The role of Vitamin D3 metabolism in prostate cancer.
Lou YR, Qiao S, Talonpoika R, Syvälä H, Tuohimaa P.
J Steroid Biochem Mol Biol. 2004 Nov;92(4):317-25. Epub 2004 Dec 19. Review.
PMID: 15663995
doi:10.1016/j.jsbmb.2004.10.007
In summary, the local metabolism of hormonal Vitamin D seems to play an important role in the development and progression of prostate cancer.
25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand.
Lou YR, Molnár F, Peräkylä M, Qiao S, Kalueff AV, St-Arnaud R, Carlberg C, Tuohimaa P.
J Steroid Biochem Mol Biol. 2009 Nov 26. [Epub ahead of print]
PMID: 19944755
doi:10.1016/j.jsbmb.2009.11.011
In conclusion, 25-hydroxyvitamin D3 is an agonistic vitamin D receptor ligand with gene regulatory and anti-proliferative properties.
Vitamin D and mood disorders among women: an integrative review.
Murphy PK, Wagner CL.
J Midwifery Womens Health. 2008 Sep-Oct;53(5):440-6. Review.
PMID: 18761297
Four of six studies reviewed imparted significant results, with all four showing an association between low 25(OH)D levels and higher incidences of four mood disorders: premenstrual syndrome, seasonal affective disorder, non-specified mood disorder, and major depressive disorder. This review indicates a possible biochemical mechanism occurring between vitamin D and mood disorders affecting women, warranting further studies of these variables using rigorous methodologies.
Vitamin D and prevention of breast cancer: pooled analysis.
Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC.
J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.
PMID: 17368188
CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.
Twice single doses of 100,000 IU of vitamin D in winter is adequate and safe for prevention of vitamin D deficiency in healthy children from Ushuaia, Tierra Del Fuego, Argentina.
Tau C, Ciriani V, Scaiola E, Acuña M.
J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):651-4. Epub 2007 Jan 25.
PMID: 17257830
doi:10.1016/j.jsbmb.2006.12.027
These results disclosed that to prevent vitamin D deficiency for children at zones of risk at the south of our country, double supplementation of 100,000 IU of vitamin D during autumn and winter, would be adequate and safe.