An increase in new onset diabetes, i.e., 3% in statin arm and 2.4% in placebo arm was reported. This was accompanied by increase in median value of glycated haemoglobin and was one of the earlier studies to report the increase in new onset diabetes in patients on statins
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Prevalence and Incidence of Androgen Deficiency in Middle-Aged and Older Men: Estimates... - 0 views
jcem.endojournals.org/...5920.full
lot T testosterone Massachusetts male aging study MMAS hypogonadism
shared by Nathan Goodyear on 20 Nov 13
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The Massachusetts male aging study found 2.4 million men with hypogonadism. They estimated 481,000 new cases annually in the age group of 40-69. This was in very stringent definition of "hypogonadism".
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Statin use and risk of diabetes mellitus - 0 views
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Even after adjustment for potential confounders, statin therapy was associated with an increased risk of new-onset diabetes mellitus
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Authors suggest that statin-induced diabetes mellitus is a medication class effect
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Another study also reported that as compared to placebo, statin group showed a higher risk of physician reported incident diabetes and it was also observed that risk was higher in women as compared to men
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Meta-analysis of randomized controlled trials by Sattar et al[25] involving 91140 non-diabetic patients showed that statin therapy was associated with 9% increased risk of incident diabetes
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A number of studies showed dose dependent association between statin administration and incident diabetes
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intensive dose of statins was associated with high incidence of new - onset diabetes
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Treatment with atorvastatin and simvastatin may be associated with an increased risk of new onset diabetes as compared to pravastatin
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Increased incidence of diabetes was seen with atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial
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Increased insulin resistance secondary to statins was demonstrated in a prospective non randomised study in patients with coronary bypass surgery
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downregulation of GLUT4
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Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
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Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
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Great review article of the increased risk of worsening insulin resistance, glycated hemoglobin, and diabetes risk. Atorvastatin appears to be the worst culprit. Mechanism partially through a decrease in GLUT4.
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Nutrients | Free Full-Text | Vitamin C Status Correlates with Markers of Metabolic and ... - 0 views
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vitamin C deficiency is the fourth most prevalent nutrient deficiency reported in the United States
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Hypovitaminosis C (defined as a plasma concentration ≤23 µmol/L)
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The CHALICE (Canterbury Health, Ageing and Lifecourse) study is a unique New Zealand study comprising a comprehensive database of determinants of health
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The CHALICE cohort of 404 individuals aged 50 years had an average vitamin C intake of ~110 mg/day, which should provide adequate plasma concentrations [14]. Despite this, a significant proportion of the participants had inadequate plasma vitamin C status
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inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
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adequate plasma levels (i.e., >50 µmol/L)
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Higher plasma vitamin C status was associated with lower weight, BMI and waist circumference
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plasma vitamin C was negatively associated with blood triglycerides, HbA1c and insulin, and positively associated with HDL levels.
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No correlation was found between plasma vitamin C and the two indicators of heart health; blood pressure and cardiovascular risk score.
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2.4% of 50-year-olds were deficient in vitamin C (i.e., <11 µmol/L)
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hypovitaminosis C (i.e., <23 µmol/L)
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A high proportion (63%) of our participants had inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
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The association of low vitamin C with obesity in this study replicates results in the literature [35,40,41,42,43,44], and it is apparent that individuals with higher weight require higher intakes of vitamin C to reach adequate vitamin C status
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higher plasma vitamin C status is associated with lower circulating levels of blood triglycerides, insulin and HbA1c
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A role for vitamin C in the prevention or management of diabetes and/or metabolic syndrome has been suggested
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In this study, we also demonstrate lower levels of mild cognitive impairment in those with high vitamin C status
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The odds of mild cognitive impairment were twice as high for those below 23 μmol/L plasma vitamin C concentration.
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Vitamin C is present at very high concentrations in the brain
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animal models have shown that the brain is the last organ to be depleted of the vitamin during prolonged deficiency
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A recent animal study has shown that moderate vitamin C deficiency may play a role in accelerating amyloid plaque accumulation in Alzheimer’s disease
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New study: vitamin C levels correlate with cognitive and metabolic health. What is your vitamin C level? Despite the adequate levels of vitamin C intake, a large % of the individuals had inadequate vitamin C levels which points to a demand issue. Higher oxidative stress, chronic inflammation... would drive demand for vitamin C higher. Lower vitamin C levels were associated with more metabolic disease, ie. DM, and more cognitive decline.