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Vitamin D3 replacement was found to decrease fasting glucose, decrease insulin, increase insulin sensitivity, and decrease total cholesterol and LDL in pregnant women with gestational diabetes.  The dosing here was 50,000 IU x 2 doses taken 3 weeks apart. 

fructose and glucose are not one in the same.  Fructose increases cholesterol problems, reduces insulin sensitivity and increases fat

Nice article out of the UK finds low glucose environment and glycolysis inhibitors improve oncolytic viral therapies.