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The heart drug digoxin, the blood thinner warfarin, the painkiller codeine and prednisone are considered mild anticholinergics. Those with the most severe effects include Paxil, Benadryl, a drug for overactive bladder called oxybutynin, and the schizophrenia drug clozapine.

It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their "immortality". The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe.

Harvard researchers have created nanodevices made of DNA that self-assemble and can be programmed to move and change shape on demand. The nanodevice structure is based on the principle of tensegrity: its strength and stability results from the way it distributes and balances the counteracting forces of tension and compression. This new technology could lead to nanoscale medical devices and drug delivery systems, such as virus mimics that introduce drugs directly into diseased cells. Or it could one day be used to reprogram human stem cells to regenerate different kinds of injured organs and tissue.

Imagine, Michael Chorost proposes, that four police officers on a drug raid are connected mentally in a way that allows them to sense what their colleagues are seeing and feeling. Tony Vittorio, the captain, is in the center room of the three-room drug den. He can sense that his partner Wilson, in the room on his left, is not feeling danger or arousal and thus has encountered no one. But suddenly Vittorio feels a distant thump on his chest. Sarsen, in the room on the right, has been hit with something, possibly a bullet fired from a gun with a silencer. Vittorio glimpses a flickering image of a metallic barrel pointed at Sarsen, who is projecting overwhelming shock and alarm. By deducing how far Sarsen might have gone into the room and where the gunman is likely to be standing, Vittorio fires shots into the wall that will, at the very least, distract the gunman and allow Sarsen to shoot back. Sarsen is saved; the gunman is dead. That scene, from his new book, "World Wide Mind," is an example of what Mr. Chorost sees as "the coming integration of humanity, machines, and the Internet." The prediction is conceptually feasible, he tells us, something that technology does not yet permit but that breaks no known physical laws.

The device could diagnose disease in the developing world and enable rapid drug screening.

Drug-resistant bacteria kills, even in top hospitals. But now tough infections like staph and anthrax may be in for a surprise. Nobel-winning chemist Kary Mullis, who watched a friend die when powerful antibiotics failed, unveils a radical new cure that shows extraordinary promise.

ScienceDaily (Dec. 3, 2010) - Will we one day design and create molecules, cells and microorganisms that produce specific chemical products from simple, readily-available, inexpensive starting materials? Will the synthetic organic chemistry now used to produce pharmaceutical drugs, plastics and a host of other products eventually be surpassed by metabolic engineering as the mainstay of our chemical industries? Yes, according to Jay Keasling, chemical engineer and one of the world's foremost practitioners of metabolic engineering.

Willerth and her team studied approximately 15,000 different versions of the virus-something that has never been done before. This information has allowed them to locate the specific genes of the virus that were resistant to the drugs-knowledge that could ultimately help researchers develop more effective treatments for HIV.

On July 29th, returning from a trip to Europe, Jacob Appelbaum, a lanky, unassuming 27-year-old wearing a black T-shirt with the slogan "Be the trouble you want to see in the world," was detained at customs by a posse of federal agents. In an interrogation room at Newark Liberty airport, he was grilled about his role in Wikileaks, the whistle-blower group that has exposed the government's most closely guarded intelligence reports about the war in Afghanistan. The agents photocopied his receipts, seized three of his cellphones - he owns more than a dozen - and confiscated his computer. They informed him that he was under government surveillance. They questioned him about the trove of 91,000 classified military documents that Wikileaks had released the week before, a leak that Vietnam-era activist Daniel Ellsberg called "the largest unauthorized disclosure since the Pentagon Papers." They demanded to know where Julian Assange, the founder of Wikileaks, was hiding. They pressed him on his opinions about the wars in Afghanistan and Iraq. Appelbaum refused to answer. Finally, after three hours, he was released. Sex, Drugs, and the Biggest Cybercrime of All Time Appelbaum is the only known American member of Wikileaks and the leading evangelist for the software program that helped make the leak possible. In a sense, he's a bizarro version of Mark Zuckerberg: If Facebook's ambition is to "make the world more open and connected," Appelbaum has dedicated his life to fighting for anonymity and privacy. An anarchist street kid raised by a heroin- addict father, he dropped out of high school, taught himself the intricacies of code and developed a healthy paranoia along the way. "I don't want to live in a world where everyone is watched all the time," he says. "I want to be left alone as much as possible. I don't want a data trail to tell a story that isn't true." We have transferred our most intimate and personal information - our bank accounts, e-mails, photographs, ph

"What, if anything, is the world trying to tell us? On some level it seems that things are getting harder - it is tougher to be a dominant player in sports given global talent pools, better training, more mimicry, etc. Similarly, science in many important areas does seem stalled, with progress proceeding glacially, whether it is drug discovery, or fundamental physics, or energy."

A 36-year-old man has received the world's first synthetic trachea, made from a synthetic scaffold seeded with his own stem cells, in an operation at the Karolinska University Hospital in Stockholm, Sweden. Professor Paolo Macchiarini of Karolinska University Hospital and Karolinska Institutet led an international team, including professor Alexander Seifalian from University College London, who designed and built the nanocomposite tracheal scaffold, and Harvard Bioscience, which produced a specifically designed bioreactor used to seed the scaffold with the patient´s own stem cells. The cells were grown on the scaffold inside the bioreactor for two days before transplantation to the patient. Because the cells used to regenerate the trachea were the patient's own, there has been no rejection of the transplant and the patient is not taking immunosuppressive drugs. "The big conceptual breakthrough is that we can move from transplanting organs to manufacturing them for patients," says David Green, the president of Harvard Bioscience in Holliston, Massachusetts. Transplantations of tissue-engineered windpipes with synthetic scaffolds in combination with the patient's own stem cells as a standard procedure means that patients will not have to wait for a suitable donor organ. Patients could benefit from earlier surgery and have a greater chance of cure. This would be of especially great value for children, since the availability of donor tracheas is much lower than for adult patients.

Vera Gorbunova and Andrei Seluanov of the University of Rochester have found that human cells undergoing oxidative stress caused by environmental chemicals or routine cellular processes produce a protein (SIRT6) that stimulates cells to repair DNA double-strand breaks, thought to be associated with premature aging and cancer. The team first measured levels of SIRT6 in stressed cells, then treated a second group of stressed cells with a drug that deactivates the protein. DNA repair in the second group stopped, confirming SIRT6′s role.  The team also found that SIRT6 acts in concert with another protein, called PARP1, to make the repairs. Furthermore, the team found that increased levels of SIRT6 lead to faster DNA repair. They suspect that the protein acts as a "master regulator," coordinating stress and DNA repair activities. Ref.: Zhiyong Mao, Christopher Hine, Xiao Tian, Michael Van Meter, Matthew Au, Amita Vaidya, Andrei Seluanov, and Vera Gorbunova. SIRT6 Promotes DNA Repair Under Stress by Activating PARP1. Science 17 June 2011: 1443-1446. [DOI:10.1126/science.1202723]