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indian-health

Votre recherche de chirurgie dentaire abordable en Inde se termine parmi les 10 meilleu... - 0 views

frenchtoindiamedicatourisml.blogspot.com/...-dental-surgeons-of-india.html

Chirurgie Dentaire Inde Coût de la chirurgie dentaire en Inde Chirurgie dentaire à faible coût en Inde Les chirurgiens dentistes en Inde  Meilleur chirurgien dentiste de l'Inde Meilleur chirurgien dentiste en Inde Top 10 des chirurgiens dentistes de l'Ind

shared by indian-health on 12 Jan 22 - No Cached
  • indian-health on 12 Jan 22
     
    Les 10 meilleurs chirurgiens-dentistes de l'Inde sont expérimentés et bien équipés pour faire face à tout type d'urgence. sont un dentiste créatif, expert et un service de haute qualité avec d'excellents résultats. Lire la suite : https://frenchtoindiamedicatourisml.blogspot.com/2022/01/belgium-affordable-dental-surgery-india-ends-at-top-10-dental-surgeons-of-india.html Appelez-nous +91-9371136499 Écrivez-nous contact@indianhealthguru.com
indian-health

Les meilleures cliniques dentaires de New Delhi sont sûres, professionnelles,... - 0 views

frenchtoindiamedicatourisml.blogspot.com/...-dental-surgeons-in-delhi.html

Chirurgie dentaire Inde Les chirurgiens dentistes à Delhi Meilleurs chirurgiens dentistes de Delhi Meilleurs chirurgiens dentistes Delhi Les 14 meilleurs chirurgiens dentistes de Delhi Meilleures cliniques dentaires de New Delhi meilleurs hôpitaux pour la

shared by indian-health on 10 Sep 22 - No Cached
  • indian-health on 10 Sep 22
     
    Chaque année, des milliers de patients du monde entier se rendent à Delhi pour se faire soigner dans les meilleures cliniques dentaires de New Delhi.
indian-health

La chirurgie dentaire en Inde offre le traitement que vous désirez et méritez - 0 views

frenchtoindiamedicatourisml.blogspot.com/...gium-dental-surgery-india.html

Chirurgie dentaire Inde Les chirurgiens dentistes à Delhi Meilleurs chirurgiens dentistes de Delhi Meilleurs chirurgiens dentistes Delhi Les 14 meilleurs chirurgiens dentistes de Delhi Meilleures cliniques dentaires de New Delhi meilleurs hôpitaux pour la

shared by indian-health on 02 Jul 22 - No Cached
  • indian-health on 02 Jul 22
     
    Chaque année, des milliers de patients du monde entier se rendent en Inde pour se faire soigner dans les meilleures cliniques dentaires de New Delhi. Le personnel médical des meilleurs hôpitaux de chirurgie dentaire en Inde est très expérimenté dans le traitement de toutes les formes de cas dentaires
spineneuro

French to India Medical Travel: L'espoir ne connaît pas de limites : rencontr... - 0 views

frenchtoindiamedicaltravel.blogspot.com/...nter-with-dr-paresh-doshi.html

Meilleur neurochirurgien en stimulation cérébrale profonde Stimulation cérébrale profonde Dr Paresh Doshi

shared by spineneuro on 31 Oct 23 - No Cached
  • spineneuro on 31 Oct 23
     
    La réputation du meilleur neurochirurgien de stimulation cérébrale profonde en tant que neurochirurgien de premier plan spécialisé dans le DBS a encore renforcé la décision de M. Adeoluwa de se faire soigner en Inde.
Nathan Goodyear

Metabolic management of brain cancer - 0 views

www.sciencedirect.com/...S0005272810006857

brain cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
  • ...37 more annotations...
  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
  • Nathan Goodyear on 17 Jun 13
     
    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
beautesante

Allergie au printemps, petits gestes contre l'allergie au pollen - 0 views

aerobic-ex.blogspot.com/...u-printemps-petits-gestes.html

allergie printemps symptome traitement remede naturel yeux que faire au symptomes cutanée pollen

shared by beautesante on 20 Feb 17 - No Cached
  • beautesante on 20 Feb 17
     
    Picotements des yeux, éternuements ou maux de tête : le printemps n'est pas encore là, mais son lot d'allergies est déjà bien présent. En cause : les pollens.
Nathan Goodyear

Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16α-hydroxyestrone rati... - 0 views

www.ncbi.nlm.nih.gov/...PMC3039007

breast cancer 2-OH-estrone 2-OH 4-OH 2:16alpha-OHE1 2:16 estrogen metabolism

shared by Nathan Goodyear on 02 Jan 13 - No Cached
  • A recent study of nine patients concluded that the urinary EMR is a good approximation for breast tissue EMR
  • A single study in young women not using oral contraceptives found fair correlation coefficients between urinary and plasma EMR
  • All of nine properly designed epidemiological studies (six prospective case-control studies and three retrospective studies) failed to show a significant relationship between urinary or circulating EMR (2OHE1/16αOHE1) and breast cancer risk
  • ...2 more annotations...
  • premenopausal studies on urinary EMR have suggested a potentially weak inverse relationship, associations were not significantly different compared with postmenopausal or overall combined studies
  • at present, there is no evidence that the EMR can predict breast cancer risk
  • Nathan Goodyear on 02 Jan 13
     
    The 2:16 OH estrone pathway is shown to not be predictive biomarker for breast cancer.
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