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For all of its wild popularity, caffeine is one seriously misunderstood substance. It's not a simple upper, and it works differently on different people with different tolerances-even in different menstrual cycles. But you can make it work better for you.

A new study suggests that a single dose of psilocybin -- the active ingredient in "Magic Mushrooms" -- can result in improved personality traits over the long term. Researchers at the Johns Hopkins University School of Medicine found that individuals who received the drug once in a clinical setting reported a greater sense of "openness" that often lasted 14 months or longer, according to study published this week in the Journal of Psychopharmacology. The study defined openness as a personality trait that "encompasses aesthetic appreciation and sensitivity, imagination and fantasy, and broad-minded tolerance of others' viewpoints and values." It is one of five main personality traits that are shared among all cultures worldwide. Of the 51 participants, 30 had personality changes that left them feeling more open. Other personality traits (extroversion, neuroticism, agreeableness and conscientiousness) were not impacted. Only the participants who said they had a "complete mystical experience" while on the drug registered an increased sense of openness. "The mystical experience has certain qualities," lead author Katherine MacLean said. "The primary one is that you feel a certain kind of connectedness and unity with everything and everyone." Because personality traits are generally considered to remain stable throughout a persons lifetime, researchers are excited about therapeutic implications of the study. "[T]his study shows that psilocybin actually changes one domain of personality that is strongly related to traits such as imagination, feeling, abstract ideas and aesthetics, and is considered a core construct underlying creativity in general," study author Roland R. Griffiths told USA Today. "And the changes we see appear to be long-term."     

Everything we do is for the purpose of altering consciousness. We form friendships so that we can feel certain emotions, like love, and avoid others, like loneliness. We eat specific foods to enjoy their fleeting presence on our tongues. We read for the pleasure of thinking another person's thoughts. Every waking moment-and even in our dreams-we struggle to direct the flow of sensation, emotion, and cognition toward states of consciousness that we value.Drugs are another means toward this end. Some are illegal; some are stigmatized; some are dangerous-though, perversely, these sets only partially intersect. There are drugs of extraordinary power and utility, like psilocybin (the active compound in "magic mushrooms") and lysergic acid diethylamide (LSD), which pose no apparent risk of addiction and are physically well-tolerated, and yet one can still be sent to prison for their use-while drugs like tobacco and alcohol, which have ruined countless lives, are enjoyed ad libitum in almost every society on earth. There are other points on this continuum-3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") has remarkable therapeutic potential, but it is also susceptible to abuse, and it appears to be neurotoxic.[1]One of the great responsibilities we have as a society is to educate ourselves, along with the next generation, about which substances are worth ingesting, and for what purpose, and which are not. The problem, however, is that we refer to all biologically active compounds by a single term-"drugs"-and this makes it nearly impossible to have an intelligent discussion about the psychological, medical, ethical, and legal issues surrounding their use. The poverty of our language has been only slightly eased by the introduction of terms like "psychedelics" to differentiate certain visionary compounds, which can produce extraordinary states of ecstasy and insight, from "narcotics" and other classic agents of stupefaction and abuse.