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Avoid using mental health terms to describe non-health issues. Don’t say that an awards show, for example, was schizophrenic.

mental illness Do not describe an individual as mentally ill unless it is clearly pertinent to a story and the diagnosis is properly sourced.

What happens inside a person’s head can have damaging effects throughout the body, as well as the other way around. An untreated mental illness can significantly increase the risk of becoming physically ill, and physical disorders may result in behaviors that make mental conditions worse.

In studies that tracked how patients with breast cancer fared, for example, Dr. David Spiegel and his colleagues at Stanford University School of Medicine showed decades ago that women whose depression was easing lived longer than those whose depression was getting worse. His research and other studies have clearly shown that “the brain is intimately connected to the body and the body to the brain,”

“The body tends to react to mental stress as if it was a physical stress.”

Anxiety disorders affect nearly 20 percent of American adults. That means millions are beset by an overabundance of the fight-or-flight response that primes the body for action.

“We often talk about depression as a complication of chronic illness,” Dr. Frownfelter wrote in Medpage Today in July. “But what we don’t talk about enough is how depression can lead to chronic disease. Patients with depression may not have the motivation to exercise regularly or cook healthy meals. Many also have trouble getting adequate sleep.”

These protective actions stem from the neurotransmitters epinephrine and norepinephrine, which stimulate the sympathetic nervous system and put the body on high alert. But when they are invoked too often and indiscriminately, the chronic overstimulation can result in all manner of physical ills, including digestive symptoms like indigestion, cramps, diarrhea or constipation, and an increased risk of heart attack or stroke.

While it’s normal to feel depressed from time to time, more than 6 percent of adults have such persistent feelings of depression that it disrupts personal relationships, interferes with work and play, and impairs their ability to cope with the challenges of daily life

“Depression diminishes a person’s capacity to analyze and respond rationally to stress,” Dr. Spiegel said. “They end up on a vicious cycle with limited capacity to get out of a negative mental state.”

Although persistent anxiety and depression are highly treatable with medications, cognitive behavioral therapy and talk therapy, without treatment these conditions tend to get worse.

When you’re stressed, the brain responds by prompting the release of cortisol, nature’s built-in alarm system. It evolved to help animals facing physical threats by increasing respiration, raising the heart rate and redirecting blood flow from abdominal organs to muscles that assist in confronting or escaping danger.

Improving sleep is especially helpful, Dr. Spiegel said, because “it enhances a person’s ability to regulate the stress response system and not get stuck in a mental rut.”

in developed countries, major and minor mental illnesses were three times as common in societies where there were bigger income differences between rich and poor. In other words, an American is likely to know three times as many people with depression or anxiety problems as someone in Japan or Germany.

One, looking at the 50 American states, discovered that after taking account of age, income and educational differences, depression was more common in states with greater income inequality

schizophrenia was about three times as common in more unequal societies as it was in more equal ones.

a wide range of mental disorders might originate in a “dominance behavioral system.” This part of our evolved psychological makeup, almost universal in mammals, enables us to recognize and respond to social ranking systems based on hierarchy and power. One brain-imaging study discovered that there were particular areas of the brain and neural mechanisms dedicated to processing social rank.

psychiatric conditions like mania and narcissism are related to our striving for status and dominance, while disorders such as anxiety and depression may involve responses to the experience of subordination

how does increasing inequality factor in? One of the important effects of wider income differences between rich and poor is to intensify the issues of dominance and subordination, and feelings of superiority and inferiority.

A new study by Dublin-based researchers of 34,000 people in 31 countries found that in countries with bigger income differences, status anxiety was more common at all levels in the social hierarchy

self-enhancement or self-aggrandizement — the tendency to present an inflated view of oneself — occurred much more frequently in more unequal societies.

In the United States, research psychologists have shown that narcissism rates, as measured by a standard academic tool known as the Narcissistic Personality Inventory, rose rapidly from the later 1980s, which would appear to track the increases in inequality

as larger differences in material circumstances create greater social distances, feelings of superiority and inferiority increase. In short, growing inequality makes us all more neurotic about “image management” and how we are seen by others.

Humans instinctively know how to cooperate and create social ties, but we also know how to engage in status competition — how to be snobs and how to talk ourselves up. We use these alternative social strategies almost every day of our lives, but crucially, inequality shifts the balance between them.

we become less nice people in more unequal societies. But we are less nice and less happy: Greater inequality redoubles status anxiety, damaging our mental health and distorting our personalities — wherever we are on the social spectrum.

Even if the doctors couldn’t pin down what was going on with me, I was so alarmed by my symptoms and the doctors’ gravest guesses that I felt anxious about whether or not I would have a future.

What was certain is that I was shrinking. Rapidly, uncontrollably.

My clothes hung loose at the waist and sloughed off my shoulders as if they belonged to a stranger, so I bought a stranger’s dress. Kate Spade, $348 retail.

I found it for $50 at an online designer consignment store while on hold with the hospital; a nurse was checking on the results of my bone marrow biopsy.

Online shopping was the sort of thing one might do if she were on hold with her cable company, not awaiting a possible blood cancer diagnosis.

I filled my cart with a cobalt dress, a blush silk blouse, a slinky skirt.

On paper, the doctors said, it looked like it could be lymphoma. The symptoms were classic: fever, night sweats, weight loss.

A biopsy of my enlarged lymph node showed it to be benign.

Two weeks earlier, a doctor had taken a surgical drill to my hip and hollowed out my bones with a syringe fit for a large horse. “Painful” was a deficient descriptor.

“I just don’t know what else to do,” my doctor said.

I sat still while my insides turned over. A cold sweat crept across my face. I closed my eyes, shook my head and returned to my shopping cart. I was not going to dwell.

No — I was going to shop. I was going to shop until I could think of nothing else. I punched in my credit card number and bought the Kate Spade.

Then I rushed to my closet, threw open the double doors and began rifling through Target impulse buys and ill-fitting hand-me-down

we’ll have to keep looking

I couldn’t breathe. I couldn’t do illness anymore. I could only do this.

I spun around in it, watching the hem rise and fall. Something about it made me feel less like a haggard patient and more like the kind of woman who went to cocktail parties dripping with perfume and family money.

Over the next few months, I made it my mission to build a new wardrobe from scratch. The process demanded every moment of my free time, every spare thought

We both knew it was impractical. The clothes were expensive and high maintenance, most of them over-the-top fancy for my modest life in nonprofit communications.

But they felt vital. I told myself I was overdue for some frivolity, that I deserved to treat myself.

For my next doctor’s appointment, I picked out a Valentino pencil skirt that fit snugly against my new, withered body.

I hurled the clothes into boxes and garbage bags. They smelled like the hospital, all burned coffee and antiseptic. I didn’t want them. I didn’t even want to look at them. I wanted silk. I wanted velvet.

“Can I see you again in six weeks? We can repeat blood work then and come up with a timeline for scans. Does that sound like an OK plan?”

“Just that I live here,” I said, gesturing at my body. “I have to live here.”

That night I ran my fingers through my hair, and a clump of blond strands fell loose into my palm. “It’s just stress,” I told my cat. I brushed my hands together, letting my hair fall into the trash, and returned to my shopping list.

Each one had lived a life before me. Now I held onto them in the dim light of my bedroom like tangible hope.

We’re forced to find hope in what we used to mock: God, the afterlife, miracles, hemp oil. Healing, by any means. Healing, against all odds.

After every appointment, after every failed attempt to name my illness, I would prop myself in bed, choose new dresses and think of all the places I would wear them.

The clothes promised me something the doctors, as they continue to search for a diagnosis, still can’t: an uncomplicated future. And I promised a future to the clothes.

This was their life after life. And they deserved that, didn’t they?

Globally, the numbers can be even worse, and the stakes often higher. “Say a person comes into the hospital in Sierra Leone with a fever and flulike symptoms,” DeRisi says. “After a few days, or a week, they die. What caused that illness? Most of the time, we never find out. Because if the cause isn’t something that we can culture and test for” — like hepatitis, or strep throat — “it basically just stays a mystery.”

It would be better, DeRisi says, to watch for rare cases of mystery illnesses in people, which often exist well before a pathogen gains traction and is able to spread.

Based on a retrospective analysis of blood samples, scientists now know that H.I.V. emerged nearly a dozen times over a century, starting in the 1920s, before it went global.

Zika was a relatively harmless illness before a single mutation, in 2013, gave the virus the ability to enter and damage brain cells.

The beauty of this approach” — running blood samples from people hospitalized all over the world through his system, known as IDseq — “is that it works even for things that we’ve never seen before, or things that we might think we’ve seen but which are actually something new.”

In this scenario, an undiscovered or completely new virus won’t trigger a match but will instead be flagged. (Even in those cases, the mystery pathogen will usually belong to a known virus family: coronaviruses, for instance, or filoviruses that cause hemorrhagic fevers like Ebola and Marburg.)

And because different types of bacteria require specific conditions in order to grow, you also need some idea of what you’re looking for in order to find it.

The same is true of genomic sequencing, which relies on “primers” designed to match different combinations of nucleotides (the building blocks of DNA and RNA).

Even looking at a slide under a microscope requires staining, which makes organisms easier to see — but the stains used to identify bacteria and parasites, for instance, aren’t the same.

The practice that DeRisi helped pioneer to skirt this problem is known as metagenomic sequencing

Unlike ordinary genomic sequencing, which tries to spell out the purified DNA of a single, known organism, metagenomic sequencing can be applied to a messy sample of just about anything — blood, mud, seawater, snot — which will often contain dozens or hundreds of different organisms, all unknown, and each with its own DNA. In order to read all the fragmented genetic material, metagenomic sequencing uses sophisticated software to stitch the pieces together by matching overlapping segments.

The assembled genomes are then compared against a vast database of all known genomic sequences — maintained by the government-run National Center for Biotechnology Information — making it possible for researchers to identify everything in the mix

Traditionally, the way that scientists have identified organisms in a sample is to culture them: Isolate a particular bacterium (or virus or parasite or fungus); grow it in a petri dish; and then examine the result under a microscope, or use genomic sequencing, to understand just what it is. But because less than 2 percent of bacteria — and even fewer viruses — can be grown in a lab, the process often reveals only a tiny fraction of what’s actually there. It’s a bit like planting 100 different kinds of seeds that you found in an old jar. One or two of those will germinate and produce a plant, but there’s no way to know what the rest might have grown into.

Such studies have revealed just how vast the microbial world is, and how little we know about it

“The selling point for researchers is: ‘Look, this technology lets you investigate what’s happening in your clinic, whether it’s kids with meningitis or something else,’” DeRisi said. “We’re not telling you what to do with it. But it’s also true that if we have enough people using this, spread out all around the world, then it does become a global network for detecting emerging pandemics

One study found more than 1,000 different kinds of viruses in a tiny amount of human stool; another found a million in a couple of pounds of marine sediment. And most were organisms that nobody had seen before.

After the Biohub opened in 2016, one of DeRisi’s goals was to turn metagenomics from a rarefied technology used by a handful of elite universities into something that researchers around the world could benefit from

metagenomics requires enormous amounts of computing power, putting it out of reach of all but the most well-funded research labs. The tool DeRisi created, IDseq, made it possible for researchers anywhere in the world to process samples through the use of a small, off-the-shelf sequencer, much like the one DeRisi had shown me in his lab, and then upload the results to the cloud for analysis.

he’s the first to make the process so accessible, even in countries where lab supplies and training are scarce. DeRisi and his team tested the chemicals used to prepare DNA for sequencing and determined that using as little as half the recommended amount often worked fine. They also 3-D print some of the labs’ tools and replacement parts, and offer ongoing training and tech support

The metagenomic analysis itself — normally the most expensive part of the process — is provided free.

But DeRisi’s main innovation has been in streamlining and simplifying the extraordinarily complex computational side of metagenomics

IDseq is also fast, capable of doing analyses in hours that would take other systems weeks.

“What IDseq really did was to marry wet-lab work — accumulating samples, processing them, running them through a sequencer — with the bioinformatic analysis,”

“Without that, what happens in a lot of places is that the researcher will be like, ‘OK, I collected the samples!’ But because they can’t analyze them, the samples end up in the freezer. The information just gets stuck there.”

Meningitis itself isn’t a disease, just a description meaning that the tissues around the brain and spinal cord have become inflamed. In the United States, bacterial infections can cause meningitis, as can enteroviruses, mumps and herpes simplex. But a high proportion of cases have, as doctors say, no known etiology: No one knows why the patient’s brain and spinal tissues are swelling.

When Saha and her team ran the mystery meningitis samples through IDseq, though, the result was surprising. Rather than revealing a bacterial cause, as expected, a third of the samples showed signs of the chikungunya virus — specifically, a neuroinvasive strain that was thought to be extremely rare. “At first we thought, It cannot be true!” Saha recalls. “But the moment Joe and I realized it was chikungunya, I went back and looked at the other 200 samples that we had collected around the same time. And we found the virus in some of those samples as well.”

Until recently, chikungunya was a comparatively rare disease, present mostly in parts of Central and East Africa. “Then it just exploded through the Caribbean and Africa and across Southeast Asia into India and Bangladesh,” DeRisi told me. In 2011, there were zero cases of chikungunya reported in Latin America. By 2014, there were a million.

Chikungunya is a mosquito-borne virus, but when DeRisi and Saha looked at the results from IDseq, they also saw something else: a primate tetraparvovirus. Primate tetraparvoviruses are almost unknown in humans, and have been found only in certain regions. Even now, DeRisi is careful to note, it’s not clear what effect the virus has on people. “Maybe it’s dangerous, maybe it isn’t,” DeRisi says. “But I’ll tell you what: It’s now on my radar.

it reveals a landscape of potentially dangerous viruses that we would otherwise never find out about. “What we’ve been missing is that there’s an entire universe of pathogens out there that are causing disease in humans,” Imam notes, “ones that we often don’t even know exist.”

“The plan was, Let’s let researchers around the world propose studies, and we’ll choose 10 of them to start,” DeRisi recalls. “We thought we’d get, like, a couple dozen proposals, and instead we got 350.”

Metagenomic sequencing is especially good at what scientists call “environmental sampling”: identifying, say, every type of bacteria present in the gut microbiome, or in a teaspoon of seawater.

“When you draw blood from someone who has a fever in Ghana, you really don’t know very much about what would normally be in their blood without fever — let alone about other kinds of contaminants in the environment. So how do you interpret the relevance of all the things you’re seeing?”

Such criticisms have led some to say that metagenomics simply isn’t suited to the infrastructure of developing countries. Along with the problem of contamination, many labs struggle to get the chemical reagents needed for sequencing, either because of the cost or because of shipping and customs holdups

we’re less likely to be caught off-guard. “With Ebola, there’s always an issue: Where’s the virus hiding before it breaks out?” DeRisi explains. “But also, once we start sampling people who are hospitalized more widely — meaning not just people in Northern California or Boston, but in Uganda, and Sierra Leone, and Indonesia — the chance of disastrous surprises will go down. We’ll start seeing what’s hidden.”

Henry balked at that idea, citing extensive testing and brain scans that supported the diagnosis of mental illness.“You can’t fake brain scans that show the brain damage,” she said.

cited defense experts who alleged Montgomery suffered from depression, borderline personality disorder and post-traumatic stress disorder.

pseudocyesis in which a woman’s false belief she is pregnant triggers hormonal and physical changes as if she was actually pregnant.

Montgomery also experiences delusions and hallucinations, believing God spoke with her through connect-the-dot puzzles, the judge said, citing defense experts.

Ms. Montgomery’s current mental state is so divorced from reality that she cannot rationally understand the government’s rationale for her execution,” the judge said.

The government has acknowledged Montgomery’s mental issues but disputes that she can’t comprehend that she is scheduled for execution for killing another person because of them.

The cerebrum has two halves, or hemispheres, that are further divided into four regions, or lobes. The frontal lobes, located behind the forehead, are involved with speech, thought, learning, emotion, and movement.

Behind them are the parietal lobes, which process sensory information such as touch, temperature, and pain.

At the rear of the brain are the occipital lobes, dealing with vision

Lastly, there are the temporal lobes, near the temples, which are involved with hearing and memory.

The second-largest part of the brain is the cerebellum, which sits beneath the back of the cerebrum.

diencephalon, located in the core of the brain. A complex of structures roughly the size of an apricot, its two major sections are the thalamus and hypothalamus

The brain is extremely sensitive and delicate, and so it requires maximum protection, which is provided by the hard bone of the skull and three tough membranes called meninges.

Want more proof that the brain is extraordinary? Look no further than the blood-brain barrier.

This led scientists to learn that the brain has an ingenious, protective layer. Called the blood-brain barrier, it’s made up of special, tightly bound cells that together function as a kind of semi-permeable gate throughout most of the organ. It keeps the brain environment safe and stable by preventing some toxins, pathogens, and other harmful substances from entering the brain through the bloodstream, while simultaneously allowing oxygen and vital nutrients to pass through.

One in five Americans suffers from some form of neurological damage, a wide-ranging list that includes stroke, epilepsy, and cerebral palsy, as well as dementia.

Alzheimer’s disease, which is characterized in part by a gradual progression of short-term memory loss, disorientation, and mood swings, is the most common cause of dementia. It is the sixth leading cause of death in the United States

50 million people suffer from Alzheimer’s or some form of dementia. While there are a handful of drugs available to mitigate Alzheimer’s symptoms, there is no cure.

Unfortunately, negative attitudes toward people who suffer from mental illness are widespread. The stigma attached to mental illness can create feelings of shame, embarrassment, and rejection, causing many people to suffer in silence.

In the United States, where anxiety disorders are the most common forms of mental illness, only about 40 percent of sufferers receive treatment. Anxiety disorders often stem from abnormalities in the brain’s hippocampus and prefrontal cortex.

Attention-deficit/hyperactivity disorder, or ADHD, is a mental health condition that also affects adults but is far more often diagnosed in children.

ADHD is characterized by hyperactivity and an inability to stay focused.

Depression is another common mental health condition. It is the leading cause of disability worldwide and is often accompanied by anxiety. Depression can be marked by an array of symptoms, including persistent sadness, irritability, and changes in appetite.

The good news is that in general, anxiety and depression are highly treatable through various medications—which help the brain use certain chemicals more efficiently—and through forms of therapy

"Kansas is one of only five states that has all-but abolished the defense -- a step that the majority upheld today. But the most important implication of the decision may be in opening the door to additional states that want to follow suit," he said.

Kagan stressed that Kansas law allows a defendant to "present psychiatric and other evidence of mental illness" through testimony to prove that "he had no intent to kill" to defend himself against a criminal charge."The defendant can use that evidence to show that his illness left him without cognitive capacity to form the requisite intent," she said. And, she said, Kansas permits a defendant to offer whatever mental health evidence he "deems relevant at sentencing."

Judging the moral meaning of Mr. Trump’s bout with Covid-19 — and our reactions to it — is no easy task.

while it is true that life is sacred, and we must honor the dignity of all persons, including Mr. Trump, society also has a legitimate moral interest in seeing wrongdoers face consequences for their actions.

The sense that justice requires punishment for wrongs runs deep and is not the same as a mere thirst for revenge or a desire to get even.

On the contrary, punishment plays an important role in any healthy moral ecosystem. When the moral order has been ruptured, punishment for wrongs helps to repair tears to the social fabric and to reinforce the validity of the moral expectations that were violated.

The moral complexity becomes greater still when we consider that from a purely consequentialist point of view, there are reasons to view Mr. Trump’s potential incapacity as the best moral outcome.

Imagining Mr. Trump’s illness as a metaphorical punishment for his misdeeds helps to satisfy at the level of fantasy a legitimate need to see justice done

consequentialism is the philosophical position that affirms that what is morally right is whatever makes the world best in the future

a consequentialist argument can be made that his speedy recovery from Covid-19 would not be the best moral outcome.

The consequentialist argument, while repugnant from the perspective of human dignity, tells us that a world in which Mr. Trump is unable to commit harm would be morally better than a world in which he continues to harm freely.

This philosophical approach to weighing moral outcomes conflicts with the principle of individual human dignity and offers no easy guideline for reconciling these powerful yet opposing ways of thinking about what is best.

the punishment that Mr. Trump’s bout of Covid-19 represents is merely symbolic, a stand-in for the real punishment he deserves, which is necessarily social in character. Mr. Trump deserves to be punished at the ballot box and to be held accountable for any possible criminal wrongdoing in a court of law.

No one should seek to die or give in to a disease they can legitimately fight. God knows how many pills I take a day to keep the virus – and all its and their side-effects at bay. But I get to live healthily and meaningfully. The way some elaborate and cutting edge treatments all but kill the patient in order to save her troubles me. It’s a loss of perspective as well as immensely expensive for the entire system.

our culture’s gradual alienation from the fact of our deaths – our distancing ourselves even from the old and infirm in ways previous cultures didn’t and couldn’t – is not, in my view a healthy thing.

these sophisticated treatments are taking healthcare money away from the young, taking up more and more of our collective healthcare resources, and extending lives only be perpetuating continuous agony and nausea and pain for the patient and devastating consequences for families and friends.

We will all die. We should not seek it. But we should not flee from it for ever.

at some point what seems to me to matter more is not the length of our lives but the content of them and the manner of our deaths.

At some point, medicine is a function of a social disease of modernity: the flight from our own mortality. But fleeing it does not defuse it. Only facing it does.

up until then I hadn’t thought much about the process of decision making. So in between M.R.I.’s, CT scans and spinal taps, I dove into the academic literature on decision making. Not just in my field but also in neuroscience, psychology, sociology, information science, political science and history.

Physicians do get things wrong, remarkably often. Studies have shown that up to one in five patients are misdiagnosed. In the United States and Canada it is estimated that 50,000 hospital deaths each year could have been prevented if the real cause of illness had been correctly identified.

Yet people are loath to challenge experts.

when confronted with the expert, it was as if the independent decision-making parts of many subjects’ brains pretty much switched off. They simply ceded their power to decide to the expert.

If we are to control our own destinies, we have to switch our brains back on and come to our medical consultations with plenty of research done, able to use the relevant jargon. If we can’t do this ourselves we need to identify someone in our social or family network who can do so on our behalf.

Anxiety, stress and fear — emotions that are part and parcel of serious illness — can distort our choices. Stress makes us prone to tunnel vision, less likely to take in the information we need. Anxiety makes us more risk-averse than we would be regularly and more deferential.

It’s not that we can’t be anxious, it’s that we need to acknowledge to ourselves that we are.

It is also crucial to ask probing questions not only of the experts but of ourselves.

we bring into our decision-making process flaws and errors of our own. All of us show bias when it comes to what information we take in. We typically focus on anything that agrees with the outcome we want.

We need to be aware of our natural born optimism, for that harms good decision making, too.

We need to acknowledge our tendency to incorrectly process challenging news and actively push ourselves to hear the bad as well as the good. It felt great when I stumbled across information that implied I didn’t need any serious treatment at all. When we find data that supports our hopes we appear to get a dopamine rush similar to the one we get if we eat chocolate, have sex or fall in love

But it’s often information that challenges our existing opinions or wishful desires that yields the greatest insights

Just how much your lunch will affect ethical decision making remains unclear; we still know very little about this “gut brain,” as Ms. Enders refers to it. But this byzantine neural architecture suggests that our intestines may play a large part in determining who we are and what we do.

cities also break traditions and fracture families, and they breed psychiatric illness. In a city you are more likely to be depressed, to fall ill with schizophrenia, and to use alcohol and drugs. Poverty and rapid urbanization sharpen these effects.

We know that social position affects both when you die and how sick you get: The higher your social position, the healthier you are. It turns out that your sense of relative social rank — where you draw a line on an abstract ladder to show where you are with respect to others — predicts many health outcomes, including depression, sometimes even more powerfully than your objective socioeconomic status.

What has exploded in India over the past few decades, but also everywhere else in the world, is information about other people. As we watch television, surf the Internet and follow events around the world, we become intimately aware of other ways of living and of others who are richer and more powerful. We place ourselves in a vast social order in which most of us are ants. It may truly be a depressing reflection.

Some of these figures might simply reflect more willingness to label an experience as a symptom. For example, until recently, most Japanese understood intense fatigue as sacrifice for one’s work and suicide as an act of reasoned will. In her book “Depression in Japan,” the anthropologist Junko Kitanaka writes that partly as a result of aggressive pharmaceutical marketing, many Japanese began to think of their fatigue and suicidal thoughts as symptoms created by a disease. The number of diagnoses of depression in that country more than doubled between 1999 and 2008.

To some extent, the brain remains a bit of a black box, as puzzling to modern-day psychiatrists as it was to turn-of-the-century charlatans. The difference is, most doctors today have the humility to admit what they don't know.

When the researchers blocked the input to these neurons, the mice began moving during their sleep, just like someone with REM sleep behavior disorder.

Narcolepsy is characterized by suddenly falling asleep at any time during the day, even in mid-sentence. Cataplexy is a related illness in which people suddenly lose muscle tone and collapse.

They tested their hypothesis using a mouse model of narcolepsy in which cataplexic attacks could be triggered by chocolate. "We found that silencing the SLD-to-ventral medial medulla reduced the number of cataplexic bouts,"

The glycinergic neurons we have identified in the ventral medial medulla could be a good target for drug therapies for people with narcolepsy, cataplexy, or REM sleep behavior disorder,

"They were connected to neurons that control voluntary movements, but not those that control muscles in the eyes or internal organs. Importantly, they were inhibitory, meaning that they can prevent muscle movement when active."

"The glycinergic neurons we have identified in the ventral medial medulla could be a good target for drug therapies for people with narcolepsy, cataplexy, or REM sleep behavior disorder,"

The results from the phase 3 trial, involving almost 1,000 dying head and neck cancer patients, were early and not statistically significant but were still “clinically meaningful”, the ICR said, with some patients living months or years longer and suffering fewer side effects.

When the research nurses called to tell me that, after two months, the tumour in my throat had completely disappeared, it was an amazing moment,” said Ambrose. “While there was still disease in my lungs at that point, the effect was staggering.”

The Bloomberg article cites a July meta-analysis in the medical journal Lancet, which found a tenuous link between higher temperatures and suicides and mental illness. But the study deems the collective evidence of “low certainty” owing to inconsistent study findings, methodologies, measured variables and definitions.

“climate change might not necessarily increase mental health issues because people might adapt over time, meaning that higher temperatures could become normal and not be experienced as anomalous or extreme.”

yes. Before the media began reporting on putative temperature records—the scientific evidence for which is also weak—heat waves were treated as a normal part of summer. Uncomfortable, but figuratively nothing to sweat about.

according to a World Health Organization report last year, the very “awareness of climate change and extreme weather events and their impacts” may lead to a host of ills, including strained social relationships, anxiety, depression, intimate-partner violence, helplessness, suicidal behavior and alcohol and substance abuse.

A study in 2021 of 16- to 25-year-olds in 10 countries including the U.S. reported that 59% were very or extremely worried about climate change, and 84% were at least moderately worried

Forty-five percent claimed they were so worried that they struggled to function on a daily basis, the definition of an anxiety disorder.

“First and foremost, it is imperative that adults understand that youth climate anxiety (also referred to as eco-anxiety, solastalgia, eco-guilt or ecological grief) is an emotionally and cognitively functional response to real existential threats,” a May 10 editorial in the journal Nature explained. “Although feelings of powerlessness, grief and fear can be profoundly disruptive—particularly for young people unaccustomed to the depth and complexity of such feelings—it is important to acknowledge that this response is a rational one.”

These anxieties are no more rational than the threats from climate change are existential.

A more apt term for such fear is climate hypochondria.

The New Yorker magazine earlier this month published a 4,400-word piece titled “What to Do With Climate Emotions” by Jia Tolentino, a woman in the throes of such neurosis

Ms. Tolentino goes on to describe how climate therapists can help patients cope. “The goal is not to resolve the intrusive feeling and put it away” but, as one therapist advises her, “to aim for a middle ground of sustainable distress.” Even the climate left’s despair must be “sustainable.”

there’s nothing normal about climate anxiety, despite the left’s claims to the contrary.

Progressives may even use climate change to displace their other anxieties—for instance, about having children

Displacement is a maladaptive mechanism by which people redirect negative emotions from one thing to another

Climate hypochondriacs deserve to be treated with compassion, much like anyone who suffers from mental illness. They shouldn’t, however, expect everyone else to enable their neuroses.

Senate Republicans have for years blocked progress on any gun safety legislation. They opposed efforts to tighten gun regulations both when they held the majority, and even now when they can threaten an indefinite filibuster if Democrats can’t come up with the 60 votes required to circumvent the stalling tactic.

“It’s much easier to scream about guns than it is to demand answer about where our culture is failing,” Cruz added in a separate social media post on Saturday.

Disapproval from Cruz and other Senate Republicans will likely doom any legislation Nadler and other House Democrats manage to pass.

Democrats dispute the claim that lawmakers need to target mental illness more so than the availability of guns to reduce shooting violence in the U.S. They say that similar rates of mental illness in other developed nations across the globe prove that mental illness alone cannot fully explain the prevalence of mass shootings in the U.S.

Despite recent gains in industrial development and increasing numbers of engineering graduates, Mexico is floundering socially, politically and economically because so many of its citizens do not read. Upon taking office in December, our new president, Enrique Peña Nieto, immediately announced a program to improve education. This is typical. All presidents do this upon taking office.

Put the leader of the teachers’ union, Elba Esther Gordillo, in jail — which he did last week. Ms. Gordillo, who has led the 1.5 million-member union for 23 years, is suspected of embezzling about $200 million.

Nobody in Mexico organizes as many strikes as the teachers’ union. And, sadly, many teachers, who often buy or inherit their jobs, are lacking in education themselves.

they learn much less. They learn almost nothing. The proportion of the Mexican population that is literate is going up, but in absolute numbers, there are more illiterate people in Mexico now than there were 12 years ago

I picked out five of the ignorant majority and asked them to tell me why they didn’t like reading. The result was predictable: they stuttered, grumbled, grew impatient. None was able to articulate a sentence, express an idea.

In 2002, President Vicente Fox began a national reading plan; he chose as a spokesman Jorge Campos, a popular soccer player, ordered millions of books printed and built an immense library. Unfortunately, teachers were not properly trained and children were not given time for reading in school. The plan focused on the book instead of the reader. I have seen warehouses filled with hundreds of thousands of forgotten books, intended for schools and libraries, simply waiting for the dust and humidity to render them garbage.

When my daughter was 15, her literature teacher banished all fiction from her classroom. “We’re going to read history and biology textbooks,” she said, “because that way you’ll read and learn at the same time.” In our schools, children are being taught what is easy to teach rather than what they need to learn. It is for this reason that in Mexico — and many other countries — the humanities have been pushed aside.

it is natural that in secondary school we are training chauffeurs, waiters and dishwashers.

he educational machine does not need fine-tuning; it needs a complete change of direction. It needs to make students read, read and read.

But perhaps the Mexican government is not ready for its people to be truly educated. We know that books give people ambitions, expectations, a sense of dignity. If tomorrow we were to wake up as educated as the Finnish people, the streets would be filled with indignant citizens and our frightened government would be asking itself where these people got more than a dishwasher’s training.