Histamine dihydrochloride and low-dose interleukin-2 as post-consolidation im... - 0 views
www.academia.edu/...rapy_in_acute_myeloid_leukemia
AML leukemia acute myeloid leukemia IL-2 histamine cancer NK cells
shared by Nathan Goodyear on 31 May 18
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IL-2 is a central T cell-derived cytokine, which induces NK cell and T cell proliferation, differentiation and activation, and also stim-ulates the production of secondary immunostimulatory cytokines
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combination of histamine and IL-2 thus triggers efficient NK cell-mediated killing of several types of leukemic cells, including freshly recovered human AML blasts
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principal action of histamine is to protect cytotoxic lymphocytes from myeloid-cell-induced inactivation, thus improving the efficiency of the T and NK cell stimulation achieved by IL-2
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random-ized Phase II study of patients with renal cell carcinoma further support the suggestion that the combination of HDC and IL-2 improves lymphocyte functions
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HDC improves the effectiveness of IL-2-induced T and NK cell activation in cancer patients, as predicted in preclinical models