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"explains how nitric oxide, a signaling molecule involved in the immune system, leads to biofilm formation. "It is estimated that about 80 percent of human pathogens form biofilms during some part of their life cycle," said Scripps Research president and CEO Michael Marletta, PhD, who led the work."

Mind Lab. How is our consciousness connected to the world? Explore the unconscious functions of the brain with visual illusions and mysterious perceptual phenomena.

"For this study, the investigators bred mice lacking TRPV4 or administered a drug to deactivate it. In the absence of TRPV4, white cells turned on a set of genes that consume energy to produce heat, rather than storing the energy as excess fat. This "thermogenic" process normally occurs in brown or beige fat (commonly called "good fat"), which is found mostly in small animals and human infants to protect against cold. When the TRPV4-deficient mice were put on a high-calorie diet for several weeks, they did not become obese, and their level of fat cell inflammation and insulin resistance was lowered. "We have identified a target that, when inhibited, can activate beige adipose tissue and suppress inflammation," said Spiegelman."

Our genetic code is translated by two super-families of modern-day enzymes. Carter's research team created and superimposed digital three-dimensional versions of the two super-families to see how their structures aligned. Carter found that all the enzymes have virtually identical cores that can be extracted to produce "molecular fossils" he calls Urzymes-Ur meaning earliest or original. The other parts, he said, are variations that were introduced later, as evolution unfolded. These two Urzymes are as close as scientists have gotten to the actual ancient enzymes that would have populated the Earth billions of years ago.

"CYBERTHREAT REAL-TIME MAP"

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