In most cancers, oncogenic driver mutations such as activation of K-ras, c-Myc and phosphatidylinositol-3 (PI3) kinase or loss of phosphatase and tensin homolog (Pten) and p53, not mutations that inactivate mitochondrial respiration complexes, promote glycolysis
The most important premise stemming from this bibliographical review is that patients with short PSADT should constitute a group in which hormonal therapy should be considered, while patients with long PSADT should be destined for salvage RT