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grayton downing

Biofuel Mimicry | The Scientist Magazine® - 0 views

  • ants create the largest colonies of any ant, with some comprising 8 million individuals. To sustain themselves, they march across the forest carrying vast quantities of leaves, piece by piece, in great green convoys, back to the nest. The ants use the leaves as fertilizer to cultivate gardens sown with bacteria and Leucoagaricus gongylophorous, a fungus that produces fruiting bodies packed with nutrients for the ants to feast on.
  • could also provide a model for the more efficient production of renewable biofuels.
  • confirmed that 145 lignocellulases were actually present. “That’s pretty definitive proof that the fungus is the primary driver of biomass breakdown,
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  • offers new insights into the contributions made by the fungus to plant degradation
  • identification of enzymes capable of degrading lignocelluloses could also be a boon for the biofuels industry. Biofuel companies already use enzyme blends to break down starches from plant biomass, most commonly corn, into sugars to be fermented into ethanol. But the enzymes currently available can’t break down tough-to-degrade molecules such as lignocelluloses on an industrial scale.
  • idea is that the genes coding for these enzymes in the fungus gardens of leafcutter ants can be mass-produced in the lab by inserting them into E. coli or yeast, then used to break down feedstocks that require less land, fewer resources, and that don’t compete with food crops. “This is a highly evolved system, so the hypothesis is that the enzymes would be highly tuned to break down plant biomass,”
  • researchers will also need to take into account the role of bacteria. “It could be that bacteria are producing some enzymes that enhance the efficacy of the fungal enzymes,” says Aylward. “Integrating the bacterial component is likely to be important, because the synergism we see with leafcutter gardens is on the level of the entire symbiosis.”
charlottedonoho

Gender and racial bias can be 'unlearnt' during sleep, new study suggests | Science | T... - 0 views

  • Now scientists have found a more noble purpose for the technique in a study that suggests deep-rooted biases about race and gender could be “unlearnt” during a short nap. The findings appear to confirm the idea that sleeping provides a unique window for accessing and altering fundamental beliefs – even prejudices that we don’t know we have.
  • Simply playing auditory cues while people slept partially undid racial and gender bias, the study found, and the effects were still evident at least a week later.
  • “These biases are well-learned,” said Hu. “They can operate efficiently even when we have the good intention to avoid such biases. Moreover, we are often not aware of their influences on our behaviour.”
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  • The study, published in Science, began with two Pavlovian-style conditioning exercises designed to counter race and gender biases.
  • However, they caution that the use of the technique in future would need strict ethical guidelines. “Sleep is a state in which the individual is without wilful consciousness and therefore vulnerable to suggestion,” they add.
  • Scientists believe the technique works because we consolidate memories by replaying them during sleep and transferring the information from the brain’s temporary storage to long-term memory. Hearing the distinctive sound would trigger the memory to be replayed repeatedly, the scientists said, enhancing the learning process.
  • “We call this Targeted Memory Reactivation, because the sounds played during sleep could produce relatively better memory for information cued during sleep compared to information not cued during sleep.
charlottedonoho

How have changes to publishing affected scientists? | Julie McDougall-Waters | Science ... - 0 views

  • That was the purpose of a recent oral history event at the Royal Society, involving four senior scientists who began their careers in the 1960s and 1970s. Rather than simply reminiscing, they were asked to recall their publishing experiences in scientific periodicals over the last fifty years. How have things changed since they published their first paper?
  • It became clear that the hierarchy of journals has changed over the last fifty years, and the pressure to publish in those considered to have the highest impact has increased considerably, partly a result of the increased volume of data being produced and the need for readers to filter relevant information from the copious amounts of less pertinent stuff available.
  • What have also changed are the technologies available to write a paper. Frith related the process she went through in writing her first paper: “I wrote my papers by long hand and then typed them myself.” Writing a biological paper before computers is one thing, but Ashmore remembered the problems of producing mathematical formulae in a typed manuscript, explaining that “you wrote the paper and probably took it along to somebody to be typed… And then it came back with spaces where you had to write in the equations.”
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  • Another change that interested the panellists was the increased number of collaborative and multiple authored papers now submitted to journals, which led them to think about the ethics of acknowledgement. In Meurig Thomas’s view the author is, simply, “the person that primarily thinks about the experiment, plans it, and writes it. I can sleep more comfortably at night this way. If I claim to be a senior author, I have to write it and I have to concoct what the experiment was, and defend it.” Chaloner suggested that authorship has grown “because of the pressure for people to have publications in their names”, with an “agreement to let you come onto this paper and I’ll get on yours next time”. Frith referred to this as “gaming”.
  • Despite all of the technological developments in the last fifty years, there has been no quick or easy response to questions over refereeing, and the event ended with the feeling that although there is no doubt technology has transformed the way science is communicated, its effect has not invariably simplified the process.
carolinewren

Scientists See How Brain Areas Communicate - 1 views

  • Carnegie Mellon Univ. neuroscientists have identified a new pathway by which several brain areas communicate within the brain's striatum.
  • the findings illustrate structural and functional connections that allow the brain to use reinforcement learning to make spatial decisions, such as the dorsolateral prefrontal (DLPFC), orbitofrontal cortex (OFC) and posterior parietal cortex (PPC).
  • Knowing how these specific pathways work together provides crucial insight into how learning occurs
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  • The hope is that more knowledge of how the connectivity is related to behavior will help scientists develop therapeutic interventions that focus on strengthening potentially weakened or damaged pathways.
  • They found that the pathways from all three areas projected to similar areas within a forebrain region called striatum, a part of the basal ganglia pathways that are most commonly associated with Parkinson's disease. The patterns were consistent across all participants
  • The results showed that the convergence zones were not only structurally connected but functionally connected as well. More importantly, the areas at the surface of the brain in all three cortical areas showed a high overlap of structure and functional connectivity
  • there may be a structural and functional network in the brain that allows us to integrate information about where we are focusing our attention in our visuospatial environment with reward and punishment signals associated with our past action choices in order to learn how to update and, hopefully improve, our future action decisions,
  • An additional implication for this study is a deeper understanding of how reinforcement learning occurs.
Javier E

The Science of Why We Don't Believe Science | Mother Jones - 2 views

  • an array of new discoveries in psychology and neuroscience has further demonstrated how our preexisting beliefs, far more than any new facts, can skew our thoughts and even color what we consider our most dispassionate and logical conclusions. This tendency toward so-called "motivated reasoning" helps explain why we find groups so polarized over matters where the evidence is so unequivocal: climate change, vaccines, "death panels," the birthplace and religion of the president (PDF), and much else. It would seem that expecting people to be convinced by the facts flies in the face of, you know, the facts.
  • The theory of motivated reasoning builds on a key insight of modern neuroscience (PDF): Reasoning is actually suffused with emotion (or what researchers often call "affect"). Not only are the two inseparable, but our positive or negative feelings about people, things, and ideas arise much more rapidly than our conscious thoughts, in a matter of milliseconds—fast enough to detect with an EEG device, but long before we're aware of it. That shouldn't be surprising: Evolution required us to react very quickly to stimuli in our environment. It's a "basic human survival skill," explains political scientist Arthur Lupia of the University of Michigan. We push threatening information away; we pull friendly information close. We apply fight-or-flight reflexes not only to predators, but to data itself.
  • reasoning comes later, works slower—and even then, it doesn't take place in an emotional vacuum. Rather, our quick-fire emotions can set us on a course of thinking that's highly biased, especially on topics we care a great deal about.
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  • Consider a person who has heard about a scientific discovery that deeply challenges her belief in divine creation—a new hominid, say, that confirms our evolutionary origins. What happens next, explains political scientist Charles Taber of Stony Brook University, is a subconscious negative response to the new information—and that response, in turn, guides the type of memories and associations formed in the conscious mind. "They retrieve thoughts that are consistent with their previous beliefs," says Taber, "and that will lead them to build an argument and challenge what they're hearing."
  • In other words, when we think we're reasoning, we may instead be rationalizing. Or to use an analogy offered by University of Virginia psychologist Jonathan Haidt: We may think we're being scientists, but we're actually being lawyers
  • Our "reasoning" is a means to a predetermined end—winning our "case"—and is shot through with biases. They include "confirmation bias," in which we give greater heed to evidence and arguments that bolster our beliefs, and "disconfirmation bias," in which we expend disproportionate energy trying to debunk or refute views and arguments that we find uncongenial.
  • That's not to suggest that we aren't also motivated to perceive the world accurately—we are. Or that we never change our minds—we do. It's just that we have other important goals b
  • esides accuracy—including identity affirmation and protecting one's sense of self—and often those make us highly resistant to changing our beliefs when the facts say we should.
Javier E

Psych, Lies, and Audiotape: The Tarnished Legacy of the Milgram Shock Experiments | - 2 views

  • subjects — 780 New Haven residents who volunteered — helped make an untenured assistant professor named Stanley Milgram a national celebrity. Over the next five decades, his obedience experiments provided the inspiration for films, fiction, plays, documentaries, pop music, prime-time dramas, and reality television. Today, the Milgram experiments are considered among the most famous and most controversial experiments of all time. They are also often used in expert testimony in cases where situational obedience leads to crime
  • Perry’s evidence raises larger questions regarding a study that is still firmly entrenched in American scientific and popular culture: if Milgram lied once about his compromised neutrality, to what extent can we trust anything he said? And how could a blatant breach in objectivity in one of the most analyzed experiments in history go undetected for so long?
  • the debate has never addressed this question: to what extent can we trust his raw data in the first place? In her riveting new book, Behind the Shock Machine: The Untold Story of the Notorious Milgram Psychology Experiments, Australian psychologist Gina Perry tackles this very topic, taking nothing for granted
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  • Her chilling investigation of the experiments and their aftereffects suggests that Milgram manipulated results, misled the public, and flat out lied in order to deflect criticism and further the thesis for which he would become famous
  • She contends that serious factual inaccuracies cloud our understanding of Milgram’s work, inaccuracies which she believes arose “partly because of Milgram’s presentation of his findings — his downplaying of contradictions and inconsistencies — and partly because it was the heart-attack variation that was embraced by the popular media
  • Perry reveals that Milgram massaged the facts in order to deliver the outcome he sought. When Milgram presented his finding — namely, high levels of obedience — both in early papers and in his 1974 book, Obedience to Authority, he stated that if the subject refused the lab coat’s commands more than four times, the subject would be classified as disobedient. But Perry finds that this isn’t what really happened. The further Milgram got in his research, the more he pushed participants to obey.
  • only after criticism of his ethics surfaced, and long after the completion of the studies, did Milgram claim that “a careful post-experimental treatment was administered to all subjects,” in which “at the very least all subjects were told that the victim had not received dangerous electric shocks.” This was, quite simply, a lie. Milgram didn’t want word to spread through New Haven that he was duping his subjects, which could taint the results of his future trials.
  • If the Milgram of Obedience to Authority were the narrator in a novel, I wouldn’t have found him terribly reliable. So why had I believed such a narrator in a work of nonfiction?
  • The answer, I found, was disturbingly simple: I trust scientists
  • I do trust them not to lie about the rules or results of their experiments. And if a scientist does lie, especially in such a famous experiment, I trust that another scientist will quickly uncover the deception. Or at least I used to.
  • At the time, Milgram was 27, fresh out of grad school and needing to make a name for himself in a hyper-competitive department, and Perry suggests that his “career depended on [the subjects’] obedience; all his preparations were aimed at making them obey.”
  • Milgram’s studies — which suggest that nearly two-thirds of subjects will, under certain conditions, administer dangerously powerful electrical shocks to a stranger when commanded to do so by an authority figure — have become a staple of psychology departments around the world. They have even helped shape the rules that govern experiments on human subjects. Along with Zimbardo’s 1971 Stanford prison experiment, which showed that college students assigned the role of “prison guard” quickly started abusing college students assigned the role of “prisoner,” Milgram’s experiments are the starting point for any meaningful discussion of the “I was only following orders” defense, and for determining how the relationship between situational factors and obedience can lead seemingly good people to do horrible things.
  • While Milgram’s defenders point to subsequent recreations of his experiments that have replicated his findings, the unethical nature, not to mention the scope and cost, of the original version have not allowed for full duplications.
grayton downing

Lost in Translation | The Scientist Magazine® - 0 views

  • excessive reporting of positive results in papers that describe animal testing of potential therapies, just like the publishing bias seen in clinical research, according to a paper published today
  • We know publication bias happens a lot in clinical trials,” said Torgerson, “so I was surprised at myself for being surprised at the results, because of course, if it happens in human research, why wouldn’t it happen in animal research?”
  • his suspicions about publication bias by performing a statistical meta-analysis of thousands of reported animal tests for various neurological interventions—a total of 4,445 reported tests of 160 different drugs and other treatments for conditions that included Alzheimer’s disease, Parkinson’s disease, brain ischemia, and more.
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  • One, as mentioned, is the suppression of negative results. The second is selective reporting of only the statistical analyses of data that provide a significant score. “Practically any data set, if it is tortured enough, will confess, and you will get a statistically significant result,”
  • , a publication bias “almost certainly” applies in other areas of preclinical research,
  • he suggested that a forum where investigators can deposit neutral or negative results in the form of articles, should be established to ensure that such findings are in the public arena and not hidden. This should help prevent other researchers from pursuing fruitless avenues of research, he said, “which is a waste of animals and a waste of research money.” Not to mention a risk to people enrolled in potentially pointless trials.
grayton downing

Mapping Disease | The Scientist Magazine® - 0 views

  • researchers and journalists have scrambled to map the spread of H7N9 bird flu through China to identify its source and highlight at risk areas. Mapping is a common response to outbreaks, especially of new diseases, but some scientists believe it must become a more proactive part of disease control
  • efforts to plot the locations of infectious diseases still tend to be reactive rather than proactive.
  • only 4 percent of important infectious diseases have been comprehensively mapped at a global scale. The rest are plagued by patchy data.
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  • audited existing maps for 174 infectious diseases of clinical importance. Following a huge systematic review, they scored the maps for each disease according to how much of the known global range is covered and the quality of the data—whether they were up-to-date and whether they relied on accurate measures like molecular diagnostics or GPS coordinates, rather than unverified expert opinion.
  • even the highest-scoring diseases have room for improvement.
  • . They argue that technology can help to plug the gaps in our maps in the future, and they point to several untapped sources of data. For example, both PubMed and GenBank, which collect biomedical literature and gene sequences respectively, contain geospatial information for the majority of diseases that the team reviewed. And social networks like Twitter can provide invaluable real-time clues about spreading symptoms and illnesses, often tagged with geographical information. During the 2009 outbreak of H1N1 swine flu, for example, Twitter predicted outbreaks 1 or 2 weeks ahead of traditional surveillance measures.
  • I struggled because governments or researchers wouldn’t share their information,” he said. “But there was all this incredible knowledge on the web being discussed through professional networks or news media.”
  • believes that the problem now is not a lack of data but a deluge of it. Sites like HealthMap and BioCaster are already using learning algorithms to filter online sources for information relevant to infections. They are also using crowdsourcing tools that ask online volunteers to check if flagged social media chatter actually relates to the disease of interest.
grayton downing

The Neurobiology of Individuality | The Scientist Magazine® - 0 views

  • a group of genetically identical mice lived in the same complex enclosure for 3 months, individuals that explored the environment more broadly grew more new neurons than less adventurous mice, according to a study
  • s a clear and quantitative demonstration that individual differences in behavior can be reflected in individual differences in brain plasticity
  • often tried to tackle the question of how individual differences in behavior and personality develop in terms of the interactions between genes and environment. “But there is next to nothing [known] about the neurobiological mechanisms underlying individuality
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  • phenomenon is to look at brain plasticity, or how the brain’s structure and function change over time. Plasticity is hard to study, however, because it mostly takes place at the synaptic level
  • found that individual differences in exploratory behavior correlated with individual differences in the numbers of new neurons generated. “To out knowledge, it’s the first example of a direct link between individual behavior and individual brain plasticity,” Kempermann said.
  • could help explain why human identical twins raised in the same family end up with different personalities. “These kinds of processes are notoriously difficult to study in people, because we can’t control human environments experimentally,” said Eric Turkheimer, a psychologist at the University of Virginia, who studies how differences in the personalities of identical twins emerge over time. “That’s why an animal model is so important.”
  • with an animal model to help address the ways living our lives make us who we are,” said Kempermann. “So we have touched on an approach that allows us start to get the small part of an answer to a very big question.”
grayton downing

Bird Flu Mutation Risk | The Scientist Magazine® - 0 views

  • some strains of both viruses are just one mutation away from getting a better grip on the cells in our upper airways. If wild viruses accrue those mutations, they may find it far easier to spread from infected to uninfected people, increasing the risk of a pandemic.
  • “These viruses are rapidly evolving and our stockpiles of vaccine are largely based on outdated strains,” he said. “We hope that our discoveries will help us to stay ahead of the curve by ensuring that vaccines are stockpiled against strains that are closest to adapting to humans.”
  • rather than focusing on these previously identified mutations, the team took a new approach. They modeled the way HA interacts with different glycans, and identified four structural features that bestow the protein with a preference for human receptors over bird ones.
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  • they analyzed the diversity of existing H5N1 strains and found that many wild viruses are already tantalizingly close to becoming potentially contagious among humans.
  • we know very little about the actual receptors in human airways that are relevant for flu viruses.” Even the so-called “human” receptors can vary significantly, and it’s unclear which ones are found in different parts of the airways, or how common they are.
  • identified should be tested in ferret experiments to see if they genuinely are more efficient at spreading between mammals. However, given the controversy surrounding the development of potentially contagious flu strains, Fouchier wonders “whether we would be allowed to empirically test this newly acquired knowledge in animal models.”
grayton downing

Optogenetics and OCD | The Scientist Magazine® - 0 views

  • abnormal brain activity seen in patients with obsessive-compulsive disorder (OCD) is a likely cause of the condition, according to two papers published today (June 6) in Science. Both studies used optogenetic techniques, which allow specific brain cells to be turned on and off at the flick of a light switch, to link the abnormal brain activity to OCD behavior in mice.
  • relationship between [neural] circuit abnormalities and [OCD-like] behavior,
  • “so I’m very aware of how severe the illness is and how important it is for us to develop new and more effective treatments.” The problem is, she added, “we don’t have a very good understanding of the pathologic changes that lead to OCD.”
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  • Ahmari turned to mice and to optogenetics—whereby specific types of brain cells can be switched on and off in response to light. The cells of interest were engineered to express light-responsive ion channels, such that when the cells are exposed to light—by means of a fiber optic cable pointing a laser at the relevant brain region—the channels open, ions flood in, and nerve impulses fire.
  • But crucially, the teams had very slightly different targets in the striatum—the general ventral striatum in the case of Ahmari’s study and the specific fast-spiking inhibitory interneurons of the centromedial striatum in Graybiel’s study, suggesting that different neural circuits send inhibitory and stimulatory signals for certain OCD-like behaviors.
  • “they’ve been able to really delineate a pathway for compulsive behaviors in a more refined way than we’ve ever been able to do in humans, and that’s exciting because it points us in the direction of pathogenesis and pathophysiology of the disorder, but also . . . to new targets for potential intervention.”
grayton downing

Inhibit Mitochondria to Live Longer? | The Scientist Magazine® - 0 views

  • Although previous work had indirectly suggested that changing mitochondrial function affected lifespan, “this is the first clear demonstration [that it] extends mouse lifespan,” Miller added.
  • well known that mitochondria are linked to health. Some evidence suggests that inhibiting mitochondrial function can be harmful—as in the case of diabetes or obesity—but earlier data from nematodes and fruit flies also suggest a link to lifespan increase. The latest findings are a step toward untangling one of the current debates in the field—whether inhibiting mitochondrial function is detrimental or beneficial,
  • The average lifespan of BXD mice range from 1 year to almost 2.5 years. The researchers were able to link 3 genes to longevity variability, including mitochondrial ribosomal protein S5 (Mrps5), which encodes a protein integral to mitochondrial protein synthesis. They found that BXD strains with 50 percent less Mrps5 expression lived about 250 days longer than BXD mice with more robust Mrps5 expression.
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  • researchers were also able to activate the mitochondrial UPR via pharmacological means. Dosing worms with the antibiotic doxycyline, which inhibits bacterial and mitochondrial protein translation, also activated the mitochondrial UPR and extended worm lifespans. Rapamycin, shown to enhance longevity in mice, also extended worm lifespan and induced mitonuclear protein imbalance and the mitochondrial UPR in mouse hepatocytes.
  • mitochondrial ribosomal proteins are not to be trifled with. “There are a number of well-defined severe disorders in humans, including neonatal lethality, due to defects in those exact proteins,”
  • is beginning to cast a wider net, looking to see whether mitonuclear protein imbalance could explain longevity induced by other means, such as caloric restriction. Auwerx hopes that the work will aid in designing a drug intervention “to pump up this response via pharmacological tools.”
  • he’s optimistic that his team has identified a “common thread” demonstrating that longevity is not affected so much by inhibiting or stimulating mitochondria, but how the organelles “deal with proteins.”
grayton downing

Epigenetics Play Cupid for Prairie Voles | The Scientist Magazine® - 0 views

  • It’s the first time anyone’s shown any epigenetic basis for partner preference,
  • Mohamed Kabbaj, a neuroscientist at Florida State University and an author of the paper, said that work in other species gave him clues that epigenetics could be important for social behavior. For instance, previous work suggests that modifications are involved in bonds between mothers and offspring in rats.
  • the researchers blocked vasopressin or oxytocin receptors in the animals, the TSA had no effect on pair bond formation, supporting the theory that oxytocin and vasopressin were mediating the effects of the epigenetic modification.
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  • The mating and cohabitation produced the exact same effects [as TSA],” said Bruce Cushing, a behavioral neuroscientist at the University of Akron who was not involved in the study. “That is really powerful.”
grayton downing

Three-Way Parenthood | The Scientist Magazine® - 0 views

  • The ability to manipulate human reproduction was viewed in many circles as an attack on the traditional family and an odious attempt to assert human dominion over nature. Terms such as “designer babies” and “playing God” were commonly applied to IVF.
  • proposed the concept of a “three-parent” fertility procedure to treat mitochondrial disorders
  • prevent defective mtDNA from being passed from mother to child, scientists in the U.K. are planning to offer a “three-parent” fertility procedure.
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  • potential for creating children from multiple parents is not limited to the halting of the passage of mitochondrial disorders.
  • these genetic engineering procedures raise both legal and ethical concerns. Legal issues include: Who are the legal parents of a child generated from genetic material obtained from multiple donors? Would such a child have the right to know the identity of all his gene donors? In an article to be published in the Harvard Journal of Law and Gender (in press), we propose a legal solution to address some of these issues
  • many ethical concerns raised by such technologies is whether these advances in reproductive medicine could lead to the creation of “designer babies,” in which parents select the genetic composition of their children for enhancement or for health reasons. The fear in creating designer babies is that it may herald a new era of “consumer eugenics” with potentially unknown consequences for humankind.
grayton downing

Send in the Bots | The Scientist Magazine® - 0 views

  • any hypothesis, his idea needed to be tested. But measuring brain activity in a moving ant—the most direct way to determine cognitive processing during animal decision making—was not possible. So Garnier didn’t study ants; he studied robots. U
  • The robots then navigated the environment by sensing light intensity through two sensors on their “heads.”
  • , several groups have used autonomous robots that sense and react to their environments to “debunk the idea that you need higher cognitive processing to do what look like cognitive things,”
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  • a growing number of scientists are using autonomous robots to interrogate animal behavior and cognition. Researchers have designed robots to behave like ants, cockroaches, rodents, chickens, and more, then deployed their bots in the lab or in the environment to see how similarly they behave to their flesh-and-blood counterparts.
  • robots give behavioral biologists the freedom to explore the mind of an animal in ways that would not be possible with living subjects, says University of Sheffield researcher James Marshall, who in March helped launch a 3-year collaborative project to build a flying robot controlled by a computer-run simulation of the entire honeybee brain.
  • “I really think there is a lot to be discovered by doing the engineering side along with the science.”
  • Not only did the bots move around the space like the rat pups did, they aggregated in remarkably similar ways to the real animals.3 Then Schank realized that there was a bug in his program. The robots weren’t following his predetermined rules; they were moving randomly.
  • Animal experiments are still needed to advance neuroscience.” But, he adds, robots may prove to be an indispensable new ethological tool for focusing the scope of research. “If you can have good physical models,” Prescott says, “then you can reduce the number of experiments and only do the ones that answer really important questions.”
  • animal-mimicking robots is not easy, however, particularly when knowledge of the system’s biology is lacking.
  • However, when the researchers also gave the robots a sense of flow, and programmed them to assume that odors come from upstream, the bots much more closely mimicked real lobster behavior. “That was a demonstration that the animals’ brains were multimodal—that they were using chemical information and flow information,” says Grasso, who has since worked on robotic models of octopus arms and crayfish.
  • some sense, the use of robotics in animal-behavior research is not that new. Since the inception of the field of ethology, researchers have been using simple physical models of animals—“dummies”—to examine the social behavior of real animals, and biologists began animating their dummies as soon as technology would allow. “The fundamental problem when you’re studying an interaction between two individuals is that it’s a two-way interaction—you’ve got two players whose behaviors are both variable,”
  • building a robot that animals will accept as one of their own is complicated, to say the least.
  • handful of other researchers have also successfully integrated robots with live animals—including fish, ducks, and chickens. There are several notable benefits to intermixing robots and animals; first and foremost, control. “One of the problems when studying behavior is that, of course, it’s very difficult to have control of animals, and so it’s hard for us to interpret fully how they interact with each other
Javier E

Many Psychology Findings Not as Strong as Claimed, Study Says - The New York Times - 1 views

  • a painstaking yearslong effort to reproduce 100 studies published in three leading psychology journals has found that more than half of the findings did not hold up when retested. The analysis was done by research psychologists, many of whom volunteered their time to double-check what they considered important work. Their conclusions, reported Thursday in the journal Science, have confirmed the worst fears of scientists who have long worried that the field needed a strong correction.
  • The vetted studies were considered part of the core knowledge by which scientists understand the dynamics of personality, relationships, learning and memory. Therapists and educators rely on such findings to help guide decisions, and the fact that so many of the studies were called into question could sow doubt in the scientific underpinnings of their work.
  • The new analysis, called the Reproducibility Project, found no evidence of fraud or that any original study was definitively false. Rather, it concluded that the evidence for most published findings was not nearly as strong as originally claimed.
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  • r. John Ioannidis, a director of Stanford University’s Meta-Research Innovation Center, who once estimated that about half of published results across medicine were inflated or wrong, noted the proportion in psychology was even larger than he had thought.
  • He said the problem could be even worse in other fields, including cell biology, economics, neuroscience, clinical medicine, and animal research.
  • The act of double-checking another scientist’s work has been divisive. Many senior researchers resent the idea that an outsider, typically a younger scientist, with less expertise, would critique work that often has taken years of study to pull off.
  • The overall “effect size,” a measure of the strength of a finding, dropped by about half across all of the studies. Yet very few of the redone studies contradicted the original ones; their results were simply weaker.
  • The project’s authors write that despite the painstaking effort to duplicate the original research, there could be differences in the design or context of the reproduced work that account for the different findings. Many of the original authors certainly agree.
grayton downing

Darwin Still Rules, but Some Biologists Dream of a Paradigm Shift - New York Times - 1 views

  • Paradigm shifts are the stuff of scientific revolutions. They change how we view the world, the sorts of questions that scientists consider worth asking, and even how we do science.
  • Many scientists suffer from a kind of split personality. We believe that this is the most exciting time to be working while yearning for the excitement of a revolution. What ambitious scientist would not want to be part of a paradigm shift? Not surprisingly, this yearning occasionally manifests itself in proclamations that a revolution is at hand.
  • Comparative studies of development have illuminated how genes operate, and evolve, and this places less emphasis on the gradual accumulation of small genetic changes emphasized by the modern synthesis. Work in ecology has emphasized the role organisms play in building their own environments, and studies of the fossil record raise questions about the role of competition.
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  • One advantage developmental biologists have over paleontologists is that they can experiment on the development of these animals.
  • The failure to consider how biodiversity grows reflects an even more troubling flaw in the modern synthesis: it lacks any real sense of history.
Javier E

Global Warming 'Hiatus' Challenged by NOAA Research - NYTimes.com - 0 views

  • Scientists have long labored to explain what appeared to be a slowdown in global warming that began at the start of this century as, at the same time, heat-trapping emissions of carbon dioxide were soaring. The slowdown, sometimes inaccurately described as a halt or hiatus, became a major talking point for people critical of climate science.
  • When adjustments are made to compensate for recently discovered problems in the way global temperatures were measured, the slowdown largely disappears, the National Oceanic and Atmospheric Administration declared in a scientific paper published Thursday. And when the particularly warm temperatures of 2013 and 2014 are averaged in, the slowdown goes away entirely, the agency said.
  • “The notion that there was a slowdown in global warming, or a hiatus, was based on the best information we had available at the time,” said Thomas R. Karl, director of the National Centers for Environmental Information, a NOAA unit in Asheville, N.C. “Science is always working to improve.”
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  • senior climate scientists at other agencies were in no hurry to embrace NOAA’s specific adjustments. Several of them said it would take months of discussion in the scientific community to understand the data corrections and come to a consensus about whether to adopt them broadly.
  • NOAA said the improvements in its data set included the addition of a huge number of land measurements from around the world, as a result of improving international cooperation in sharing weather records. But the disappearance of the slowdown comes largely from adjustments in ocean temperatures.
  • A leading hypothesis to explain the slowdown is that natural fluctuations in the Pacific Ocean may have temporarily pulled some heat out of the atmosphere, producing a brief flattening in the long-term increase of surface temperatures.
  • Yet the temperature record is plagued by many problems: thermometers and recording practices changed through time, weather stations were moved, cities grew up around once-rural stations, and so on. Entire scientific careers are devoted to studying these issues and making corrections.
  • NOAA is one of four agencies around the world that attempts to produce a complete record of global temperatures dating to 1880. They all get similar results, showing a long-term warming of the planet that scientists have linked primarily to the burning of fossil fuels and the destruction of forests. A huge body of physical evidence — notably, that practically every large piece of land ice on the planet has started to melt — suggests the temperature finding is correct.
  • ocean measurements in particular are rife with difficulties.
  • Even if the warming slowdown in the early 21st century was real, there seems to be little question that it is ending. By a small margin, the global temperature hit a record in 2014, and developing weather patterns suggest that record will likely be broken by a larger margin in 2015.
Javier E

The Politics Of Science, Ctd - The Dish | By Andrew Sullivan - The Daily Beast - 0 views

  • This won't do. The "anti-science" charge has little to with morality. When someone like Rick Perry - an avowed anthropogenic climate change and evolution denialist - is accused of rejecting science, it's an attack on Perry's epistemological beliefs rather than moral values. Even though the scientific consensus is clear on both questions, Perry refuses to accept both. By rejecting well-supported scientific truths on, say, theological grounds, he is implicitly denying that the scientific method (rather than, say, theological reasoning) is the best way to determine truths about the natural world. That's what being "anti-science" is.
  • Being pro-science may mean being committed to the idea that advancing scientific knowledge is good for the world, sure, but that scientific knowledge doesn't always say we should try to control the natural world. Science is at its core is a reasoning process - we arrive at certain conclusions through experiments, peer evaluation, etc. So if the best scientific evidence suggests "humans do bad things when they mess with the natural world in fashion X" then the science is telling us not to mess with the natural world in fashion X! Indeed, scientific findings often serve as evidence in debates over the environmental impact of new technology, oftentimes on both sides. There's nothing intrinsic to scientific epistemology or practice that implies a moral commitment to increasing human control over the natural world or to widespread commercial use of the new technologies its discoveries enable
  • Another way to put it is that scientists have a goal of advancing human knowledge. They often do that with particular ends in mind (e.g., cancer scientists want to cure cancer), but there's no reason to believe that end is always increasing human control. It could be that a scientist might want to demonstrate the dangers of certain technologies or the limits of human ability to successfully interfere with the workings of the natural world. 
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  • ultimately, it's not whether Levin's broader argument that's really important in this specific case. It's that he's is using obscure conceptual arguments to shield genuinely ignorant people like Perry from criticism. Even if every one of the above arguments is wrong, there's a huge difference between some subtle ethical conflicts and flat-0ut denying the theory of evolution or anthropogenic climate change.
johnsonma23

Unprecedented Level of Human Harm to Sea Life Is Forecast - NYTimes.com - 0 views

  • Unprecedented Level of Human Harm to Sea Life Is Forecast
  • A team of scientists, in a groundbreaking analysis of data from hundreds of sources, has concluded that humans are on the verge of causing unprecedented damage to the oceans and the animals living in them.
  • A number of experts said the result was a remarkable synthesis, along with a nuanced and encouraging prognosis.
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  • “We may be sitting on a precipice of a major extinction event,”
  • There are clear signs already that humans are harming the oceans to a remarkable degree, the scientists found. Some ocean species are certainly overharvested, but even greater damage results from large-scale habitat loss, which is likely to accelerate as technology advances the human footprint, the scientists reported.
  • Coral reefs, for example, have declined by 40 percent worldwide,
  • Fragile ecosystems like mangroves are being replaced by fish farms, which are projected to provide most of the fish we consume within 20 years.
  • Mining operations, too, are poised to transform the ocean. Contracts for seabed mining now cover 460,000 square miles underwater, the researchers found, up from zero in 2000.
  • ecosystems may seem impervious to change.
  • The fossil record indicates that a number of large animal species became extinct as humans arrived on continents and islands.
  • But it was only after 1800, with the Industrial Revolution, that extinctions on land really accelerated.
  • Humans began to alter the habitat that wildlife depended on, wiping out forests for timber, plowing under prairie for farmland, and laying down roads and railroads across continents.
  • Over the past five centuries, researchers have recorded 514 animal extinctions on land
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