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Dennis OConnor

Covid-19 Antibody Test, Seen as Key to Reopening Country, Does Not Yet Deliver - The Ne... - 0 views

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    DeAunne Denmark, MD, PhD: "To date, the FDA has granted EUA for only these 4 companies: Cellex, Ortho Clinical Diagnostics, Chembio Diagnostic Systems and the Mount Sinai Laboratory. Really looking forward to the validation and head-to-head comparison data promised here from the FDA, Chan Zuckerberg (supposedly this week?), and others. That should be telling... "
Dennis OConnor

Detect - App Scripps Research - 0 views

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    Download the Mydatahelps app -- "When your heart beats faster than usual, it can mean that you're coming down with a cold, flu, coronavirus, or other viral infection. That's the conclusion of recent medical research. So wearable devices that measure your resting heart rate-made by Apple, Fitbit, Garmin, and others-might help scientists spot viral outbreaks, and also give you more insight into your own health. At Scripps Research, we've designed DETECT (Digital Engagement & Tracking for Early Control & Treatment), a study that will monitor your heart rate and allow you to record symptoms like fever or coughing."
Dennis OConnor

COVID-19 Wearables Data Study | Stanford Healthcare Innovation Lab - 0 views

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    "Join us in our crowdsourced effort to analyze and predict potential COVID-19 cases by donating your wearables data. " This page describes study participation opportunities: Wearables Data Study, Molecular Profiling, and Global Relief Coalition
Dennis OConnor

COVID-19 Coronavirus Data & Resources - 1 views

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    Wolfram is offering free access to their data tools for educators and researchers.
Dennis OConnor

Mimi Guarneri MD Covid-19 Antibody Tests, Immune Support - YouTube - 0 views

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    In this video, Dr. Guarneri explains basic antibody concepts and shares some insights from small N research at Pacific Pearl
Dennis OConnor

Mimi Guarneri: Coronavirus Patient Testing & Care Health Services Flowchart - Pacific P... - 0 views

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    "How Will Coronavirus Patients Flow through Health Services? Many of you have called asking to be tested for Coronavirus. Given recent testing challenges, the CDC and County have provided physicians with a simple coronavirus patient testing & care health services flowchart. As you can see, if symptoms are mild, testing is not indicated at this time. It is my hope that we will soon be able to test everyone! The 211 number mentioned below is a San Diego County information line that helps people efficiently access appropriate services, and provides vital data and trend information. The website for 211 is https://211sandiego.org/"
Dennis OConnor

Can a Wearable Detect Covid-19 Before Symptoms Appear? - WIRED - 0 views

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    This overview article mentions Ben Smarr's work along with Eric Topol's research and a newly launched project from Stanford.
Dennis OConnor

Antibodies and coronavirus immunity: everything we know. - 0 views

  • Antibodies will probably be key to getting us out of this—in one way or another. By Shannon Palus
  • one promising solution is the idea of antibodies and antibody tests.
  • as with everything about the virus, it’s not yet clear what role antibody tests will be able to play in getting us out of this, and it’s even not completely clear how much getting the coronavirus once prevents you from getting it again
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  • What is an antibody?
  • How do I get the anti-coronavirus antibodies?
  • The most basic (and worst) way to get the antibodies is to get the coronavirus.
  • So once you have the antibodies, you are immune against the virus?
  • We can’t count on immunity right now.
  • Wait, but aren’t there people out there who have gotten the novel coronavirus twice, within a short period of time?
  • So if I’ve been sick with COVID-19 already, should I assume I’m immune, or not?
  • OK. Let’s get to the tests. What’s the deal?
  • The fantasy of antibody tests is that they might be deployed to help us determine who can go back to work and school and normal social gatherings.
  • That sounds very promising!
  • even though the tests can provide a guess at immunity, even a positive result cannot guarantee anything.
  • So what are antibody tests actually good for right now?
  • They are tools to gather more data.
  • This is why the National Institutes of Health is currently recruiting 10,000 volunteers to take antibody tests.
  • There’s one clear way that they could help right now on an individual level: We’ve all been asked to basically assume we have the coronavirus; an antibody test could help clarify our own narratives.
  • If you test positive, you can also apply to donate plasma.
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    Recommended by Dr. Michael Kurisu D.O. 4/15/2020 Good summary. Not scientific or too detailed but good overall big picture view
Dennis OConnor

Apple and Google have a clever way of encouraging people to install contact-tracing app... - 0 views

  • Apple and Google surprised us with an announcement that the companies are spinning up a system to enable widespread contact tracing in an effort to contain the COVID-19 pandemic.
  • The basic idea is that as jurisdictions flatten the curve of infection and begin to consider re-opening parts of society, they need to implement a comprehensive “test and trace” scheme.
  • First, the companies said that by phase two of their effort, when contact tracing is enabled at the level of the operating system, they will notify people who have opted in to their potential exposure to COVID-19 even if they have not downloaded the relevant app from their public health authority.
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  • Apple and Google said they recognized the importance of not allowing people to trigger alerts based on unverified claims of a COVID-19 infection. Instead, they said, people who are diagnosed will be given a one-time code by the public health agency, which the newly diagnosed will have to enter to trigger the alert.
  • Google said it would distribute the operating system update through Google Play services, a part of Android controlled by the company that allows it to reach the majority of active devices.
  • Singapore saw only 12 percent adoption of its national contact-tracing app. Putting notifications at the system level represents a major step forward for this effort, even if still requires people to opt in.
  • the companies promised to use the system only for contact tracing, and to dismantle the network when it becomes appropriate.
Dennis OConnor

Free Webinar: How to Be a Statistical Detective - 0 views

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    This is an on-demand webinar. "Statistical errors are all too common in medical literature, and contribute to the reproducibility crisis currently plaguing science. Fortunately, you don't need a degree in statistics to catch these errors. While some errors are impossible to spot without access to the underlying dataset, many are detectable just by reviewing the information available in the paper. In many cases nothing more than common sense and simple arithmetic is required. In addition, there is an ever-increasing number of free, easy-to-use online statistical tools that facilitate error detection."
Dennis OConnor

American Gut by American Gut Project (UC San Diego) - 0 views

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    "The Microsetta Initiative and its subsidiaries, including the American Gut Project, have pivoted to COVID-19 research, and are revising our kits to support this effort. We are working as hard as we can, but please be patient as these changes have required a complete overhaul of our infrastructure. Please check back soon: we are setting up a form to gather information about people who are interested in receiving a kit when they are ready."
Dennis OConnor

Testing ramps up in California - 0 views

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    Source: LA Times 4/8/2020 As of Tuesday, California said it had results for 143,172 tests - or 362 per 100,000 people. That's a sharp increase from two weeks ago when just 39 of every 100,000 residents had been tested. Yet for all its deep sources of innovation, the state is behind the national average of 596 tests per 100,000, according to the COVID Tracking Project. In New York, which has far more people hospitalized with severe symptoms, testing has reached 1,748 of every 100,000.
Dennis OConnor

COVID-19/Coronavirus Real Time Updates With Credible Sources in US and Canada | 1Point3... - 2 views

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    Dr. Michael Kurisu D.O. "This is from a former student at CalIt2 that has a GREAT site connecting people. It has all great interactive data coming in from national sites about COVID Cases. As it says on top... Made with love by first-generation Chinese Americans.. Also has a 'matching' program for hospital that need PPEs and quantity of them AND.. has a matching program for grocery store chains and what they have in stock etc... AND has a 'job posting' arena trying to get people matched up where jobs are available. AWESOME citizen-run project by computer programmers and students… Why oh WHY is our government not running something like this??
Dennis OConnor

Coronavirus Treatment: Hundreds of Scientists Scramble to Find One - The New York Times - 0 views

  • Working at a breakneck pace, a team of hundreds of scientists has identified 50 drugs that may be effective treatments for people infected with the coronavirus.
  • Quantitative Biosciences Institute Coronavirus Research Group
  • Mount Sinai Hospital in New York and at the Pasteur Institute in Paris
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  • no antiviral drug proven to be effective against the virus
  • If the research effort succeeds, it will be a significant scientific achievement: an antiviral identified in just months to treat a virus that no one knew existed until January.
  • Roche Pharma Research and Early Development
  • Quantitative Biosciences Institute
  • Global Health and Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai Hospital.
  • Pasteur Institute in Paris
  • In February, a team of researchers found that remdesivir could eliminate the coronavirus from infected cells. Since then, five clinical trials have begun to see if the drug will be safe and effective against Covid-19 in people.
  • On Saturday, Stanford University researchers reported using the gene-editing technology Crispr to destroy coronavirus genes in infected cells.
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    Recommended by DeAunne Denmark, MD, PhD - Magnificent resource
Dennis OConnor

N-OF-1 RESOURCES Guides, Papers, and Posts on N-of-1 - 0 views

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    DeAunne Denmark, MD, PhD - Magnificent resource N-of-1 guide An interactive explainer on what N-of-1 is and it's purpose.
Dennis OConnor

INGH Institute for Next Generation Healthcare - 0 views

  • We offer an inspirational ecosystem for healthcare professionals, patients, scientists and entrepreneurs determined to close the gap between health and care at a time when the failures of the current healthcare system call for an innovation movement to bring transformational change.
  • All our innovations will have the human experience at heart
  • The Institute for Next Generation Healthcare at Mount Sinai launched an ambitious project called LymeMIND
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    DeAunne Denmark, MD, PhD - OUR CORE PREMISE: To improve health, we must close the gap between what we know and what we do. "INGH has a new facility and venture that is the best I've seen anywhere to get a whole slew of high-resolution data collected in one shot. And supposedly, it is "not that expensive"...
Dennis OConnor

Eric Topol M.D. (@EricTopol) / Twitter - 2 views

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    Recommended by DeAunne Denmark, MD, PhD. Eric Topol's professional background: Gary & Mary West Endowed Chair of Innovative Medicine, Scripps Research Executive VP, Scripps Research Professor, Molecular Medicine, Scripps Research Director & Founder, Scripps Research Translational Institute Department of Molecular Medicine California Campus
Dennis OConnor

The Coronavirus Conundrum: ACE2 and Hypertension Edition - NephJC - 0 views

  • Hypertension and COVID19
  • Are patients with hypertension more likely to get COVID19?For this, we need a well-designed cohort study with incidence rates of COVID19 in patients with hypertension (HT) and those without HT, in which exposure history is able to be carefully accounted for.
  • Amongst the patients with COVID19, it seems the prevalence of prior h/o HT is higher in those who develop severe disease than those who do not.
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  • Hypertension does seem to be a common comorbidity, even more so than diabetes - but these are all data from one country, so one should be careful before generalization.
  • Why might there be a link between high blood pressure and COVID19?As you can read so far, we are not convinced the data show a strong, robust link. However, the virus uses the renin-angiotensin system - hence all the speculation. Read about the science behind the speculation below.
  • Can ARB/ACEi use (and potentially increased ACE2) actually be beneficial in coronavirus and other viral pneumonias?This is an interesting question and has been looked at in both animal model and human studies (retrospective). This study looked at patients (humans) with viral pneumonia and demonstrated an association with improved outcomes in patients with continued ACEi use during viral pneumonia. However, you could argue that patients with viral pneumonia who had continued use of ACEi while hospitalized were not “as sick” as patients in which it was discontinued. 
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    Recommended by DeAunne Denmark, MD, PhD: "... this excellent international society and expert consensus site regarding anti-hypertensives and ACE2, the protein used by both SARS for host cell.
Dennis OConnor

A serological assay to detect SARS-CoV-2 seroconversion in humans | medRxiv - 0 views

  • While molecular assays to directly detect the viral genetic material are available for the diagnosis of acute infection, we currently lack serological assays suitable to specifically detect SARS-CoV-2 antibodies.
  • Methods: Here we describe serological enzyme-linked immunosorbent assays (ELISA) that we developed using recombinant antigens derived from the spike protein of SARS-CoV-2.
  • Conclusion: Serological assays are of critical importance to determine seroprevalence in a given population, define previous exposure and identify highly reactive human donors for the generation of convalescent serum as therapeutic.
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    Recommended by DeAunne Denmark, MD, PhD: This study is under peer review. Published via the medRxiv preprint server for health sciences.
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