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Contents contributed and discussions participated by Dennis OConnor

Dennis OConnor

Qualifying and quantifying the precision medicine rhetoric - 0 views

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    Background With the rise of precision medicine efforts worldwide, our study objective was to describe and map the emerging precision medicine landscape. A Google search was conducted between June 19, 2017 to July 20, 2017 to examine how "precision medicine" and its analogous terminology were used to describe precision medicine efforts. Resulting web-pages were reviewed for geographic location, data type(s), program aim(s), sample size, duration, and the key search terms used and recorded in a database. Descriptive statistics were applied to quantify terminology used to describe specific precision medicine efforts. Qualitative data were analyzed for content and patterns.
Dennis OConnor

Bizarre New Quantum Research: Reality Itself May Be Subjective - 0 views

  • “Schrödinger’s cat” thought experiment.
  • aim was to scientifically prove that measurements in quantum mechanics are actually subjective to a particular observer.
  • Eventually, we succeeded in showing that quantum mechanics might indeed be incompatible with the assumption of objective facts — we violated the inequality!”
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  • quantum observers may indeed be entitled to their own facts
  • these are all deeply philosophical questions about the fundamental nature of reality
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    "Researchers are making a counter-intuitive claim: reality itself may be subjective, thanks to quantum weirdness on a microscopic scale."
Dennis OConnor

Risks and remedies for artificial intelligence in health care - 0 views

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    "A rapidly entering health care and serving major roles, from automating drudgery and routine tasks in medical practice to managing patients and medical resources. As developers create AI systems to take on these tasks, several risks and challenges emerge, including the risk of injuries to patients from AI system errors, the risk to patient privacy of data acquisition and AI inference, and more. Potential solutions are complex but involve investment in infrastructure for high-quality, representative data; collaborative oversight by both the Food and Drug Administration and other health-care actors; and changes to medical education that will prepare providers for shifting roles in an evolving system."
Dennis OConnor

Focus on cardiometabolic disease - 0 views

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    "Nature Medicine and Nature Metabolism present a Focus on the global burden of cardiometabolic diseases. The articles span topics from the basic mechanisms regulating metabolic and cardiovascular functions to clinical practice and the societal impact of these diseases globally."
Dennis OConnor

The Digital Revolution: The Potential Promise and Ethical Perils in Research - 0 views

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    Camille Nebeker* 11/13
Dennis OConnor

I Tried to Get My DNA Back From 23andMe. Here's What Happened. - 0 views

  • I did want to find out what exactly happens to someone’s DNA when they send it to one of these companies, and more importantly, if getting a sample back from them is possible.
  • DNA testing isn’t an exact science
  • I wanted to understand what was happening with my actual genetic information.
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  • I had chosen to “biobank” my sample in case I desired further testing,
  • one of the concerns about 23andMe, as well as other DNA testing services like Ancestry and My Heritage, is that they’re not the ones directly processing your sample.
  • Winston says that when it comes to arbitration, 23andMe goes a bit further than other companies in that there’s a “fee-shifting provision,”
  • basically all of these companies work with pharmaceutical companies in one way or another
  • my DNA has been sold to them if I consented to take part in their research
  • they’re creating a mass database of information that they can now monetize by selling it to pharmaceutical companies
  • “Clearly, their goal is to acquire this information for medical and pharmaceutical purposes.”
  • While they do send aggregated data, there have been cases where individual data has proven to be useful to big companies.
  • if they receive an actual warrant, he doesn’t see how they could refuse
  • While life insurance companies can’t get that data yet, Winston says that they can ask if you’ve taken any such test, which might tell them if you’re predisposed to breast cancer or something like that.
  • their terms of service, also known as their verbal chloroform.
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    "I want it like I never dealt with 23andMe, which, as it turns out, is pretty much impossible - at least for the next decade."
Dennis OConnor

Why we shouldn't have a self-help movement - Lynne McTaggart - 0 views

  • Among the pleasure seekers, the psychologists were amazed to discover high levels of inflammation, considered a marker for degenerative illnesses, and lower levels of gene expression involved in antibody synthesis, the body’s response to outside attack.
  • Those whose lives were not as affluent or stress-free but were purposeful and filled with meaning, on the other hand, had low inflammatory markers and a down regulation of stress-related gene expression, both indicative of rude good health.
  • hoosing a life of meaning over one just chasing pleasure is undeniably better for your health.
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  • “making a connection
  • “a sense of purpose.”
  • The key to a long and healthy life is living a life that concerns itself with a meaning beyond satisfying the needs of number one.
  • The quickest route to rewriting your own life’s script was simply reaching out to someone else.
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    "The unhealthy effects of the good life"
Dennis OConnor

Chronic Pain Eased With Meditation And Lower Doses Of Opioids : Shots - Health News : NPR - 0 views

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    "To deal with chronic pain, Pamela Bobb's morning routine now includes stretching and meditation at home in Fairfield Glade, Tenn. Bobb says this mind-body awareness intervention has greatly reduced the amount of painkiller she needs. Jessica Tezak for NPR" ~ 6 minute listen
Dennis OConnor

Sharon F. Terry is President and CEO of Genetic Alliance - 0 views

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    President and Chief Executive Officer sterry (AT) geneticalliance (DOT) org Biographical Sketch Sharon F. Terry is President and CEO of Genetic Alliance, an enterprise engaging individuals, families and communities to transform health. Genetic Alliance works to provide programs, products and tools for ordinary people to take charge of their health and to further biomedical research.
Dennis OConnor

Why we need a small data paradigm | BMC Medicine | Full Text - 0 views

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    "There is great interest in and excitement about the concept of personalized or precision medicine and, in particular, advancing this vision via various 'big data' efforts. While these methods are necessary, they are insufficient to achieve the full personalized medicine promise. A rigorous, complementary 'small data' paradigm that can function both autonomously from and in collaboration with big data is also needed. By 'small data' we build on Estrin's formulation and refer to the rigorous use of data by and for a specific N-of-1 unit (i.e., a single person, clinic, hospital, healthcare system, community, city, etc.) to facilitate improved individual-level description, prediction and, ultimately, control for that specific unit."
Dennis OConnor

Design and Implementation of Participant-Led Research - Quantified Self - 0 views

  • THE QUANTIFIED SELF is about making personally relevant discoveries using our own self-collected data. We call this practice everyday science, a name that emphasizes its nonprofessional character. Lately we’ve begun organizing small group projects that show how collaboration can make individual projects easier. Sometimes, joining forces with others who share our question can make it possible to create both personal and generalizable health knowledge. Following the scholar Effy Vayena, we use the term “participant-led research” (PLR) to describe this approach.
  • PLR
    • Dennis OConnor
       
      Apollo / Chi gong? Is this our PLR.? Mainly n=1. No collaboration on a mutual research project.
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    THE QUANTIFIED SELF is about making personally relevant discoveries using our own self-collected data. We call this practice everyday science, a name that emphasizes its nonprofessional character. Lately we've begun organizing small group projects that show how collaboration can make individual projects easier. Sometimes, joining forces with others who share our question can make it possible to create both personal and generalizable health knowledge. Following the scholar Effy Vayena, we use the term "participant-led research" (PLR) to describe this approach.
Dennis OConnor

The 17th annual FiRe Conference - 0 views

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    ""The best technology conference in the world." - The Economist REGISTER NOWThe 18th annual Future in Review Conference Oct. 6-9, 2020 - The Lodge at Torrey Pines, La Jolla, CA  A Strategic News Service Presentation"
Dennis OConnor

ŌURA + Helsinki Design Museum - How did you sleep last night? - 1 views

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    "Want to see your sleep data at the Helsinki Design Museum? ŌURA is proud to be participating in "Enter and Encounter", a joint exhibition by Helsinki Design Museum and the Finnish Association of Designers Ornamo. This unique exhibition celebrates contemporary Finnish design and Finland's centenary anniversary. As part of the exhibition, we are happy to invite 100 active ŌURA users to share their sleep data and participate in the media installation "How did you sleep last night?"."
Dennis OConnor

Evidence Based Medicine Explained - YouTube - 1 views

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    "In this Sketchy EBM video, we explore the definition of Evidence-Based Medicine and a few of the risks."
Dennis OConnor

Michael Merzenich: Growing evidence of brain plasticity | TED Talk - 0 views

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    "Neuroscientist Michael Merzenich looks at one of the secrets of the brain's incredible power: its ability to actively re-wire itself. He's researching ways to harness the brain's plasticity to enhance our skills and recover lost function. This talk was presented at an official TED conference, and was featured by our editors on the home page."
Dennis OConnor

Norman Doidge: The Brain That Changes Itself - Full documentary - YouTube - 0 views

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    "The Brain That Changes Itself - Full documentary" Norman Doidge, FRCPC, is a psychiatrist, psychoanalyst, and author of The Brain that Changes Itself and The Brain's Way of Healing.
Dennis OConnor

Empowered Patient Podcast: Overcoming Fear of Aging with Heidi Rataj Documentary Produc... - 1 views

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    "Heidi Rataj is an award-winning documentary producer and director and a caregiver for her mom.  Heidi talks about her own fear of aging and the search for a new narrative for seniors as they age.  While we need to be respectful of all journeys, activating seniors to allow them to accomplish goals is key to a healthier individual and society.  She also points out how digital technology plays a role in coordinating care and enabling people to age in place. @UCSDHealthyAging"
Dennis OConnor

Milasen: The drug that went from idea to injection in 10 months - 0 views

  • itting in freezer at Boston Children’s Hospital is a drug you won’t find anywhere else. It’s called milasen, and the 18 g that the hospital custom-ordered nearly 2 years ago should last for decades. That’s because milasen was designed to treat a single patient—a now 8-year-old girl named Mila Makovec. Milasen was built on decades of work on a class of drugs called antisense oligonucleotides. But after Boston Children’s Hospital scientist Timothy Yu diagnosed Mila with a never-before-seen genetic mutation, he took only 10 months to go from idea to injection. It’s a record-shattering sprint in the typical drug-development marathon, and an unprecedented degree of personalization for a chemical drug.
  • While the story of milasen could be seen as a template for other highly personalized drugs—what the field has come to call n-of-1 therapies—it also raises questions: Who should get these treatments? How will they be funded? And how will the US Food and Drug Administration regulate these projects?
  • Yu was intrigued. He reached out and offered to do whole-genome sequencing on Mila, her parents, and her younger brother.
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  • Mila’s mom, Julia Vitarello, had started a group called Mila’s Miracle Foundation to raise money to develop a gene therapy for her daughter.
  • Julia Vitarello, Mila's mother In March, Yu’s team found that a piece of DNA called a retrotransposon—the genetic remnants of viruses scattered throughout all of our genomes—had spontaneously inserted itself in the middle of a noncoding region of Mila’s CLN7 gene.
  • Black told Yu to renegotiate with the FDA. The 3-month safety study in rats, followed by another couple months to report the data, would take too long. After a letter from Vitarello outlining Mila’s decline, the FDA made a concession: Mila could get the drug after just 1 month of testing, so long as the rat studies continued to 3 months to understand any long-term toxicity.
  • Today, Mila continues to get injections of her drug approximately every 2 months. She used to have up to 30 seizures a day, each lasting more than a minute. Now, she only has a few a day, and they don’t last long,
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    "Sitting in freezer at Boston Children's Hospital is a drug you won't find anywhere else. It's called milasen, and the 18 g that the hospital custom-ordered nearly 2 years ago should last for decades. That's because milasen was designed to treat a single patient-a now 8-year-old girl named Mila Makovec. Milasen was built on decades of work on a class of drugs called antisense oligonucleotides. But after Boston Children's Hospital scientist Timothy Yu diagnosed Mila with a never-before-seen genetic mutation, he took only 10 months to go from idea to injection. It's a record-shattering sprint in the typical drug-development marathon, and an unprecedented degree of personalization for a chemical drug."
Dennis OConnor

Aging Successfully | Conversation | re'flect - 0 views

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    "Gray Matters, the new podcast series, will continue our mission to discuss how we can all age successfully.   re'flect, the documentary series has aired nationally on over 50 PBS stations in over 40 cities and is spreading the positive aging conversation around the US. "
Dennis OConnor

Team | reflect-copy - 1 views

  • HEIDI RATAJ
  • THERESA HOILES
  • PRODUCER, DIRECTOR & SPEAKE
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  • PRODUCER & WRITER
  • What’s more important, quality of life or quantity?”
  • Theresa learned early that age is not an excuse to slow down.
  • Through storytelling, she wants to break the stereotypes associated with aging.
  • This series convinced Heidi that life should be measured in quality not quantity
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    "Gray Matters, the new podcast series, will continue our mission to discuss how we can all age successfully. Heidi Rataj, MA Producer, Gerontologist & Entrepreneur re'flect, the documentary series has aired nationally on over 50 PBS stations in over 40 cities and is spreading the positive aging conversation around the US. "
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