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Phase III study finds that IV mistletoe reversed operative NK suppressio pointed to the increase NK effect of mistletoe.

Mistletoe Lectin 1 induced tumor regression in mouse xenograft study. Of note in this study, there was an increase in intratumoral dendrites found. In this xenograft study, it is suggested that mistletoe via Lectins 1 induced increased innate immunity in the local tumor microenvironment.

intratumoral + IV mistletoe found to be helpful in reduction in cancer cell proliferation.

Mistletoe induces apoptosis of lymphoblastic leukemic cells in in vivo study. Other studies have pointed to the increase NK activity as the primary mechanism

Study finds that mistletoe augments NK activity not via an increase in NK numbers.

Review on IV mistletoe

Review of mistletoe

Mistletoe lectins stimulate apoptosis

Mistletoe reduced ascites in case study

Iscador mistletoe effective in long-term treatment and remission of NHL.

Study finds IL-2 reduces cancer proliferation and metastasis; however, mistletoe alone found to stimulate proliferation, though at very low doses i.e. 1 ng/kg, in mouse model.

Mistletoe found to inhibit cancer cell proliferation and reduce chemo-resistance.

Mistletoe promotes apoptosis via p53 independent stimulation.

Mistletoe increases CD4:CD8 due to increase in Th1 but decrease in Treg; also increase in NK cells. Very important immunomodulatory effect.

Mistletoe for Fever induction therapy.

Intratumoral mistletoe injections reduces proliferation and increases apoptosis in breast cancer mouse model.

IV and Intratumoral mistletoe induced hypereosinophilia in pancreatic cancer case study.

Mistletoe increases dendritic cell activation.

Mistletoe increases maturation of dendritic cells.