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"04.01.2010 15:00 D-vitamiini ja kalisum vähentävät lonkkamurtumapotilaiden kuolleisuutta, osoittaa tuore suomalaistutkimus. Lonkkamurtuma on vaikein osteoporoosin eli luukadon heikentämän luun murtuma, ja siihen liittyy huomattava ylikuolleisuus ja toimintakyvyn heikkeneminen. Drugs Aging -lehdessä (2009;26:409-421) hiljattain julkaistun suomalaistutkimuksen mukaan kalsiumin ja D-vitamiinin samanaikaisella käytöllä lonkkamurtumapotilaiden kuolleisuutta voitaisiin kuitenkin vähentää. Dosentti Peter Lüthje työryhmineen tutki Päijät-Hämeen keskussairaalan ja Kuusankosken aluesairaalan vastuualueella vuosina 2003-2004 hoidettujen lonkkamurtumapotilaiden elimistön D-vitamiinipitoisuuksia ja D-vitamiinin käytön yhteyttä murtuman jälkeiseen selviytymiseen. Tutkimusaineisto koostui 221 lonkkamurtumapotilaasta. Naisten keski-ikä oli 81 vuotta ja miesten 73 vuotta. Potilaiden selviytymistä seurattiin murtuman jälkeen 37-52 kuukautta. 28 kuukauden seurannan kohdalla 221 tutkimukseen kuuluvasta potilaasta elossa oli 137 potilasta (62 %). Tilastoanalyysissa tärkeimmäksi lonkkamurtumasta selviytymistä selittäväksi tekijäksi osoittautui D-vitamiinin ja kalsiumin käyttö (kalsium- ja D-vitamiinilääkitys). Toiseksi tärkein selittävä tekijä oli osteoporoosilääkitys"

Prevalence of vitamin D insufficiency in Brazilian adolescents. Peters BS, dos Santos LC, Fisberg M, Wood RJ, Martini LA. Ann Nutr Metab. 2009;54(1):15-21. Epub 2009 Feb 5. PMID: 19194104 DOI: 10.1159/000199454 CONCLUSIONS: The present study suggests that even in a sunny climate like Brazil the prevalence of vitamin D insufficiency in adolescents is high. Most likely this is due to low intakes of vitamin D in this group. Due to the limited extent of natural dietary sources of vitamin D, a policy of vitamin D food fortification should be considered in the future, and in the meantime greater use of vitamin D supplements in this population group should be encouraged to provide the increased amounts of this essential nutrient for optimal health.

Why is it that vitamin D deficiency can manifest in so many different ways in different people? One big reason is something called vitamin D receptor (VDR) genotypes, the variation in the receptor for vitamin D. Why is it that the dose of vitamin D necessary to reach a specific level differs so widely from one person to the next? VDR genotype, again. Variation in blood levels of 25-hydroxy vitamin D from a specific dose of vitamin D can vary three-fold, as shown by a University of Toronto study. In other words, a dose of 4000 units per day may yield a 25-hydroxy vitamin D blood level of 30 ng/ml in Mary, 60 ng/ml in Paul, and 90 ng/ml in Pete--same dose, different blood levels

Serum vitamin D concentration and prostate cancer risk: a nested case-control study. Ahn J, Peters U, Albanes D, Purdue MP, Abnet CC, Chatterjee N, Horst RL, Hollis BW, Huang WY, Shikany JM, Hayes RB; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Project Team. J Natl Cancer Inst. 2008 Jun 4;100(11):796-804. Epub 2008 May 27. PMID: 18505967 doi:10.1093/jnci/djn152 CONCLUSION: The findings of this large prospective study do not support the hypothesis that vitamin D is associated with decreased risk of prostate cancer; indeed, higher circulating 25(OH)D concentrations may be associated with increased risk of aggressive disease. In summary, results from this large prospective study of men who underwent standardized prostate cancer screening in the context of a screening trial do not support the hypothesis that higher serum vitamin D status is associated with decreased risk of prostate cancer. The study showed no association of vitamin D level with nonaggressive disease; however, it raises the possibility that higher vitamin D level may be associated with increased risks for aggressive disease, although a clear monotonic dose-response relationship was lacking. Along with recent reports of adverse associations for higher vitamin D status and risk of pancreatic (32) and esophageal (33,34) cancer, caution should be taken in recommending high doses of vitamin D or sunlight exposure to the general public for prostate cancer prevention. Future analyses are warranted to confirm these results and to further clarify the effects of vitamin D on aggressive prostate cancer.

"It's well known that African Americans have low levels of vitamin D in their blood. In fact, this seems to be generally true for humans of tropical origin. In a study from Hawaii, vitamin D status was assessed in healthy, visibly tanned young adults who averaged 22.4 hours per week of unprotected sun exposure. Yet 51% had levels below the current recommended minimum of 75 nmol/L (Binkley et al., 2007). In a study from south India, levels below 50 nmol/L were found in 44% of the men and 70% of the women. The subjects are described as "agricultural workers starting their day at 0800 and working outdoors until 1700 with their face, chest, back, legs, arms, and forearms exposed to sunlight" (Harinarayan et al., 2007). In a study from Saudi Arabia, levels below 25 nmol/L were found in respectively 35%, 45%, 53%, and 50% of normal male university students of Saudi, Jordanian, Egyptian, and other origins (Sedrani, 1984)."