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anonymous

Microbes as Guardians of the Earth - 1 views

Microbes go about as gatekeepers of our planet guaranteeing that minerals such as carbon and nitrogen, are continually reused. Despite the fact that the Earth presently populated with green plants,...

research in microbiology

started by anonymous on 08 Jan 15 no follow-up yet
Erich Feldmeier

uBiome -- Sequencing Your Microbiome | Indiegogo - 0 views

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    "uBiome is a citizen science project that allows the public access to cutting edge sequencing technology to understand their health through the microbiome. How does the microbiome affect my health? We are all covered in trillions of microbes -- in fact, they outnumber human cells 10:1. The trillions of bacteria live on and in us are collectively called the microbiome. Like the rainforest, the healthy human microbiome is a balanced ecosystem. The correct balance of microbes keeps potential pathogens in check and regulates our immune system. Microbes also perform essential functions such as digesting food and synthesizing vitamins. Studies have also linked the microbiome to human mood and behavior, as well as many gut disorders, eczema, and chronic sinusitis."
Erich Feldmeier

Gut Microbes May Foster Heart Disease | Wired Science | Wired.com - 0 views

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    ""We probably have underestimated the role our microbial flora play in modulating disease risk," says Daniel Rader, a heart disease specialist at the University of Pennsylvania School of Medicine. Rader, who was not involved in the study, says that gut bacteria may not be as big a factor in causing heart disease as diabetes or smoking, but could be important in tipping some people toward sickness. Researchers led by Stanley Hazen, a cardiologist at the Cleveland Clinic, didn't start out to study gut bacteria. In fact, says Hazen, he had "no clue - zero," that intestinal microbes were involved in heart disease. "I'd never even considered it or thought of the concept." Hazen and his colleagues compared blood plasma from healthy people to plasma from people who had had heart attacks, strokes or died to see if substances in the blood could predict who is in danger from heart disease. The researchers found 18 small molecules associated with fat buildup in the arteries. One of the best predictors turned out to be a byproduct made when gut bacteria break down a fat called choline (also known as lecithin). The more of this byproduct, called trimethylamine N-oxide or TMAO, a person or mouse has in the blood, the higher the risk of getting heart disease, the researchers found. Gut bacteria are actually middlemen in TMAO production. The microbes convert lecithin to a gas that smells like rotten fish. Then an enzyme in the liver changes the foul-smelling gas to TMAO."
Erich Feldmeier

Hachung Chung Species-Specific Microbes May Be Key to a Healthy Immune System: Scientif... - 0 views

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    "Mice have a jungle of bacteria, viruses and fungi in their stomachs-and so do we. These microorganisms help both mice and us break down dinner. As we are finding, these bugs also help to regulate the immune system. But we are just starting to learn how these tiny organisms influence us and how changing their composition changes us... Interestingly, though, the mice with these microbes did not: their immune systems remained underdeveloped. Even when researchers gave rat microbiota to mice, the mice's immune systems failed to mature"
anonymous

Pioneering Genetic Research With The Help Of Microbes - 0 views

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    Microbes are preferably suitable for joint biochemical as well as genetic research and studies and have been effective in providing evidence about the genetic code and the regulation of gene activity.
Erich Feldmeier

Stanley Hazen: Red Meat Clogs Arteries Because of Gut Bacteria: Scientific American - 0 views

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    "The results are published in Nature Medicine today. Co-author Stanley Hazen, head of cardiovascular medicine at the Cleveland Clinic in Ohio, says that the study could signal a new approach to diet and health. In some cases, an individual's collection of intestinal microbes may be as important to their diet as anything on a nutrition label, he says. "Bacteria make a whole slew of molecules from food," he says, "and those molecules can have a huge effect on our metabolic processes.""
Erich Feldmeier

Rob Dunn: Domestic Biomes: The Wild Life of Our Bodies and Homes | Your Wild Life - 0 views

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    " Moving Beyond Belly Button Biodiversity…we will study the species living with you on your body but also in the other biomes of YOUR household. If you want to know who is hiding in your refrigerator or mating in the pillow where you rest your head, we can help you. When you look beside you in bed, you notice no more than one animal (alternative lifestyles and cats notwithstanding). For nearly all of our history, our beds and lives were shared by multitudes. Live in a mud-walled hut in the Amazon, and bats will sleep above you, spiders beside you, the dog and cat not far away, and then there are the insects beating themselves stupid against the dwindling animal-fat flame. In addition, your gut would be filled with intestinal worms, your body (and nearly everything else) covered in multitudes of unnamed microbes, and your lungs occupied by a fungus uniquely your own."
Erich Feldmeier

@biogarage Jason Shear: 3D-Printed Bacteria May Unlock Secrets of Disease - 0 views

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    Bacteria are often social creatures. Suspended in colonies of varying shapes and sizes, these microbes communicate with their brethren and even other bacterial species - interactions that can sometimes make them more deadly or more resistant to antibiotics. Now, bacterial colonies sculpted into custom shapes by a 3-D printer could be a key to understanding how some antibiotic-resistant infections develop. The new technique uses methods similar to those employed by commercial 3-D printers, which extrude plastic, to create gelatin-based bacterial breeding grounds. These microbial condos can be carved into almost any three-dimensional shape, including pyramids and nested spheres.
anonymous

Introduction To Dna Fingerprinting - 1 views

We read and see a lot of news reports where the police seemed to have solved a murder case by the blood or hair strand left behind by the criminal. It is all possible thanks to DNA fingerprinting o...

DNA fingerprinting genetics research

started by anonymous on 06 Jan 15 no follow-up yet
anonymous

Mahendra Trivedi - Bacterial Identification Based on 16S rDNA - 0 views

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    Information about close homologs for the microbe can be found over the Trivedi Science website.
anonymous

Bacterial Identification By Mahendra Trivedi - 0 views

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    Get information about close homologs for the microbe at Trivedi Science website.
anonymous

The Vast Expanse Of Microbiology And Its Uses To Human Life - 1 views

Microbiology is the branch of science that deals with the study of micro-organisms that are either made up of single cells or cell clusters. Micro-organisms cannot be seen with the naked human eye ...

microbiological research in microbiology mahendra positive thinking medical trivedi science

started by anonymous on 20 Dec 14 no follow-up yet
Erich Feldmeier

Jessica Lee Green, BioBE, Biology & Built Environmet Center @jessicaleegreen - 0 views

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    We make decisions every day based on the visible world around us. Yet much of our lives is shaped by what we can't see. Jessica Green wants people to see the important role microbes, ecology and evolution play in every facet of our lives. "Touring a building with Jessica Green can be an unsettling experience. "We live nearly 90 percent of our lives indoors, but we know almost nothing about that environment.""
Skeptical Debunker

New study shows sepsis and pneumonia caused by hospital-acquired infections kill 48,000... - 1 views

  • This is the largest nationally representative study to date of the toll taken by sepsis and pneumonia, two conditions often caused by deadly microbes, including the antibiotic-resistant bacteria MRSA. Such infections can lead to longer hospital stays, serious complications and even death. "In many cases, these conditions could have been avoided with better infection control in hospitals," said Ramanan Laxminarayan, Ph.D., principal investigator for Extending the Cure, a project examining antibiotic resistance based at the Washington, D.C. think-tank Resources for the Future. "Infections that are acquired during the course of a hospital stay cost the United States a staggering amount in terms of lives lost and health care costs," he said. "Hospitals and other health care providers must act now to protect patients from this growing menace." Laxminarayan and his colleagues analyzed 69 million discharge records from hospitals in 40 states and identified two conditions caused by health care-associated infections: sepsis, a potentially lethal systemic response to infection and pneumonia, an infection of the lungs and respiratory tract. The researchers looked at infections that developed after hospitalization. They zeroed in on infections that are often preventable, like a serious bloodstream infection that occurs because of a lapse in sterile technique during surgery, and discovered that the cost of such infections can be quite high: For example, people who developed sepsis after surgery stayed in the hospital 11 days longer and the infections cost an extra $33,000 to treat per person. Even worse, the team found that nearly 20 percent of people who developed sepsis after surgery died as a result of the infection. "That's the tragedy of such cases," said Anup Malani, a study co-author, investigator at Extending the Cure, and professor at the University of Chicago. "In some cases, relatively healthy people check into the hospital for routine surgery. They develop sepsis because of a lapse in infection control—and they can die." The team also looked at pneumonia, an infection that can set in if a disease-causing microbe gets into the lungs—in some cases when a dirty ventilator tube is used. They found that people who developed pneumonia after surgery, which is also thought to be preventable, stayed in the hospital an extra 14 days. Such cases cost an extra $46,000 per person to treat. In 11 percent of the cases, the patient died as a result of the pneumonia infection.
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    Two common conditions caused by hospital-acquired infections (HAIs) killed 48,000 people and ramped up health care costs by $8.1 billion in 2006 alone, according to a study released today in the Archives of Internal Medicine.
Skeptical Debunker

Human cells exhibit foraging behavior like amoebae and bacteria - 0 views

  • "As far as we can tell, this is the first time this type of behavior has been reported in cells that are part of a larger organism," says Peter T. Cummings, John R. Hall Professor of Chemical Engineering, who directed the study that is described in the March 10 issue of the Public Library of Science journal PLoS ONE. The discovery was the unanticipated result of a study the Cummings group conducted to test the hypothesis that the freedom with which different cancer cells move - a concept called motility - could be correlated with their aggressiveness: That is, the faster a given type of cancer cell can move through the body the more aggressive it is. "Our results refute that hypothesis—the correlation between motility and aggressiveness that we found among three different types of cancer cells was very weak," Cummings says. "In the process, however, we began noticing that the cell movements were unexpectedly complicated." Then the researchers' interest was piqued by a paper that appeared in the February 2008 issue of the journal Nature titled, "Scaling laws of marine predator search behaviour." The paper contained an analysis of the movements of a variety of radio-tagged marine predators, including sharks, sea turtles and penguins. The authors found that the predators used a foraging strategy very close to a specialized random walk pattern, called a Lévy walk, an optimal method for searching complex landscapes. At the end of the paper's abstract they wrote, "...Lévy-like behaviour seems to be widespread among diverse organisms, from microbes to humans, as a 'rule' that evolved in response to patchy resource distributions." This gave Cummings and his colleagues a new perspective on the cell movements that they were observing in the microscope. They adopted the basic assumption that when mammalian cells migrate they face problems, such as efficiently finding randomly distributed targets like nutrients and growth factors, that are analogous to those faced by single-celled organisms foraging for food. With this perspective in mind, Alka Potdar, now a post-doctoral fellow at Case Western Reserve University and the Cleveland Clinic, cultured cells from three human mammary epithelial cell lines on two-dimensional plastic plates and tracked the cell motions for two-hour periods in a "random migration" environment free of any directional chemical signals. Epithelial cells are found throughout the body lining organs and covering external surfaces. They move relatively slowly, at about a micron per minute which corresponds to two thousandths of an inch per hour. When Potdar carefully analyzed these cell movements, she found that they all followed the same pattern. However, it was not the Lévy walk that they expected, but a closely related search pattern called a bimodal correlated random walk (BCRW). This is a two-phase movement: a run phase in which the cell travels primarily in one direction and a re-orientation phase in which it stays in place and reorganizes itself internally to move in a new direction. In subsequent studies, currently in press, the researchers have found that several other cell types (social amoeba, neutrophils, fibrosarcoma) also follow the same pattern in random migration conditions. They have also found that the cells continue to follow this same basic pattern when a directional chemical signal is added, but the length of their runs are varied and the range of directions they follow are narrowed giving them a net movement in the direction indicated by the signal.
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    When cells move about in the body, they follow a complex pattern similar to that which amoebae and bacteria use when searching for food, a team of Vanderbilt researchers have found. The discovery has a practical value for drug development: Incorporating this basic behavior into computer simulations of biological processes that involve cell migration, such as embryo development, bone remodeling, wound healing, infection and tumor growth, should improve the accuracy with which these models can predict the effectiveness of untested therapies for related disorders, the researchers say.
anonymous

Pseudomonas Aeruginosa Treated with the Trivedi Effect - 0 views

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    Bacterial Identification Service based on 16S rDNA data. Treated Pseudomonas Aeruginosa experiment and research based on Trivedi Effect.
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