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Nathan Goodyear

Low-dose metronomic chemotherapy as an efficient treatment option in metastatic breast ... - 0 views

link.springer.com/...s10549-020-05711-5

MTD metastatic LDMC breast low-dose chemotherapy low-dose metronomic chemotherapy cancer) maximum tolerated chemotherapy

shared by Nathan Goodyear on 23 Feb 23 - No Cached
  • Nathan Goodyear on 23 Feb 23
     
    LDMC equal to out performing MTD in metastatic breast cancer.
Nathan Goodyear

Low-Dose Chemotherapy with Insulin (Insulin Potentiation Therapy) in Combination with H... - 0 views

www.ncbi.nlm.nih.gov/...PMC3357525

prostate cancer IPTLD low-dose chemotherapy cancer chemotherapy insulin potentiation therapy LDMC low-dose metronomic chemotherapy IPT

shared by Nathan Goodyear on 25 Jan 18 - No Cached
  • The method of insulin potentiation therapy was empirically invented in 1930 from Mexican doctor D. Perez Garsia
  • increases the permeability of cell membrane
  • influences the metabolic processes in human body with the increase of the regenerating processes
  • ...9 more annotations...
  • facilitates the transport of intra and extra cellular liquids which helps the organism to eliminate the toxic products
  • The increased number of insulin receptors on the tumor cell, in comparison to the normal one, allows the before mentioned 2 factors to act predominantly
  • Increased permeability after the insulin effect on the cellular membrane results in increased intracellular quantity of antitumor agents
  • have other endocrine effects: directly stimulates suprarenal gland to produce epinephrine and glucocorticoid hormones and stimulates ACTH secretion. These endocrine effects also have a positive influence on the regenerating processes
  • Insulin influences the intracellular metabolism of the tumor cell, which leads to increase of the number of cells in phase S, where they are with highly sensitive to specific chemotherapeutics.
  • After the first 6 IPT applications overall (groups A and B) response to treatment on PSA criteria shows partial effect and stabilization in 12 of 16 (75%) patients
  • After the 10th IPTLD application or 3 months after starting treatment, complete response, partial response, and stabilization were observed in 4 of 9 (66.6%), while in 3 of 9 (33.3%) was registered complete effect
  • the advanced stage of disease in patients treated
  • Quality of life after the second IPTLD application is significantly improved
  • Nathan Goodyear on 25 Jan 18
     
    IPT found to be effextive in treated castrate-resistant prostate cancer.
Nathan Goodyear

Topoisomerase I inhibitors: the relevance of prolonged exposure for present clinical de... - 0 views

www.nature.com/...bjc1997491

cancer metronomic chemotherapy low-dose chemotherapy

shared by Nathan Goodyear on 09 Nov 20 - No Cached
  • Nathan Goodyear on 09 Nov 20
     
    Metronomic dosing out performs maximum tolerated chemotherapy in in vitro study.
Nathan Goodyear

Long-term metronomic docetaxel chemotherapy for inoperative angiosarcoma of the scalp -... - 0 views

pubmed.ncbi.nlm.nih.gov/21352341

metronomic chemotherapy low-dose chemotherapy angiosarcoma cancer

shared by Nathan Goodyear on 13 Jan 21 - No Cached
  • Nathan Goodyear on 13 Jan 21
     
    Case study of long-term survival in angiosarcoma with metronomic chemotherapy.
Nathan Goodyear

The effect of whole-body hyperthermia combined with 'metronomic' chemotherapy on rat ma... - 0 views

pubmed.ncbi.nlm.nih.gov/12623634

hyperthermia metronomic chemotherapy low-dose chemotherapy

shared by Nathan Goodyear on 20 Feb 21 - No Cached
  • Nathan Goodyear on 20 Feb 21
     
    Animal study finds synergistic effects of hyperthermia, whole body, and metronomic chemotherapy after tumor removal to prevent metastasis.
Nathan Goodyear

Metronomic Chemotherapy for Metastatic Breast Cancer - a Systematic Review of the Liter... - 0 views

www.ncbi.nlm.nih.gov/...PMC4873299

metronomic chemotherapy low-dose chemotherapy cancer

shared by Nathan Goodyear on 03 Jul 20 - No Cached
  • Nathan Goodyear on 03 Jul 20
     
    Awesome read on the review of the effects of metronomic chemotherapy.
Nathan Goodyear

Metronomic chemotherapy - 0 views

www.ncbi.nlm.nih.gov/...PMC4156829

metronomic chemotherapy low-dose chemotherapy cancer

shared by Nathan Goodyear on 03 Jul 20 - No Cached
  • Nathan Goodyear on 03 Jul 20
     
    Great review of metronomic chemotherapy
Nathan Goodyear

Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience - 0 views

www.ncbi.nlm.nih.gov/...PMC6446118

cancer therapy HIF-1alpha metastasis CSC metronomic chemotherapy cancer stem cells cancer treatment VEGF angiogenesis

shared by Nathan Goodyear on 06 Aug 20 - No Cached
  • Nathan Goodyear on 06 Aug 20
     
    Awesome article on how metronomic, low-dose chemotherapy reduces angiogenesis via decrease in HIF-1alpha and VEGF. Many other effects.
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