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indiacardiacsurg

The Bentall Procedure: Is the Gold Standard for Aortic Valve Disease - 101 Press Release - 0 views

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    With several years of experience in treating aortic defects and problems, the top hospitals in India offer the best service for a high Bentall surgery success rate. The Bentall surgery success rate is very high, and these surgeons have sent numerous successfully recovered happy patients home with total satisfaction.
spineneuro

Latest Gamma Knife Radiosurgery® Perfexion™ Installed for Non-invasive Treatm... - 0 views

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    The best gamma knife neurosurgeon in Delhi India now offers the latest Gamma knife radiosurgery ® technology for even greater precision to reduce or eliminate tumors or lesions in the brain without traditional surgery.
Nathan Goodyear

The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A... - 0 views

  • vitamins A, B, C, E, B6, B12, folate, zinc, iron, copper, and selenium
  • White blood cells, including neutrophils and monocytes, accumulate concentrations of vitamin C up to 100 times greater than that of plasma
  • Vitamin C is a crucial component of both the innate (nonspecific) and adaptive (specific) portions of the immune system
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  • play a role during the initial chemotactic response of neutrophils shortly after infection
  • following vitamin C supplementation, a 20% increase in neutrophil chemotactic activity was observed
  • also contributes to the phagocytosis and killing of microbes by neutrophils
  • low levels of vitamin C occurring in high-stress situations
  • maturation, proliferation, and viability of T cells have all been shown to be upregulated by the presence of normal physiologic concentrations of vitamin C
  • Vitamin C has been shown to directly affect the number of Igs released from B cells
  • vitamin C among healthy young adult males showed a significant increase in serum levels of IgA, IgG, and IgM
  • effects of high-dose vitamin C on cytokine levels in cancer patients, finding decreased amounts of the cytokines Interleukin-1 alpha (IL-1 alpha), IL-2, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after high-dose vitamin C infusion
  • when vitamin C was supplemented with vitamin E in healthy adults, it increased the production of cytokines IL-1 beta and TNF-alpha
  • vitamin C acts to modulate the levels of cytokines to prevent them from fluctuating in either direction
  • vitamin C also acts as an important antioxidant to the cells of the immune system.
  • human leukocytes, neutrophils, in particular, possess the ability to transport the oxidized form of vitamin C across its membrane to use as a defense mechanism against ROS produced during an immune response
  • Vitamin C also can recover other endogenous antioxidants in the body such as vitamin E and glutathione, returning them to their active state
  • vitamin C can decrease the activation of NF-kB
  • can reduce harmful nitrogen-based compounds such as N-nitrosamines and nitrosamides, both of which are carcinogenic 
  • subjects taking oral vitamin C supplementation saw a 60% to 90% reduction in oxidative stress compared to a placebo control
  • subjects infused with vitamin C alone had a 516% increase in glutathione levels compared to subjects not provided the 500 mg daily supplementation
  • hydroxylating proline and lysine
  • mature and stabilize the tissue of a healing wound
  • healing
  • oral surgery
  • improved soft tissue regeneration
  • vitamin C increases the mRNA levels of type I and type III collagen in the human dermis
  • Studies have demonstrated that those with low levels of vitamin C are at a significantly higher risk of respiratory infection compared to those with normal levels
  • viral cold duration was reduced by about 8% in adults and 13.5% in children using prophylactic daily doses of 200 mg of oral vitamin C
  • prophylactically supplementing vitamin C decreases the risk of infection with respiratory viruses such as the common cold
  • combined with probiotics, oral vitamin C supplementation showed a 33% decrease in the incidence of respiratory tract infections in preschool-age children [
  • high-dose oral supplementation of vitamin C managed to prevent or reduce symptoms if taken before or just after the onset of cold- or flu-like symptoms
  • improvements in oxygen saturation and decreased IL-6 levels (a marker of inflammation) in the treatment group compared to the control group
  • 8 g doses of oral vitamin C
  • there is a negative correlation between age and serum levels of vitamin C
  • Patients with COVID-19 will likely also experience depletion in serum levels of vitamin C as a direct result of the upregulation of the immune system to combat the infection
  • Colunga et al. suggested that oral vitamin C can be combined with oral Quercetin, an antiviral flavonoid, to improve Quercetin’s ability to block viral membrane fusion of SARS-CoV-2
  • high doses of 1-2 g/day of oral vitamin C could prevent other upper respiratory infections
  • It appears vitamin C supplementation by itself does not provide a striking benefit in preventing COVID-19 infection for those without a deficiency
    • Nathan Goodyear
       
      Flawed statement. What is normal? Vitamin D. Many variables effect levels and dose, including the two compartment kinetics and absorption.
  • Hiedra et al. were able to show decreases in inflammatory biomarkers, such as D-dimer and ferritin
  • some evidence to support that prophylactic use of vitamin C helps reduce the severity of respiratory infection symptoms once a subject has already been infected
  • oral vitamin C in combination with zinc provided the largest amount of antibody titers 42 days
  • linear relationship between days of vitamin C therapy and survival duration
  • other studies were unable to find any definitive improvement concerning therapy with vitamin C
    • Nathan Goodyear
       
      Either these studies are designed to fail or the authors are lacking some basic understanding of pharmacokinetics and pharmacodynamics with vitamin C.
  • Fowler et al. aimed to see if a high-dose vitamin C infusion would benefit patients affected by ARDS, but they were unable to conclude that vitamin C infusion, compared to a placebo, could decrease vascular inflammation and damage in ARDS
    • Nathan Goodyear
       
      At what dose, duration, frequency???
  • in a sample of 67 COVID-19-positive ICU patients, 82% of them displayed plasma vitamin C levels below 0.4 mg/dL
    • Nathan Goodyear
       
      They are kind of make the point from my earlier note.
  • continuous vitamin C infusion at a rate of 60 mg/kg/day for four days decreased the need for mechanical ventilation and vasopressor use but had no significant effect on overall mortality
    • Nathan Goodyear
       
      Again, designed to fail or ignorance designed the study which failed
  • Carr et al. suggested that high-dose IV vitamin C is most effective when treating sepsis as septic patients receiving the normal daily recommendations through diet still showed decreased vitamin C levels
  • High-dose IV vitamin C treatment has also been shown by Kakodkar et al. to decrease syndecan-1, an endothelial glycocalyx that contributes to mortality in septic patients
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • reduced overall mortality
  • reduced overall mortality
  • propose the use for high-dose vitamin C to aid in the treatment of septic shock-induced hypotension
  • treatment of severe sepsis using a high dose (up to 200 mg/kg/day) of IV vitamin C was explored in phase I, a double-blind, randomized, placebo-controlled trial by Fowler et al. [75]. Their findings included a reduction in SOFA scores and decreased vascular injury compared to a placebo control group, all while showing minimal adverse side effects
    • Nathan Goodyear
       
      High dose here is laughable. Again, duration and frequency also.
  • Maintaining a daily intake of 75 and 100 mg for men and women, respectively, as recommended by the U.S. Institute of Medicine
    • Nathan Goodyear
       
      This recommendation is FRANK IGNORANCE
Nathan Goodyear

Chemotherapy-induced release of circulating-tumor cells into the bloodstream in collect... - 0 views

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    CTCs increase by 60% after first dose of full dose chemotherapy
spineneuro

Embrace a Better Posture: Exploring VBT Surgery in India - 101 Press Release - 0 views

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    The top hospital for VBT surgery in India is centered on relieving the sufferers of their back pain and helping them get rid of their spine disorders. With the modern-day generation at the top hospital for VBT surgery in India, spinal fusion surgical procedure in India reports an accuracy of about eighty-ninety percent.
indiacardiacsurg

ICD Implant Procedure in India Make Your Heart Healthy - 101 Press Release - 0 views

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    Low-cost ICD implantation in India is no less than a boon for international patients, which provides them a possibility to get healed at a lower price rate than in their home country. One of the key benefits of choosing low-cost ICD implantation in India is the availability of superior quality care.
spineneuro

Flexible Spines, Stronger Lives: Vertebral Body Tethering Surgery in India - ... - 0 views

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    India is an ideal destination for Vertebral Body Tethering (VBT) surgery and other spine-related illnesses and ailments. The cost of VBT surgery India is one of the primary reasons why the country remains ahead of other countries as a top medical destination for spine surgery.
indiacardiacsurg

Dr. Rajiv Parakh Medanta Improving Surgical Strategies: PAD and Critical Limb Ischemia ... - 0 views

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    Almost 2 million people dwelling with limb loss in India. Amongst the ones residing with limb loss, the primary causes are vascular ailment (54%) - inclusive of diabetes and peripheral arterial disorder. nearly 185,000 amputations arise in India each year. Write to Doctor - dr.rajivparakh@indiacardiacsurgerysite.com Call for Appointment- +91-9370586696
spineneuro

Best Gamma Knife Neurosurgeon in Fortis Uses Next Generation Gamma Knife Technique - 10... - 0 views

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    More than 300,000 sufferers have obtained success rate of gamma knife radiosurgery in India. "History of innovation in radiosurgery started in 1987 whilst we installed first unit, which we've got used to treat more than 14,000 sufferers," said best gamma knife neurosurgeon in Fortis. Phone No.: +91-9325887033 Email: dr.sandeepvaishya@neurospinehospital.com
spineneuro

New PROTI 360° Family of Implants to Enhance Spinal Fusion Surgery India - 10... - 0 views

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    About 400,000 sufferers undergo spinal fusion surgery India annually to help lessen pain and nerve root infection in India alone. During this method, a disc is eliminated and an interbody spacer is implanted to doubtlessly restore natural height between two vertebrae and create solid bone. International Helpline Number : +91-9325887033 Email Id: enquiry@spineandneurosurgeryhospitalindia.com
spineneuro

First Augmented Reality in Spine Surgery By Dr. Vidyadhara S Manipal Hospital - 101 Pre... - 0 views

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    "I worry that many people are unnecessarily living in pain due to the fact they fear they may need a surgical operation, or due to the fact they've put off seeing a medical doctor during the COVID-19 pandemic," Best spine specialist Manipal Hospital Bangalore said.
spineneuro

Dr. Sandeep Vaishya India Offering the Nation's Leading Neurosurgery Programs - 101 Pre... - 0 views

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    Dr. Sandeep Vaishya India routinely sends their most complex surgical cases, knowing that there's no case we can't handle. Best neurosurgeons at Fortis Hospital Delhi, are guided by a simple philosophy: the patient always comes first.
spineneuro

Artificial Intelligence Expedites Brain Tumor Diagnosis during Brain Tumor Surgery in W... - 0 views

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    Before the new technology may be elevated to different centers and institutions, "robust testing with more patients and increasing the generation to include rare brain tumors are substantially needed," Top 10 brain tumor surgeons in world said.
spineneuro

Dr. Vipul Gupta for Stroke & Neurovascular Diseases - 101 Press Release - 0 views

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    The stroke program by Dr. Vipul Gupta brings collectively leading professionals in vascular neurology, neurosurgery, neurocritical care, neuro-interventional radiology, neuroradiology medicine that focus on diagnosing and treating people with disorders affecting vessels of the brain and spinal cord.
spineneuro

Dr. Sandeep Vaishya Fortis Gurgaon Bringing New Gamma Knife Icon Technology - 101 Press... - 0 views

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    Dr. Sandeep Vaishya Fortis Gurgaon is announcing today it will be the first in India to offer the new leksell gamma knife® icon™ stereotactic radiosurgery device. Gamma knife icon radiosurgery typically requires only a one-time treatment but may be used more than once for patients with brain metastases.
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