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In a landmark trial, a cocktail of immunotherapy medications harnessed patients’ immune systems to kill their own cancer cells and prompted “a positive trend in survival”, according to researchers at the Institute of Cancer Research (ICR), London, and the Royal Marsden NHS foundation trust.

Scientists found the combination of nivolumab and ipilimumab medications led to a reduction in the size of tumours in terminally-ill head and neck patients. In some, their cancer vanished altogether, with doctors stunned to find no detectable sign of disease.

the immunotherapy treatment also triggered far fewer side-effects compared with the often gruelling nature of “extreme” chemotherapy,

“It was really moving to Texas that set me on this path of figuring out how to communicate about climate change,” she told me. “I was the only climate scientist within two hundred miles.”

She records the questions she is asked afterward, using an app, and the two most frequent are: “What gives you hope?” and “How do I talk to my [blank] about climate change?

In the late nineties, a Gallup poll found that forty-six per cent of Democrats and forty-seven per cent of Republicans agreed that the effects of global warming had already begun.

I work as a psychotherapist and my specialism is ultra-high net worth individuals.

I got into working with billionaires by accident. I had one wealthy client, who passed my name around to their acquaintances. They are called the 1% for a reason: there are not that many of them and so the circle is tight.

Over the years, I have developed a great deal of empathy for those who have far too much. The television programme Succession, now in its third season, does such a good job of exploring the kinds of toxic excess my clients struggle with that when my wife is watching it I have to leave the room; it just feels like work.

To test Darwin’s theory, the researchers quizzed people on several topics, such as grammar, logical reasoning and humor. After each test, they asked the participants how they thought they did. Specifically, participants were asked how many of the other quiz-takers they beat.

Dunning was shocked by the results, even though it confirmed his hypothesis. Time after time, no matter the subject, the people who did poorly on the tests ranked their competence much higher. On average, test takers who scored as low as the 10th percentile ranked themselves near the 70th percentile. Those least likely to know what they were talking about believed they knew as much as the experts.

Dunning and Kruger’s results have been replicated in at least a dozen different domains: math skills, wine tasting, chess, medical knowledge among surgeons and firearm safety among hunters.

there also seems to be little doubt that is corroding the web.

, two new studies offered some cause for alarm. (I discovered both in the latest edition of Import AI, the indispensable weekly newsletter from Anthropic co-founder and former journalist Jack Clark.)

The first study, which had an admittedly small sample size, found that crowd-sourced workers on Amazon’s Mechanical Turks platforms increasingly admit to using LLMs to perform text-based tasks.

After Jason Moore, from Portland, Oregon, saw headlines from national news sources on Google News about the Buffalo shooting at a local supermarket on Saturday afternoon, he did a quick search for the incident on Wikipedia. When no results appeared, he drafted a single sentence: "On May 14, 2022, 10 people were killed in a mass shooting in Buffalo, New York." He hit save and published the entry on Wikipedia in less than a minute.

That article, which as of Friday has been viewed more than 900,000 times, has since undergone 1,071 edits by 223 editors who've voluntarily updated the page on the internet's free and largest crowdsourced encyclopedia.

He's credited with creating 50,000 entries

Since he started pursuing his $44 billion purchase of Twitter — and for years before that — the world’s richest man has made clear that advertising is not a priority.

Ads account for roughly 90 percent of Twitter’s revenue.

They have cited a litany of complaints, including that the company cannot target ads nearly as well as competitors like Facebook, Google and Amazon.

At a talk on ethical artificial intelligence, the speaker brought up a variation on the famous trolley problem, which outlines a philosophical choice between two undesirable outcomes.

Say a self-driving car is traveling down a narrow alley with an elderly woman walking on one side and a small child on the other, and no way to thread between both without a fatality. Who should the car hit?

To get a sense of what this means, suppose that regulators require that any public health content — for example, on vaccines — not be vastly different for politically left- and right-leaning users. How should auditors check that a social media platform complies with this regulation? Can a platform be made to comply with the regulation without damaging its bottom line? And how does compliance affect the actual content that users do see?

When asked, years later, why she had failed to photograph what she said she’d seen on the enhanced bedsheet, Yezzo replied, “This is one time that I didn’t manage to get it soon enough.” She added: “Operator error.”

The words were deployed as definitive by prosecutors—“the evidence is uncontroverted by the scientist, totally uncontroverted”

Michael Donnelly, now a justice on the Ohio Supreme Court, did not preside over this case, but he has had ample exposure to the use of forensic evidence. “As a trial judge,” he told me, “I sat there for 14 years. And when forensics experts testified, the jury hung on their every word.”

The roots of Slate Star Codex trace back more than a decade to a polemicist and self-described A.I. researcher named Eliezer Yudkowsky, who believed that intelligent machines could end up destroying humankind. He was a driving force behind the rise of the Rationalists.

Because the Rationalists believed A.I. could end up destroying the world — a not entirely novel fear to anyone who has seen science fiction movies — they wanted to guard against it. Many worked for and donated money to MIRI, an organization created by Mr. Yudkowsky whose stated mission was “A.I. safety.”

The community was organized and close-knit. Two Bay Area organizations ran seminars and high-school summer camps on the Rationalist way of thinking.

Congress needs to develop a way of better funding the F.D.A. review process. Perhaps a small excise tax could be levied on over-the-counter sales or fees assessed to makers of over-the-counter drugs to fund the F.D.A. review process or to fund studies into drugs that went on the market before 1962. Leaders need to suggest more options. There should also be a way to prioritize which drugs to look at first. The agency should review old drugs for which there are already many complaints about lack of effectiveness in the manner it did recently for phenylephrine.

Right now, Americans spend billions on drugs that contain ingredients that will not help them. That’s not just a waste of money — it could mean they are delaying appropriate treatment, which can lead to more severe illnesses. This is risky not only for health but also for trust. The American public deserves medicines that do what they are advertised to do.

Essay generation is neither theoretical nor futuristic at this point. In May, a student in New Zealand confessed to using AI to write their papers, justifying it as a tool like Grammarly or spell-check: ​​“I have the knowledge, I have the lived experience, I’m a good student, I go to all the tutorials and I go to all the lectures and I read everything we have to read but I kind of felt I was being penalised because I don’t write eloquently and I didn’t feel that was right,” they told a student paper in Christchurch. They don’t feel like they’re cheating, because the student guidelines at their university state only that you’re not allowed to get somebody else to do your work for you. GPT-3 isn’t “somebody else”—it’s a program.

The essay, in particular the undergraduate essay, has been the center of humanistic pedagogy for generations. It is the way we teach children how to research, think, and write. That entire tradition is about to be disrupted from the ground up

“You can no longer give take-home exams/homework … Even on specific questions that involve combining knowledge across domains, the OpenAI chat is frankly better than the average MBA at this point. It is frankly amazing.”

February 2020, Harriet de Wit, a professor of psychiatry and behavioural science at the University of Chicago, was running an experiment on whether the drug MDMA increased the pleasantness of social touch in healthy volunteers

The latest participant in the double-blind trial, a man named Brendan, had filled out a standard questionnaire at the end. Strangely, at the very bottom of the form, Brendan had written in bold letters: "This experience has helped me sort out a debilitating personal issue. Google my name. I now know what I need to do."

They googled Brendan's name, and up popped a disturbing revelation: until just a couple of months before, Brendan had been the leader of the US Midwest faction of Identity Evropa, a notorious white nationalist group rebranded in 2019 as the American Identity Movement. Two months earlier, activists at Chicago Antifascist Action had exposed Brendan's identity, and he had lost his job.

Twitter executives deceived federal regulators and the company’s own board of directors about “extreme, egregious deficiencies” in its defenses against hackers, as well as its meager efforts to fight spam, according to an explosive whistleblower complaint from its former security chief.

The complaint from former head of security Peiter Zatko, a widely admired hacker known as “Mudge,” depicts Twitter as a chaotic and rudderless company beset by infighting, unable to properly protect its 238 million daily users including government agencies, heads of state and other influential public figures.

Among the most serious accusations in the complaint, a copy of which was obtained by The Washington Post, is that Twitter violated the terms of an 11-year-old settlement with the Federal Trade Commission by falsely claiming that it had a solid security plan. Zatko’s complaint alleges he had warned colleagues that half the company’s servers were running out-of-date and vulnerable software and that executives withheld dire facts about the number of breaches and lack of protection for user data, instead presenting directors with rosy charts measuring unimportant changes.

major social platforms have grown less and less relevant in the past year. In response, some users have left for smaller competitors such as Bluesky or Mastodon. Some have simply left. The internet has never felt more dense, yet there seem to be fewer reliable avenues to find a signal in all the noise. One-stop information destinations such as Facebook or Twitter are a thing of the past. The global town square—once the aspirational destination that social-media platforms would offer to all of us—lies in ruins, its architecture choked by the vines and tangled vegetation of a wild informational jungle

Musk has turned X into a deepfake version of Twitter—a facsimile of the once-useful social network, altered just enough so as to be disorienting, even terrifying.

At the same time, Facebook’s user base began to erode, and the company’s transparency reports revealed that the most popular content circulating on the platform was little more than viral garbage—a vast wasteland of CBD promotional content and foreign tabloid clickbait.

Why is it so annoying when people interrupt? For many of us, it can feel diminishing and condescending, said Maria Venetis, an associate professor of communication at Rutgers University. Sometimes it’s even “enraging,” she added, “because it suggests that my ideas or my participation aren’t valid.”

Interrupters often have more “achieved or ascribed power” and are used to having people quiet down when they want to speak

If you decide to cut in, Swann suggested “lifting your hand up ever so slightly and saying, ‘Hold on, I’d like to finish my thought.’”

Some behavioral interventions do seem to lead to positive changes, such as automatically enrolling children in school free lunch programs or simplifying mortgage information for aspiring homeowners. (Whether one might call such interventions “nudges,” however, is debatable.)

it’s not clear we need to appeal to psychology studies to make some common-sense changes, especially since the scientific rigor of these studies is shaky at best.

Nudges are related to a larger area of research on “priming,” which tests how behavior changes in response to what we think about or even see without noticing

I have learned something profound along the way. Being openhearted is a prerequisite for being a full, kind and wise human being. But it is not enough. People need social skills

The real process of, say, building a friendship or creating a community involves performing a series of small, concrete actions well: being curious about other people; disagreeing without poisoning relationships; revealing vulnerability at an appropriate pace; being a good listener; knowing how to ask for and offer forgiveness; knowing how to host a gathering where everyone feels embraced; knowing how to see things from another’s point of view.

People want to connect. Above almost any other need, human beings long to have another person look into their faces with love and acceptance