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fill the vacancy at the top of the Bureau of Alcohol, Tobacco, Firearms, and Explosives (ATF), which has been without a director for six years.

requires the federal government to compel states to submit all necessary records on felons, domestic abusers, the seriously mentally ill and others to the background check system.

make gun trafficking a felony. Gun rights advocates agree that penalties for illegal use and possession of guns should be stiffened -- and so should penalties on those who are engaged in gun trafficking.

step up its prosecution of gun criminals who try to buy guns. In 2009, 71,000 people who had been convicted of gun crimes tried to buy guns by lying on their background checks. Yet the federal government prosecuted only 77 of those cases.

crack down on rogue gun dealers.

. If President Obama and Congress fail to lead, 48,000 Americans will be killed with guns over the next four years.

Dr. Arthur Beaudet, a professor at the Baylor College of Medicine and the chairman of its department of molecular and human genetics, applaud the effort. He believes that the acts committed by men like Mr. Lanza and the gunmen in other rampages in recent years — at Columbine High School and in Aurora, Colo., in Norway, in Tucson and at Virginia Tech — are so far off the charts of normal behavior that there must be genetic changes driving them.

Everything known about mental illness, these skeptics say, argues that there are likely to be hundreds of genes involved in extreme violent behavior, not to mention a variety of environmental influences, and that all of these factors can interact in complex and unpredictable ways.

The National Institutes of Health was embroiled in controversy about 20 years ago simply for proposing to study the biological underpinnings of violence. Critics accused researchers of racism and singling out minorities, especially black men.

Studies of people at the far end of a bell curve can be especially informative, because the genetic roots of their conditions can be stark and easy to spot, noted J. H. Pate Skene, a Duke University neurobiologist. “I think doing research on outliers, people at an end of a spectrum on something of concern like violent behavior, is certainly a good idea,” he said, but he advised tempering expectations.

“If we know someone has a 2 percent chance or a 10 percent chance or a 20 percent chance of violent behavior, what would you do with that person?” Dr. Skene said. “They have not been convicted of anything — have not done anything wrong.”

Ultimately, understanding the genetics of violence might enable researchers to find ways to intervene before a person commits a horrific crime. But that goal would be difficult to achieve, and the pursuit of it risks jeopardizing personal liberties.

The creators of the D.S.M. in the 1960s and ’70s “were real heroes at the time,” said Dr. Steven E. Hyman, a psychiatrist and neuroscientist at the Broad Institute and a former director at the National Institute of Mental Health. “They chose a model in which all psychiatric illnesses were represented as categories discontinuous with ‘normal.’ But this is totally wrong in a way they couldn’t have imagined. So in fact what they produced was an absolute scientific nightmare. Many people who get one diagnosis get five diagnoses, but they don’t have five diseases — they have one underlying condition.”

Decades of spending on neuroscience have taught scientists mostly what they do not know, undermining some of their most elemental assumptions. Genetic glitches that appear to increase the risk of schizophrenia in one person may predispose others to autism-like symptoms, or bipolar disorder. The mechanisms of the field’s most commonly used drugs — antidepressants like Prozac, and antipsychosis medications like Zyprexa — have revealed nothing about the causes of those disorders. And major drugmakers have scaled back psychiatric drug development, having virtually no new biological “targets” to shoot for.

Dr. Insel is one of a growing number of scientists who think that the field needs an entirely new paradigm for understanding mental disorders, though neither he nor anyone else knows exactly what it will look like.

Dr. Hyman, Dr. Insel and other experts said they hoped that the science of psychiatry would follow the direction of cancer research, which is moving from classifying tumors by where they occur in the body to characterizing them by their genetic and molecular signatures.

Dr. Insel said in the interview that his motivation was not to disparage the D.S.M. as a clinical tool, but to encourage researchers and especially outside reviewers who screen proposals for financing from his agency to disregard its categories and investigate the biological underpinnings of disorders instead.

most subjects divided their tokens nearly equally between the public and private accounts

Economics students, by contrast, invested only 20 percent of their tokens in the public fund, on average.

Three quarters of non-economists reported that a "fair" investment of tokens would necessitate putting at least half of their tokens in the public fund. A third of economists didn't answer the question or gave "complex, uncodable responses." The remaining economics students were much more likely than their non-economist peers to say that "little or no contribution was 'fair'."

Other studies have found economics students to exhibit a stronger tendency towards anti-social positions compared to their peers.

Carter and Irons had both economics students and non-economics students play the "ultimatum" game -- a two-player game where one player is given a sum of money to divide between the two. The other player is then given a chance to accept or reject the offer; if she accepts it, then each player receives the portion of money proposed by the offerer. If she declines, then neither player gets any money. Carter and Irons found that, relative to non-economics students, economics students were much more likely to offer their partners small sums, and, thus, deviate from a "fair" 50/50 spilt.

Finally, researchers had both economics and non-economics students fill out two "honesty surveys" -- one at the start of the semester and one at the conclusion -- regarding how likely they were to either report being undercharged for a purchase or return found money to its owner. The authors found that, after taking an economics class, students' responses to the end-of-the-semester survey were more likely to reflect a decline in honest behavior than students who studied astronomy.

Other studies supported these key findings. They found that economics students are less likely to consider a vendor who increases the price of bottled water on a hot day to be acting "unfairly." Economics students who played a lottery game were willing to commit less of their potential winnings to fund a consolation prize for losers than were their peers. And such students were significantly more willing to accept bribes than other students. Moreover, economics students valued personal achievement and power more than their peers while attributing less importance to social justice and equality.

results show that it is not just selection that is responsible for the reported increase in immoral attitudes

Later studies support this conclusion. They found ideological differences between lower-level economics students and upper-level economics students that are similar in kind to the measured differences between the ideology of economics students as a whole and their peers. He finds that upper-level students are even less likely to support egalitarian solutions to distribution problems than lower-level students, suggesting that time spent studying economics does have an indoctrination effect.

The problem is not only that students are exposed to such views, but that there are no "balancing" courses taught in typical American colleges, in which a different view of economics is presented. Moreover, while practically all economic classes are taught in the "neoclassical" (libertarian, self centered) viewpoint, in classes by non-economists -- e.g., in social philosophy, political science, and sociology -- a thousand flowers bloom such that a great variety of approaches are advanced, thereby leaving students with a cacophony of conflicting pro-social views. What is needed is a systematic pro-social economics, that combines appreciation for the common good and for others as well as for the service of self.

angst and sadness promote “information-processing strategies best suited to dealing with more-demanding situations.” This helps explain why test subjects who are melancholy — Forgas induces the mood with a short film about death and cancer — are better at judging the accuracy of rumors and recalling past events; they’re also much less likely to stereotype strangers and make fewer arithmetic mistakes.

shoppers in the “low mood” condition remembered nearly four times as many of the trinkets. The wet weather made them sad, and their sadness made them more aware and attentive.

There are two important lessons of this research. The first is that our fleeting feelings can change the way we think. While sadness makes us more focused and diligent — the spotlight of attention is sharpened — happiness seems to have the opposite effect, so that good moods make us 20 percent more likely to have a moment of insight. The second takeaway is that many of our creative challenges involve tasks that require diligence, persistence and focus. It’s not easy making a collage or writing a poem or solving a hard technical problem, which is why sometimes being a little miserable can improve our creative performance.

Why is mental illness so closely associated with creativity? Andreasen argues that depression is intertwined with a “cognitive style” that makes people more likely to produce successful works of art. In the creative process, Andreasen says, “one of the most important qualities is persistence.”

While Andreasen acknowledges the burden of mental illness — she quotes Robert Lowell on depression not being a “gift of the Muse” and describes his reliance on lithium to escape the pain — she argues that many forms of creativity benefit from the relentless focus it makes possible. “Unfortunately, this type of thinking is often inseparable from the suffering,” she says. “If you’re at the cutting edge, then you’re going to bleed.”

Rabies moves at a predictable rate, replicating every eight to 10 hours, moving rapidly through chains of neurons and revealing a network. The researchers could allow the virus to move up the nervous system and reach the brain but could sacrifice the monkey before it showed any symptoms of infection.

When the virus has had enough time to travel a predictable distance, the researchers anesthetize the animal, wash out its blood, perfuse the central nervous system with fixatives, and use antibodies to detect where the virus has spread. The kills were timed to various stages to create a map. By the time you’ve gone through several sets of synapses that mapping is an enormous task. There’s an exponential increase in the number of neurons.

the researchers were astounded at what they saw. The motor areas in the brain connect to the adrenal glands. In the primary motor cortex of the brain, there’s a map of the human body—areas that correspond to the face, arm, and leg area, as well as a region that controls the axial body muscles (known to many people now as “the core”).

“Something about axial control has an impact on stress responses,” Strick reasons. “There’s all this evidence that core strengthening has an impact on stress. And when you see somebody that's depressed or stressed out, you notice changes in their posture. When you stand up straight, it has an effect on how you project yourself and how you feel.  Well, lo and behold, core muscles have an impact on stress. And I suspect that if you activate core muscles inappropriately with poor posture, that’s going to have an impact on stress.”

“These neural pathways might explain our intuitive sense for why there are many different strategies for coping with stress,” said Bruno. “I like the examples they give in the paper—that maybe this is why yoga and pilates are so successful. But there are lots of other things where people talk about mental imagery and all sorts of other ways that people deal with stress. I think having so many neural pathways having direct lines to the stress control system, that’s really interesting.”

Bruno specializes more in sensory neuroscience, so he read a more into the findings in the primary somatosensory cortex. Some of these tactile areas in the brain seem to be providing as much input to the adrenal medulla as the cortical areas. “To me that's really new and interesting,” said Bruno. “It might explain why certain sensations we find very relaxing or stressful.”

“It's not clear to me—from our work, and from their work—that what we call motor cortex is really motor cortex,” he said. “Maybe the primary sensory cortex is doing something more than we thought. When I see results like these, I go, hm, maybe these areas aren’t so simple.”

With this come implications for what’s currently known as “psychosomatic illness”—how the mind has an impact over organ functions. The name tends to have a bad connotation. The notion that this mind-body connection isn’t really real; that psychosomatic illnesses are “all in your head.” Elaborate connections like this would explain that, yes, it is all in your head. The fact that cortical areas in the brain that have multi-synaptic connections that control organ function could strip the negative connotations

As he put it, “How we move, think, and feel have an impact on the stress response through real neural connections.”

it’s unclear whether infectious virus can persist in blood or stool

the infection can spread through the mucous membranes, from the nose down to the rectum.

while the virus appears to zero in on the lungs, it may also be able to infect cells in the gastrointestinal system, experts say. This may be why some patients have symptoms like diarrhea or indigestion

“The virus will actually land on organs like the heart, the kidney, the liver, and may cause some direct damage to those organs,

some patients in China recovered but got sick again, apparently because they had damaged and vulnerable lung tissue that was subsequently attacked by bacteria in their body.

As the body’s immune system shifts into high gear to battle the infection, the resulting inflammation may cause those organs to malfunction, he said.

About 80 percent of people infected with the new coronavirus have relatively mild symptoms. But about 20 percent of people become more seriously ill and in about 2 percent of patients in China, which has had the most cases, the disease has been fatal.

the effects appear to depend on how robust or weakened a person’s immune system is. Older people or those with underlying health issues, like diabetes or another chronic illness, are more likely to develop severe symptoms

the course a patient’s coronavirus will take is not yet fully understood.

Some patients can remain stable for over a week and then suddenly develop pneumonia, Dr. Diaz said. Some patients seem to recover but then develop symptoms again.

more than half of 121 patients in China had normal CT scans early in their disease.

Coronavirus particles have spiked proteins sticking out from their surfaces, and these spikes hook onto cell membranes, allowing the virus’s genetic material to enter the human cell.

That genetic material proceeds to “hijack the metabolism of the cell and say, in effect, ‘Don’t do your usual job. Your job now is to help me multiply and make the virus,’

As copies of the virus multiply, they burst out and infect neighboring cells. The symptoms often start in the back of the throat with a sore throat and a dry cough.

The virus then “crawls progressively down the bronchial tubes,”

That can damage the alveoli or lung sacs and they have to work harder to carry out their function of supplying oxygen to the blood

The swelling and the impaired flow of oxygen can cause those areas in the lungs to fill with fluid, pus and dead cells. Pneumonia, an infection in the lung, can occur

Some people have so much trouble breathing they need to be put on a ventilator

Dr. Krogan and his colleagues set about finding proteins in our cells that the coronavirus uses to grow. Normally, such a project might take two years. But the working group, which includes 22 laboratories, completed it in a few weeks.

In 2011, Dr. Krogan and his colleagues developed a way to find all the human proteins that viruses use to manipulate our cells — a “map,” as Dr. Krogan calls it. They created their first map for H.I.V.

That virus has 18 genes, each of which encodes a protein. The scientists eventually found that H.I.V. interacts, in one way or another, with 435 proteins in a human cell.

In February, the research group synthesized genes from the coronavirus and injected them into cells. They uncovered over 400 human proteins that the virus seems to rely on.

The flulike symptoms observed in infected people are the result of the coronavirus attacking cells in the respiratory tract.

The new map shows that the virus’s proteins travel throughout the human cell, engaging even with proteins that do not seem to have anything to do with making new viruses.

Kevan Shokat, a chemist at U.C.S.F., is poring through 20,000 drugs approved by the Food and Drug Administration for signs that they may interact with the proteins on the map created by Dr. Krogan’s lab.

If promising drugs are found, investigators plan to try them in an animal infected with the coronavirus — perhaps ferrets, because they’re known to get SARS, an illness closely related to Covid-19.

Even if some of these drugs are effective treatments, scientists will still need to make sure they are safe for treating Covid-19. It may turn out, for example, that the dose needed to clear the virus from the body might also lead to dangerous side effects.

In past studies on animals, remdesivir blocked a number of viruses. The drug works by preventing viruses from building new genes.

In February, a team of researchers found that remdesivir could eliminate the coronavirus from infected cells. Since then, five clinical trials have begun to see if the drug will be safe and effective against Covid-19 in people.

Other researchers have taken startling new approaches. On Saturday, Stanford University researchers reported using the gene-editing technology Crispr to destroy coronavirus genes in infected cells.

I've grown very close to new people whose perspectives are radically different than mine.

It floors me: These individuals are all repositories of wisdom. They've gleaned it from experiences I'll never have, assumptions I don't share, and brains wired different than mine. I want to learn what they know.

Does that get us anywhere? A little ways, I think.

"Are we stuck with a passé traditionalism on one hand, and total laissez-faire on the other?" Is there common ground shared by the orthodox-Christian sexual ethics of a Rod Dreher and those who treat consent as their lodestar?

Gobry suggests that Emmanuel Kant provides a framework everyone can and should embrace, wherein consent isn't nearly enough to make a sexual act moral--we must, in addition, treat the people in our sex lives as ends, not means.

Here's how Kant put it: "Act in such a way that you treat humanity, whether in your own person or in the person of any other, never merely as a means to an end, but always at the same time as an end."

the disappearance of a default sexual ethic in America and the divergence of our lived experiences means we have more to learn from one another than ever, even as our different choices raise the emotional stakes.

Nor does it seem intuitively obvious that a suffering, terminally ill 90-year-old is regarding himself as a means, or an object, if he prefers to end his life with a lethal injection rather than waiting three months in semi-lucid agony for his lungs to slowly shut down and suffocate him. (Kant thought suicide impermissible.) The terminally ill man isn't denigrating his own worth or the preciousness of life or saying it's permissible "any time" it is difficult. He believes ending his life is permissible only because the end is nigh, and the interim affords no opportunity for "living" in anything except a narrow biological sense.

It seems to me that, whether we're talking about a three-week college relationship or a 60-year marriage, it is equally possible to treat one's partner as a means or as an end (though I would agree that "treating as means" is more common in hookups than marriage)

my simple definition is this: It is wrong to treat human persons in such a way that they are reduced to objects. This says nothing about consent: a person may consent to be used as an object, but it is still wrong to use them that way. It says nothing about utility: society may approve of using some people as objects; whether those people are actual slaves or economically oppressed wage-slaves it is still wrong to treat them like objects. What it says, in fact, is that human beings have intrinsic worth and dignity such that treating them like objects is wrong.

what it means to treat someone as a means, or as an object, turns out to be in dispute.

Years ago, I interviewed a sister who was acting as a surrogate for a sibling who couldn't carry her own child. The notion that either regarded the other (or themselves) as an object seems preposterous to me. Neither was treating the other as a means, because they both freely chose, desired and worked in concert to achieve the same end.

It seems to me that the Kantian insight is exactly the sort of challenge traditionalist Christians should make to college students as they try to persuade them to look more critically at hookup culture. I think a lot of college students casually mislead one another about their intentions and degree of investment, feigning romantic interest when actually they just want to have sex. Some would say they're transgressing against consent. I think Kant has a more powerful challenge. 

Ultimately, Kant only gets us a little way in this conversation because, outside the realm of sex, he thinks consent goes a long way toward mitigating the means problem, whereas in the realm of sex, not so much. This is inseparable from notions he has about sex that many of us just don't share.

two Biblical passages fit my moral intuition even better than Kant. "Love your neighbor as yourself." And "therefore all things whatsoever would that men should do to you, do ye even so to them.

"do unto others..." is extremely demanding, hard to live up to, and a very close fit with my moral intuitions.

"Do unto others" is also enough to condemn all sorts of porn, and to share all sorts of common ground with Dreher beyond consent. Interesting that it leaves us with so many disagreements too. "Do unto others" is core to my support for gay marriage.

Are our bones always to be trusted?) The sexual behavior parents would be mortified by is highly variable across time and cultures. So how can I regard it as a credible guide of inherent wrong? Professional football and championship boxing are every bit as violent and far more physically damaging to their participants than that basement scene, yet their cultural familiarity is such that most people don't feel them to be morally suspect. Lots of parents are proud, not mortified, when a son makes the NFL.

"Porn operates in fantasy the way boxing and football operate in fantasy. The injuries are quite real." He is, as you can see, uncomfortable with both. Forced at gunpoint to choose which of two events could proceed on a given night, an exact replica of the San Francisco porn shoot or an Ultimate Fighting Championship tournament--if I had to shut one down and grant the other permission to proceed--what would the correct choice be?

insofar as there is something morally objectionable here, it's that the audience is taking pleasure in the spectacle of someone being abused, whether that abuse is fact or convincing illusion. Violent sports and violent porn interact with dark impulses in humanity, as their producers well know.

If Princess Donna was failing to "do unto others" at all, the audience was arguably who she failed. Would she want others to entertain her by stoking her dark human impulses? Then again, perhaps she is helping to neuter and dissipate them in a harmless way. That's one theory of sports, isn't it? We go to war on the gridiron as a replacement for going to war? And the rise in violent porn has seemed to coincide with falling, not rising, incidence of sexual violence. 

On all sorts of moral questions I can articulate confident judgments. But I am confident in neither my intellect nor my gut when it comes to judging Princess Donna, or whether others are transgressing against themselves or "nature" when doing things that I myself wouldn't want to do. Without understanding their mindset, why they find that thing desirable, or what it costs them, if anything, I am loath to declare that it's grounded in depravity or inherently immoral just because it triggers my disgust instinct, especially if the people involved articulate a plausible moral code that they are following, and it even passes a widely held standard like "do unto others."

Here's another way to put it. Asked to render moral judgments about sexual behaviors, there are some I would readily label as immoral. (Rape is an extreme example. Showing the topless photo your girlfriend sent to your best friend is a milder one.) But I often choose to hold back and error on the side of not rendering a definitive judgment, knowing that occasionally means I'll fail to label as unethical some things that actually turn out to be morally suspect.

Partly I take that approach because, unlike Dreher, I don't see any great value or urgency in the condemnations, and unlike Douthat, I worry more about wrongful stigma than lack of rightful stigmas

In a society where notions of sexual morality aren't coercively enforced by the church or the state, what purpose is condemnation serving?

People are great! Erring on the side of failing to condemn permits at least the possibility of people from all of these world views engaging in conversation with one another.

Dreher worries about the fact that, despite our discomfort, neither Witt nor I can bring ourselves to say that the sexual acts performed during the S.F. porn shoot were definitely wrong. Does that really matter? My interlocutors perhaps see a cost more clearly than me, as well they might. My bias is that just arguing around the fire is elevating.

the trends persisted, across several years and a series of national surveys. The changes weren’t just in degree, but in kind.

The biggest difference between the Millennials and their predecessors was in how they viewed the world; teens today differ from the Millennials not just in their views but in how they spend their time. The experiences they have every day are radically different from those of the generation that came of age just a few years before them.

it was exactly the moment when the proportion of Americans who owned a smartphone surpassed 50 percent.

theirs is a generation shaped by the smartphone and by the concomitant rise of social media. I call them iGen

Born between 1995 and 2012, members of this generation are growing up with smartphones, have an Instagram account before they start high school, and do not remember a time before the internet.

iGen’s oldest members were early adolescents when the iPhone was introduced, in 2007, and high-school students when the iPad entered the scene, in 2010. A 2017 survey of more than 5,000 American teens found that three out of four owned an iPhone.

. I had grown accustomed to line graphs of trends that looked like modest hills and valleys. Then I began studying Athena’s generation.

More comfortable in their bedrooms than in a car or at a party, today’s teens are physically safer than teens have ever been. They’re markedly less likely to get into a car accident and, having less of a taste for alcohol than their predecessors, are less susceptible to drinking’s attendant ills.

Psychologically, however, they are more vulnerable than Millennials were: Rates of teen depression and suicide have skyrocketed since 2011. It’s not an exaggeration to describe iGen as being on the brink of the worst mental-health crisis in decades. Much of this deterioration can be traced to their phones.

the twin rise of the smartphone and social media has caused an earthquake of a magnitude we’ve not seen in a very long time, if ever. There is compelling evidence that the devices we’ve placed in young people’s hands are having profound effects on their lives—and making them seriously unhappy.

But the allure of independence, so powerful to previous generations, holds less sway over today’s teens, who are less likely to leave the house without their parents. The shift is stunning: 12th-graders in 2015 were going out less often than eighth-graders did as recently as 2009.

Today’s teens are also less likely to date. The initial stage of courtship, which Gen Xers called “liking” (as in “Ooh, he likes you!”), kids now call “talking”—an ironic choice for a generation that prefers texting to actual conversation. After two teens have “talked” for a while, they might start dating.

only about 56 percent of high-school seniors in 2015 went out on dates; for Boomers and Gen Xers, the number was about 85 percent.

The decline in dating tracks with a decline in sexual activity. The drop is the sharpest for ninth-graders, among whom the number of sexually active teens has been cut by almost 40 percent since 1991. The average teen now has had sex for the first time by the spring of 11th grade, a full year later than the average Gen Xer

The teen birth rate hit an all-time low in 2016, down 67 percent since its modern peak, in 1991.

Nearly all Boomer high-school students had their driver’s license by the spring of their senior year; more than one in four teens today still lack one at the end of high school.

In conversation after conversation, teens described getting their license as something to be nagged into by their parents—a notion that would have been unthinkable to previous generations.

In the late 1970s, 77 percent of high-school seniors worked for pay during the school year; by the mid-2010s, only 55 percent did. The number of eighth-graders who work for pay has been cut in half.

Beginning with Millennials and continuing with iGen, adolescence is contracting again—but only because its onset is being delayed. Across a range of behaviors—drinking, dating, spending time unsupervised— 18-year-olds now act more like 15-year-olds used to, and 15-year-olds more like 13-year-olds. Childhood now stretches well into high school.

In an information economy that rewards higher education more than early work history, parents may be inclined to encourage their kids to stay home and study rather than to get a part-time job. Teens, in turn, seem to be content with this homebody arrangement—not because they’re so studious, but because their social life is lived on their phone. They don’t need to leave home to spend time with their friends.

eighth-, 10th-, and 12th-graders in the 2010s actually spend less time on homework than Gen X teens did in the early 1990s.

The time that seniors spend on activities such as student clubs and sports and exercise has changed little in recent years. Combined with the decline in working for pay, this means iGen teens have more leisure time than Gen X teens did, not less.

So what are they doing with all that time? They are on their phone, in their room, alone and often distressed.

despite spending far more time under the same roof as their parents, today’s teens can hardly be said to be closer to their mothers and fathers than their predecessors were. “I’ve seen my friends with their families—they don’t talk to them,” Athena told me. “They just say ‘Okay, okay, whatever’ while they’re on their phones. They don’t pay attention to their family.” Like her peers, Athena is an expert at tuning out her parents so she can focus on her phone.

The number of teens who get together with their friends nearly every day dropped by more than 40 percent from 2000 to 2015; the decline has been especially steep recently.

Eighth-graders who are heavy users of social media increase their risk of depression by 27 percent, while those who play sports, go to religious services, or even do homework more than the average teen cut their risk significantly.

The roller rink, the basketball court, the town pool, the local necking spot—they’ve all been replaced by virtual spaces accessed through apps and the web.

The results could not be clearer: Teens who spend more time than average on screen activities are more likely to be unhappy, and those who spend more time than average on nonscreen activities are more likely to be happy.

There’s not a single exception. All screen activities are linked to less happiness, and all nonscreen activities are linked to more happiness

Eighth-graders who spend 10 or more hours a week on social media are 56 percent more likely to say they’re unhappy than those who devote less time to social media

If you were going to give advice for a happy adolescence based on this survey, it would be straightforward: Put down the phone, turn off the laptop, and do something—anything—that does not involve a screen

Social-networking sites like Facebook promise to connect us to friends. But the portrait of iGen teens emerging from the data is one of a lonely, dislocated generation. Teens who visit social-networking sites every day but see their friends in person less frequently are the most likely to agree with the statements “A lot of times I feel lonely,” “I often feel left out of things,” and “I often wish I had more good friends.” Teens’ feelings of loneliness spiked in 2013 and have remained high since.

This doesn’t always mean that, on an individual level, kids who spend more time online are lonelier than kids who spend less time online.

Teens who spend more time on social media also spend more time with their friends in person, on average—highly social teens are more social in both venues, and less social teens are less so.

The more time teens spend looking at screens, the more likely they are to report symptoms of depression.

It’s not only a matter of fewer kids partying; fewer kids are spending time simply hanging out

Teens who spend three hours a day or more on electronic devices are 35 percent more likely to have a risk factor for suicide, such as making a suicide plan. (That’s much more than the risk related to, say, watching TV.)

Since 2007, the homicide rate among teens has declined, but the suicide rate has increased. As teens have started spending less time together, they have become less likely to kill one another, and more likely to kill themselves. In 2011, for the first time in 24 years, the teen suicide rate was higher than the teen homicide rate.

For all their power to link kids day and night, social media also exacerbate the age-old teen concern about being left out.

Today’s teens may go to fewer parties and spend less time together in person, but when they do congregate, they document their hangouts relentlessly—on Snapchat, Instagram, Facebook. Those not invited to come along are keenly aware of it. Accordingly, the number of teens who feel left out has reached all-time highs across age groups.

Forty-eight percent more girls said they often felt left out in 2015 than in 2010, compared with 27 percent more boys. Girls use social media more often, giving them additional opportunities to feel excluded and lonely when they see their friends or classmates getting together without them.

Social media levy a psychic tax on the teen doing the posting as well, as she anxiously awaits the affirmation of comments and likes. When Athena posts pictures to Instagram, she told me, “I’m nervous about what people think and are going to say. It sometimes bugs me when I don’t get a certain amount of likes on a picture.”

Girls have also borne the brunt of the rise in depressive symptoms among today’s teens. Boys’ depressive symptoms increased by 21 percent from 2012 to 2015, while girls’ increased by 50 percent—more than twice as much

The rise in suicide, too, is more pronounced among girls. Although the rate increased for both sexes, three times as many 12-to-14-year-old girls killed themselves in 2015 as in 2007, compared with twice as many boys

Social media give middle- and high-school girls a platform on which to carry out the style of aggression they favor, ostracizing and excluding other girls around the clock.

I asked my undergraduate students at San Diego State University what they do with their phone while they sleep. Their answers were a profile in obsession. Nearly all slept with their phone, putting it under their pillow, on the mattress, or at the very least within arm’s reach of the bed. They checked social media right before they went to sleep, and reached for their phone as soon as they woke up in the morning

the smartphone is cutting into teens’ sleep: Many now sleep less than seven hours most nights. Sleep experts say that teens should get about nine hours of sleep a night; a teen who is getting less than seven hours a night is significantly sleep deprived

Fifty-seven percent more teens were sleep deprived in 2015 than in 1991. In just the four years from 2012 to 2015, 22 percent more teens failed to get seven hours of sleep.

Two national surveys show that teens who spend three or more hours a day on electronic devices are 28 percent more likely to get less than seven hours of sleep than those who spend fewer than three hours, and teens who visit social-media sites every day are 19 percent more likely to be sleep deprived.

Teens who read books and magazines more often than the average are actually slightly less likely to be sleep deprived—either reading lulls them to sleep, or they can put the book down at bedtime.

Sleep deprivation is linked to myriad issues, including compromised thinking and reasoning, susceptibility to illness, weight gain, and high blood pressure. It also affects mood: People who don’t sleep enough are prone to depression and anxiety.

correlations between depression and smartphone use are strong enough to suggest that more parents should be telling their kids to put down their phone.

What’s at stake isn’t just how kids experience adolescence. The constant presence of smartphones is likely to affect them well into adulthood. Among people who suffer an episode of depression, at least half become depressed again later in life. Adolescence is a key time for developing social skills; as teens spend less time with their friends face-to-face, they have fewer opportunities to practice them

Significant effects on both mental health and sleep time appear after two or more hours a day on electronic devices. The average teen spends about two and a half hours a day on electronic devices. Some mild boundary-setting could keep kids from falling into harmful habits.

‘I was so happy to read about this, because my doctor thought I was crazy when I mentioned tinnitus and now I know I’m not the only one.’”

A study published late last year in the journal Frontiers in Public Health surveyed 3,100 people with tinnitus and found that 40 percent of the 237 respondents who had contracted Covid-19 reported that their symptoms were “significantly exacerbated” following the infection.

A very small group of people in Dr. Beukes’s study — seven — reported that Covid-19 brought on tinnitus for the first time. Just over half of people with tinnitus said the illness had left their symptoms unchanged.

Patients in this study had a mean age of 44 years, so were very much part of the young, working-age population. Only 18% had been hospitalised with COVID-19, meaning organ damage may occur even after a non-severe infection.

Another piece of early research (awaiting peer review) suggests that SARS-CoV-2 could also have a long-term impact on people’s organs.

Perhaps unsurprisingly, people with more severe disease initially – characterised by more than five symptoms – seem to be at increased risk of long COVID. Older age and being female also appear to be risk factors for having prolonged symptoms, as is having a higher body mass index.

Rather harder to explore is the symptom of fatigue. Another recent large-scale study has shown that this symptom is common after COVID-19 – occurring in more than half of cases – and appears unrelated to the severity of the early illness.

While men are at increased risk of severe infection, that women seem to be more affected by long COVID may reflect their different or changing hormone status.

Some symptoms of long COVID overlap with menopausal symptoms, and hormone replacement using medication may be one route to reducing the impact of symptoms.

What is clear, however, is that long-term symptoms after COVID-19 are common, and that research into the causes and treatments of long COVID will likely be needed long after the outbreak itself has subsided.

Her husband, Brad Buchanan, was late for family dinner. She found him in the bathroom, coughing up blood — a lot of it.

Doctors found that a tumor had ruptured in one of his lungs and he urgently needed chemo. As her husband became critically ill, Ms. Washington, a freelance writer, was thrust into the role of nurse.

“My hands were shaking,” she said as she remembered apprehensively pushing in the drugs for the first time and feeling the weight of keeping her husband alive.

Mr. Buchanan had a stem cell transplant that left him with graft-versus-host disease

Depending on the analysis, between 61 and 75 percent of caregivers are women

When she explained that she had two children who also had needs, he said, “Well, usually family steps in, and it works out fine.”

Ms. Washington felt the burden of responsibility, but also the sting

The U.S. health care system relies on and takes for granted the “invisible army” of people — mostly women — who keep the system functioning by performing home care for the many people who are “too well for the hospital” but “too sick for home,” as well as for those on end-of-life care.

In 2017, AARP found that about 41 million family caregivers in America perform roughly $470 billion worth of unpaid labor a year.

they tend to do more personal care tasks like helping patients bathe and use the toilet than their male counterparts, who are more likely to oversee finances and arrangement of care.

The historical roots are complex, but as Evelyn Glenn puts it in “Forced to Care,”

emale caregivers put in more hours — 22 to men’s 17

they are also more likely to stand by their partner through a serious illness

Many people who take on caregiving roles experience negative health impacts, but women are especially at risk of the fallout from caregiver stress.

Female caregivers are also 2.5 times more likely to live in poverty as non-caregiver

A 2011 study found that women who left their jobs to care for a parent lost an average of $324,000 in wages and benefits over their lifetimes.

Ms. Washington was able to dip into savings and a recent inheritance to help pay for supplemental in-home care, but it was still a struggle, causing stress, resentment and lost income.

It was hard to have my life put on hold. Everything kind of slipped away.

I lost a sense of who I was. I was going to pick up a prescription for myself, the only prescription I had when my husband was sick, and the pharmacist asked for my date of birth, and I gave his date of birth

People talk about how it’s the most important job in the world, taking care of our children or taking care of our vulnerable elders, and yet those are some of the worst paid jobs.

How much is a quarterback paid versus someone who is doing care for a vulnerable elderly person?

How did care work become so undervalued?

A doctor told Ms. Washington that her husband would need 24-hour care and “could not be left alone for even a moment.”

Western culture has long framed care work done by women as a moral duty or obligation, rather than an economic activity.

If your earnings are lower than they would normally be because you’re busy caring for a family member, and you can’t save and pay into social security, it can lock whole families into a cycle of lower wealth and economic instability.

And what should someone not do

Don’t tell someone to stay positive. For me, there was no staying about it, because I didn’t feel positive to start with. It brought up this feeling

My time isn’t my own, but surely my emotions can be

The quality of mathematics research in the United States today is the envy of the scientific world. This is a direct result of the openness and inclusivity of the profession.

Can Americans maintain this unmatched excellence in the future? There are worrisome signs that suggest not.

The Organization for Economic Cooperation and Development compares mathematical proficiency among 15-year-olds by country worldwide. According to its 2018 report, America ranked 37th while China, America’s main competitor for world leadership, came in first.

This is despite the fact that the United States is the fifth-highest spender per pupil among the 37 developed OECD nations

This massive failure of our K-12 education system trickles through the STEM pipeline.

At the undergraduate level, too few American students are prepared for higher-level mathematics courses. These students are then unprepared for rigorous graduate-level work

According to our own experiences at the universities where we teach, an overwhelming majority of American students with strong math backgrounds are either foreign-born or first-generation students who have additional support from their education-conscious families. At all levels, STEM disciplines are more and more dependent on a constant flow of foreign talent.

There are many reasons for this failure, but the way that we educate and prepare teachers is particularly influential. The vast majority of K-12 math teachers are graduates of teacher-preparation programs that teach very little substantive mathematics

This has led to a constant stream of ill-advised and dumbed-down reforms. One of the latest fads is anti-racist mathematics. Promoted in several states, the bizarre doctrine threatens to further degrade the teaching of mathematics.

Another major concern is the twisted interpretation of diversity, equity, and inclusion (DEI).

Under the banner of DEI, universities are abandoning the use of standardized tests like the SAT and GRE in admissions, and cities are considering scrapping academic tracking and various gifted programs in schools, which they deem “inequitable.”

such programs are particularly effective, when properly implemented, at discovering and encouraging talented children from disadvantaged backgrounds.

The new 2021 Mathematics Framework, currently under consideration by California’s Department of Education, does away “with all tracking, acceleration, gifted programs, or any instruction that involves clustering by individual differences, without expressing any awareness of the impact these drastic alterations would have in preparing STEM-ready candidates.”

These measures will not only hinder the progress of the generations of our future STEM workforce but also contribute to structural inequalities, as they are uniquely detrimental to students whose parents cannot send them to private schools or effective enrichment programs.

These are just a few examples of an unprecedented fervor for revolutionary change in the name of Critical Race Theory (CRT), a doctrine that views the world as a fierce battleground for the narratives of various identity groups.

This will only lead to a further widening of racial disparities in educational outcomes while lowering American children’s rankings in education internationally.

Ill-conceived DEI policies, often informed by CRT, and the declining standards of K-12 math education feed each other in a vicious circle

Regarding minorities, in particular, public K-12 education all too often produces students unprepared to compete, thus leading to large disparities in admissions at universities, graduate programs, and faculty positions. This disparity is then condemned as a manifestation of structural racism, resulting in administrative measures to lower the evaluation criteria. Lowering standards at all levels leads eventually to even worse outcomes and larger disparities, and so on in a downward spiral.

A case in point is the recent report by the American Mathematical Society that accuses the entire mathematics community, with the thinnest of specific evidence, of systemic racial discrimination. A major justification put forward for such a grave accusation is the lack of sufficient representation of Black mathematicians in the professio

the report, while raising awareness of several ugly facts from the long-ago past, makes little effort to address the real reasons for this, mainly the catastrophic failure of the K-12 mathematical educational system.

The National Science Foundation, a federal institution meant to support fundamental research, is now diverting some of its limited funding to various DEI initiatives of questionable benefit.

Meanwhile, other countries, especially China, are doing precisely the opposite, following the model of our past dedication to objective measures of excellence. How long before we will see a reverse exodus, away from the United States?

The present crisis can still be reversed by focusing on a few concrete actions:

Improve schools in urban areas and inner-city neighborhoods by following the most promising education programs. These programs demonstrate that inner-city children benefit if they are challenged by high standards and a nurturing environment.

Follow the lead of other highly successful rigorous programs such as BASIS schools and Math for America, which focus on rigorous STEM curricula, combined with 21st-century teaching methods, and recruit talented teachers to help them build on their STEM knowledge and teaching methods.

Increase, rather than eliminate, tailored instruction, both for accelerated and remedial math courses.

Reject the soft bigotry of low expectations, that Black children cannot do well in competitive mathematics programs and need dumbed-down ethnocentric versions of mathematics.

Uphold the objective selection process based on merit at all levels of education and research.

They found that economics students are less likely to consider a vendor who increases the price of bottled water on a hot day to be acting “unfairly.”

They found ideological differences between lower-level economics students and upper-level economics students that are similar in kind to the measured differences between the ideology of economics students as a whole and their peers. He finds that upper-level students are even less likely to support egalitarian solutions to distribution problems than lower-level students, suggesting that time spent studying economics does have an indoctrination effect.

"This has been a long and painful fight, but we will attempt to find closure even though this is a wound that will never, ever fully heal,"

the "university accepts legal and moral responsibility for the mistakes that our training staff made on that fateful workout day."

"This is not at all a reflection of my opinion of Coach Durkin as a person. However, a departure is in the best interest of the university,"

The treatment helped 13.4% of patients with their addiction, compared with 2.5% of the placebo group.

This medication therapy provides another tool for doctors to try with patients.

"As we understand the complexity of the human brain, it becomes very much of a magical thinking that one pill will solve the problem of addiction,"

The treatment regimen in the trial combined two medications that have been studied separately for treating methamphetamine addiction with limited success.

This clinical trial was successful enough that the National Institute on Drug Addiction's Volkow says she expects to move forward toward securing FDA approval.

lack of medical treatments for those addicted to meth has complicated efforts to curb demand for the drug.

The human cost has been catastrophic. Researchers say overdose deaths linked to meth increased fourfold over the last decade.

Even users who don't overdose often experience damage to the heart and other tissues, and can see their lives spiral out of control.

"For heroin users, there's methadone, there's suboxone. I just wonder why we haven't researched [treatments for] this drug yet,"

"It's about evidence-based care, it's about empathy and it's about survivability,"