Estradiol-17β Upregulates Pyruvate Kinase M2 Expression to Coactivate Estrogen Receptor-α and to Integrate Metabolic Reprogramming With the Mitogenic Response in Endometrial Cells: The Journal of Clinical Endocrinology & Metabolism: Vol 99, No 10 - 0 views
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Nathan Goodyear on 07 Oct 14This is an important study. Study found that Estradiol increased the transcription of pyruvate kinase M (PKM2)production in endometrial stromal cells. This increase in PKM2 shifted metabolism to a aerobic glycolysis pattern similar to the Warburg effect described in cancer. Additionally, increased PKM2 via Estradiol increased ER alpha transcription and functioned as a ER alpha coactivator.