effects in men and women living in the general community.
itamin D and autoimmunity: new aetiological and therapeutic considerations.
Arnson Y, Amital H, Shoenfeld Y.
Ann Rheum Dis. 2007 Sep;66(9):1137-42. Epub 2007 Jun 8. Review.
PMID: 17557889
doi:10.1136/ard.2007.069831
Vitamin D status in apparently healthy adults in Kashmir Valley of Indian subcontinent.
Zargar AH, Ahmad S, Masoodi SR, Wani AI, Bashir MI, Laway BA, Shah ZA.
Postgrad Med J. 2007 Nov;83(985):713-6.
PMID: 17989271
doi:10.1136/pgmj.2007.059113
Conclusions: In spite of abundant sunlight, healthy individuals in Kashmir valley are vitamin D deficient, particularly women. Serum 25 (OH) D concentrations are significantly related to sun exposure
Vitamin D may suppress infections which lead to development of Multiple Sclerosis
Steven R Brenner, None (16 August 2007)
J Neurol Neurosurg Psychiatry 2008
I read the article with reference to the inverse relationship between multiple sclerosis clinical activity and deficiency of vitamin D by Soilu-Hannienen (1) with interest, and was considering what mechanism could be in play to cause such a relationship.
25-hydroxylated metabolites of vitamin D act as intracellular regulators of the synthesis and action of defensin (2) molecules against bacterial antigens, defensin being an endogenously synthesized antimicrobial substance (2).
Human cathelicidin antimicrobial peptide gene is a target of vitamin D receptor and is strongly up-regulated by 1,25-dihydroxyvitamin D3, indicating vitamin D receptor and the 1,25-dihydroxyvitaminD3 regulate primate innate immunity (3)
A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis.
Soilu-Hänninen M, Laaksonen M, Laitinen I, Erälinna JP, Lilius EM, Mononen I.
J Neurol Neurosurg Psychiatry. 2008 Feb;79(2):152-7. Epub 2007 Jun 19.
PMID: 17578859
doi:10.1136/jnnp.2006.105320
Conclusions: The endocrine circuitry regulating serum calcium may be altered in MS. There is an inverse relationship between serum vitamin D level and MS clinical activity. The role of vitamin D in MS must be explored further.
Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.
Lee DM, Tajar A, Ulubaev A, Pendleton N, O'Neill TW, O'Connor DB, Bartfai G, Boonen S, Bouillon R, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Punab M, Silman AJ, Vanderschueren D, Wu FC; EMAS study group.
J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):722-9. Epub 2009 May 21.
PMID: 19460797
doi:10.1136/jnnp.2008.165720
Conclusion: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.