High Progesterone Receptor Expression in Prostate Cancer Is Associated with Clinical Failure - 0 views
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Currently, there is a general agreement of PGR presence in the stromal cells of PCa
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expressed in both stromal and tumor cells of the PCa tissue
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In univariate analysis, a high density level of PGR in both TE and TS was associated with CF
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STudy finds that increased Progesterone receptor expression on epithelial and stromal cells is associated with increased clinical failure of therapy. Several proposed mechanisms: 88% homologous with androgen receptor suggesting cross-stimulation and via progesterone induced increased androgen receptor gene stimulation i.e. epigenetics.