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upervised learning depends on annotated data: images, audio or text that is painstakingly labeled by hordes of workers. They circle people or outline bicycles on pictures of street traffic. The labeled data is fed to computer algorithms, teaching the algorithms what to look for. After ingesting millions of labeled images, the algorithms become expert at recognizing what they have been taught to see.

There is also reinforcement learning, with very limited supervision that does not rely on training data. Reinforcement learning in computer science,

is modeled after reward-driven learning in the brain: Think of a rat learning to push a lever to receive a pellet of food. The strategy has been developed to teach computer systems to take actions.

My money is on self-supervised learning,” he said, referring to computer systems that ingest huge amounts of unlabeled data and make sense of it all without supervision or reward. He is working on models that learn by observation, accumulating enough background knowledge that some sort of common sense can emerge.

redict outcomes and choose a course of action. “Everybody agrees we need predictive learning, but we disagree about how to get there,”

A more inclusive term for the future of A.I., he said, is “predictive learning,” meaning systems that not only recognize patterns but also p

A huge fraction of what we do in our day-to-day jobs is constantly refining our mental models of the world and then using those mental models to solve problems,” he said. “That encapsulates an awful lot of what we’d like A.I. to do.”Image

Currently, robots can operate only in well-defined environments with little variation.

“Our working assumption is that if we build sufficiently general algorithms, then all we really have to do, once that’s done, is to put them in robots that are out there in the real world doing real things,”

"These THUGS are dishonoring the memory of George Floyd, and I won't let that happen," Trump wrote on his personal account. "Just spoke to Governor Tim Walz and told him that the Military is with him all the way. Any difficulty and we will assume control but, when the looting starts, the shooting starts. Thank you!"

"I've let the word filter down that when the looting starts, the shooting starts," said Miami Police Chief Walter Headley in 1967 as he announced a campaign against crime that included using dogs, guns and a "stop and frisk" policy.

He spoke out forcefully against NFL quarterback Colin Kaepernick, whose kneeling protest during the playing of the National Anthem was meant to shine a spotlight on racial injustice and harsh police tactics. Trump's vice president, Mike Pence, even stormed out of an Indianapolis Colts game when some players kneeled during the anthem.

Instead, Trump has been more likely to mock that phrase, which has been used by Black Lives Matter protesters ever since. In 2016, he made fun of Mitt Romney by bringing his hands to his neck and shouting "I can't breathe" to illustrate Romney "choking" in the 2012 presidential election.

He called the death of Ahmaud Arbery, who was shot by a white man while jogging in February, a "heartbreaking thing." His Justice Department is investigating the killing as a federal hate crime, though Trump has held out the possibility that "something that we didn't see on tape" could explain the killing.

n Mischel’s marshmallow experiment, only a quarter of the subjects were able to resist eating the marshmallow for fifteen minutes. This implies that a large majority of us lack the self-control required to succeed in life.

They were most successful at adopting productive behaviors not when they resolved to do better, or distracted themselves from temptation, but when they altered their environment. Instead of studying on a couch in a dorm, with a TV close by, they went to the library. They ate better when they removed junk food from the dorm refrigerator. “Successful self-control,” Wood writes, “came from essentially covering up the marshmallow.”

Both, too, emphasize the role of conscious effort—not in resisting habit but in analyzing it, the better to formulate a strategy for reform.

Wood advises us to come up with new rewards as substitutes for the ones the phone provided. I listened to music on the car radio. In the evening, instead of scrolling through tweets and e-mails, I sought out authors I’d never read. At the end of each day, I felt calmer, and free.

Clive Wynne, a psychologist specializing in dog behavior, contends that what makes your furry friend special is not its intellect but its ability to bond with you. And not just with you. The dog’s ability to bond across species — with sheep, goats, even (horrors!) cats

Thirteen species of salmon and steelhead trout are considered threatened or endangered in the Northwest’s Columbia basin region

The fish are a keystone food source for other species, and an endangered population of orcas may be starving for lack of enough wild salmon to eat. Many scientists favor removing dams on some rivers to save the orcas and the fish. But the idea faces resistance from government agencies that manage the rivers.

A video of salmon traveling through a long tube went viral in 2019. You probably watched it. But the Whooshh cannon — its actual name — is a serious tool that conservationists are testing not only to help fish migrate, but to contain invasive carp that foul North American waterways.

A New and Improved Table could come in handy: As more superheavy elements are discovered, their behaviors could challenge the integrity of Mendeleev’s memorable chart.

Haidt argues that people are fundamentally intuitive, not rational.

Politics isn’t just about ­manipulating people who disagree with you. It’s about learning from them.

They exalt families, armies and communities. They assume that people should be treated differently according to social role or status — elders should be honored, subordinates should be protected.

Is it wrong to have sex with a dead chicken? How about with your sister? Is it O.K. to defecate in a urinal? If your dog dies, why not eat it? Under interrogation, most subjects in psychology experiments agree these things are wrong. But none can explain why.

They do reason. But their arguments aim to support their conclusions, not yours.

Haidt’s account of reason is a bit too simple — his whole book, after all, is a deployment of reason to advance learning — and his advice sounds cynical.

Haidt replies: We were never designed to listen to reason. When you ask people moral questions, time their responses and scan their brains, their answers and brain activation patterns indicate that they reach conclusions quickly and produce reasons later only to justify what they’ve decided.

The Tea Party hates redistribution because it interferes with letting people reap what they earn. Faith, patriotism, valor, chastity, law and order — these Republican themes touch all six moral foundations, whereas Democrats, in Haidt’s analysis, focus almost entirely on care and fighting oppression.

When it comes to morality, conservatives are more broad-minded than liberals. They serve a more varied diet.

He figures that if voters like Republican messages, there’s something in Republican messages worth liking. He chides psychologists who try to “explain away” conservatism, treating it as a pathology.

parochial altruism, the inclination to care more about members of your group — particularly those who have made sacrifices for it —than about outsiders.

The hardest part, Haidt finds, is getting liberals to open their minds.

“fewer people believe that righteous ends justify violent means.”

Can we tolerate cultures of female subjugation? And how far should we trust our instincts? Should people who find homosexuality repugnant overcome that reaction?

But Haidt is right that we must learn what we have been, even if our nature is to transcend it.

The algorithms are showing you things to see what you react to and showing you more of the things that prompt an emotional response, that make it harder to leave Facebook or Instagram or any of the other social networks.

really if your goal is to maximize engagement that is of course what you’d do since anger is a far more compelling and powerful emotion than appreciation.

Facebook didn’t do that. That’s coded into our neurology. Facebook really is an extremism generating machine. It’s really an inevitable part of the core engine.

it’s not just Facebook. Or perhaps you could say it’s not even Facebook at all. It’s the mix of machine learning and the business models of all the social networks

They have real upsides. They connect us with people. Show us fun videos. But they are also inherently destructive. And somehow we have to take cognizance of that – and not just as a matter of the business decisions of one company.

the social networks – meaning the mix of machine learning and advertising/engagement based business models – are really something new under the sun. They’re addiction and extremism generating systems. It’s what they’re designed to do.

when Mr. Nichol tweaked his requests a little, adding or subtracting a few words here or there, it provided what he wanted. When he asked for “a piano in a living room filled with sand,” the image looked more like a beach in a living room.

DALL-E is what artificial intelligence researchers call a neural network, which is a mathematical system loosely modeled on the network of neurons in the brain.

the same technology that recognizes the commands spoken into smartphones and identifies the presence of pedestrians as self-driving cars navigate city streets.

A neural network learns skills by analyzing large amounts of data. By pinpointing patterns in thousands of avocado photos, for example, it can learn to recognize an avocado.

DALL-E looks for patterns as it analyzes millions of digital images as well as text captions that describe what each image depicts. In this way, it learns to recognize the links between the images and the words.

For some, the only speech they feel should be truly public should also be “professional.” Hence: LinkedIn, where the only associated image is a professional headshot, and the only conversations are those related to work.

Which is how some people really would like to navigate the public sphere: with total freedom and total impunity

Twitter is where you could publicly (if often anonymously) fight, troll, dunk, harass, joke, and generally speak without consequence; it’s also where the mundane status update/life musing (once the foundation of Facebook) could live peacefully.

Twitter was for publicly observing — through the scroll, but also by tweeting, retweeting, quote tweeting — while remaining effectively invisible, a reply-guy amongst reply-guys, a troll amongst trolls.

The Facebook of the 2010s was for broadcasting ideological stances under your real name and fighting with your close and extended community about them; now it’s (largely) about finding advice (and fighting about advice) in affinity groups (often) composed of people you’ve never met.

It rewards the esoteric, the visually witty, the mimetic — even more than Twitter.

Tiktok is for monologues, for expertise, for timing and performance. It’s without pretense.

On TikTok, you don’t reshare memes, you use them as the soundtrack to your reimagining, even if that reimagining is just “what if I do the same dance, only with my slightly dorky parents?

Instagram is serious and sincere (see: the success of the social justice slideshow) and almost never ironic — maybe because static visual irony is pretty hard to pull off.

Like YouTube, far fewer people are posting than consuming, which means that most people aren’t speaking at all.

And then there’s Instagram. People think Instagram is for extroverts, for people who want to broadcast every bit of their lives, but most Instagram users I know are shy — at least with public words. Instagram is where parents post pictures of their kids with the caption “these guys right here” or a picture of their dog with “a very good boy.”

The text doesn’t matter; the photo speaks loudest. Each post becomes overdetermined, especially when so readily viewed within the context of the greater grid

The more you understand your value as the sum of your visual parts, the more addictive, essential, and anxiety-producing Instagram becomes.

That emphasis on aesthetic perfection is part of what feminizes Instagram — but it’s also what makes it the most natural home for brands, celebrities, and influencers.

a static image can communicate a whole lifestyle — and brands have had decades of practice honing the practice in magazine ads and catalogs.

And what is an influencer if not a conduit for brands? What is a celebrity if not a conduit for their own constellation of brands?

If LinkedIn is the place where you can pretend that your whole life and personality is “business,” then Instagram is where you can pretend it’s all some form of leisure — or at least fun

A “fun” work trip, a “fun” behind-the-scenes shot, a brand doing the very hard work of trying to get you to click through and make a purchase with images that are fun fun fun.

On the flip side, Twitter was where you spoke with your real (verified) name — and with great, algorithm-assisted importance. You could amass clout simply by rephrasing others’ scoops in your own words, declaring opinions as facts, or just declaring. If Twitter was gendered masculine — which it certainly was, and is arguably even more so now — it was only because all of those behaviors are as well.

Instagram is a great place to post an announcement and feel celebrated or consoled but not feel like you have to respond to people

The conversation is easier to both control and ignore; of all the social networks, it most closely resembles the fawning broadcast style of the fan magazine, only the celebs control the final edit, not the magazine publisher

Celebrities initially glommed to Twitte

But its utility gradually faded: part of the problem was harassment, but part of it was context collapse, and the way it allowed words to travel across the platform and out of the celebrity’s control.

Instagram was just so much simpler, the communication so clearly in the celebrity wheelhouse. There is very little context collapse on Instagram — it’s all curation and control. As such, you can look interesting but say very little.

“By making advertiser targeting criteria available for analysis and reporting on ads run about social issues, elections and politics, we hope to help people better understand the practices used to reach potential voters on our technologies,” the company said in a statement.

Meta said it had been bound by privacy rules and regulations on what types of data it could share with outsiders. In an interview, Jeff King, a vice president in Meta’s business integrity unit, said the company had hired thousands of workers over the past few years to review those privacy issues.

“Every single thing we release goes through a privacy review now,” he said. “We want to make sure we give people the right amount of data, but still remain privacy conscious while we do it.”

I believe “Twitter poisoning” is a real thing. It is a side effect that appears when people are acting under an algorithmic system that is designed to engage them to the max. It’s a symptom of being part of a behavior-modification scheme.

The same could be said about any number of other figures, including on the left. Examples are found in the excesses of cancel culture and joyless orthodoxies in fandom, in vain attention competitions and senseless online bullying.

The human brain did not evolve to handle modern chemicals or modern media technology and is vulnerable to addiction. That is true for me and for us all.

Behavioral changes occur as a side effect of something called operant conditioning, which is the underlying mechanism of social media addiction. This is the core mechanism analogous to the role alcohol plays in alcoholism.

In the case of digital platforms, the purpose is usually “engagement,” a concept that is hard to distinguish from addiction. People receive little positive and negative jolts of social feedback — getting followed or liked, or being ignored or even humiliated.

Before social media, that kind of tight feedback loop had rarely been present in human communications outside of laboratories or marriages. (This is part of why marriage can be hard, I suspect.)  

was around when Google and other companies that operate on the personalized advertising model were created, and I can say that at least in the early days, operant conditioning was not part of the plan.

What happened was that the algorithms that optimized the individualized advertising model found their way into it automatically, unintentionally rediscovering methods that had been tested on dogs and pigeons.

There is a childish insecurity, where before there was pride. Instead of being above it all, like traditional strongmen throughout history, the modern social media-poisoned alpha male whines and frets.

What do I think are the symptoms of Twitter poisoning?

o be clear, whiners are much better than Stalins. And yet there have been plenty of more mature and gracious leaders who are better than either

When we were children, we all had to negotiate our way through the jungle of human power relationships at the playground

When we feel those old humiliations, anxieties and sadisms again as adults — over and over, because the algorithm has settled on that pattern as a powerful way to engage us — habit formation restimulates old patterns that had been dormant. We become children again, not in a positive, imaginative sense, but in a pathetic way.

Twitter poisoning makes sufferers feel more oppressed than is reasonable in response to reasonable rules. The scope of fun is constricted to transgressions.

Unfortunately, scale changes everything. Taunts become dangerous hate when amplified. A Twitter-poisoned soul will often complain of a loss of fun when someone succeeds at moderating the spew of hate.

the afflicted lose all sense of proportion about their own powers. They can come to believe they have almost supernatural abilities

The degree of narcissism becomes almost absolute. Everything is about what someone else thinks of you.

These observations should inform our concerns about TikTok. The most devastating way China might use TikTok is not to misdirect our elections or to prefer pro-China posts, but to generally ramp up social media disease, so as to make Americans more divided, less able to talk to one another and less able to put up a coordinated, unified front.

uide society. Whether that idea appeals or not, when technology degrades the minds of those same engineers, then the result can only be dysfunction.

Jaron Lanier is a computer scientist who pioneered research in virtual reality and whose books include “Ten Arguments for Deleting Your Social Media Accounts Right Now.” He is Microsoft’s “prime unifying scientist” but does not speak for the company.

it is comforting to think that scientific truth inevitably emerges and scientific frauds will be caught and punished.

Dr. Hwang’s scandal suggests something different. Researchers don’t always have the resources or motivation to replicate others’ experiments

Even if they try to replicate and fail, it is the institution where the scientist works that has the right and responsibility to investigate possible fraud. Research institutes and universities, facing the prospect of an embarrassing scandal, might not do so.

Industry leaders believe the new A.I. systems could be as important as the introduction of the web browser in the early 1990s and could lead to breakthroughs in areas ranging from drug research to education.

But gnawing at many industry insiders is a fear that they are releasing something dangerous into the wild. Generative A.I. can already be a tool for misinformation. Soon, it could be a risk to jobs. Somewhere down the line, tech’s biggest worriers say, it could be a risk to humanity.

“It is hard to see how you can prevent the bad actors from using it for bad things,” Dr. Hinton said.

After the San Francisco start-up OpenAI released a new version of ChatGPT in March, more than 1,000 technology leaders and researchers signed an open letter calling for a six-month moratorium on the development of new systems because A.I technologies pose “profound risks to society and humanity.

Several days later, 19 current and former leaders of the Association for the Advancement of Artificial Intelligence, a 40-year-old academic society, released their own letter warning of the risks of A.I. That group included Eric Horvitz, chief scientific officer at Microsoft, which has deployed OpenAI’s technology across a wide range of products, including its Bing search engine.

Dr. Hinton, often called “the Godfather of A.I.,” did not sign either of those letters and said he did not want to publicly criticize Google or other companies until he had quit his job

Dr. Hinton, a 75-year-old British expatriate, is a lifelong academic whose career was driven by his personal convictions about the development and use of A.I. In 1972, as a graduate student at the University of Edinburgh, Dr. Hinton embraced an idea called a neural network. A neural network is a mathematical system that learns skills by analyzing data. At the time, few researchers believed in the idea. But it became his life’s work.

Dr. Hinton is deeply opposed to the use of artificial intelligence on the battlefield — what he calls “robot soldiers.”

In 2012, Dr. Hinton and two of his students in Toronto, Ilya Sutskever and Alex Krishevsky, built a neural network that could analyze thousands of photos and teach itself to identify common objects, such as flowers, dogs and cars.

In 2018, Dr. Hinton and two other longtime collaborators received the Turing Award, often called “the Nobel Prize of computing,” for their work on neural networks.

Around the same time, Google, OpenAI and other companies began building neural networks that learned from huge amounts of digital text. Dr. Hinton thought it was a powerful way for machines to understand and generate language, but it was inferior to the way humans handled language.

Then, last year, as Google and OpenAI built systems using much larger amounts of data, his view changed. He still believed the systems were inferior to the human brain in some ways but he thought they were eclipsing human intelligence in others.

“Maybe what is going on in these systems,” he said, “is actually a lot better than what is going on in the brain.”

As companies improve their A.I. systems, he believes, they become increasingly dangerous. “Look at how it was five years ago and how it is now,” he said of A.I. technology. “Take the difference and propagate it forwards. That’s scary.”

Until last year, he said, Google acted as a “proper steward” for the technology, careful not to release something that might cause harm. But now that Microsoft has augmented its Bing search engine with a chatbot — challenging Google’s core business — Google is racing to deploy the same kind of technology. The tech giants are locked in a competition that might be impossible to stop, Dr. Hinton said.

His immediate concern is that the internet will be flooded with false photos, videos and text, and the average person will “not be able to know what is true anymore.”

He is also worried that A.I. technologies will in time upend the job market. Today, chatbots like ChatGPT tend to complement human workers, but they could replace paralegals, personal assistants, translators and others who handle rote tasks. “It takes away the drudge work,” he said. “It might take away more than that.”

Down the road, he is worried that future versions of the technology pose a threat to humanity because they often learn unexpected behavior from the vast amounts of data they analyze. This becomes an issue, he said, as individuals and companies allow A.I. systems not only to generate their own computer code but actually run that code on their ow

And he fears a day when truly autonomous weapons — those killer robots — become reality.

“The idea that this stuff could actually get smarter than people — a few people believed that,” he said. “But most people thought it was way off. And I thought it was way off. I thought it was 30 to 50 years or even longer away. Obviously, I no longer think that.”

Many other experts, including many of his students and colleagues, say this threat is hypothetical. But Dr. Hinton believes that the race between Google and Microsoft and others will escalate into a global race that will not stop without some sort of global regulation.

But that may be impossible, he said. Unlike with nuclear weapons, he said, there is no way of knowing whether companies or countries are working on the technology in secret. The best hope is for the world’s leading scientists to collaborate on ways of controlling the technology. “I don’t think they should scale this up more until they have understood whether they can control it,” he said.

Dr. Hinton said that when people used to ask him how he could work on technology that was potentially dangerous, he would paraphrase Robert Oppenheimer, who led the U.S. effort to build the atomic bomb: “When you see something that is technically sweet, you go ahead and do it.”

He does not say that anymore.

Essentially, Lasch was attacking the notion, fashionable as Americans basked in their seeming victory over the Soviet Union in the Cold War, that history had a direction — and that one would be wise to stay on the “right side” of it.

Francis Fukuyama expressed a version of this triumphalist idea in his famous 1992 book, “The End of History and the Last Man,” in which he celebrated the notion that History with a capital “H,” in the sense of a battle between competing ideas, was ending with communism left to smolder on Ronald Reagan’s famous ash heap.

One of Martin Luther King Jr.’s most frequently quoted lines speaks to a similar thought, albeit in a different context: “T​he arc of the moral universe is long, but it bends toward justice.” Though he had read Lasch, Obama quoted that line often, just as he liked to say that so-and-so would be “on the wrong side of history” if they didn’t live up to his ideals — whether the issue was same-sex marriage, health policy or the Russian occupation of Crimea.

The memo goes on to list two sets of words: “Optimistic Positive Governing Words” and “Contrasting Words,” which carried negative connotations. One of the latter group was the word “liberal,” sandwiched between “intolerant” and “lie.”

So what’s the difference between a progressive and a liberal?To vastly oversimplify matters, liberal usually refers to someone on the center-left on a two-dimensional political spectrum, while progressive refers to someone further left.

But “liberal” has taken a beating in recent decades — from both left and right.

In the late 1980s and 1990s, Republicans successfully demonized the word “liberal,” to the point where many Democrats shied away from it in favor of labels like “conservative Democrat” or, more recently, “progressive.”

“Is the story of the 20th century about the defeat of the Soviet Union, or was it about two world wars and a Holocaust?” asked Matthew Sitman, the co-host of the “Know Your Enemy” podcast, which recently hosted a discussion on Lasch and the fascination many conservatives have with his ideas. “It really depends on how you look at it.”

None of this was an accident. In 1996, Representative Newt Gingrich of Georgia circulated a now-famous memo called “Language: A Key Mechanism of Control.”

The authors urged their readers: “The words and phrases are powerful. Read them. Memorize as many as possible.”

Republicans subsequently had a great deal of success in associating the term “liberal” with other words and phrases voters found uncongenial: wasteful spending, high rates of taxation and libertinism that repelled socially conservative voters.

Many on the left began identifying themselves as “progressive” — which had the added benefit of harking back to movements of the late 19th and early 20th centuries that fought against corruption, opposed corporate monopolies, pushed for good-government reforms and food safety and labor laws and established women’s right to vote.

Allies of Bill Clinton founded the Progressive Policy Institute, a think tank associated with so-called Blue Dog Democrats from the South.

Now, scrambling the terminology, groups like the Progressive Change Campaign Committee agitate on behalf of proudly left-wing candidates

In 2014, Charles Murray, the polarizing conservative scholar, urged readers of The Wall Street Journal’s staunchly right-wing editorial section to “start using ‘liberal’ to designate the good guys on the left, reserving ‘progressive’ for those who are enthusiastic about an unrestrained regulatory state.”

As Sanders and acolytes like Representative Alexandria Ocasio-Cortez of New York have gained prominence over the last few election cycles, many on the left-wing end of the spectrum have begun proudly applying other labels to themselves, such as “democratic socialist.”

To little avail so far, Kazin, the Georgetown historian, has been urging them to call themselves “social democrats” instead — as many mainstream parties do in Europe.“It’s not a good way to win elections in this country, to call yourself a socialist,” he said.

onic constipation, a functional bowel disorder, affects approximately 14% of adults worldwide [1]. Slow transit constipation (STC) is the major cause of chronic constipation which is characterized by markedly prolonged colonic transit time as a result of the colonic motility function disorde

Usually, patients with STC suffer from a common sense of abdominal pain, nausea, depression and sickness, which seriously influence their social ability and health-related quality of life [4–6

Current clinical treatments include cathartics, prokinetics and aggressive surgery which can increase bowel movement frequency to a certain degree.

However, pharmacological interventions is prone to drug dependency and relapse after drug withdrawal [3]

Surgical treatments such as subtotal colectomy and total colectomy in STC patients may adversely affect the quality of life due to the risk of postoperative diarrhea or incontinence, and result in a heavy healthcare burden

The enteric nervous system (ENS), located in the intestinal wall, regulates various functions including contraction of intestine, homeostasis and blood flow [10]. As the ‘second brain’, the ENS contains large amounts of neurons working independently from the central nervous system [11]. Researches have identified that STCs are mostly caused by disorders of the relevant nerves, especially the ENS [12,13].

McCallum et al. [35] found that gastric electrical stimulation in combination with pharmacological treatment could also enhance emptying in patients with gastroparesis. Especially, gastric electrical stimulation has been approved as a clinical therapy method for gastroparesis and obesity in European and American countries [36].

we employed pulse train stimulation and implanted electrodes at the proximal colon in dogs.

After CES treatment, we observed the colonic transit time of the sham treatment group was longer than that of CES treatment and control groups, and electrical stimulation significantly enhanced the colonic electromyogram (EMG) signal.

histopathology and TEM analysis showed increased ganglia and synaptic vesicles existing in the colon myenteric plexus of the CES treatment group as compared with that of the sham CES group

Our results suggested that CES might reduce the degeneration of the myenteric plexus neurons, thereby contributing to the therapeutic effect on STC beagles.

the defecating frequency and the feces characteristics of STC beagles returned to normal after CES treatment. The result indicated that CES could improve the symptoms of STC.

The colonic EMG signal was strongly promoted by CES

Especially, the colonic EMG signal of the beagles with STC was remarkably enhanced by CES (Figure 3), indicating that CES could not only improve the colonic content emptying, but also enhance the EMG signal to promote colonic motility.

Colonic electrical stimulation (CES), a valuable alternative for the treatment of STC, was reported to improve the colon motility by adjusting the bioelectrical activity in animal models or patients with STC [17]. However, little report focuses on the underlying nervous mechanism to normalize the delayed colonic emptying and relieve symptoms. We hypothesized that CES may also repair the disorders of the relevant nerves and then improve the colonic motility.

The first study regarding the CES to modulate colonic motility was performed by Hughes et al. [37]. Since then, many researchers employed short-pulse CES in canine descending colon or pig cecum [20,21,38]. Researchers also applied long-pulse CES to stimulate the colon of human or animals [39]

Recently, studies showed that the prokinetic effect of pulse train CES is better than that of short-pulse CES or long-pulse CES [25]

Our study indicated that CES could enhance the colonic motility, and then accelerate the colonic content emptying. Thereafter, we investigated the underlying mechanism and presumed that CES might improve the STC symptom through the repairment of the ENS.

The neuropathy in ENS is considered to be responsible for various kinds of disordered motility including STC and the related pathophysiologic symptoms [40]. In agreement with this view, our study discovered the decreased number of ganglia in the myenteric plexus, as well as the destruction of the enteric nerve axon terminals and synaptic vesicles in the sham CES group beagles

The present study proves that CES with pulse trains has curative effects on the colonic motility and content emptying in STC beagles. The up-regulation of intestinal nerve related proteins such as SYP, PGP9.5, CAD and S-100B in the colonic myenteric plexus suggests that CES might reduce the degeneration of the myenteric plexus neurons, thereby producing the therapeutic effect on STC beagles. Further investigation for the underlying mechanism of nerve regeneration is necessary to better understand how CES promotes the recovery of delayed colonic motility induced by STC.

The corporate gig, as a social media director for a tech platform, was a revelation. “I could just show up to work and do work,” Ms. Tilghman said. After she was done, she could leave. She didn’t have to be a brand. There’s no comments section at an office job.

In 2019, a Morning Consult report found that 54 percent of Gen Z and millennial Americans were interested in becoming influencers. (Eighty-six percent said they would be willing to post sponsored content for money.)

If social media has made audiences anxious, it’s driving creators to the brink. In 2021, the TikTok breakout star Charli D’Amelio said she had “lost the passion” for posting videos. A few months later, Erin Kern announced to her 600,000 Instagram followers that she would be deactivating her account @cottonstem; she had been losing her hair, and her doctors blamed work-induced stress

Other influencers faded without fanfare — teens whose mental health had taken too much of a hit and amateur influencers who stopped posting after an algorithm tweak tanked their metrics. Some had been at this for a decade or more, starting at 12 or 14 or 19.

She posted less, testing out new identities that she hoped wouldn’t touch off the same spiral that wellness had. There were dancing videos, dog photos, interior design. None of it stuck. (“You can change the niche, but you’re still going to be performing your life for content,” she explained over lunch.)

Ms. Tilghman’s problem — as the interest in the workshop, which she decided to cap at 15, demonstrated — is that she has an undeniable knack for this. In 2022, she started a Substack to continue writing, thinking of it as a calling card while she applied to editorial jobs; it soon amassed 20,000 subscribers. It once had a different name, but now it’s called “Offline Time.” The paid tier costs $5 a month.

Casey Lewis, who helms the After School newsletter about Gen Z consumer trends, predicts more pivots and exits. TikTok has elevated creators faster than other platforms and burned them out quicker, she said.

Ms. Lewis expects a swell of former influencers taking jobs with P.R. agencies, marketing firms and product development conglomerates. She pointed out that creators have experience not just in video and photo editing, but in image management, crisis communication and rapid response. “Those skills do transfer,” she said.