Genomes aren't orderly and neat; they're exceedingly messy and complex, filled with "noise" from which subtle signals are difficult to filter. A disease can arise from one or two mutations, or from the cumulative action of hundreds. This means finding genome mutations responsible for diseases is both incredibly difficult and also often fruitless: The variation in individual genomes is so large that nearly every single potential disease-causing mutation typically turns out to be benign.
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