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Dennis OConnor

Antibodies and coronavirus immunity: everything we know. - 0 views

slate.com/...dies-immunity-coronavirus.html

covid testing research

shared by Dennis OConnor on 16 Apr 20 - No Cached
  • Antibodies will probably be key to getting us out of this—in one way or another. By Shannon Palus
  • one promising solution is the idea of antibodies and antibody tests.
  • as with everything about the virus, it’s not yet clear what role antibody tests will be able to play in getting us out of this, and it’s even not completely clear how much getting the coronavirus once prevents you from getting it again
  • ...16 more annotations...
  • What is an antibody?
  • How do I get the anti-coronavirus antibodies?
  • The most basic (and worst) way to get the antibodies is to get the coronavirus.
  • So once you have the antibodies, you are immune against the virus?
  • We can’t count on immunity right now.
  • Wait, but aren’t there people out there who have gotten the novel coronavirus twice, within a short period of time?
  • So if I’ve been sick with COVID-19 already, should I assume I’m immune, or not?
  • OK. Let’s get to the tests. What’s the deal?
  • The fantasy of antibody tests is that they might be deployed to help us determine who can go back to work and school and normal social gatherings.
  • That sounds very promising!
  • even though the tests can provide a guess at immunity, even a positive result cannot guarantee anything.
  • So what are antibody tests actually good for right now?
  • They are tools to gather more data.
  • This is why the National Institutes of Health is currently recruiting 10,000 volunteers to take antibody tests.
  • There’s one clear way that they could help right now on an individual level: We’ve all been asked to basically assume we have the coronavirus; an antibody test could help clarify our own narratives.
  • If you test positive, you can also apply to donate plasma.
  • Dennis OConnor on 16 Apr 20
     
    Recommended by Dr. Michael Kurisu D.O. 4/15/2020 Good summary. Not scientific or too detailed but good overall big picture view
Dennis OConnor

Apple and Google have a clever way of encouraging people to install contact-tracing app... - 0 views

www.theverge.com/...s-pros-cons-quarantine-testing

data tracking covid

shared by Dennis OConnor on 14 Apr 20 - No Cached
  • Apple and Google surprised us with an announcement that the companies are spinning up a system to enable widespread contact tracing in an effort to contain the COVID-19 pandemic.
  • The basic idea is that as jurisdictions flatten the curve of infection and begin to consider re-opening parts of society, they need to implement a comprehensive “test and trace” scheme.
  • First, the companies said that by phase two of their effort, when contact tracing is enabled at the level of the operating system, they will notify people who have opted in to their potential exposure to COVID-19 even if they have not downloaded the relevant app from their public health authority.
  • ...4 more annotations...
  • Singapore saw only 12 percent adoption of its national contact-tracing app. Putting notifications at the system level represents a major step forward for this effort, even if still requires people to opt in.
  • Google said it would distribute the operating system update through Google Play services, a part of Android controlled by the company that allows it to reach the majority of active devices.
  • Apple and Google said they recognized the importance of not allowing people to trigger alerts based on unverified claims of a COVID-19 infection. Instead, they said, people who are diagnosed will be given a one-time code by the public health agency, which the newly diagnosed will have to enter to trigger the alert.
  • the companies promised to use the system only for contact tracing, and to dismantle the network when it becomes appropriate.
Dennis OConnor

Free Webinar: How to Be a Statistical Detective - 0 views

learn.stanford.edu/D-Registration-2020-02-11.html

data webinar

shared by Dennis OConnor on 10 Apr 20 - No Cached
  • Dennis OConnor on 10 Apr 20
     
    This is an on-demand webinar. "Statistical errors are all too common in medical literature, and contribute to the reproducibility crisis currently plaguing science. Fortunately, you don't need a degree in statistics to catch these errors. While some errors are impossible to spot without access to the underlying dataset, many are detectable just by reviewing the information available in the paper. In many cases nothing more than common sense and simple arithmetic is required. In addition, there is an ever-increasing number of free, easy-to-use online statistical tools that facilitate error detection."
Dennis OConnor

Recommended Twitter Feeds for Expert Advice on Science and Medicine - 1 views

21cif.blogspot.com/...-twitter-feeds-for-expert.html

twitter

shared by Dennis OConnor on 31 Mar 20 - No Cached
  • Dennis OConnor on 31 Mar 20
     
    Recommended by DeAunne Denmark, MD, PhD & Meg Sweeney
Dennis OConnor

What This Chart Actually Means for COVID-19 - YouTube - 0 views

www.youtube.com/watch

covid

shared by Dennis OConnor on 29 Mar 20 - No Cached
  • Dennis OConnor on 29 Mar 20
     
    Recommended by Sharon Wampler
Dennis OConnor

Up-to-Date Coronavirus (SARS-CoV-2 / COVID-19) Information - Peter Attia MD - 0 views

peterattiamd.com/covid-19

covid research testing

shared by Dennis OConnor on 21 Mar 20 - No Cached
  • Currently, my entire clinical and research team are working on trying to make sense of the SARS-CoV-2 / COVID-19 pandemic.
  • We’re constantly in contact with leading experts and doctors working on this issue around the world,
  • We will tell you what we know, when we know it, and what we don’t know.
  • ...1 more annotation...
  • Information will continue to be passed through podcasts, patient memos, and videos.
  • Dennis OConnor on 21 Mar 20
     
    Recommended by Vicky Newman & Erin Raskin
Dennis OConnor

How to Protect Yourself from COVID-19: Supporting Your Immune System When You May Need ... - 0 views

drhyman.com/...protect-yourself-from-covid-19

covid research immune-system

shared by Dennis OConnor on 21 Mar 20 - No Cached
  • How Can I Protect Myself, My Family, and My Community
  • How to Avoid Infection with COVID-19 
  • How to Support Your Immune System: Remember, Let Food Be Your Medicine! 
  • ...1 more annotation...
  • How to Supplement for Immune Function 
  • Dennis OConnor on 21 Mar 20
     
    Recommended by Erin Raskin, DACM, L.Ac
Dennis OConnor

Anthony S. Fauci, M.D., NIAID Director | NIH: National Institute of Allergy and Infecti... - 0 views

www.niaid.nih.gov/director

covid research reliable-sources

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • Dr. Fauci was appointed Director of NIAID in 1984.
  • Dr. Fauci has advised six Presidents on HIV/AIDS and many other domestic and global health issues.
  • Dennis OConnor on 20 Mar 20
     
    DeAunne Denmark, MD, PhD - Recommends Dr. Anthony Fauci as a highly credible source of information.
Dennis OConnor

Integrative Considerations during the COVID 3.18.20.pdf - 1 views

covid Integrative-spaces

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • Dennis OConnor on 20 Mar 20
     
    Recommended by Dr. Michael Kurisu D.O.: There is a high level of interest in integrative strategies to augment public health measures to prevent COVID-19 infection and associated pneumonia. Unfortunately, no integrative measures have been validated in human trials. Notwithstanding, this is an opportune time to be proactive. Using available in-vitro evidence, an understanding of the virulence of COVID-19, as well as data from similar, but different, viruses, we offer the following strategies to consider. Again, we stress that these are supplemental considerations to the current recommendations that emphasize regular hand washing, social distancing, stopping non-essential travel, and getting tested if you develop symptoms.
Dennis OConnor

Exporting Your Data with Oura on the Web - Oura Help - 0 views

support.ouraring.com/...ownloading-Your-Data-from-Oura

oura data data visualization

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • Dennis OConnor on 20 Mar 20
     
    Here is how you login to Oura to see your data: https://cloud.ouraring.com/account/login
Dennis OConnor

This Is How We Beat the Coronavirus - The Atlantic - 1 views

www.theatlantic.com/...608389

covid testing research

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • We’re closing schools and businesses and committing to social (really, physical) distancing. But as the sobering charts from the analysis show, this isn’t enough.
  • Asian countries have engaged in suppression; we are only engaging in mitigation.
  • At the moment, we can’t even test everyone who is sick.
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  • Testing will allow us to isolate the infected so they can’t infect others. We need to be vigilant, and willing to quarantine people with absolute diligence.
  • To achieve this, we need to test many, many people, even those without symptoms.
  • buried in the Imperial College report is reason for optimism. The analysis finds that in the do-nothing scenario, many people die and die quickly. With serious mitigation, though, many of the measures we’re taking now slow things down. By the summer, the report calculates, the number of people who become sick will eventually reduce to a trickle.
  • Our efforts are good, temporizing measures.
  • Social distancing cannot prevent these infections, as they’ve already happened. Therefore, things will appear to get worse for some time, even if what we’re doing is making things better in the long run.
  • Our primary approach is social distancing—asking people to stay away from one another.
  • We can create a third path. We can decide to meet this challenge head-on. It is absolutely within our capacity to do so. We could develop tests that are fast, reliable, and ubiquitous. If we screen everyone, and do so regularly, we can let most people return to a more normal life. We can reopen schools and places where people gather. If we can be assured that the people who congregate aren’t infectious, they can socialize.
  • We can build health-care facilities that do rapid screening and care for people who are infected, apart from those who are not.
  • We can even commit to housing infected people apart from their healthy family members, to prevent transmission in households.
  • We will need to massively strengthen our medical infrastructure. We will need to build ventilators and add hospital beds. We will need to train and redistribute physicians, nurses, and respiratory therapists to where they are most needed. We will need to focus our factories on turning out the protective equipment—masks, gloves, gowns, and so forth—to ensure we keep our health-care workforce safe.
  • most importantly, we need to pour vast sums of intellectual and financial resources into developing a vaccine that would finally bring this nightmare to a close
  • If we commit to social distancing, however, at some point in the next few months the rate of spread will slow. We’ll be able to catch our breath. We’ll be able to ease restrictions, as some early hit countries are doing. We can move toward some semblance of normalcy.
  • The temptation then will be to think we have made it past the worst. We cannot give in to that temptation. That will be the time to redouble our efforts. We will need to prepare for the coming storm. We’ll need to build up our stockpiles, create strategies, and get ready.
  • We need to keep time on the clock, time to find a treatment or a vaccine.
  • We all have a choice to make. We can look at the coming fire and let it burn. We can hunker down, and hope to wait it out—or we can work together to get through it with as little damage as possible.
Dennis OConnor

In the Footsteps of Thich Nhat Hanh Online Summit - 0 views

promo.lionsroar.com/t-thich-nhat-hanh-aff-00urvpxn

mindfulness

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • Cultivate joy and transform suffering with wisdom from leading teachers in the Plum Village tradition of mindfulness, compassion, and peace.
  • Discover the beauty and brilliance of Thich Nhat Hanh’s wisdom with guidance from some of those who know him best. Join 9 incredible teachers from his lineage as they offer intimate insights inspired by his most powerful teachings.
  • “We have more possibilities available in each moment than we realize.”~ Thich Nhat Hanh
  • Dennis OConnor on 20 Mar 20
     
    Recommended by Erin Raskin: Free Online Event - March 25-26, 2020
Dennis OConnor

A serological assay to detect SARS-CoV-2 seroconversion in humans | medRxiv - 0 views

www.medrxiv.org/...2020.03.17.20037713v1

covid research testing

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • While molecular assays to directly detect the viral genetic material are available for the diagnosis of acute infection, we currently lack serological assays suitable to specifically detect SARS-CoV-2 antibodies.
  • Methods: Here we describe serological enzyme-linked immunosorbent assays (ELISA) that we developed using recombinant antigens derived from the spike protein of SARS-CoV-2.
  • Conclusion: Serological assays are of critical importance to determine seroprevalence in a given population, define previous exposure and identify highly reactive human donors for the generation of convalescent serum as therapeutic.
  • Dennis OConnor on 20 Mar 20
     
    Recommended by DeAunne Denmark, MD, PhD: This study is under peer review. Published via the medRxiv preprint server for health sciences.
Dennis OConnor

Substantial undocumented infection facilitates the rapid dissemination of novel coronav... - 0 views

science.sciencemag.org/...science.abb3221

covid research testing

shared by Dennis OConnor on 21 Mar 20 - No Cached
  • AbstractEstimation of the prevalence and contagiousness of undocumented novel coronavirus (SARS-CoV2) infections is critical for understanding the overall prevalence and pandemic potential of this disease. Here we use observations of reported infection within China, in conjunction with mobility data, a networked dynamic metapopulation model and Bayesian inference, to infer critical epidemiological characteristics associated with SARS-CoV2, including the fraction of undocumented infections and their contagiousness. We estimate 86% of all infections were undocumented (95% CI: [82%–90%]) prior to 23 January 2020 travel restrictions. Per person, the transmission rate of undocumented infections was 55% of documented infections ([46%–62%]), yet, due to their greater numbers, undocumented infections were the infection source for 79% of documented cases. These findings explain the rapid geographic spread of SARS-CoV2 and indicate containment of this virus will be particularly challenging.
  • Dennis OConnor on 21 Mar 20
     
    Recommended by Jessica Block
Dennis OConnor

CDC - Recommended Guidance for Extended Use and Limited Reuse of N95 Filtering Facepiec... - 0 views

www.cdc.gov/...recommendedguidanceextuse.html

testing covid first-responders safety

shared by Dennis OConnor on 21 Mar 20 - No Cached
  • This document recommends practices for extended use and limited reuse of NIOSH-certified N95 filtering facepiece respirators (commonly called “N95 respirators”). The recommendations are intended for use by professionals who manage respiratory protection programs in healthcare institutions to protect health care workers from job-related risks of exposure to infectious respiratory illnesses.
  • Minimize the number of individuals who need to use respiratory protection through the preferential use of engineering and administrative controls;
  • Use alternatives to N95 respirators (e.g., other classes of filtering facepiece respirators, elastomeric half-mask and full facepiece air purifying respirators, powered air purifying respirators) where feasible;
  • ...5 more annotations...
  • mplement practices allowing extended use and/or limited reuse of N95 respirators, when acceptable; and
  • Prioritize the use of N95 respirators for those personnel at the highest risk of contracting or experiencing complications of infection.
  • Respirator Reuse Recommendations
  • There is no way of determining the maximum possible number of safe reuses for an N95 respirator as a generic number to be applied in all cases. Safe N95 reuse is affected by a number of variables that impact respirator function and contamination over time.
  • Risks of Extended Use and Reuse of Respirators
  • Dennis OConnor on 21 Mar 20
     
    Recommended by Jessica Block
Dennis OConnor

What We Know So Far About SARS-CoV-2 - The Atlantic - 0 views

www.theatlantic.com/...608338

covid research testing

shared by Dennis OConnor on 23 Mar 20 - No Cached
  • March 20, 2020
  • One of the few mercies during this crisis is that, by their nature, individual coronaviruses are easily destroyed.
  • These viruses don’t endure in the world. They need bodies.
  • ...30 more annotations...
  • To be clear, SARS-CoV-2 is not the flu. It causes a disease with different symptoms, spreads and kills more readily,
  • his family, the coronaviruses, includes just six other members that infect humans
  • OC43, HKU1, NL63, and 229E—have been gently annoying humans for more than a century, causing a third of common colds
  • MERS and SARS (or “SARS-classic,” as some virologists have started calling it)—both cause far more severe disease.
  • hy was this seventh coronavirus the one to go pandemic?
  • The structure of the virus provides some clues about its success. In shape, it’s essentially a spiky ball. Those spikes recognize and stick to a protein called ACE2
  • This is the first step to an infection
  • he exact contours of SARS-CoV-2’s spikes allow it to stick far more strongly to ACE2 than SARS-classic did
  • But in SARS-CoV-2, the bridge that connects the two halves can be easily cut by an enzyme called furin, which is made by human cells and—crucially—is found across many tissues. “This is probably important for some of the really unusual things we see in this virus,” says Kristian Andersen of Scripps Research Translational Institute.
  • SARS-CoV-2 seems to infect both upper and lower airways,
  • his double whammy could also conceivably explain why the virus can spread between people before symptoms show up
  • All of this is plausible but totally hypothetical; the virus was only discovered in January, and most of its biology is still a mystery.
  • The closest wild relative of SARS-CoV-2 is found in bats, which suggests it originated in a bat, then jumped to humans either directly or through another species.
  • Another coronavirus found in wild pangolins also resembles SARS-CoV-2
  • Indeed, why some coronaviruses are deadly and some are not is unclear. “There’s really no understanding at all of why SARS or SARS-CoV-2 are so bad but OC43 just gives you a runny nose,” Frieman says.
  • Once in the body, it likely attacks the ACE2-bearing cells that line our airways.
  • The immune system fights back and attacks the virus; this is what causes inflammation and fever
  • in extreme cases, the immune system goes berserk
  • These damaging overreactions are called cytokine storms.
  • they’re probably behind the most severe cases of COVID-19.
  • During a cytokine storm, the immune system isn’t just going berserk but is also generally off its game, attacking at will without hitting the right targets.
  • But why do some people with COVID-19 get incredibly sick, while others escape with mild or nonexistent symptoms
  • Age is a factor.
  • other factors—a person’s genes, the vagaries of their immune system, the amount of virus they’re exposed to, the other microbes in their bodies
  • “it’s a mystery why some people have mild disease, even within the same age group,”
  • Coronaviruses, much like influenza, tend to be winter viruses.
  • In the heat and humidity of summer, both trends reverse, and respiratory viruses struggle to get a foothold.
  • irus is tearing through a world of immunologically naive people, and that vulnerability is likely to swamp any seasonal variations.
  • And one recent modeling study concluded that “SARS-CoV-2 can proliferate at any time of year.
  • Unless people can slow the spread of the virus by sticking to physical-distancing recommendations, the summer alone won’t save us.
  • Dennis OConnor on 23 Mar 20
     
    Dr. Michael Kurisu D.O.: We've known about SARS-CoV-2 for only three months, but scientists can make some educated guesses about where it came from and why it's behaving in such an extreme way.
Dennis OConnor

We need #masks4all - YouTube - 0 views

www.youtube.com/watch

covid data

shared by Dennis OConnor on 29 Mar 20 - No Cached
  • Dennis OConnor on 29 Mar 20
     
    Recommended by Sharon Wampler
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