Researchers at Oregon Health and Science University scanned the brains of nine healthy, normal-weight subjects in the minutes after each got an infusion of equal volumes of glucose, of fructose and of saline. The brain scans aimed to capture activity in a relatively small swath of the human brain in and around the hypothalamus, which plays a key but complex role in setting appetite levels and directing production of metabolic hormones.
The researchers, led by Dr. John Purnell, found that "cortical control areas"--broad swaths of gray matter that surrounded the hypothalamus -- responded quite differently to the infusion of fructose than they did to glucose. Across the limited regions of the brain they scanned, Purnell and his colleagues saw that glucose significantly raised the level of neural activity for about 20 minutes following the infusion. Fructose had the opposite effect, causing activity in the same areas to drop and stay low for 20 minutes after the infusion. Saline--the control condition in this trial--had no effect either way.