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It was a primitive trip with a sophisticated goal: to understand how heavy use of digital devices and other technology changes how we think and behave, and how a retreat into nature might reverse those effects.

Cellphones, which in the last few years have become full-fledged computers with high-speed Internet connections, let people relieve the tedium of exercising, the grocery store line, stoplights or lulls in the dinner conversation.

The technology makes the tiniest windows of time entertaining, and potentially productive. But scientists point to an unanticipated side effect: when people keep their brains busy with digital input, they are forfeiting downtime that could allow them to better learn and remember information, or come up with new ideas.

“Almost certainly, downtime lets the brain go over experiences it’s had, solidify them and turn them into permanent long-term memories,” said Loren Frank, assistant professor in the department of physiology at the university, where he specializes in learning and memory. He said he believed that when the brain was constantly stimulated, “you prevent this learning process.”

“Exercise is a form of stress,” she pointed out. So is social isolation. Each, independently, induces the release of stress hormones (primarily corticosterone in rodents and cortisol in people). These hormones have been found, in multiple studies, to reduce neurogenesis. Except after exercise; then, despite increased levels of the hormones, neurogenesis booms. It’s possible, Dr. Stranahan said, that social connections provide a physiological buffer, a calming, that helps neurogenesis to proceed despite the stressful nature of exercise. Social isolation removes that protection and simultaneously pumps more stress hormones into the system, blunting exercise’s positive effects on brainpower.

"--fish oil (The omega-3 fatty acids in fish oil, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), appear to be most effective at lowering triglycerides, an artery-clogging fat in the blood. ... Fish-oil supplements are probably safe for most people when taken in doses of 3 grams or less per day

--plant stanols and sterols (Those substances—which occur naturally in nuts, seeds, and whole grains—appear to reduce the amount of cholesterol the body absorbs from food.

--fiber (It's generally best to get fiber—which appears to lower LDL cholesterol, possibly by absorbing fat in the gut—from foods, such as beans, oats, produce, and whole grains.

Proprioceptive cues are images and other sensory cues that enable you to modify your running stride for the better as you think about them while running.

Using proprioceptive cues effectively requires concentration and discipline. Our natural tendency is to let our thoughts wander aimlessly while running. If you're serious about improving your stride, you must fight this tendency by forcing yourself to concentrate on and execute a particular proprioceptive cue for hundreds of consecutive strides.

You'll get the best results from proprioceptive cues if you use one at a time throughout the entire length of a run and you use them generally at least three times a week every week. Because proprioceptive cues require you to use your muscles differently than they are accustomed to being used, certain muscles may fatigue more quickly, so it's best to begin using each specific proprioceptive cue only during short recovery runs.

A study of German college students suggests that urbanite brains are more susceptible to stress, particularly social stress, than those of country dwellers.

Meyer-Lindenberg’s findings, published June 23 in Nature, are a neurological investigation into the underpinnings of a disturbing social trend: As a rule, city life seems to generate mental illness. Compared to their rural counterparts, city dwellers have higher levels of anxiety and mood disorders. The schizophrenia risk of people raised in cities is almost double. Literature on the effect is so thorough that researchers say it’s not just correlation, as might be expected if anxious people preferred to live in cities. Neither is it a result of heredity. It’s a cause-and-effect relationship between environment and mind.

cities are hyper-social places, in which residents must be constantly on guard, and have mathematically more opportunity to experience stressful interaction. Too much stress may ultimately alter the brain, leaving it ill-equipped to handle further stress and prone to mental illness.