addition to neuroimaging techniques that can reveal regional brain activity, brain lesioning can also help shed light on the most important targets for a particular disorder. In brain lesioning, misfiring neurons or their connections are destroyed, most commonly using a heating probe inserted in the brain. Once the first patients are treated, data on effectiveness and side effects, in combination with continued neuroimaging, can help further focus the targets. Lesioning is an alternative to DBS in certain specific cases and can be effective, but it is irreversible, and any untoward effects can be permanent. Because the dose of DBS at the same site can be adjusted down if adverse effects emerge, it is considered to be a potentially safer alternative.