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spineneuro

Opt For Spine Surgery in India By Dr. Vidyadhara S in Manipal Hospital - 0 views

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    Top spine specialist in Bangalore, he conducts more outpatient, minimally invasive spine procedures each month than any other spine practitioner worldwide. Dr. Vidyadhara S Manipal Hospital is equipped to provide advice, recommendations, and spine surgical procedures to assist you in reclaiming a full and comfortable life.
Nathan Goodyear

Run for your life … at a comfortable speed and not too far -- O'Keefe and Lavie -- Heart - 0 views

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    Running beyond 25 miles weekly is damaging to the heart according to this editorial.  
Day Spa Adelaide

A Gratifying Day Spa Experience - 1 views

All my friends were raving about this day spa in Blackwood Hills called Shantai. They do mas-sages, waxing, body treatments, facials, and lots of other day spa stuff. It is so great, you feel total...

started by Day Spa Adelaide on 07 Feb 13 no follow-up yet
jasminegibbons

How to Age Gracefully with Proper Posture - 0 views

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    Aging is inevitable but you can always slow it down. As I said, start with posture.
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    Aging is inevitable but you can always slow it down. As I said, start with posture.
Craftmatic Beds

The Perfect Bed for My Nana - 1 views

My grandnana always complain about waking up in the morning with muscle pains and backaches. She is already 86 years old and it pains me to hear that she is not having a good night sleep. So I deci...

craftmatic adjustable beds

started by Craftmatic Beds on 23 Nov 11 no follow-up yet
Day Spa Adelaide

A Gratifying Day Spa Experience - 1 views

All my friends were raving about this day spa in Blackwood Hills called Shantai. They do mas-sages, waxing, body treatments, facials, and lots of other day spa stuff. It is so great, you feel total...

started by Day Spa Adelaide on 20 Sep 12 no follow-up yet
felipp windsor

Thank You The Dental Co. - 1 views

I was deeply worried when I noticed that my 9 year-old daughter got some problems with her teeth. I then brought her to a nearby dentist, but I found out that she was not that capable of answering ...

started by felipp windsor on 30 Sep 13 no follow-up yet
wheelchairindia9

Tricycle For Disabled Children - 0 views

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    The tricycles are individually designed to meet the needs of each disabled child and help provide physiotherapy, build muscle tone and promote play. Italso help benefit growth and development in children with disabilities, enabling them to keep active and retain their independence. Disabled children get huge physical and emotional benefits from having the specially tricycles, which are each custom made to suit the individual child's needs. Riding a tricycle provides both fun and fitness, and is a therapeutic activity that allows children to exercise their lower extremities. As the muscles move through cycling motions, they are flexed, extended and stretched. This range of motion is crucial for children with disabilities, because muscles are incapable of keeping up with bone growth unless fully extended. Tricycles are provided to severely disabled children and adults and come in two sizes, 20 inch and 24 inch models. These trikes are grant funded and to qualify for one of these, an individual must suffer from a condition such as, but not limited to, Cerebral Palsy, Down Syndrome, Traumatic Brain Injury or Autism. Trunk support system is ideal for riders who have trouble remaining upright while seated. An optional headrest is available. A headrest can be purchased with either a flat or contoured headpiece, and adjusts both horizontally and vertically for optimum positioning. The Front Pulley System maintains a level pedal position for children whose extreme tone forces the front of the pedal downward. Turn the oval knob to raise and lower the handlebar. A handbrake for the conventional handlebar will arrive installed on Large tricycle. Open access combined with a low transfer step makes it easy to get on and off trikes. Tricycle Deluxe Double Hand Drive: Frame : Made by E.R.W. Tubes 38.0 mm-16 G. 25.4 mm & 22.22 mm- 18 G. Seat & Back : M S, C.R.C. Sheet. Seat Size 18"x 16" Wheel Size : Wheel Diameter 24"x 1 1/2" Tyre and Tube Standard Company. Pa
wheelchairindia9

Wheelchair 4 Wheel Drive - 0 views

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    A wheelchair is a wheeled mobility device in which the user sits. The device is propelled either manually (by turning the wheels by the hand) or via various automated systems. Wheelchairs are used by people for whom walking is difficult or impossible due to illness (physiological or physical), injury, or disability. The chair seat size (width and depth), seat-to-floor height, footrests/leg rests, front caster outriggers, adjustable backrests, controls, and many other features can be customized on, or added to, many basic models, while some users, often those with specialised needs, may have wheelchairs custom-built. The usual size of the rear wheel ranges from twenty to twenty-six inches in diameter. A larger wheel increases the height of the seat off the ground and decreases the rolling resistance, thus easing the effort of pushing. The rear wheels can be solid or pneumatic. Solid wheels have a low rolling resistance and are very easy to maintain. They are ideal for use in institutional settings or for indoor use in noncarpeted areas. Pneumatic wheels have better grip on carpeted surfaces and are better if there is going to be significant outdoor use, but they run the risk of flats and require higher maintenance. The flat tire problem can be circumvented by the use of a foam insert that can prevent leaks. Wire spokes are lighter in weight but higher in maintenance. Most older persons will select large plastic spokes referred to as mag wheels. The wheels can be offset posteriorly to decrease the risk of tipping backwards. Wheelchair With 4 Small Wheels: Wheelchair With 4 Small Wheels foldable frame wheelchair made of chrome with 18" inches seat width, 8" Inches Front and Rear wheel, total weight 14 kg helps physical challenged person to move around indoor. Wheelchair With 4 Small Wheels Measurements: Seat Width : 16 inch., 18 inch. Frame Style : Foldable Frame Material : M.S. Chrome open position wheel to wheel width in : 22" (inches) Seat Width : 1
wheelchairindia9

Wheelchair Detachable Wheels - 0 views

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    Wheelchairs is designed for those who prefer a removable armrest wheelchair. A removable armrest allows for easy patient transfer in and out of the chair.This chair is available in a different seat width and comes complete with swingaway footrests. It also incorporates solid rubber casters for a smooth and easy roll. Both detachable and flip-back arms are designed for easier lateral transfers. Most Wheelchairs in this category have Desk-Length arms, a shorter arm that allows rolling up to a desk or table. All are folding-frame chairs and are available in different seat widths. Detachable armrest for use in conjunction with wheelchairs. The armrest is comprised of a horizontal member supported at one end by a vertical member. The horizontal and vertical members are releasably attached to the wheelchair frame, and the attachment of the horizontal member to the wheelchair frame allows rotation of the horizontal member from the normal position to a position of non-use behind the back of the wheelchair. Wheelchairs - Arm Rests: The armrests support the arms and shoulders in comfortable positions and are often used to push off of for transferring from sitting to standing or held on to for balance. Desk-length armrests are shorter than standard length rests and are often chosen so that a person can pull up to a desk or table for easier access. The shorter length of these armrests is undesirable if the wheelchair user needs to use them to assist pushing into a standing position. In this case a full-length armrest would be preferred. Wheelchairs - Footrests: The footrest and legrest support protect the lower leg and feet. If they are too high they decrease the weight carried through the back of the thighs and can cause increased pressure over the buttock region. If they are two low they can cause pressure over the posterior thighs and cause problems with clearing barriers in the environment such as incline transitions. The suggested height of the footrest from th
wheelchairindia9

Karma 8020 Wheelchair - 0 views

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    Heavy duty wheelchair can either be manually-operated or motorized, each with its own pros and cons. A manual heavy-duty wheelchair gives full control of motion to the user, but the added weight from the reinforcements makes pushing or propelling the wheelchair much harder than normal. A motorized heavy duty wheelchair offers a solution to this dilemma, but is often more expensive and harder to maintain than a manual wheelchair. Some designs offer a combination of both, with a small motor assisting those pushing the wheelchair. The proper choice between types of Heavy Duty wheelchair depends largely on the user's expected level of activity. Heavy duty wheelchairs typically have larger seats than conventional wheelchairs. The frames of these wheelchairs can be made from several different reinforced metals, although a titanium wheelchair is often the most popular choice. The wheels themselves are made of thicker rubber than normal, preventing any possible failure due to the greater amount of weight supported. Most makes of heavy duty wheelchairs fold like regular wheelchairs, making storage relatively easy despite the wheelchair increased size. Heavy Duty Wheelchair specialy design for disabled and handicapped persons. They are two types of Heavy Duty Wheelchair for handicapped and disability product like- Karma 8020 X Heavy Duty Wheelchair Karma 8520 Heavy Duty Wheelchair Karma 8020 X Heavy Duty Wheelchair: It comes with detachable swing away footrests. The wheel chair has flip-back armrests. It comes with centre of gravity adjustment. The wheel chair has wide profile casters. Seat Size 20'' inch & 22'' inch Total Weight 17 K.G. Designed for maximum strength & weight capacity for people over 250 lbs. These end to be heavier and wider. This heavy duty bariatric wheelchair has seat dimensions of 24 inches wide by 18 inches deep to accommodate a weight capacity of up to 400 lbs. This wheelchair is dual axle, which means that the floor to seat heigh
Ciara Usher

Quality Bed that Contributes to Healthy Living - 1 views

I like my new Craftmatic bed! I am having a quality sleep every night because I am sleeping on my new Craftmatic bed. It really helps me every time my back sores. Its amazing adjustability allows m...

Craftmatic adjustable beds

started by Ciara Usher on 20 May 11 no follow-up yet
Ciara Usher

The Best Bed I Ever Had - 1 views

Craftmatic electric and adjustable bed is the best bed I have ever had! It only takes a second to fall asleep whenever I sleep on it. I like the massage because it eases my body after a tiring day...

Craftmatic adjustable beds

started by Ciara Usher on 20 May 11 no follow-up yet
Ciara Usher

My Craftmatic Bed Helped Me Sleep - 1 views

Funny thing, when I graduated from college and went straight to work, I started to have restless nights. At first, I thought it was because I kept on thinking of my work and the stress it carried. ...

Craftmatic

started by Ciara Usher on 27 Oct 11 no follow-up yet
Nathan Goodyear

Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2 | npj Precision Oncology - 0 views

  • Chen et al. have revealed that ascorbate at pharmacologic concentrations (0.3–20 mM) achieved only by intravenously (i.v.) administration selectively kills a variety of cancer cell lines in vitro, but has little cytotoxic effect on normal cells.
  • Ascorbic acid (the reduced form of vitamin C) is specifically transported into cells by sodium-dependent vitamin C transporters (SVCTs)
  • SVCT-1 is predominantly expressed in epithelial tissues
  • ...41 more annotations...
  • whereas the expression of SVCT-2 is ubiquitous
  • differential sensitivity to VC may result from variations in VC flow into cells, which is dependent on SVCT-2 expression.
  • high-dose VC significantly impaired both the tumorspheres initiation (Fig. 4d, e) and the growth of established tumorspheres derived from HCC cells (Fig. 4f, g) in a time-dependent and dose-dependent manner.
  • Hepatocellular carcinoma (HCC)
  • The antioxidant, N-acetyl-L-cysteine (NAC), preventing VC-induced ROS production (a ROS scavenger), completely restored the viability and colony formation among VC-treated cells
  • DNA double-strand damage was found following VC treatment
  • DNA damage was prevented by NAC
  • Interestingly, the combination of VC and cisplatin was even more effective in reducing tumor growth and weight
  • Consistent with the in vitro results, stemness-related genes expressions in tumor xenograft were remarkably reduced after VC or VC+cisplatin treatment, whereas conventional cisplatin therapy alone led to the increase of CSCs
  • VC is one of the numerous common hepatoprotectants.
  • Interestingly, at extracellular concentrations greater than 1 mM, VC induces strong cytotoxicity to cancer cells including liver cancer cells
  • we hypothesized that intravenous VC might reduce the risk of recurrence in HCC patients after curative liver resection.
  • Intriguingly, the 5-year disease-free survival (DFS) for patients who received intravenous VC was 24%, as opposed to 15% for no intravenous VC-treated patients
  • Median DFS time for VC users was 25.2 vs. 18 months for VC non-users
  • intravenous VC use is linked to improved DFS in HCC patients.
  • In this study, based on the elevated expression of SVCT-2, which is responsible for VC uptake, in liver CSCs, we revealed that clinically achievable concentrations of VC preferentially eradicated liver CSCs in vitro and in vivo
    • Nathan Goodyear
       
      the authors here made similar mistakes to the Mayo authors i.e. under doses here in this study.  They dosed at only 2 grams IVC.  A woefully low dose of IVC.
  • Additionally, we found that intravenous VC reduced the risk of post-surgical HCC progression in a retrospective cohort study.
    • Nathan Goodyear
       
      positive results despite a low dose used.
    • Nathan Goodyear
       
      Their comfort zone was 1mM.  They should have targeted 20-40 mM.
  • Three hundred thirty-nine participants (55.3%) received 2 g intravenous VC for 4 or more days after initial hepatectomy
  • As the key protein responsible for VC uptake in the liver, SVCT-2 played crucial roles in regulating the sensitivity to ascorbate-induced cytotoxicity
  • we also observed that SVCT-2 was highly expressed in human HCC samples and preferentially elevated in liver CSCs
  • SVCT-2 might serve as a potential CSC marker and therapeutic target in HCC
  • CSCs play critical roles in regulating tumor initiation, relapse, and chemoresistance
  • we revealed that VC treatment dramatically reduced the self-renewal ability, expression levels of CSC-associated genes, and percentages of CSCs in HCC, indicating that CSCs were more susceptible to VC-induced cell death
  • as a drug for eradicating CSCs, VC may represent a promising strategy for treatment of HCC, alone or particularly in combination with chemotherapeutic drugs
  • In HCC, we found that VC-generated ROS caused genotoxic stress (DNA damage) and metabolic stress (ATP depletion), which further activated the cyclin-dependent kinase inhibitor p21, leading to G2/M phase cell cycle arrest and caspase-dependent apoptosis in HCC cells
  • we demonstrated a synergistic effect of VC and chemotherapeutic drug cisplatin on killing HCC both in vitro and in vivo
  • Intravenous VC has also been reported to reduce chemotherapy-associated toxicity of carboplatin and paclitaxel in patients,38 but the specific mechanism needs further investigation
    • Nathan Goodyear
       
      so, exclude the benefit to patients until the exact mechanism of action, which will never be fully elicited?!?!?
  • Our retrospective cohort study also showed that intravenous VC use (2 g) was related to the improved DFS in HCC patients after initial hepatectomy
    • Nathan Goodyear
       
      Terribly inadequate dose.  Target is 20-40 mM which other studies have found occur with 50-75 grams of IVC.
  • several clinical trials of high-dose intravenous VC have been conducted in patients with advanced cancer and have revealed improved quality of life and prolonged OS
  • high-dose VC was not toxic to immune cells and major immune cell subpopulations in vivo
  • high recurrence rate and heterogeneity
  • tumor progression, metastasis, and chemotherapy-resistance
  • SVCT-2 was highly expressed in HCC samples in comparison to peri-tumor tissues
  • high expression (grade 2+/3+) of SVCT-2 was in agreement with poorer overall survival (OS) of HCC patients (Fig. 1c) and more aggressive tumor behavior
  • SVCT-2 is enriched in liver CSCs
  • these data suggest that SVCT-2 is preferentially expressed in liver CSCs and is required for the maintenance of liver CSCs.
  • pharmacologic concentrations of plasma VC higher than 0.3 mM are achievable only from i.v. administration
  • The viabilities of HCC cells were dramatically decreased after exposure to VC in dose-dependent manner
  • VC and cisplatin combination further caused cell apoptosis in tumor xenograft
  • These results verify that VC inhibits tumor growth in HCC PDX models and SVCT-2 expression level is associated with VC response
  • qPCR and IHC analysis demonstrated that expression levels of CSC-associated genes and percentages of CSCs in PDXs dramatically declined after VC treatment, confirming the inhibitory role of VC in liver CSCs
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    IV vitamin C in vitro and in vivo found to "preferentially" eradicate cancer stem cells.  In addition, IV vitamin C was found to be adjunctive to chemotherapy, found to be hepatoprotectant.  This study also looked at SVCT-2, which is the transport protein important in liver C uptake.
jasminegibbons

Posture and the Secret Behind that Corporate Success - 0 views

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    The best chair for posture commands respect. Strange enough, these chairs enable you to convey an aura of respectability because it allows you to display the kind of position that befits your personality, especially if you're a manager.
ashleyobama

Buy best painkillers online without prescripton . - 0 views

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    Finding some of the best pain killers can be a tricky task for many of us. You can also go to the internet and buy painkillers online. To make your life more comfortable, we provide you with a list of the best pain killers.
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